Human Disease Genes with no Mouse Orthologs with hits in the FANTOM2 set

Human
LocusID
number of
FANTOM2
clones
Human
Gene Symbol
Phenotype OMIM GI Human
Chromosomal
Position
Human Gene Name (Disease Name)
305 ACAA1 Pseudo-Zellweger syndrome 604054 6 3p23-p22 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)
313 ACACA Acetyl-CoA carboxylase deficiency 200350 2 17q21 acetyl-Coenzyme A carboxylase alpha
1256 ADH1B Alcoholism, susceptibility to 103720 11 4q21-q23 alcohol dehydrogenase IB (class I), beta polypeptide
5852 BBS4 Bardet-Biedl syndrome 4 600374 3 15q22.3-q23 Bardet-Biedl syndrome 4
6426 BLMH Alzheimer disease, susceptibility to 602403 3 17q11.2 bleomycin hydrolase
7165 C1S C1r/C1s deficiency, combined 120580 5 12p13 complement component 1, s subcomponent
7312 C8A C8 deficiency, type I 120950 3 1p32 complement component 8, alpha polypeptide
12034 CLN5 Ceroid-lipofuscinosis, neuronal-5, variant late infantile 256731 2 13q21.1-q32 ceroid-lipofuscinosis, neuronal 5
15282 CYB5 Methemoglobinemia due to cytochrome b5 deficiency 250790 4 18q23 cytochrome b-5
15403 CYLD Cylindromatosis, familial 605018 6 16q12.1 cylindromatosis (turban tumor syndrome)
155924 CYP2C9 Warfarin sensitivity 601130 6 10q24 cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9
17572 SARDH Sarcosinemia 604455 4 9q33-q34 sarcosine dehydrogenase
18061 DPYD Thymine-uraciluria 274270 6 1p22 dihydropyrimidine dehydrogenase
216212 F13A1 Factor XIIIA deficiency 134570 6 6p25.3-p24.3 coagulation factor XIII, A1 polypeptide
22027 EFEMP1 Doyne honeycomb degeneration of retina 601548 3 2p16 EGF-containing fibulin-like extracellular matrix protein 1
25288 FUT6 Fucosyltransferase-6 deficiency 136836 10 19p13.3 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
279912 GNS Sanfilippo syndrome, type D 252940 2 12q14 glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)
29982 GYS2 Glycogen storage disease, type 0 138571 3 12p12.2 glycogen synthase 2 (liver)
30005 GUCY2D Cone-rod dystrophy 6 600179 4 17p13.1 guanylate cyclase 2D, membrane (retina-specific)
30304 HADHA LCHAD deficiency 600890 5 2p23 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
30324 HADHB Trifunctional protein deficiency, type II 143450 2 2p23 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
303926 HBA1 Thalassemias, alpha- 141800 9 16p13.3 hemoglobin, alpha 1
304846 HBG2 HPFH, nondeletion type G 142250 12 11p15.5 hemoglobin, gamma G
31152 HLA-DPB1 Beryllium disease, chronic, susceptibility to 142858 11 6p21.3 major histocompatibility complex, class II, DP beta 1
35013 IGHG2 IgG2 deficiency, selective 147110 1 14q32.33 immunoglobulin heavy constant gamma 2 (G2m marker)
384816 KRT1 Cyclic ichthyosis with epidermolytic hyperkeratosis 139350 5 12q12-q13 keratin 1 (epidermolytic hyperkeratosis)
385016 KRT3 Meesmann corneal dystrophy 148043 7 12q12-q13 keratin 3
385722 KRT9 Epidermolytic palmoplantar keratoderma 144200 5 17q21.1-q21.2 keratin 9 (epidermolytic palmoplantar keratoderma)
40182 LPA Coronary artery disease, susceptibility to 152200 2 6q26-q27 lipoprotein, Lp(a)
402616 LPP Lipoma 600700 3 3q27-q28 LIM domain containing preferred translocation partner in lipoma
41602 MC4R Obesity, autosomal dominant 155541 3 18q22 melanocortin 4 receptor
42471 MGAT2 Carbohydrate-deficient glycoprotein syndrome, type II 602616 3 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
43062 NR3C2 Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy 600983 3 4q31.1 nuclear receptor subfamily 3, group C, member 2
45521 MTRR Homocystinuria-megaloblastic anemia, cbl E type 602568 6 5p15.3-p15.2 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
47192 NDUFS1 Lactic acidosis due to defect in iron-sulfur cluster of complex I 157655 4 2q33-q34 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
49262 NUMA1 Leukemia, acute promyelocytic, NUMA/RARA type 164009 3 11q13 nuclear mitotic apparatus protein 1
51906 PEX6 Peroxisomal biogenesis disorder, complementation group 6 601498 3 6p21.1 peroxisomal biogenesis factor 6
520518 ATP8B1 Cholestasis, progressive familial intrahepatic-1 602397 3 18q21 ATPase, Class I, type 8B, member 1
53781 PMS1 Colorectal cancer, hereditary nonpolyposis, type 3 600258 2 2q31.1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
55195 PPP2R1B Lung cancer 603113 3 11q23 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform
564413 PRSS1 Pancreatitis, hereditary 276000 4 7q34 protease, serine, 1 (trypsin 1)
63141 SCA7 Spinocerebellar ataxia-7 164500 7 3p21.1-p12 spinocerebellar ataxia 7 (olivopontocerebellar atrophy with retinal degeneration)
63922 SDHD Paragangliomas, familial nonchromaffin, 1, with and without deafness 602690 8 11q23 succinate dehydrogenase complex, subunit D, integral membrane protein
64732 SHOX Short stature, idiopathic familial 400020 7 Xpter-p22.32;Yp11.3 short stature homeobox
66874 SPG7 Spastic paraplegia-7 602783 3 16q24.3 spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive)
678517 ELOVL4 Stargardt disease 3 605512 4 6q14 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
69069 SERPINA7 Euthyroidal hyper- and hypothyroxinemia 314200 5 Xq22.2 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
74011 USH3A Usher syndrome, type 3 606397 3 3q21-q25 Usher syndrome 3A
78401 ALMS1 Alstrom syndrome 606844 3 2p13 Alstrom syndrome 1
80211 NUP214 Leukemia, acute myeloid 114350 3 9q34.1 nucleoporin 214kDa
80506 Lacticacidemia due to PDX1 deficiency 245349 3 11p13 Pyruvate dehydrogenase complex, lipoyl-containing component X; E3-binding protein
80866 AAAS Achalasia-addisonianism-alacrimia syndrome 605378 7 12q13 achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A)
83012 PICALM Leukemia, acute T-cell lymphoblastic 603025 2 11q14 phosphatidylinositol binding clathrin assembly protein
85405 AGPS Rhizomelic chondrodysplasia punctata, type 3 603051 2 2q31 alkylglycerone phosphate synthase
86591 ALDH4A1 Hyperprolinemia, type II 606811 4 1p36 aldehyde dehydrogenase 4 family, member A1
98251 SPATA2 4 20q13.1-q13.2 spermatogenesis associated 2
105942 PRPF8 Retinitis pigmentosa-13 600059 4 17p13.3 PRP8 pre-mRNA processing factor 8 homolog (yeast)
111417 IL1RAPL1 Mental retardation, X-linked 1, non-dysmorphic 300206 3 Xp22.1-p21.3 interleukin 1 receptor accessory protein-like 1
232309 CHAC Choreoacanthocytosis 605978 6 9q21 chorea acanthocytosis
261191 Hypercholesterolemia, familial, autosomal recessive 605747 2 1p36-p35 LDL receptor adaptor protein
575915 MKL1 Megakaryoblastic leukemia, acute 606078 8 22q13 megakaryoblastic leukemia (translocation) 1
605061 NYX Night blindness, congenital stationary, type 1 300278 3 Xp11.4 nyctalopin
641274 CARD15 Crohn disease 605956 5 16q12 caspase recruitment domain family, member 15
651252 PRKWNK1 Pseudohypoaldosteronism, type IIC 605232 5 12p13.3 protein kinase, lysine deficient 1
652661 PRKWNK4 Pseudohypoaldosteronism type II 601844 3 17q21-q22 protein kinase, lysine deficient 4
802071 OPA3 3-methylglutaconicaciduria, type III 606580 3 19q13.32 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
1145488 CIAS1 Muckle-Wells syndrome 606416 8 1q44 cold autoinflammatory syndrome 1
LocusIDs with asterisks(*) are entries that have no proteins.