Coexpression cluster:C3060

Full id: C3060_cord_glioblastoma_Fibroblast_adult_Hair_mesenchymal_Mesenchymal

Phase1 CAGE Peaks

Hg19::chr10:95139640..95139659,-	p@chr10:95139640..95139659 -
Hg19::chr10:95139664..95139690,-	p@chr10:95139664..95139690 -
Hg19::chr10:95139698..95139709,-	p@chr10:95139698..95139709 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
animal cell	3.09e-21	679
eukaryotic cell	3.09e-21	679
non-terminally differentiated cell	1.33e-16	180
mesodermal cell	3.75e-16	119
somatic cell	5.42e-16	591
native cell	4.18e-14	722
embryonic cell	1.14e-13	248
muscle precursor cell	1.77e-10	57
myoblast	1.77e-10	57
multi-potent skeletal muscle stem cell	1.77e-10	57
squamous epithelial cell	1.78e-10	62
fibroblast	6.09e-10	75
muscle cell	2.33e-09	54
contractile cell	3.88e-09	59
mesothelial cell	4.71e-08	19
smooth muscle cell	1.30e-07	42
smooth muscle myoblast	1.30e-07	42
skin fibroblast	1.77e-07	23
lining cell	3.57e-07	57
barrier cell	3.57e-07	57
electrically responsive cell	3.78e-07	60
electrically active cell	3.78e-07	60
vascular associated smooth muscle cell	5.38e-07	32

Uber Anatomy

Ontology term	p-value	n
somite	1.30e-12	83
paraxial mesoderm	1.30e-12	83
presomitic mesoderm	1.30e-12	83
presumptive segmental plate	1.30e-12	83
trunk paraxial mesoderm	1.30e-12	83
presumptive paraxial mesoderm	1.30e-12	83
multilaminar epithelium	1.17e-10	82
dermomyotome	1.74e-10	70
vasculature	5.22e-10	79
vascular system	5.22e-10	79
integument	5.73e-09	45
integumental system	5.73e-09	45
surface structure	1.12e-08	95
skeletal muscle tissue	1.44e-08	61
striated muscle tissue	1.44e-08	61
myotome	1.44e-08	61
skin of body	2.30e-08	40
blood vessel	2.44e-08	60
epithelial tube open at both ends	2.44e-08	60
blood vasculature	2.44e-08	60
vascular cord	2.44e-08	60
musculoskeletal system	5.26e-08	167
artery	7.93e-08	42
arterial blood vessel	7.93e-08	42
arterial system	7.93e-08	42
vessel	8.10e-08	69
muscle tissue	9.69e-08	63
musculature	9.69e-08	63
musculature of body	9.69e-08	63
trunk mesenchyme	1.42e-07	143
mesoderm	2.46e-07	448
mesoderm-derived structure	2.46e-07	448
presumptive mesoderm	2.46e-07	448

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	3	24.3578017923036	6.91705216281876e-05	0.00109855536927103
FOS#2353	3	8.9979553088944	0.00137249927241713	0.00894716007190391
JUN#3725	3	12.5128291923363	0.000510331399272625	0.00443046558675259

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.