MCL coexpression mm9:2692

Phase1 CAGE Peaks

	Short description
Mm9::chr11:59015982..59016031,+	p1@Mrpl55
Mm9::chr1:53370480..53370526,+	p1@Osgepl1
Mm9::chr5:65782762..65782804,+	p1@Lias

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016992	lipoate synthase activity	0.00225977866507979
GO:0017140	lipoic acid synthase activity	0.00225977866507979
GO:0000273	lipoic acid metabolic process	0.00225977866507979
GO:0008450	O-sialoglycoprotein endopeptidase activity	0.00225977866507979
GO:0009107	lipoate biosynthetic process	0.00225977866507979
GO:0009106	lipoate metabolic process	0.00225977866507979
GO:0051538	3 iron, 4 sulfur cluster binding	0.00225977866507979
GO:0009105	lipoic acid biosynthetic process	0.00225977866507979
GO:0016979	lipoate-protein ligase activity	0.00301287313719803
GO:0051539	4 iron, 4 sulfur cluster binding	0.0171583259954854
GO:0051536	iron-sulfur cluster binding	0.0311305298009297
GO:0051540	metal cluster binding	0.0311305298009297
GO:0005739	mitochondrion	0.0311305298009297
GO:0046483	heterocycle metabolic process	0.0424637174339405
GO:0009108	coenzyme biosynthetic process	0.0497947883096622

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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