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Coexpression cluster:C3314: Difference between revisions

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|full_id=C3314_leiomyoma_Endothelial_Renal_Monocytederived_testicular_smallcell_mesenchymal
|full_id=C3314_leiomyoma_Endothelial_Renal_Monocytederived_testicular_smallcell_mesenchymal
|id=C3314
|id=C3314
|ontology_enrichment_celltype=CL:0000066!3.62e-25!254;CL:0002078!6.67e-15!44;CL:0000115!2.25e-14!35;CL:0002321!1.95e-13!248;CL:0000220!5.45e-13!246;CL:0000213!8.55e-13!57;CL:0000215!8.55e-13!57;CL:0002139!1.58e-12!24;CL:0000076!2.17e-10!62;CL:0000071!8.05e-10!18;CL:0002546!8.05e-10!18;CL:0000222!2.00e-07!119;CL:1000449!3.59e-07!16;CL:0002076!4.87e-07!43;CL:0002681!8.46e-07!13;CL:0002584!8.46e-07!13
|ontology_enrichment_celltype=CL:0000066!2.27e-24!253;CL:0002078!1.35e-13!45;CL:0000115!5.76e-13!36;CL:0002321!1.02e-12!250;CL:0000213!1.42e-11!58;CL:0000215!1.42e-11!58;CL:0002139!2.86e-10!24;CL:0000076!1.12e-08!63;CL:1000449!6.42e-08!15;CL:0000071!6.83e-08!18;CL:0002546!6.83e-08!18;CL:0002681!2.17e-07!12;CL:0002584!2.17e-07!12;CL:0000222!3.47e-07!121;CL:1000497!5.74e-07!17;CL:0002518!5.74e-07!17;CL:0002077!7.44e-07!34
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000468!1.06e-23!659;UBERON:0000467!2.14e-21!625;UBERON:0000480!2.39e-21!626;UBERON:0000922!7.87e-21!612;UBERON:0002050!3.14e-18!605;UBERON:0005423!3.14e-18!605;UBERON:0000923!6.10e-18!604;UBERON:0005291!6.10e-18!604;UBERON:0006598!6.10e-18!604;UBERON:0002532!6.10e-18!604;UBERON:0004111!2.83e-16!241;UBERON:0000477!5.01e-16!286;UBERON:0000062!1.35e-12!511;UBERON:0000055!5.72e-11!69;UBERON:0000487!4.55e-10!22;UBERON:0001986!8.05e-10!18;UBERON:0004638!8.05e-10!18;UBERON:0004852!8.05e-10!18;UBERON:0001981!2.42e-09!60;UBERON:0007500!2.42e-09!60;UBERON:0004537!2.42e-09!60;UBERON:0006965!2.42e-09!60;UBERON:0006914!3.31e-09!25;UBERON:0002049!4.18e-09!79;UBERON:0007798!4.18e-09!79;UBERON:0000926!7.25e-09!448;UBERON:0004120!7.25e-09!448;UBERON:0006603!7.25e-09!448;UBERON:0004876!1.01e-08!20;UBERON:0000483!1.17e-08!309;UBERON:0000064!1.20e-08!219;UBERON:0000119!1.30e-08!312;UBERON:0000464!1.34e-08!104;UBERON:0003914!3.00e-08!118;UBERON:0000025!3.32e-08!194;UBERON:0000080!5.87e-08!18;UBERON:0002120!5.87e-08!18;UBERON:0004875!5.87e-08!18;UBERON:0005721!5.87e-08!18;UBERON:0005754!5.87e-08!18;UBERON:0007297!5.87e-08!18;UBERON:0000481!8.27e-08!347;UBERON:0003064!9.11e-08!37;UBERON:0006555!2.36e-07!17;UBERON:0005103!2.36e-07!17;UBERON:0000083!2.36e-07!17;UBERON:0009201!2.36e-07!17;UBERON:0004819!2.36e-07!17;UBERON:0006553!2.36e-07!17;UBERON:0003074!2.36e-07!17;UBERON:0003060!2.36e-07!17;UBERON:0001004!3.10e-07!72;UBERON:0004211!3.59e-07!16;UBERON:0001285!3.59e-07!16;UBERON:0007684!3.59e-07!16;UBERON:0003220!3.59e-07!16;UBERON:0004208!3.59e-07!16;UBERON:0000161!4.04e-07!35;UBERON:0000165!5.14e-07!28;UBERON:0000930!5.14e-07!28;UBERON:0000166!5.41e-07!21;UBERON:0001008!6.54e-07!45;UBERON:0006554!7.08e-07!44;UBERON:0000058!7.77e-07!26;UBERON:0001225!8.46e-07!13;UBERON:0008987!8.46e-07!13;UBERON:0004119!9.08e-07!169;UBERON:0000925!9.08e-07!169;UBERON:0006595!9.08e-07!169
|ontology_enrichment_uberon=UBERON:0000468!2.45e-22!656;UBERON:0000480!1.46e-20!625;UBERON:0000467!1.72e-20!624;UBERON:0000922!4.55e-18!592;UBERON:0000477!7.19e-17!373;UBERON:0005423!2.53e-16!581;UBERON:0004111!1.37e-15!240;UBERON:0002050!2.43e-14!564;UBERON:0000923!4.74e-13!560;UBERON:0010316!4.74e-13!560;UBERON:0005291!4.74e-13!560;UBERON:0006598!4.74e-13!560;UBERON:0010317!4.74e-13!560;UBERON:0002532!4.74e-13!560;UBERON:0000062!2.65e-12!503;UBERON:0000055!8.54e-10!68;UBERON:0000481!2.29e-09!342;UBERON:0000119!2.39e-09!309;UBERON:0000483!2.59e-09!306;UBERON:0000064!8.17e-09!218;UBERON:0007500!2.79e-08!59;UBERON:0001981!2.79e-08!59;UBERON:0004537!2.79e-08!59;UBERON:0006965!2.79e-08!59;UBERON:0000487!3.44e-08!22;UBERON:0002049!3.52e-08!78;UBERON:0007798!3.52e-08!78;UBERON:0006555!4.59e-08!16;UBERON:0004819!4.59e-08!16;UBERON:0004211!6.42e-08!15;UBERON:0009773!6.42e-08!15;UBERON:0001231!6.42e-08!15;UBERON:0001285!6.42e-08!15;UBERON:0007684!6.42e-08!15;UBERON:0004208!6.42e-08!15;UBERON:0004638!6.83e-08!18;UBERON:0001986!6.83e-08!18;UBERON:0004852!6.83e-08!18;UBERON:0003914!7.10e-08!117;UBERON:0000025!7.56e-08!192;UBERON:0006914!1.58e-07!25;UBERON:0001225!2.17e-07!12;UBERON:0008987!2.17e-07!12;UBERON:0001004!4.34e-07!74;UBERON:0004119!5.25e-07!160;UBERON:0000925!5.25e-07!160;UBERON:0006595!5.25e-07!160;UBERON:0000475!7.52e-07!264;UBERON:0000161!7.62e-07!36;UBERON:0000033!8.19e-07!56
|tf_chipseq_enrich=ESR1#2099;3:30.7686032961545:3.43136389821584e-05:0.000674385047357478
|tf_chipseq_enrich=ESR1#2099;3:30.7686032961545:3.43136389821584e-05:0.000674385047357478
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}}
}}

Revision as of 15:00, 19 October 2012


Full id: C3314_leiomyoma_Endothelial_Renal_Monocytederived_testicular_smallcell_mesenchymal



Phase1 CAGE Peaks

Hg19::chr12:6309493..6309505,+p2@CD9
Hg19::chr12:6309517..6309575,+p1@CD9
Hg19::chr12:6344660..6344678,+p@chr12:6344660..6344678
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
multi-cellular organism2.45e-22656
anatomical group1.46e-20625
anatomical system1.72e-20624
embryo4.55e-18592
anatomical cluster7.19e-17373
developing anatomical structure2.53e-16581
anatomical conduit1.37e-15240
embryonic structure2.43e-14564
germ layer4.74e-13560
germ layer / neural crest4.74e-13560
embryonic tissue4.74e-13560
presumptive structure4.74e-13560
germ layer / neural crest derived structure4.74e-13560
epiblast (generic)4.74e-13560
organ2.65e-12503
vessel8.54e-1068
multi-tissue structure2.29e-09342
cell layer2.39e-09309
epithelium2.59e-09306
organ part8.17e-09218
epithelial tube open at both ends2.79e-0859
blood vessel2.79e-0859
blood vasculature2.79e-0859
vascular cord2.79e-0859
simple squamous epithelium3.44e-0822
vasculature3.52e-0878
vascular system3.52e-0878
excretory tube4.59e-0816
kidney epithelium4.59e-0816
nephron epithelium6.42e-0815
renal tubule6.42e-0815
nephron tubule6.42e-0815
nephron6.42e-0815
uriniferous tubule6.42e-0815
nephrogenic mesenchyme6.42e-0815
blood vessel endothelium6.83e-0818
endothelium6.83e-0818
cardiovascular system endothelium6.83e-0818
epithelial tube7.10e-08117
tube7.56e-08192
squamous epithelium1.58e-0725
cortex of kidney2.17e-0712
renal parenchyma2.17e-0712
respiratory system4.34e-0774
endoderm-derived structure5.25e-07160
endoderm5.25e-07160
presumptive endoderm5.25e-07160
organism subdivision7.52e-07264
orifice7.62e-0736
head8.19e-0756


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ESR1#2099330.76860329615453.43136389821584e-050.000674385047357478



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.