Coexpression cluster:C315: Difference between revisions
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{{Coexpression_clusters | 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ion binding!0.0138219499543876!23770;1311;51150;6748;10398$GO:0051043!regulation of membrane protein ectodomain proteolysis!0.01680365693209!7076$GO:0051045!negative regulation of membrane protein ectodomain proteolysis!0.01680365693209!7076$GO:0048513!organ development!0.01680365693209!23770;1311;7076;1134$GO:0005789!endoplasmic reticulum membrane!0.01680365693209!23770;9415;6748$GO:0042175!nuclear envelope-endoplasmic reticulum network!0.01680365693209!23770;9415;6748$GO:0044432!endoplasmic reticulum part!0.0197111800970318!23770;9415;6748$GO:0044446!intracellular organelle part!0.0207947129244736!6141;23770;9415;51150;6748;10398$GO:0044422!organelle part!0.0207947129244736!6141;23770;9415;51150;6748;10398$GO:0003012!muscle system process!0.0207947129244736!1134;10398$GO:0006936!muscle contraction!0.0207947129244736!1134;10398$GO:0048731!system development!0.0207947129244736!23770;1311;7076;1134$GO:0005784!translocon complex!0.0207947129244736!6748$GO:0005796!Golgi lumen!0.0207947129244736!51150$GO:0033559!unsaturated fatty acid metabolic process!0.0207947129244736!9415$GO:0006636!unsaturated fatty acid biosynthetic process!0.0207947129244736!9415$GO:0044444!cytoplasmic part!0.0218859500403191!6141;23770;9415;51150;6748;10398$GO:0043249!erythrocyte maturation!0.0218859500403191!7076$GO:0045861!negative regulation of proteolysis!0.0218859500403191!7076$GO:0031594!neuromuscular junction!0.0249463112312134!1134$GO:0048821!erythrocyte development!0.0277140445166692!7076$GO:0005783!endoplasmic reticulum!0.0310440415863154!23770;9415;6748$GO:0048856!anatomical structure development!0.0311691245971762!23770;1311;7076;1134$GO:0007274!neuromuscular synaptic transmission!0.0311691245971762!1134$GO:0007528!neuromuscular junction development!0.0332421739419477!1134$GO:0030867!rough endoplasmic reticulum membrane!0.0348352846073642!6748$GO:0012505!endomembrane system!0.0348352846073642!23770;9415;6748$GO:0016717!oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water!0.0348352846073642!9415$GO:0033619!membrane protein proteolysis!0.0348352846073642!7076$GO:0005892!nicotinic acetylcholine-gated receptor-channel complex!0.0348352846073642!1134$GO:0006509!membrane protein ectodomain proteolysis!0.0348352846073642!7076$GO:0007224!smoothened signaling pathway!0.0354739566774395!23770$GO:0032501!multicellular organismal process!0.0354739566774395!23770;1311;7076;1134;10398$GO:0007275!multicellular organismal development!0.0354739566774395!23770;1311;7076;1134$GO:0001708!cell fate specification!0.0355904200985641!23770$GO:0030162!regulation of proteolysis!0.0371404727022243!7076$GO:0008191!metalloendopeptidase inhibitor activity!0.0371404727022243!7076$GO:0005791!rough endoplasmic reticulum!0.0371404727022243!6748$GO:0048468!cell development!0.0425221972773797!23770;7076;1134$GO:0015464!acetylcholine receptor activity!0.0435597955985175!1134$GO:0042166!acetylcholine binding!0.0445144965050405!1134$GO:0004889!nicotinic acetylcholine-activated cation-selective channel activity!0.0454231554612994!1134$GO:0005578!proteinaceous extracellular matrix!0.0467722061889542!1311;7076$GO:0005859!muscle myosin complex!0.047114905005606!10398$GO:0016460!myosin II 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| ||
|full_id=C315_Osteoblast_Preadipocyte_mesenchymal_Smooth_Cardiac_leiomyoma_Adipocyte | |||
|id=C315 | |||
}} |
Latest revision as of 11:20, 17 September 2013
Full id: C315_Osteoblast_Preadipocyte_mesenchymal_Smooth_Cardiac_leiomyoma_Adipocyte
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0005509 | calcium ion binding | 0.0138219499543876 |
GO:0051043 | regulation of membrane protein ectodomain proteolysis | 0.01680365693209 |
GO:0051045 | negative regulation of membrane protein ectodomain proteolysis | 0.01680365693209 |
GO:0048513 | organ development | 0.01680365693209 |
GO:0005789 | endoplasmic reticulum membrane | 0.01680365693209 |
GO:0042175 | nuclear envelope-endoplasmic reticulum network | 0.01680365693209 |
GO:0044432 | endoplasmic reticulum part | 0.0197111800970318 |
GO:0044446 | intracellular organelle part | 0.0207947129244736 |
GO:0044422 | organelle part | 0.0207947129244736 |
GO:0003012 | muscle system process | 0.0207947129244736 |
GO:0006936 | muscle contraction | 0.0207947129244736 |
GO:0048731 | system development | 0.0207947129244736 |
GO:0005784 | translocon complex | 0.0207947129244736 |
GO:0005796 | Golgi lumen | 0.0207947129244736 |
GO:0033559 | unsaturated fatty acid metabolic process | 0.0207947129244736 |
GO:0006636 | unsaturated fatty acid biosynthetic process | 0.0207947129244736 |
GO:0044444 | cytoplasmic part | 0.0218859500403191 |
GO:0043249 | erythrocyte maturation | 0.0218859500403191 |
GO:0045861 | negative regulation of proteolysis | 0.0218859500403191 |
GO:0031594 | neuromuscular junction | 0.0249463112312134 |
GO:0048821 | erythrocyte development | 0.0277140445166692 |
GO:0005783 | endoplasmic reticulum | 0.0310440415863154 |
GO:0048856 | anatomical structure development | 0.0311691245971762 |
GO:0007274 | neuromuscular synaptic transmission | 0.0311691245971762 |
GO:0007528 | neuromuscular junction development | 0.0332421739419477 |
GO:0030867 | rough endoplasmic reticulum membrane | 0.0348352846073642 |
GO:0012505 | endomembrane system | 0.0348352846073642 |
GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | 0.0348352846073642 |
GO:0033619 | membrane protein proteolysis | 0.0348352846073642 |
GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | 0.0348352846073642 |
GO:0006509 | membrane protein ectodomain proteolysis | 0.0348352846073642 |
GO:0007224 | smoothened signaling pathway | 0.0354739566774395 |
GO:0032501 | multicellular organismal process | 0.0354739566774395 |
GO:0007275 | multicellular organismal development | 0.0354739566774395 |
GO:0001708 | cell fate specification | 0.0355904200985641 |
GO:0030162 | regulation of proteolysis | 0.0371404727022243 |
GO:0008191 | metalloendopeptidase inhibitor activity | 0.0371404727022243 |
GO:0005791 | rough endoplasmic reticulum | 0.0371404727022243 |
GO:0048468 | cell development | 0.0425221972773797 |
GO:0015464 | acetylcholine receptor activity | 0.0435597955985175 |
GO:0042166 | acetylcholine binding | 0.0445144965050405 |
GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | 0.0454231554612994 |
GO:0005578 | proteinaceous extracellular matrix | 0.0467722061889542 |
GO:0005859 | muscle myosin complex | 0.047114905005606 |
GO:0016460 | myosin II complex | 0.0479035766969372 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
fibroblast | 3.64e-19 | 76 |
contractile cell | 2.98e-17 | 59 |
muscle precursor cell | 2.40e-16 | 58 |
myoblast | 2.40e-16 | 58 |
multi-potent skeletal muscle stem cell | 2.40e-16 | 58 |
muscle cell | 6.86e-16 | 55 |
electrically responsive cell | 1.92e-14 | 61 |
electrically active cell | 1.92e-14 | 61 |
smooth muscle cell | 3.48e-14 | 43 |
smooth muscle myoblast | 3.48e-14 | 43 |
non-terminally differentiated cell | 4.03e-14 | 106 |
multi fate stem cell | 9.27e-13 | 427 |
somatic stem cell | 6.00e-12 | 433 |
stem cell | 1.39e-11 | 441 |
vascular associated smooth muscle cell | 2.02e-10 | 32 |
somatic cell | 3.00e-10 | 588 |
preadipocyte | 1.20e-09 | 12 |
fat cell | 1.48e-07 | 15 |
Ontology term | p-value | n |
---|---|---|
ovarian cancer | 7.78e-07 | 14 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.723937 |
MA0004.1 | 0.473448 |
MA0006.1 | 0.376693 |
MA0007.1 | 2.75326 |
MA0009.1 | 0.340234 |
MA0014.1 | 0.0229062 |
MA0017.1 | 1.11838 |
MA0019.1 | 0.128034 |
MA0024.1 | 0.261871 |
MA0025.1 | 0.448136 |
MA0027.1 | 1.8578 |
MA0028.1 | 0.216725 |
MA0029.1 | 0.275814 |
MA0030.1 | 0.267514 |
MA0031.1 | 0.222414 |
MA0038.1 | 0.341188 |
MA0040.1 | 0.280083 |
MA0041.1 | 0.0671563 |
MA0042.1 | 0.0551182 |
MA0043.1 | 0.34048 |
MA0046.1 | 0.331797 |
MA0048.1 | 0.187755 |
MA0050.1 | 0.203478 |
MA0051.1 | 0.335663 |
MA0052.1 | 0.282917 |
MA0055.1 | 0.0434088 |
MA0056.1 | 0 |
MA0057.1 | 0.979302 |
MA0058.1 | 0.29447 |
MA0059.1 | 0.292272 |
MA0060.1 | 0.263127 |
MA0061.1 | 0.735081 |
MA0063.1 | 0 |
MA0066.1 | 1.15073 |
MA0067.1 | 0.607707 |
MA0068.1 | 0.350743 |
MA0069.1 | 0.328825 |
MA0070.1 | 0.320241 |
MA0071.1 | 1.51648 |
MA0072.1 | 0.84963 |
MA0073.1 | 1.81965 |
MA0074.1 | 3.65336 |
MA0076.1 | 0.13753 |
MA0077.1 | 0.310955 |
MA0078.1 | 0.473318 |
MA0081.1 | 0.292548 |
MA0083.1 | 0.346089 |
MA0084.1 | 0.778769 |
MA0087.1 | 0.314949 |
MA0088.1 | 0.646938 |
MA0089.1 | 0 |
MA0090.1 | 1.87305 |
MA0091.1 | 1.25479 |
MA0092.1 | 0.403964 |
MA0093.1 | 0.634557 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.359565 |
MA0101.1 | 0.391992 |
MA0103.1 | 1.23717 |
MA0105.1 | 1.61194 |
MA0106.1 | 0.125937 |
MA0107.1 | 0.108386 |
MA0108.2 | 0.220346 |
MA0109.1 | 0 |
MA0111.1 | 0.372993 |
MA0113.1 | 0.830796 |
MA0114.1 | 1.19703 |
MA0115.1 | 0.540206 |
MA0116.1 | 0.64523 |
MA0117.1 | 0.369828 |
MA0119.1 | 2.0458 |
MA0122.1 | 0.390603 |
MA0124.1 | 0.504249 |
MA0125.1 | 0.433225 |
MA0130.1 | 0 |
MA0131.1 | 0.16707 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.364077 |
MA0136.1 | 0.108168 |
MA0139.1 | 0.170947 |
MA0140.1 | 0.288493 |
MA0141.1 | 1.22794 |
MA0142.1 | 0.201309 |
MA0143.1 | 0.134991 |
MA0144.1 | 0.0884648 |
MA0145.1 | 0.431123 |
MA0146.1 | 0.649926 |
MA0147.1 | 0.243119 |
MA0148.1 | 0.245107 |
MA0149.1 | 0.276655 |
MA0062.2 | 0.0942332 |
MA0035.2 | 0.287623 |
MA0039.2 | 0.0259269 |
MA0138.2 | 0.156943 |
MA0002.2 | 0.829038 |
MA0137.2 | 0.0905108 |
MA0104.2 | 0.428693 |
MA0047.2 | 0.76306 |
MA0112.2 | 1.59005 |
MA0065.2 | 1.7508 |
MA0150.1 | 0.1453 |
MA0151.1 | 0 |
MA0152.1 | 0.0881336 |
MA0153.1 | 0.419293 |
MA0154.1 | 1.87309 |
MA0155.1 | 0.814432 |
MA0156.1 | 0.0921754 |
MA0157.1 | 0.540861 |
MA0158.1 | 0 |
MA0159.1 | 2.07856 |
MA0160.1 | 0.945152 |
MA0161.1 | 0 |
MA0162.1 | 0.106228 |
MA0163.1 | 2.29611 |
MA0164.1 | 0.437358 |
MA0080.2 | 0.945206 |
MA0018.2 | 0.126682 |
MA0099.2 | 0.0882962 |
MA0079.2 | 0.185244 |
MA0102.2 | 0.813509 |
MA0258.1 | 3.54425 |
MA0259.1 | 0.451002 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.