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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 12:03, 17 September 2013


Full id: C2320_neuroblastoma_cerebellum_retinoblastoma_pituitary_rectum_putamen_pineal



Phase1 CAGE Peaks

Hg19::chr14:89259135..89259181,-p2@EML5
Hg19::chr14:89259211..89259225,-p3@EML5
Hg19::chr14:89259247..89259263,-p6@EML5
Hg19::chr14:89259268..89259310,-p1@EML5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
lymphoid lineage restricted progenitor cell6.64e-0752
Uber Anatomy
Ontology termp-valuen
adult organism2.78e-36114
neural tube2.06e-3356
neural rod2.06e-3356
future spinal cord2.06e-3356
neural keel2.06e-3356
regional part of nervous system3.63e-3153
regional part of brain3.63e-3153
central nervous system5.38e-2781
nervous system5.43e-2789
regional part of forebrain7.28e-2741
forebrain7.28e-2741
anterior neural tube7.28e-2741
future forebrain7.28e-2741
brain6.03e-2568
future brain6.03e-2568
neural plate8.80e-2582
presumptive neural plate8.80e-2582
neurectoderm3.00e-2386
brain grey matter1.57e-2134
gray matter1.57e-2134
telencephalon2.22e-2134
cerebral hemisphere2.80e-2032
regional part of telencephalon5.27e-2032
pre-chordal neural plate9.18e-2061
ecto-epithelium3.32e-18104
regional part of cerebral cortex5.71e-1822
neocortex2.73e-1620
cerebral cortex9.58e-1525
pallium9.58e-1525
organ system subdivision3.87e-14223
structure with developmental contribution from neural crest2.84e-13132
ectoderm-derived structure3.65e-13171
ectoderm3.65e-13171
presumptive ectoderm3.65e-13171
neural nucleus2.06e-089
nucleus of brain2.06e-089
basal ganglion3.27e-089
nuclear complex of neuraxis3.27e-089
aggregate regional part of brain3.27e-089
collection of basal ganglia3.27e-089
cerebral subcortex3.27e-089
posterior neural tube8.57e-0815
chordal neural plate8.57e-0815
diencephalon5.48e-077
future diencephalon5.48e-077
telencephalic nucleus6.73e-077


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.8989
MA0004.10.71247
MA0006.12.26728
MA0007.10.6918
MA0009.11.20602
MA0014.13.08565
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.791759
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.11.29536
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.11.25938
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.21.5472
MA0138.20.928035
MA0002.21.75253
MA0137.20.558189
MA0104.21.01696
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.14.24646
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.23.12283
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90546.336201576962630.0006203100587215640.00511645571180078
CTCF#1066445.360256373075030.001211145381643620.00816333091406765
E2F1#186944.907389214879320.001724022357361790.0106377863039411
EGR1#195844.988179094810140.001615011500076050.0101346022986507
HMGN3#932448.178547723350590.0002234570284440470.00247877096055952
RAD21#5885410.35503389545638.6948481184721e-050.00129172296251082
REST#597837.237521537096020.004104697304192610.0195766956686716
TAF1#687243.343046285745290.008005664898701650.0321714431627035
ZBTB7A#5134147.35190930787590.000342223540015990.00346164496810944



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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