MCL coexpression mm9:1173: Difference between revisions
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{{MCL_coexpression_mm9| | 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disc;0.0336303655618914;13346!GO:0005924;cell-substrate adherens junction;0.0336303655618914;20411!GO:0031674;I band;0.0336303655618914;13346!GO:0045121;lipid raft;0.0336303655618914;20411!GO:0030055;cell-matrix junction;0.0336303655618914;20411!GO:0005856;cytoskeleton;0.0350829367583903;20411,13346!GO:0007015;actin filament organization;0.0350829367583903;20411!GO:0004702;receptor signaling protein serine/threonine kinase activity;0.0373363523487017;65964!GO:0019901;protein kinase binding;0.0373363523487017;20411!GO:0032403;protein complex binding;0.0373363523487017;20411!GO:0019900;kinase binding;0.0373363523487017;20411!GO:0005912;adherens junction;0.040279051340258;20411!GO:0008643;carbohydrate transport;0.040279051340258;20411!GO:0007160;cell-matrix adhesion;0.040279051340258;20411!GO:0006996;organelle organization and biogenesis;0.040279051340258;20411,65964!GO:0030017;sarcomere;0.040279051340258;13346!GO:0031589;cell-substrate adhesion;0.040279051340258;20411!GO:0044449;contractile fiber part;0.040279051340258;13346!GO:0016323;basolateral plasma membrane;0.040279051340258;20411!GO:0030016;myofibril;0.0418958932992277;13346!GO:0043292;contractile fiber;0.0418958932992277;13346!GO:0005057;receptor signaling protein activity;0.0453981741645729;65964!GO:0005200;structural constituent of cytoskeleton;0.0453981741645729;13346!|ontology_enrichment_celltype=|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0007100!8.06e-10!18;UBERON:0000948!8.06e-10!18;UBERON:0005498!8.06e-10!18;UBERON:0004140!8.06e-10!18;UBERON:0009881!8.06e-10!18;UBERON:0004141!8.06e-10!18;UBERON:0003084!8.06e-10!18;UBERON:0007005!8.06e-10!18;UBERON:0004139!8.06e-10!18;UBERON:0004291!8.06e-10!18;UBERON:0004872!1.79e-09!33;UBERON:0004535!1.35e-07!23;UBERON:0001009!1.35e-07!23|tfbs_overrepresentation_for_novel_motifs=0.438063,0.161863,1.05921,0.480627,0.810002,0.495263,0.587291,0.594722,1.15776,0.478312,0.542749,0.575086,0.59526,0.599731,0.315771,0,0.795315,0.291368,1.06769,0.731589,0.374752,0.586604,0.598814,0.29769,0.419327,0.62766,0.184473,0.516511,0.911169,0.446946,0.50223,0.897561,0.78719,0.498917,0.316253,0.468714,0.766323,0.57142,0.717242,0.652422,0.800988,0.507468,0.54842,0.317766,0.277561,0.469348,0.714592,0.532496,0.219744,0.347313,0.777641,0.654933,0.431711,1.04034,1.0579,0.606984,0.356236,0.56214,1.00328,0.604914,0.877332,0.664501,0.226529,0.766235,0.618279,0.807219,1.19497,1.54543,0.872612,1.39786,0.392734,1.14464,0.611537,1.09164,0.17012,0.159969,0.166511,0.703064,0.859987,0.98764,0.212973,0.812889,0.663039,0.580284,0.975495,0.146394,0.164297,0.447265,0.719558,1.70793,1.26498,0.980512,0.910485,0.305079,0.708155,0.237542,0.589174,0.913319,0.71485,0.79664,0.7665,0.897279,1.02279,0.778243,0.777175,0.507021,0.837607,0.528416,0.383871,0.376549,0.430942,1.02459,0.380122,0.547992,1.27206,0.293461,0.735764,2.10934,0.796633,0.757997,1.09707,0.745011,0.629509,0.702145,1.32639,0.863723,0.595563,0.903645,1.19345,0.308038,1.00568,0.473246,1.16374,0.620831,1.29374,0.275843,0.446555,0.508896,1.24438,2.07659,1.67603,1.19971,0.641722,0.908128,0.770616,0.507927,0.717753,2.03691,0.448938,0.300961,0.147909,0.927167,1.04192,0.243291,0.619892,1.12411,0.655955,0.874089,1.11101,0.446272,1.25393,0.974632,0.864173,1.09603,0.767269,0.612377,0.278874,0.573477,1.42871|tfbs_overrepresentation_jaspar=MA0003.1;0.339775,MA0004.1;0.481116,MA0006.1;0.311391,MA0007.1;0.465969,MA0009.1;0.92425,MA0014.1;0.0886247,MA0017.1;0.337808,MA0019.1;0.740036,MA0024.1;0.880057,MA0025.1;1.15921,MA0027.1;2.57545,MA0028.1;0.321735,MA0029.1;0.858105,MA0030.1;0.864739,MA0031.1;0.828781,MA0038.1;0.62758,MA0040.1;0.936879,MA0041.1;0.404721,MA0042.1;0.391504,MA0043.1;1.02178,MA0046.1;0.960497,MA0048.1;0.40238,MA0050.1;0.520357,MA0051.1;0.636645,MA0052.1;0.945011,MA0055.1;0.648475,MA0056.1;0,MA0057.1;0.117936,MA0058.1;0.384683,MA0059.1;0.397033,MA0060.1;1.22438,MA0061.1;0.261749,MA0063.1;0,MA0066.1;1.49567,MA0067.1;1.27078,MA0068.1;0.385183,MA0069.1;0.945354,MA0070.1;0.93557,MA0071.1;0.519509,MA0072.1;0.927016,MA0073.1;0.00782298,MA0074.1;0.580087,MA0076.1;0.356883,MA0077.1;0.905143,MA0078.1;0.670113,MA0081.1;0.420276,MA0083.1;1.02098,MA0084.1;1.59945,MA0087.1;0.977537,MA0088.1;0.0841779,MA0089.1;0,MA0090.1;0.446539,MA0091.1;0.494398,MA0092.1;0.446857,MA0093.1;0.329976,MA0095.1;0,MA0098.1;0,MA0100.1;0.568369,MA0101.1;0.406019,MA0103.1;0.348572,MA0105.1;0.162418,MA0106.1;0.677988,MA0107.1;0.342432,MA0108.2;0.763162,MA0109.1;0,MA0111.1;0.460823,MA0113.1;0.649407,MA0114.1;0.259463,MA0115.1;1.0246,MA0116.1;0.311187,MA0117.1;0.992087,MA0119.1;0.40661,MA0122.1;1.01209,MA0124.1;1.21735,MA0125.1;1.14291,MA0130.1;0,MA0131.1;0.735438,MA0132.1;0,MA0133.1;0,MA0135.1;1.05845,MA0136.1;0.600242,MA0139.1;0.585936,MA0140.1;0.568252,MA0141.1;0.964041,MA0142.1;0.814115,MA0143.1;0.665982,MA0144.1;1.33652,MA0145.1;0.631666,MA0146.1;0.108739,MA0147.1;0.274511,MA0148.1;1.24416,MA0149.1;0.411562,MA0062.2;0.167299,MA0035.2;0.573016,MA0039.2;0.790799,MA0138.2;0.727395,MA0002.2;0.592533,MA0137.2;0.365364,MA0104.2;0.218974,MA0047.2;0.626803,MA0112.2;0.304722,MA0065.2;0.633155,MA0150.1;0.465855,MA0151.1;0,MA0152.1;0.626912,MA0153.1;1.07519,MA0154.1;0.397336,MA0155.1;0.687925,MA0156.1;0.356017,MA0157.1;0.781683,MA0158.1;0,MA0159.1;1.4173,MA0160.1;0.50056,MA0161.1;0,MA0162.1;0.127623,MA0163.1;0.82914,MA0164.1;1.46244,MA0080.2;0.343316,MA0018.2;0.610433,MA0099.2;0.721008,MA0079.2;0.0190804,MA0102.2;1.65195,MA0258.1;0.246285,MA0259.1;0.26402,MA0442.1;0}} | ||
Latest revision as of 16:30, 17 September 2013
Phase1 CAGE Peaks
| Short description | |
|---|---|
| Mm9::chr19:40439533..40439550,- | p@chr19:40439533..40439550 - |
| Mm9::chr19:40588204..40588282,- | p1@Sorbs1 |
| Mm9::chr1:75356896..75356913,+ | p1@Des |
| Mm9::chr1:75358757..75358798,- | p@chr1:75358757..75358798 - |
| Mm9::chr1:75363386..75363422,- | p@chr1:75363386..75363422 - |
| Mm9::chr1:75363702..75363741,+ | p@chr1:75363702..75363741 + |
| Mm9::chr2:72135952..72135969,+ | p9@B230120H23Rik |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0043149 | stress fiber formation | 0.0336303655618914 |
| GO:0048041 | focal adhesion formation | 0.0336303655618914 |
| GO:0007010 | cytoskeleton organization and biogenesis | 0.0336303655618914 |
| GO:0005626 | insoluble fraction | 0.0336303655618914 |
| GO:0051017 | actin filament bundle formation | 0.0336303655618914 |
| GO:0005158 | insulin receptor binding | 0.0336303655618914 |
| GO:0044430 | cytoskeletal part | 0.0336303655618914 |
| GO:0004709 | MAP kinase kinase kinase activity | 0.0336303655618914 |
| GO:0001725 | stress fiber | 0.0336303655618914 |
| GO:0032432 | actin filament bundle | 0.0336303655618914 |
| GO:0008286 | insulin receptor signaling pathway | 0.0336303655618914 |
| GO:0005913 | cell-cell adherens junction | 0.0336303655618914 |
| GO:0015758 | glucose transport | 0.0336303655618914 |
| GO:0008645 | hexose transport | 0.0336303655618914 |
| GO:0042383 | sarcolemma | 0.0336303655618914 |
| GO:0015749 | monosaccharide transport | 0.0336303655618914 |
| GO:0030018 | Z disc | 0.0336303655618914 |
| GO:0005924 | cell-substrate adherens junction | 0.0336303655618914 |
| GO:0031674 | I band | 0.0336303655618914 |
| GO:0045121 | lipid raft | 0.0336303655618914 |
| GO:0030055 | cell-matrix junction | 0.0336303655618914 |
| GO:0005856 | cytoskeleton | 0.0350829367583903 |
| GO:0007015 | actin filament organization | 0.0350829367583903 |
| GO:0004702 | receptor signaling protein serine/threonine kinase activity | 0.0373363523487017 |
| GO:0019901 | protein kinase binding | 0.0373363523487017 |
| GO:0032403 | protein complex binding | 0.0373363523487017 |
| GO:0019900 | kinase binding | 0.0373363523487017 |
| GO:0005912 | adherens junction | 0.040279051340258 |
| GO:0008643 | carbohydrate transport | 0.040279051340258 |
| GO:0007160 | cell-matrix adhesion | 0.040279051340258 |
| GO:0006996 | organelle organization and biogenesis | 0.040279051340258 |
| GO:0030017 | sarcomere | 0.040279051340258 |
| GO:0031589 | cell-substrate adhesion | 0.040279051340258 |
| GO:0044449 | contractile fiber part | 0.040279051340258 |
| GO:0016323 | basolateral plasma membrane | 0.040279051340258 |
| GO:0030016 | myofibril | 0.0418958932992277 |
| GO:0043292 | contractile fiber | 0.0418958932992277 |
| GO:0005057 | receptor signaling protein activity | 0.0453981741645729 |
| GO:0005200 | structural constituent of cytoskeleton | 0.0453981741645729 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| primary circulatory organ | 8.06e-10 | 18 |
| heart | 8.06e-10 | 18 |
| primitive heart tube | 8.06e-10 | 18 |
| primary heart field | 8.06e-10 | 18 |
| anterior lateral plate mesoderm | 8.06e-10 | 18 |
| heart tube | 8.06e-10 | 18 |
| heart primordium | 8.06e-10 | 18 |
| cardiac mesoderm | 8.06e-10 | 18 |
| cardiogenic plate | 8.06e-10 | 18 |
| heart rudiment | 8.06e-10 | 18 |
| splanchnic layer of lateral plate mesoderm | 1.79e-09 | 33 |
| cardiovascular system | 1.35e-07 | 23 |
| circulatory system | 1.35e-07 | 23 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.339775 |
| MA0004.1 | 0.481116 |
| MA0006.1 | 0.311391 |
| MA0007.1 | 0.465969 |
| MA0009.1 | 0.92425 |
| MA0014.1 | 0.0886247 |
| MA0017.1 | 0.337808 |
| MA0019.1 | 0.740036 |
| MA0024.1 | 0.880057 |
| MA0025.1 | 1.15921 |
| MA0027.1 | 2.57545 |
| MA0028.1 | 0.321735 |
| MA0029.1 | 0.858105 |
| MA0030.1 | 0.864739 |
| MA0031.1 | 0.828781 |
| MA0038.1 | 0.62758 |
| MA0040.1 | 0.936879 |
| MA0041.1 | 0.404721 |
| MA0042.1 | 0.391504 |
| MA0043.1 | 1.02178 |
| MA0046.1 | 0.960497 |
| MA0048.1 | 0.40238 |
| MA0050.1 | 0.520357 |
| MA0051.1 | 0.636645 |
| MA0052.1 | 0.945011 |
| MA0055.1 | 0.648475 |
| MA0056.1 | 0 |
| MA0057.1 | 0.117936 |
| MA0058.1 | 0.384683 |
| MA0059.1 | 0.397033 |
| MA0060.1 | 1.22438 |
| MA0061.1 | 0.261749 |
| MA0063.1 | 0 |
| MA0066.1 | 1.49567 |
| MA0067.1 | 1.27078 |
| MA0068.1 | 0.385183 |
| MA0069.1 | 0.945354 |
| MA0070.1 | 0.93557 |
| MA0071.1 | 0.519509 |
| MA0072.1 | 0.927016 |
| MA0073.1 | 0.00782298 |
| MA0074.1 | 0.580087 |
| MA0076.1 | 0.356883 |
| MA0077.1 | 0.905143 |
| MA0078.1 | 0.670113 |
| MA0081.1 | 0.420276 |
| MA0083.1 | 1.02098 |
| MA0084.1 | 1.59945 |
| MA0087.1 | 0.977537 |
| MA0088.1 | 0.0841779 |
| MA0089.1 | 0 |
| MA0090.1 | 0.446539 |
| MA0091.1 | 0.494398 |
| MA0092.1 | 0.446857 |
| MA0093.1 | 0.329976 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.568369 |
| MA0101.1 | 0.406019 |
| MA0103.1 | 0.348572 |
| MA0105.1 | 0.162418 |
| MA0106.1 | 0.677988 |
| MA0107.1 | 0.342432 |
| MA0108.2 | 0.763162 |
| MA0109.1 | 0 |
| MA0111.1 | 0.460823 |
| MA0113.1 | 0.649407 |
| MA0114.1 | 0.259463 |
| MA0115.1 | 1.0246 |
| MA0116.1 | 0.311187 |
| MA0117.1 | 0.992087 |
| MA0119.1 | 0.40661 |
| MA0122.1 | 1.01209 |
| MA0124.1 | 1.21735 |
| MA0125.1 | 1.14291 |
| MA0130.1 | 0 |
| MA0131.1 | 0.735438 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.05845 |
| MA0136.1 | 0.600242 |
| MA0139.1 | 0.585936 |
| MA0140.1 | 0.568252 |
| MA0141.1 | 0.964041 |
| MA0142.1 | 0.814115 |
| MA0143.1 | 0.665982 |
| MA0144.1 | 1.33652 |
| MA0145.1 | 0.631666 |
| MA0146.1 | 0.108739 |
| MA0147.1 | 0.274511 |
| MA0148.1 | 1.24416 |
| MA0149.1 | 0.411562 |
| MA0062.2 | 0.167299 |
| MA0035.2 | 0.573016 |
| MA0039.2 | 0.790799 |
| MA0138.2 | 0.727395 |
| MA0002.2 | 0.592533 |
| MA0137.2 | 0.365364 |
| MA0104.2 | 0.218974 |
| MA0047.2 | 0.626803 |
| MA0112.2 | 0.304722 |
| MA0065.2 | 0.633155 |
| MA0150.1 | 0.465855 |
| MA0151.1 | 0 |
| MA0152.1 | 0.626912 |
| MA0153.1 | 1.07519 |
| MA0154.1 | 0.397336 |
| MA0155.1 | 0.687925 |
| MA0156.1 | 0.356017 |
| MA0157.1 | 0.781683 |
| MA0158.1 | 0 |
| MA0159.1 | 1.4173 |
| MA0160.1 | 0.50056 |
| MA0161.1 | 0 |
| MA0162.1 | 0.127623 |
| MA0163.1 | 0.82914 |
| MA0164.1 | 1.46244 |
| MA0080.2 | 0.343316 |
| MA0018.2 | 0.610433 |
| MA0099.2 | 0.721008 |
| MA0079.2 | 0.0190804 |
| MA0102.2 | 1.65195 |
| MA0258.1 | 0.246285 |
| MA0259.1 | 0.26402 |
| MA0442.1 | 0 |
