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{{CL
{{CL
|id=CL:0000097
|alt_id=
|name=mast cell
|namespace=cell;;efo
|def="A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A.11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811]
|xref=BTO:0000830;;FMA:66784
|is_a=CL:0000766;;CL:0002274
|synonym="histaminocyte" EXACT [];;"labrocyte" EXACT [ISBN:0721601464];;"mastocyte" EXACT [ISBN:0721601464];;"tissue basophil" RELATED [ISBN:068340007X]
|comment=Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
|comment=Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A.11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811]
|subset=
|derives_from=
|derives_from=
|develops_from=CL:0000831
|develops_from=CL:0000831
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000097
|is_a=CL:0000766 ;;CL:0002274
|is_obsolete=
|located_in=
|located_in=
|name=mast cell
|namespace=cell;;efo
|obo_creation_date=
|part_of=
|part_of=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="histaminocyte" EXACT [];;"labrocyte" EXACT [ISBN:0721601464];;"mastocyte" EXACT [ISBN:0721601464];;"tissue basophil" RELATED [ISBN:068340007X]
|union_of=
|xref=BTO:0000830;;FMA:66784
}}
}}

Revision as of 10:13, 12 September 2014

Name:mast cell
Namespace:cell;;efo
Definition:"A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A.11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811]
Xrefs:
links:

BTO:0000830

FMA:66784
Synonyms: "histaminocyte" EXACT []
"labrocyte" EXACT [ISBN:0721601464]
"mastocyte" EXACT [ISBN:0721601464]
"tissue basophil" RELATED [ISBN:068340007X]
Comments:Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000766(myeloid leukocyte),CL:0002274(histamine secreting cell)
develops_from:CL:0000831(mast cell progenitor)



Children


derives from:FF:0000260 (mast cell sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000097 (mast cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
2.45e-195FFCP PHASE2:Hg19::chr3:148583254..148583275,+#_c72160135251738249757a8bab1f5009p@chr3:148583254..148583275, +
2.45e-195FFCP PHASE2:Hg19::chr2:102922332..102922360,+#_c72160135251738249757a8bab1f5009p@chr2:102922332..102922360, +
2.45e-195FFCP PHASE1:Hg19::chr3:14425446..14425450,+#_c72160135251738249757a8bab1f5009p@chr3:14425446..14425450, +
2.45e-195FFCP PHASE2:Hg19::chr4:95261065..95261071,+#_c72160135251738249757a8bab1f5009p@chr4:95261065..95261071, +
2.45e-195FFCP PHASE1:Hg19::chr2:160085182..160085196,+#_c72160135251738249757a8bab1f5009p@chr2:160085182..160085196, +
2.45e-195FFCP PHASE1:Hg19::chr16:1280084..1280116,-#_c72160135251738249757a8bab1f5009p2@TPSB2
2.45e-195FFCP PHASE2:Hg19::chr4:55406116..55406147,+#_c72160135251738249757a8bab1f5009p@chr4:55406116..55406147, +
2.45e-195FFCP PHASE2:Hg19::chr5:108071789..108071807,+#_c72160135251738249757a8bab1f5009p@chr5:108071789..108071807, +
2.45e-195FFCP PHASE2:Hg19::chr14:24042158..24042170,-#_c72160135251738249757a8bab1f5009p18@JPH4
2.45e-195FFCP PHASE1:Hg19::chrX:100617644..100617655,-#_c72160135251738249757a8bab1f5009p5@BTK
2.45e-195FFCP PHASE2:Hg19::chr7:106372896..106372907,-#_c72160135251738249757a8bab1f5009p3@ENST00000490856
2.45e-195FFCP PHASE2:Hg19::chr15:69612281..69612294,-#_c72160135251738249757a8bab1f5009p@chr15:69612281..69612294, -
2.45e-195FFCP PHASE1:Hg19::chr11:59855794..59855805,+#_c72160135251738249757a8bab1f5009p5@MS4A2
2.45e-195FFCP PHASE2:Hg19::chr2:160085182..160085196,+#_c72160135251738249757a8bab1f5009p@chr2:160085182..160085196, +
2.45e-195FFCP PHASE1:Hg19::chr11:123985831..123985858,+#_c72160135251738249757a8bab1f5009p2@VWA5A
2.45e-195FFCP PHASE2:Hg19::chr3:148601435..148601446,+#_c72160135251738249757a8bab1f5009p@chr3:148601435..148601446, +
2.45e-195FFCP PHASE1:Hg19::chr10:131653288..131653294,-#_c72160135251738249757a8bab1f5009p@chr10:131653288..131653294, -
2.45e-195FFCP PHASE1:Hg19::chr15:69612281..69612294,-#_c72160135251738249757a8bab1f5009p@chr15:69612281..69612294, -
2.45e-195FFCP PHASE2:Hg19::chr19:56673770..56673786,-#_c72160135251738249757a8bab1f5009p@chr19:56673770..56673786, -
2.45e-195FFCP PHASE1:Hg19::chr4:55523948..55523989,+#_c72160135251738249757a8bab1f5009p3@KIT
2.45e-195FFCP PHASE2:Hg19::chr19:7923338..7923341,-#_c72160135251738249757a8bab1f5009p@chr19:7923338..7923341, -
2.45e-195FFCP PHASE1:Hg19::chr19:56673816..56673830,-#_c72160135251738249757a8bab1f5009p@chr19:56673816..56673830, -
2.45e-195FFCP PHASE1:Hg19::chr14:24042158..24042170,-#_c72160135251738249757a8bab1f5009p18@JPH4
2.45e-195FFCP PHASE1:Hg19::chrX:29959760..29959772,+#_c72160135251738249757a8bab1f5009p@chrX:29959760..29959772, +
2.45e-195FFCP PHASE2:Hg19::chr19:51961061..51961069,-#_c72160135251738249757a8bab1f5009p@chr19:51961061..51961069, -
2.45e-195FFCP PHASE1:Hg19::chr1:203732858..203732876,-#_c72160135251738249757a8bab1f5009p@chr1:203732858..203732876, -
2.45e-195FFCP PHASE1:Hg19::chr7:106372896..106372907,-#_c72160135251738249757a8bab1f5009p3@ENST00000490856
2.45e-195FFCP PHASE1:Hg19::chr11:59857223..59857242,+#_c72160135251738249757a8bab1f5009p@chr11:59857223..59857242, +
2.45e-195FFCP PHASE1:Hg19::chr11:123988337..123988344,+#_c72160135251738249757a8bab1f5009p@chr11:123988337..123988344, +
2.45e-195FFCP PHASE1:Hg19::chr5:108071574..108071598,-#_c72160135251738249757a8bab1f5009p@chr5:108071574..108071598, -
2.45e-195FFCP PHASE2:Hg19::chr15:50556017..50556029,-#_c72160135251738249757a8bab1f5009p3@HDC
2.45e-195FFCP PHASE1:Hg19::chr2:202655190..202655199,+#_c72160135251738249757a8bab1f5009p14@CDK15
2.45e-195FFCP PHASE2:Hg19::chr15:42221779..42221787,+#_c72160135251738249757a8bab1f5009p@chr15:42221779..42221787, +
2.45e-195FFCP PHASE2:Hg19::chr11:123967181..123967213,-#_c72160135251738249757a8bab1f5009p@chr11:123967181..123967213, -
2.45e-195FFCP PHASE2:Hg19::chr1:20513747..20513758,-#_c72160135251738249757a8bab1f5009p@chr1:20513747..20513758, -
2.45e-195FFCP PHASE1:Hg19::chr6:16547983..16547995,-#_c72160135251738249757a8bab1f5009p@chr6:16547983..16547995, -
2.45e-195FFCP PHASE1:Hg19::chr15:42221779..42221787,+#_c72160135251738249757a8bab1f5009p@chr15:42221779..42221787, +
2.45e-195FFCP PHASE2:Hg19::chr4:175501777..175501788,-#_c72160135251738249757a8bab1f5009p@chr4:175501777..175501788, -
2.45e-195FFCP PHASE1:Hg19::chr15:50556017..50556029,-#_c72160135251738249757a8bab1f5009p3@HDC
2.45e-195FFCP PHASE2:Hg19::chr1:247737511..247737525,+#_c72160135251738249757a8bab1f5009p@chr1:247737511..247737525, +
2.45e-195FFCP PHASE2:Hg19::chr4:80665456..80665463,-#_c72160135251738249757a8bab1f5009p@chr4:80665456..80665463, -
2.45e-195FFCP PHASE2:Hg19::chr7:106372908..106372919,-#_c72160135251738249757a8bab1f5009p2@ENST00000490856
2.45e-195FFCP PHASE2:Hg19::chr2:202655190..202655199,+#_c72160135251738249757a8bab1f5009p14@CDK15
2.45e-195FFCP PHASE1:Hg19::chr11:47175922..47175952,+#_c72160135251738249757a8bab1f5009p3@C11orf49
2.45e-195FFCP PHASE2:Hg19::chr19:52033117..52033128,-#_c72160135251738249757a8bab1f5009p@chr19:52033117..52033128, -
2.45e-195FFCP PHASE1:Hg19::chr1:204074045..204074052,+#_c72160135251738249757a8bab1f5009p@chr1:204074045..204074052, +
2.45e-195FFCP PHASE2:Hg19::chr9:75770556..75770567,+#_c72160135251738249757a8bab1f5009p@chr9:75770556..75770567, +
2.45e-195FFCP PHASE1:Hg19::chr7:106372908..106372919,-#_c72160135251738249757a8bab1f5009p2@ENST00000490856
2.45e-195FFCP PHASE2:Hg19::chrX:29959742..29959751,+#_c72160135251738249757a8bab1f5009p@chrX:29959742..29959751, +
2.45e-195FFCP PHASE2:Hg19::chr1:194021388..194021407,+#_c72160135251738249757a8bab1f5009p@chr1:194021388..194021407, +
2.45e-195FFCP PHASE2:Hg19::chr14:54899928..54899942,-#_c72160135251738249757a8bab1f5009p@chr14:54899928..54899942, -
2.45e-195FFCP PHASE2:Hg19::chr6:16388717..16388738,-#_c72160135251738249757a8bab1f5009p@chr6:16388717..16388738, -
2.45e-195FFCP PHASE1:Hg19::chr6:23456883..23456894,+#_c72160135251738249757a8bab1f5009p@chr6:23456883..23456894, +
2.45e-195FFCP PHASE2:Hg19::chr11:59855794..59855805,+#_c72160135251738249757a8bab1f5009p5@MS4A2
2.45e-195FFCP PHASE1:Hg19::chr14:54899928..54899942,-#_c72160135251738249757a8bab1f5009p@chr14:54899928..54899942, -
2.45e-195FFCP PHASE2:Hg19::chr11:123985831..123985858,+#_c72160135251738249757a8bab1f5009p2@VWA5A
2.45e-195FFCP PHASE2:Hg19::chr3:14425446..14425450,+#_c72160135251738249757a8bab1f5009p@chr3:14425446..14425450, +
2.45e-195FFCP PHASE1:Hg19::chr6:57326117..57326124,+#_c72160135251738249757a8bab1f5009p@chr6:57326117..57326124, +
2.45e-195FFCP PHASE1:Hg19::chr9:116457979..116457994,+#_c72160135251738249757a8bab1f5009p@chr9:116457979..116457994, +
2.45e-195FFCP PHASE2:Hg19::chrX:100617644..100617655,-#_c72160135251738249757a8bab1f5009p5@BTK
2.45e-195FFCP PHASE2:Hg19::chr14:24974148..24974156,+#_c72160135251738249757a8bab1f5009p@chr14:24974148..24974156, +
2.45e-195FFCP PHASE2:Hg19::chr10:131653288..131653294,-#_c72160135251738249757a8bab1f5009p@chr10:131653288..131653294, -
2.45e-195FFCP PHASE2:Hg19::chr6:57326117..57326124,+#_c72160135251738249757a8bab1f5009p@chr6:57326117..57326124, +
2.45e-195FFCP PHASE1:Hg19::chr11:123986842..123986855,+#_c72160135251738249757a8bab1f5009p@chr11:123986842..123986855, +
2.45e-195FFCP PHASE1:Hg19::chr19:52034316..52034326,-#_c72160135251738249757a8bab1f5009p@chr19:52034316..52034326, -
2.45e-195FFCP PHASE1:Hg19::chr6:16388683..16388699,-#_c72160135251738249757a8bab1f5009p@chr6:16388683..16388699, -
2.45e-195FFCP PHASE1:Hg19::chr4:79698211..79698260,+#_c72160135251738249757a8bab1f5009p@chr4:79698211..79698260, +
2.45e-195FFCP PHASE1:Hg19::chr3:148583254..148583275,+#_c72160135251738249757a8bab1f5009p@chr3:148583254..148583275, +
2.45e-195FFCP PHASE2:Hg19::chr19:56673816..56673830,-#_c72160135251738249757a8bab1f5009p@chr19:56673816..56673830, -
2.45e-195FFCP PHASE1:Hg19::chr8:81214082..81214083,+#_c72160135251738249757a8bab1f5009p@chr8:81214082..81214083, +
2.45e-195FFCP PHASE2:Hg19::chr11:59857223..59857242,+#_c72160135251738249757a8bab1f5009p@chr11:59857223..59857242, +
2.45e-195FFCP PHASE2:Hg19::chr11:123988337..123988344,+#_c72160135251738249757a8bab1f5009p@chr11:123988337..123988344, +
2.45e-195FFCP PHASE1:Hg19::chr14:24974148..24974156,+#_c72160135251738249757a8bab1f5009p@chr14:24974148..24974156, +
2.45e-195FFCP PHASE2:Hg19::chr4:55523948..55523989,+#_c72160135251738249757a8bab1f5009p3@KIT
2.45e-195FFCP PHASE2:Hg19::chr1:203732858..203732876,-#_c72160135251738249757a8bab1f5009p@chr1:203732858..203732876, -
2.45e-195FFCP PHASE1:Hg19::chr4:55406116..55406147,+#_c72160135251738249757a8bab1f5009p@chr4:55406116..55406147, +
2.45e-195FFCP PHASE1:Hg19::chr4:95261065..95261071,+#_c72160135251738249757a8bab1f5009p@chr4:95261065..95261071, +
2.45e-195FFCP PHASE2:Hg19::chrX:29959760..29959772,+#_c72160135251738249757a8bab1f5009p@chrX:29959760..29959772, +
2.45e-195FFCP PHASE2:Hg19::chr16:1280084..1280116,-#_c72160135251738249757a8bab1f5009p2@TPSB2
2.45e-195FFCP PHASE2:Hg19::chr5:108071574..108071598,-#_c72160135251738249757a8bab1f5009p@chr5:108071574..108071598, -
2.45e-195FFCP PHASE2:Hg19::chr8:81214082..81214083,+#_c72160135251738249757a8bab1f5009p@chr8:81214082..81214083, +
2.45e-195FFCP PHASE1:Hg19::chr5:108071789..108071807,+#_c72160135251738249757a8bab1f5009p@chr5:108071789..108071807, +
2.45e-195FFCP PHASE1:Hg19::chr7:138317555..138317567,-#_c72160135251738249757a8bab1f5009p@chr7:138317555..138317567, -
2.45e-195FFCP PHASE1:Hg19::chr3:148601435..148601446,+#_c72160135251738249757a8bab1f5009p@chr3:148601435..148601446, +
2.45e-195FFCP PHASE2:Hg19::chr13:109328158..109328167,+#_c72160135251738249757a8bab1f5009p@chr13:109328158..109328167, +
2.45e-195FFCP PHASE1:Hg19::chr2:160085237..160085246,+#_c72160135251738249757a8bab1f5009p@chr2:160085237..160085246, +
2.45e-195FFCP PHASE1:Hg19::chr19:56673770..56673786,-#_c72160135251738249757a8bab1f5009p@chr19:56673770..56673786, -
2.45e-195FFCP PHASE2:Hg19::chr11:47175922..47175952,+#_c72160135251738249757a8bab1f5009p3@C11orf49
2.45e-195FFCP PHASE1:Hg19::chr19:7923338..7923341,-#_c72160135251738249757a8bab1f5009p@chr19:7923338..7923341, -
2.45e-195FFCP PHASE2:Hg19::chr7:138317555..138317567,-#_c72160135251738249757a8bab1f5009p@chr7:138317555..138317567, -
2.45e-195FFCP PHASE2:Hg19::chr6:16547983..16547995,-#_c72160135251738249757a8bab1f5009p@chr6:16547983..16547995, -
2.45e-195FFCP PHASE1:Hg19::chr19:51961061..51961069,-#_c72160135251738249757a8bab1f5009p@chr19:51961061..51961069, -
2.45e-195FFCP PHASE1:Hg19::chr13:109328158..109328167,+#_c72160135251738249757a8bab1f5009p@chr13:109328158..109328167, +
2.45e-195FFCP PHASE2:Hg19::chr2:160085237..160085246,+#_c72160135251738249757a8bab1f5009p@chr2:160085237..160085246, +
2.45e-195FFCP PHASE2:Hg19::chr1:204074045..204074052,+#_c72160135251738249757a8bab1f5009p@chr1:204074045..204074052, +
2.45e-195FFCP PHASE2:Hg19::chr14:25464405..25464415,-#_c72160135251738249757a8bab1f5009p@chr14:25464405..25464415, -
2.45e-195FFCP PHASE1:Hg19::chr1:20513747..20513758,-#_c72160135251738249757a8bab1f5009p@chr1:20513747..20513758, -
2.45e-195FFCP PHASE1:Hg19::chr4:80665456..80665463,-#_c72160135251738249757a8bab1f5009p@chr4:80665456..80665463, -
2.45e-195FFCP PHASE1:Hg19::chr4:175501777..175501788,-#_c72160135251738249757a8bab1f5009p@chr4:175501777..175501788, -
2.45e-195FFCP PHASE2:Hg19::chr7:106372888..106372891,-#_c72160135251738249757a8bab1f5009p5@ENST00000490856

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