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{{UBERON
{{UBERON
|id=UBERON:0002360
|name=meninx
|namespace=
|def="Membrane organ that surrounds the brain and the spinal cord // Wikipedia: system of membranes which envelops the central nervous system. Whereas cyclostomes and fishes only have a single envelope called the primitive meninx, amphibians have two layers, consisting of an outer dura mater which is extremely dense and protective, and a pia-arachnoid or secondary meninx which is more delicate and vascular. Mammals have three meninges: pia mater (which follows all the convolutions of the brain and is the most interior), the arachnoid layer (which is delicate and sends strands to the pia mater), and the dura mater (the outer, more protective meninx). The area between the dura mater and the arachnoid layer is called the subdural space; the area between the arachnoid layer is called the subarachnoid space. An additional layer of tissue lies between the two hemispheres of the cerebrum and is called the falx cerebri. " [http://www.shsu.edu/~bio_mlt/Chap15.html, Wikipedia:Meninx]
|xref=BTO:0000144;;EFO:0000584;;EFO:0000867;;EHDAA2:0004661;;EV:0100312;;FMA:9589;;GAID:687;;http://upload.wikimedia.org/wikipedia/commons/thumb/4/48/Illu_meninges.jpg/200px-Illu_meninges.jpg;;MA:0001113;;MAT:0000113;;MESH:A.08.186.566;;ncithesaurus:Meninges;;NIF_GrossAnatomy:nlx_anat_090204;;OpenCyc:Mx4rwDOl8JwpEbGdrcN5Y29ycA;;SCTID:362879001;;VHOG:0001295;;ZFA:0001355
|is_a=UBERON:0000094;;UBERON:0004120;;UBERON:0004121
|synonym="meninges" EXACT PLURAL []
|comment=Editor note: consider separate term for meninges aka collection of meninges. Note in EHDAA2 pia mater etc are part of the meninges
|alt_id=UBERON:FMA_9589-MA_0001113
|alt_id=UBERON:FMA_9589-MA_0001113
|disjoint_from=
|comment=Editor note: consider separate term for meninges aka collection of meninges. Note in EHDAA2 pia mater etc are part of the meninges. Also consider a new class for primary/primitive meninx. AO notes: Not consider part of the CNS/neuraxis in FMA. Taxon notes: Whereas cyclostomes and fishes only have a single envelope called the primitive meninx, amphibians have two layers, consisting of an outer dura mater which is extremely dense and protective, and a pia-arachnoid or secondary meninx which is more delicate and vascular. Mammals have three meninges: pia mater (which follows all the convolutions of the brain and is the most interior), the arachnoid layer (which is delicate and sends strands to the pia mater), and the dura mater (the outer, more protective meninx).
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="Membrane organ that surrounds the brain and the spinal cord." [FMA:9589, http://www.shsu.edu/~bio_mlt/Chap15.html, Wikipedia:Meninx]
|subset=organ_slim;;uberon_slim;;vertebrate_core
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=UBERON:0000926;;UBERON:0002342;;UBERON:0007645
|develops_from=
|disjoint_from=
|has_quality=
|has_quality=
|id=UBERON:0002360
|is_a=UBERON:0000094 ;;UBERON:0004121 ;;UBERON:0010314
|is_obsolete=
|located_in=
|located_in=
|part_of=UBERON:0001017
|name=meninx
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.obo.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|namespace=FANTOM
|is_obsolete=
|obo_creation_date=
|part_of=UBERON:0010743
|preceded_by=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|subset=organ_slim;;uberon_slim;;vertebrate_core
|synonym="layer of meninges" EXACT [];;"meningeal layer" EXACT []
|union_of=
|xref=BTO:0000144;;EFO:0000584;;EFO:0000867;;EV:0100312;;FMA:9589;;GAID:687;;http://upload.wikimedia.org/wikipedia/commons/thumb/4/48/Illu_meninges.jpg/200px-Illu_meninges.jpg;;MA:0001113;;MAT:0000113;;MESH:A.08.186.566;;ncithesaurus:Meninges;;NIF_GrossAnatomy:nlx_anat_090204;;OpenCyc:Mx4rwDOl8JwpEbGdrcN5Y29ycA;;TAO:0001355;;VHOG:0001295;;ZFA:0001355
}}
}}

Latest revision as of 17:30, 12 September 2014

Name:meninx
Namespace:FANTOM
Definition:"Membrane organ that surrounds the brain and the spinal cord." [FMA:9589, http://www.shsu.edu/~bio_mlt/Chap15.html, Wikipedia:Meninx]
Xrefs:
links:

BTO:0000144
EFO:0000584
EFO:0000867
EV:0100312
FMA:9589
GAID:687
[1]
MA:0001113
MAT:0000113
MESH:A.08.186.566
ncithesaurus:Meninges
NIF_GrossAnatomy:nlx_anat_090204
OpenCyc:Mx4rwDOl8JwpEbGdrcN5Y29ycA
TAO:0001355
VHOG:0001295

ZFA:0001355
Synonyms: "layer of meninges" EXACT []
"meningeal layer" EXACT []
Comments:Editor note: consider separate term for meninges aka collection of meninges. Note in EHDAA2 pia mater etc are part of the meninges. Also consider a new class for primary/primitive meninx. AO notes: Not consider part of the CNS/neuraxis in FMA. Taxon notes: Whereas cyclostomes and fishes only have a single envelope called the primitive meninx, amphibians have two layers, consisting of an outer dura mater which is extremely dense and protective, and a pia-arachnoid or secondary meninx which is more delicate and vascular. Mammals have three meninges: pia mater (which follows all the convolutions of the brain and is the most interior), the arachnoid layer (which is delicate and sends strands to the pia mater), and the dura mater (the outer, more protective meninx).
Alt_id: UBERON:FMA_9589-MA_0001113
Subset: organ_slim
uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000094(membrane organ),UBERON:0004121(ectoderm-derived structure),UBERON:0010314(structure with developmental contribution from neural crest)
part_of:UBERON:0010743(meningeal cluster)



Children

is a:UBERON:0000391 (leptomeninx),UBERON:0002363 (dura mater),UBERON:0010115 (future dura mater)
derives from:FF:0010188 (human cerebral meninges - adult sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002360 (meninx), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.75e-130FFCP PHASE1:Hg19::chr6:55740051..55740056,-#_b01e53c867af9c4f756a02f351416a82p5@BMP5
1.75e-130FFCP PHASE2:Hg19::chr6:55740051..55740056,-#_b01e53c867af9c4f756a02f351416a82p5@BMP5
1.55e-98FFCP PHASE2:Hg19::chr3:112931366..112931373,-#_2540e27173afd3eddb1e488ae9563bbbp@chr3:112931366..112931373, -
1.55e-98FFCP PHASE1:Hg19::chr3:112931383..112931390,-#_2540e27173afd3eddb1e488ae9563bbbp@chr3:112931383..112931390, -
1.55e-98FFCP PHASE1:Hg19::chr2:217560615..217560623,-#_2540e27173afd3eddb1e488ae9563bbbp73@IGFBP5
1.55e-98FFCP PHASE2:Hg19::chr3:112931383..112931390,-#_2540e27173afd3eddb1e488ae9563bbbp@chr3:112931383..112931390, -
1.55e-98FFCP PHASE1:Hg19::chr10:79398656..79398666,-#_2540e27173afd3eddb1e488ae9563bbbp25@KCNMA1
1.55e-98FFCP PHASE1:Hg19::chr3:112931404..112931414,-#_2540e27173afd3eddb1e488ae9563bbbp@chr3:112931404..112931414, -
1.55e-98FFCP PHASE1:Hg19::chr2:45234395..45234400,-#_2540e27173afd3eddb1e488ae9563bbbp@chr2:45234395..45234400, -
1.55e-98FFCP PHASE2:Hg19::chr2:217560615..217560623,-#_2540e27173afd3eddb1e488ae9563bbbp73@IGFBP5
1.55e-98FFCP PHASE2:Hg19::chr3:112931404..112931414,-#_2540e27173afd3eddb1e488ae9563bbbp@chr3:112931404..112931414, -
1.55e-98FFCP PHASE1:Hg19::chr3:112931435..112931445,-#_2540e27173afd3eddb1e488ae9563bbbp@chr3:112931435..112931445, -
1.55e-98FFCP PHASE1:Hg19::chr4:154712764..154712772,-#_2540e27173afd3eddb1e488ae9563bbbp@chr4:154712764..154712772, -
1.55e-98FFCP PHASE2:Hg19::chr2:45234395..45234400,-#_2540e27173afd3eddb1e488ae9563bbbp@chr2:45234395..45234400, -
1.55e-98FFCP PHASE1:Hg19::chr5:39892092..39892099,+#_2540e27173afd3eddb1e488ae9563bbbp@chr5:39892092..39892099, +
1.55e-98FFCP PHASE1:Hg19::chr8:43349847..43349852,+#_2540e27173afd3eddb1e488ae9563bbbp@chr8:43349847..43349852, +
1.55e-98FFCP PHASE2:Hg19::chr10:78078199..78078208,+#_2540e27173afd3eddb1e488ae9563bbbp8@C10orf11
1.55e-98FFCP PHASE2:Hg19::chr3:112931435..112931445,-#_2540e27173afd3eddb1e488ae9563bbbp@chr3:112931435..112931445, -
1.55e-98FFCP PHASE2:Hg19::chr4:154712764..154712772,-#_2540e27173afd3eddb1e488ae9563bbbp@chr4:154712764..154712772, -
1.55e-98FFCP PHASE1:Hg19::chr5:122434930..122434939,+#_2540e27173afd3eddb1e488ae9563bbbp@chr5:122434930..122434939, +
1.55e-98FFCP PHASE2:Hg19::chr8:43349847..43349852,+#_2540e27173afd3eddb1e488ae9563bbbp@chr8:43349847..43349852, +
1.55e-98FFCP PHASE2:Hg19::chr5:39892092..39892099,+#_2540e27173afd3eddb1e488ae9563bbbp@chr5:39892092..39892099, +
1.55e-98FFCP PHASE1:Hg19::chr8:48651813..48651830,-#_2540e27173afd3eddb1e488ae9563bbbp14@CEBPD
1.55e-98FFCP PHASE1:Hg19::chr3:112931366..112931373,-#_2540e27173afd3eddb1e488ae9563bbbp@chr3:112931366..112931373, -
1.55e-98FFCP PHASE2:Hg19::chr5:122434930..122434939,+#_2540e27173afd3eddb1e488ae9563bbbp@chr5:122434930..122434939, +
1.55e-98FFCP PHASE2:Hg19::chr10:79398656..79398666,-#_2540e27173afd3eddb1e488ae9563bbbp25@KCNMA1
1.55e-98FFCP PHASE1:Hg19::chr10:78078199..78078208,+#_2540e27173afd3eddb1e488ae9563bbbp8@C10orf11
1.55e-98FFCP PHASE2:Hg19::chr8:48651813..48651830,-#_2540e27173afd3eddb1e488ae9563bbbp14@CEBPD
1.16e-78FFCP PHASE2:Hg19::chr2:18695697..18695706,-#_58935e1aaf8f188b7ab0a72e9ee23094p@chr2:18695697..18695706, -
1.16e-78FFCP PHASE1:Hg19::chr2:18695697..18695706,-#_58935e1aaf8f188b7ab0a72e9ee23094p@chr2:18695697..18695706, -
2.74e-50FFCP PHASE1:Hg19::chr1:66031903..66031907,+#_d349b09c3c0de3f893d0727092ed4cbap@chr1:66031903..66031907, +
2.74e-50FFCP PHASE1:Hg19::chr4:154711058..154711075,+#_d349b09c3c0de3f893d0727092ed4cbap@chr4:154711058..154711075, +
2.74e-50FFCP PHASE1:Hg19::chr9:23524699..23524703,-#_d349b09c3c0de3f893d0727092ed4cbap@chr9:23524699..23524703, -
2.74e-50FFCP PHASE1:Hg19::chr3:147794257..147794262,+#_d349b09c3c0de3f893d0727092ed4cbap@chr3:147794257..147794262, +
2.74e-50FFCP PHASE1:Hg19::chr8:43349758..43349771,+#_d349b09c3c0de3f893d0727092ed4cbap@chr8:43349758..43349771, +
2.74e-50FFCP PHASE2:Hg19::chr19:2309357..2309359,+#_d349b09c3c0de3f893d0727092ed4cbap@chr19:2309357..2309359, +
2.74e-50FFCP PHASE1:Hg19::chr16:73094120..73094122,-#_d349b09c3c0de3f893d0727092ed4cbap@chr16:73094120..73094122, -
2.74e-50FFCP PHASE2:Hg19::chr1:66031903..66031907,+#_d349b09c3c0de3f893d0727092ed4cbap@chr1:66031903..66031907, +
2.74e-50FFCP PHASE2:Hg19::chr4:154711058..154711075,+#_d349b09c3c0de3f893d0727092ed4cbap@chr4:154711058..154711075, +
2.74e-50FFCP PHASE2:Hg19::chr9:23524699..23524703,-#_d349b09c3c0de3f893d0727092ed4cbap@chr9:23524699..23524703, -
2.74e-50FFCP PHASE2:Hg19::chr3:147794257..147794262,+#_d349b09c3c0de3f893d0727092ed4cbap@chr3:147794257..147794262, +
2.74e-50FFCP PHASE2:Hg19::chr8:43349758..43349771,+#_d349b09c3c0de3f893d0727092ed4cbap@chr8:43349758..43349771, +
2.74e-50FFCP PHASE1:Hg19::chr7:115135068..115135092,-#_d349b09c3c0de3f893d0727092ed4cbap@chr7:115135068..115135092, -
2.74e-50FFCP PHASE1:Hg19::chr8:43349794..43349803,+#_d349b09c3c0de3f893d0727092ed4cbap@chr8:43349794..43349803, +
2.74e-50FFCP PHASE1:Hg19::chr18:14221875..14221879,-#_d349b09c3c0de3f893d0727092ed4cbap@chr18:14221875..14221879, -
2.74e-50FFCP PHASE2:Hg19::chr8:43349794..43349803,+#_d349b09c3c0de3f893d0727092ed4cbap@chr8:43349794..43349803, +
2.74e-50FFCP PHASE2:Hg19::chr7:115135068..115135092,-#_d349b09c3c0de3f893d0727092ed4cbap@chr7:115135068..115135092, -
2.74e-50FFCP PHASE1:Hg19::chr8:72274182..72274188,-#_d349b09c3c0de3f893d0727092ed4cbap18@EYA1
2.74e-50FFCP PHASE2:Hg19::chr16:73094120..73094122,-#_d349b09c3c0de3f893d0727092ed4cbap@chr16:73094120..73094122, -
2.74e-50FFCP PHASE1:Hg19::chr19:2309357..2309359,+#_d349b09c3c0de3f893d0727092ed4cbap@chr19:2309357..2309359, +
2.74e-50FFCP PHASE2:Hg19::chr18:14221875..14221879,-#_d349b09c3c0de3f893d0727092ed4cbap@chr18:14221875..14221879, -
2.74e-50FFCP PHASE2:Hg19::chr8:72274182..72274188,-#_d349b09c3c0de3f893d0727092ed4cbap18@EYA1
4.52e-50FFCP PHASE2:Hg19::chr1:183775501..183775512,+#_0731a0c8f59d4d5e761dfd2fbabbcff1p13@RGL1
4.52e-50FFCP PHASE2:Hg19::chr11:44360838..44360846,+#_0731a0c8f59d4d5e761dfd2fbabbcff1p@chr11:44360838..44360846, +
4.52e-50FFCP PHASE1:Hg19::chr1:65990750..65990756,+#_0731a0c8f59d4d5e761dfd2fbabbcff1p@chr1:65990750..65990756, +
4.52e-50FFCP PHASE1:Hg19::chr11:44360838..44360846,+#_0731a0c8f59d4d5e761dfd2fbabbcff1p@chr11:44360838..44360846, +
4.52e-50FFCP PHASE2:Hg19::chr1:65990750..65990756,+#_0731a0c8f59d4d5e761dfd2fbabbcff1p@chr1:65990750..65990756, +
4.52e-50FFCP PHASE1:Hg19::chr1:183775501..183775512,+#_0731a0c8f59d4d5e761dfd2fbabbcff1p13@RGL1
4.49e-40FFCP PHASE1:Hg19::chr9:74167593..74167609,-#_6d0f789fc40014983620cd1204967225p@chr9:74167593..74167609, -
4.49e-40FFCP PHASE2:Hg19::chr9:74167593..74167609,-#_6d0f789fc40014983620cd1204967225p@chr9:74167593..74167609, -
3.28e-37FFCP PHASE1:Hg19::chr2:201521549..201521593,+#_ff40207c5e660305c42b25b46ce7b702p@chr2:201521549..201521593, +
3.28e-37FFCP PHASE2:Hg19::chr2:201521549..201521593,+#_ff40207c5e660305c42b25b46ce7b702p@chr2:201521549..201521593, +
3.61e-34FFCP PHASE2:Hg19::chr4:26165179..26165190,+#_14396e55d1ce1491a5b19261428e3ba0p47@RBPJ
3.61e-34FFCP PHASE1:Hg19::chr4:154711263..154711272,+#_14396e55d1ce1491a5b19261428e3ba0p@chr4:154711263..154711272, +
3.61e-34FFCP PHASE1:Hg19::chr9:23524722..23524736,-#_14396e55d1ce1491a5b19261428e3ba0p@chr9:23524722..23524736, -
3.61e-34FFCP PHASE2:Hg19::chr4:154711263..154711272,+#_14396e55d1ce1491a5b19261428e3ba0p@chr4:154711263..154711272, +
3.61e-34FFCP PHASE2:Hg19::chr9:23524722..23524736,-#_14396e55d1ce1491a5b19261428e3ba0p@chr9:23524722..23524736, -
3.61e-34FFCP PHASE1:Hg19::chr9:23524772..23524783,-#_14396e55d1ce1491a5b19261428e3ba0p@chr9:23524772..23524783, -
3.61e-34FFCP PHASE2:Hg19::chr9:23524772..23524783,-#_14396e55d1ce1491a5b19261428e3ba0p@chr9:23524772..23524783, -
3.61e-34FFCP PHASE1:Hg19::chr3:112931461..112931474,-#_14396e55d1ce1491a5b19261428e3ba0p@chr3:112931461..112931474, -
3.61e-34FFCP PHASE1:Hg19::chr2:45715445..45715482,-#_14396e55d1ce1491a5b19261428e3ba0p@chr2:45715445..45715482, -
3.61e-34FFCP PHASE1:Hg19::chr4:26165179..26165190,+#_14396e55d1ce1491a5b19261428e3ba0p47@RBPJ
3.61e-34FFCP PHASE2:Hg19::chr3:112931461..112931474,-#_14396e55d1ce1491a5b19261428e3ba0p@chr3:112931461..112931474, -
3.61e-34FFCP PHASE2:Hg19::chr2:45715445..45715482,-#_14396e55d1ce1491a5b19261428e3ba0p@chr2:45715445..45715482, -
5.04e-34FFCP PHASE2:Hg19::chr5:176047686..176047693,-#_df8360237dc497acf7a881b5d0116b4cp@chr5:176047686..176047693, -
5.04e-34FFCP PHASE1:Hg19::chr5:175223687..175223688,+#_df8360237dc497acf7a881b5d0116b4cp29@CPLX2
5.04e-34FFCP PHASE1:Hg19::chr1:1914706..1914716,-#_df8360237dc497acf7a881b5d0116b4cp@chr1:1914706..1914716, -
5.04e-34FFCP PHASE2:Hg19::chr17:53398728..53398764,+#_df8360237dc497acf7a881b5d0116b4cp@chr17:53398728..53398764, +
5.04e-34FFCP PHASE2:Hg19::chr5:175223687..175223688,+#_df8360237dc497acf7a881b5d0116b4cp29@CPLX2
5.04e-34FFCP PHASE2:Hg19::chr1:1914706..1914716,-#_df8360237dc497acf7a881b5d0116b4cp@chr1:1914706..1914716, -
5.04e-34FFCP PHASE1:Hg19::chr5:176047686..176047693,-#_df8360237dc497acf7a881b5d0116b4cp@chr5:176047686..176047693, -
5.04e-34FFCP PHASE1:Hg19::chr17:53398728..53398764,+#_df8360237dc497acf7a881b5d0116b4cp@chr17:53398728..53398764, +
7.05e-34FFCP PHASE2:Hg19::chr13:66878571..66878580,-#_90d45e6cd89477fc78d24c803bb851b4p@chr13:66878571..66878580, -
7.05e-34FFCP PHASE2:Hg19::chr2:44903688..44903705,+#_90d45e6cd89477fc78d24c803bb851b4p7@CAMKMT
7.05e-34FFCP PHASE1:Hg19::chr1:157069619..157069633,-#_90d45e6cd89477fc78d24c803bb851b4p3@ETV3L
7.05e-34FFCP PHASE1:Hg19::chr6:102487198..102487211,+#_90d45e6cd89477fc78d24c803bb851b4p@chr6:102487198..102487211, +
7.05e-34FFCP PHASE1:Hg19::chr13:66878571..66878580,-#_90d45e6cd89477fc78d24c803bb851b4p@chr13:66878571..66878580, -
7.05e-34FFCP PHASE2:Hg19::chr1:157069619..157069633,-#_90d45e6cd89477fc78d24c803bb851b4p3@ETV3L
7.05e-34FFCP PHASE2:Hg19::chr6:102487198..102487211,+#_90d45e6cd89477fc78d24c803bb851b4p@chr6:102487198..102487211, +
7.05e-34FFCP PHASE1:Hg19::chr20:36979501..36979520,-#_90d45e6cd89477fc78d24c803bb851b4p@chr20:36979501..36979520, -
7.05e-34FFCP PHASE2:Hg19::chr11:44360939..44360945,+#_90d45e6cd89477fc78d24c803bb851b4p@chr11:44360939..44360945, +
7.05e-34FFCP PHASE2:Hg19::chr20:36979501..36979520,-#_90d45e6cd89477fc78d24c803bb851b4p@chr20:36979501..36979520, -
7.05e-34FFCP PHASE1:Hg19::chr2:44903688..44903705,+#_90d45e6cd89477fc78d24c803bb851b4p7@CAMKMT
7.05e-34FFCP PHASE1:Hg19::chr11:44360939..44360945,+#_90d45e6cd89477fc78d24c803bb851b4p@chr11:44360939..44360945, +
4.04e-31FFCP PHASE1:Hg19::chr6:160679846..160679859,-#_f2de405958d03f6aebd97438abc007f2p1@SLC22A2
4.04e-31FFCP PHASE2:Hg19::chr6:160679846..160679859,-#_f2de405958d03f6aebd97438abc007f2p1@SLC22A2
1.02e-30FFCP PHASE1:Hg19::chr8:17351823..17351832,+#_f388cc85784beec31f5c5acb0f573a8fp@chr8:17351823..17351832, +
1.02e-30FFCP PHASE2:Hg19::chr8:17351823..17351832,+#_f388cc85784beec31f5c5acb0f573a8fp@chr8:17351823..17351832, +
4.08e-26FFCP PHASE1:Hg19::chr20:4904851..4904855,-#_40f07111a89f762c67eab64c73320543p@chr20:4904851..4904855, -
4.08e-26FFCP PHASE2:Hg19::chr20:4904851..4904855,-#_40f07111a89f762c67eab64c73320543p@chr20:4904851..4904855, -

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