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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 11:42, 17 September 2013


Full id: C1317_Eosinophils_CD14CD16_CD14_Neutrophils_Basophils_Peripheral_CD4



Phase1 CAGE Peaks

Hg19::chr10:60026761..60026776,-p@chr10:60026761..60026776
-
Hg19::chr10:60026993..60027012,+p@chr10:60026993..60027012
+
Hg19::chr14:91976078..91976111,+p@chr14:91976078..91976111
+
Hg19::chr16:284853..284868,+p4@ITFG3
Hg19::chr6:166795389..166795393,+p@chr6:166795389..166795393
+
Hg19::chr7:27135705..27135768,+p2@HOTAIRM1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte9.33e-66136
hematopoietic lineage restricted progenitor cell4.13e-55120
classical monocyte4.97e-5542
CD14-positive, CD16-negative classical monocyte4.97e-5542
nongranular leukocyte1.10e-53115
hematopoietic stem cell2.06e-53168
angioblastic mesenchymal cell2.06e-53168
myeloid leukocyte1.52e-4972
hematopoietic cell3.42e-49177
hematopoietic oligopotent progenitor cell4.34e-49161
hematopoietic multipotent progenitor cell4.34e-49161
defensive cell3.55e-4648
phagocyte3.55e-4648
granulocyte monocyte progenitor cell2.46e-4467
macrophage dendritic cell progenitor8.96e-4061
myeloid lineage restricted progenitor cell3.27e-3966
monopoietic cell1.57e-3759
monocyte1.57e-3759
monoblast1.57e-3759
promonocyte1.57e-3759
myeloid cell2.20e-33108
common myeloid progenitor2.20e-33108
stuff accumulating cell5.75e-2087
intermediate monocyte4.19e-159
CD14-positive, CD16-positive monocyte4.19e-159
mesenchymal cell1.37e-14354
lymphoid lineage restricted progenitor cell4.13e-1452
connective tissue cell8.72e-14361
lymphocyte1.11e-1353
common lymphoid progenitor1.11e-1353
nucleate cell7.14e-1355
motile cell1.93e-11386
granulocyte5.90e-108
CD4-positive, alpha-beta T cell2.66e-096
stem cell4.20e-09441
mature alpha-beta T cell5.17e-0918
alpha-beta T cell5.17e-0918
immature T cell5.17e-0918
mature T cell5.17e-0918
immature alpha-beta T cell5.17e-0918
multi fate stem cell7.45e-09427
somatic stem cell2.17e-08433
B cell8.22e-0714
blood cell8.79e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.58e-4198
blood island3.58e-4198
bone marrow1.81e-4076
bone element3.35e-3682
hemolymphoid system1.86e-35108
immune system6.55e-3493
skeletal element2.05e-3190
skeletal system1.55e-26100
connective tissue1.12e-13371
lateral plate mesoderm1.76e-12203
musculoskeletal system3.25e-11167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.37104
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.12.54844
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.464411
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.213007
MA0056.10
MA0057.11.41984
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.120085
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.11.61871
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.10.419295
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.314898
MA0115.11.28169
MA0116.10.865577
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.11.19942
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.811435
MA0145.10.107156
MA0146.10.718193
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.21.22729
MA0035.20.621793
MA0039.20.569061
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.20.735746
MA0047.20.695777
MA0112.20.332548
MA0065.20.109623
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.11.92418
MA0155.10.65596
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.150673
MA0163.10.113377
MA0164.11.74929
MA0080.21.02158
MA0018.20.709805
MA0099.20.629739
MA0079.21.95397
MA0102.21.58513
MA0258.10.289793
MA0259.10.893594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELF1#199753.548414965672950.003446837775721690.0175234527799541
POLR2A#543062.147453176558070.01019570676818780.0379862093023247
ZBTB7A#5134144.901272871917260.004079628118843750.0194820430317294



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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