MCL coexpression mm9:2326

Phase1 CAGE Peaks

	Short description
Mm9::chr2:119625278..119625308,+	p1@Tyro3
Mm9::chr2:119625310..119625328,+	p4@Tyro3
Mm9::chr5:123229287..123229443,-	p1@Camkk2
Mm9::chr5:135516995..135517035,+	p2@Stx1a

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0019855	calcium channel inhibitor activity	0.0268556468270756
GO:0008200	ion channel inhibitor activity	0.0268556468270756
GO:0016248	channel inhibitor activity	0.0268556468270756
GO:0005246	calcium channel regulator activity	0.0268556468270756
GO:0004683	calmodulin-dependent protein kinase activity	0.0268556468270756
GO:0016247	channel regulator activity	0.0268556468270756
GO:0015457	auxiliary transport protein activity	0.0268556468270756
GO:0000149	SNARE binding	0.0268556468270756
GO:0004672	protein kinase activity	0.0268556468270756
GO:0017156	calcium ion-dependent exocytosis	0.0282399074109683
GO:0016773	phosphotransferase activity, alcohol group as acceptor	0.0298844870419492
GO:0016301	kinase activity	0.0447116880677966
GO:0006836	neurotransmitter transport	0.0499513795386572
GO:0016772	transferase activity, transferring phosphorus-containing groups	0.0499513795386572

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
ectodermal cell	1.33e-09	44
neurectodermal cell	1.33e-09	44
neuron	1.82e-09	33
neuronal stem cell	1.82e-09	33
neuroblast	1.82e-09	33
electrically signaling cell	1.82e-09	33
neural cell	2.16e-09	43
non-terminally differentiated cell	1.95e-08	49
electrically responsive cell	3.07e-08	39
electrically active cell	3.07e-08	39

Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	5.74e-21	95
ectoderm	5.74e-21	95
presumptive ectoderm	5.74e-21	95
nervous system	3.13e-20	75
central nervous system	3.36e-20	73
ecto-epithelium	4.03e-15	73
regional part of nervous system	1.46e-14	54
neural tube	1.23e-13	52
neural rod	1.23e-13	52
future spinal cord	1.23e-13	52
neural keel	1.23e-13	52
gray matter	3.32e-13	34
neurectoderm	1.88e-12	64
neural plate	1.88e-12	64
presumptive neural plate	1.88e-12	64
brain	7.02e-12	47
future brain	7.02e-12	47
brain grey matter	1.91e-11	29
regional part of telencephalon	1.91e-11	29
telencephalon	1.91e-11	29
regional part of brain	2.42e-11	46
anterior neural tube	6.71e-10	40
regional part of forebrain	1.88e-09	39
forebrain	1.88e-09	39
future forebrain	1.88e-09	39
cerebral cortex	3.62e-09	21
cerebral hemisphere	3.62e-09	21
pallium	3.62e-09	21
regional part of cerebral cortex	7.67e-09	17
pre-chordal neural plate	4.58e-08	49
occipital lobe	6.15e-08	10
visual cortex	6.15e-08	10
neocortex	6.15e-08	10
gonad	4.90e-07	18
gonad primordium	4.90e-07	18
external genitalia	7.64e-07	17
indifferent external genitalia	7.64e-07	17
indifferent gonad	7.64e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}