MCL coexpression mm9:1173

Phase1 CAGE Peaks

	Short description
Mm9::chr19:40439533..40439550,-	p@chr19:40439533..40439550 -
Mm9::chr19:40588204..40588282,-	p1@Sorbs1
Mm9::chr1:75356896..75356913,+	p1@Des
Mm9::chr1:75358757..75358798,-	p@chr1:75358757..75358798 -
Mm9::chr1:75363386..75363422,-	p@chr1:75363386..75363422 -
Mm9::chr1:75363702..75363741,+	p@chr1:75363702..75363741 +
Mm9::chr2:72135952..72135969,+	p9@B230120H23Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0043149	stress fiber formation	0.0336303655618914
GO:0048041	focal adhesion formation	0.0336303655618914
GO:0007010	cytoskeleton organization and biogenesis	0.0336303655618914
GO:0005626	insoluble fraction	0.0336303655618914
GO:0051017	actin filament bundle formation	0.0336303655618914
GO:0005158	insulin receptor binding	0.0336303655618914
GO:0044430	cytoskeletal part	0.0336303655618914
GO:0004709	MAP kinase kinase kinase activity	0.0336303655618914
GO:0001725	stress fiber	0.0336303655618914
GO:0032432	actin filament bundle	0.0336303655618914
GO:0008286	insulin receptor signaling pathway	0.0336303655618914
GO:0005913	cell-cell adherens junction	0.0336303655618914
GO:0015758	glucose transport	0.0336303655618914
GO:0008645	hexose transport	0.0336303655618914
GO:0042383	sarcolemma	0.0336303655618914
GO:0015749	monosaccharide transport	0.0336303655618914
GO:0030018	Z disc	0.0336303655618914
GO:0005924	cell-substrate adherens junction	0.0336303655618914
GO:0031674	I band	0.0336303655618914
GO:0045121	lipid raft	0.0336303655618914
GO:0030055	cell-matrix junction	0.0336303655618914
GO:0005856	cytoskeleton	0.0350829367583903
GO:0007015	actin filament organization	0.0350829367583903
GO:0004702	receptor signaling protein serine/threonine kinase activity	0.0373363523487017
GO:0019901	protein kinase binding	0.0373363523487017
GO:0032403	protein complex binding	0.0373363523487017
GO:0019900	kinase binding	0.0373363523487017
GO:0005912	adherens junction	0.040279051340258
GO:0008643	carbohydrate transport	0.040279051340258
GO:0007160	cell-matrix adhesion	0.040279051340258
GO:0006996	organelle organization and biogenesis	0.040279051340258
GO:0030017	sarcomere	0.040279051340258
GO:0031589	cell-substrate adhesion	0.040279051340258
GO:0044449	contractile fiber part	0.040279051340258
GO:0016323	basolateral plasma membrane	0.040279051340258
GO:0030016	myofibril	0.0418958932992277
GO:0043292	contractile fiber	0.0418958932992277
GO:0005057	receptor signaling protein activity	0.0453981741645729
GO:0005200	structural constituent of cytoskeleton	0.0453981741645729

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	8.06e-10	18
heart	8.06e-10	18
primitive heart tube	8.06e-10	18
primary heart field	8.06e-10	18
anterior lateral plate mesoderm	8.06e-10	18
heart tube	8.06e-10	18
heart primordium	8.06e-10	18
cardiac mesoderm	8.06e-10	18
cardiogenic plate	8.06e-10	18
heart rudiment	8.06e-10	18
splanchnic layer of lateral plate mesoderm	1.79e-09	33
cardiovascular system	1.35e-07	23
circulatory system	1.35e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}