FFCP PHASE1:Hg19::chr20:17550458..17550476,+: Difference between revisions
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|ontology_enrichment_celltype=CL:0000066!5.24e-24!254;CL:0002076!2.80e-12!43;CL:0000223!1.79e-08!59;CL:0002251!6.04e-07!21 | |ontology_enrichment_celltype=CL:0000066!5.24e-24!254;CL:0002076!2.80e-12!43;CL:0000223!1.79e-08!59;CL:0002251!6.04e-07!21 | ||
|ontology_enrichment_celltype_v019=CL:0002076;4.59e-09;42!CL:0000082;2.25e-08;19!CL:0002368;9.00e-08;13!CL:0000349;3.71e-07;19 | |ontology_enrichment_celltype_v019=CL:0002076;4.59e-09;42!CL:0000082;2.25e-08;19!CL:0002368;9.00e-08;13!CL:0000349;3.71e-07;19 | ||
|ontology_enrichment_celltype_v019_2=CL:0000066,6.48e-15,253;CL:0002076,4.79e-12,42;CL:0000082,1.17e-08,19;CL:0000223,1.30e-08,58;CL:0002368,7.25e-08,13;CL:0000349,4.19e-07,19 | |||
|ontology_enrichment_development_v019=UBERON:0008947;2.21e-14;29 | |ontology_enrichment_development_v019=UBERON:0008947;2.21e-14;29 | ||
|ontology_enrichment_disease=DOID:305!2.80e-20!106;DOID:0050687!6.94e-14!143;DOID:1749!1.24e-08!14;DOID:162!2.26e-07!235;DOID:299!4.76e-07!25 | |ontology_enrichment_disease=DOID:305!2.80e-20!106;DOID:0050687!6.94e-14!143;DOID:1749!1.24e-08!14;DOID:162!2.26e-07!235;DOID:299!4.76e-07!25 | ||
|ontology_enrichment_disease_v019=DOID:1749;2.44e-07;14!DOID:5093;9.53e-07;4!DOID:1612;9.53e-07;4 | |ontology_enrichment_disease_v019=DOID:1749;2.44e-07;14!DOID:5093;9.53e-07;4!DOID:1612;9.53e-07;4 | ||
|ontology_enrichment_disease_v019_2=DOID:305,6.49e-14,106;DOID:0050687,3.05e-08,143;DOID:1749,1.19e-07,14;DOID:5093,9.94e-07,4;DOID:1612,9.94e-07,4 | |||
|ontology_enrichment_uberon=UBERON:0001004!2.71e-14!72;UBERON:0004119!1.66e-13!169;UBERON:0000925!1.66e-13!169;UBERON:0006595!1.66e-13!169;UBERON:0000065!2.27e-11!53;UBERON:0001007!4.17e-11!155;UBERON:0001555!4.17e-11!155;UBERON:0007026!4.17e-11!155;UBERON:0008947!7.39e-11!38;UBERON:0003258!7.39e-11!38;UBERON:0000464!9.54e-11!104;UBERON:0000077!1.71e-09!130;UBERON:0005153!3.25e-09!37;UBERON:0004921!5.93e-09!129;UBERON:0004185!5.93e-09!129;UBERON:0000072!7.84e-09!46;UBERON:0000064!1.20e-08!219;UBERON:0000466!2.77e-08!126;UBERON:0000915!3.99e-08!52;UBERON:0000062!4.18e-08!511;UBERON:0001041!5.01e-08!98;UBERON:0000481!7.29e-08!347;UBERON:0005157!1.45e-07!51;UBERON:0000475!1.46e-07!365;UBERON:0009569!2.12e-07!113;UBERON:0000063!4.00e-07!97;UBERON:0002048!4.14e-07!22;UBERON:0000117!4.14e-07!22;UBERON:0000171!4.14e-07!22;UBERON:0000170!4.14e-07!22;UBERON:0005597!4.14e-07!22;UBERON:0000118!4.14e-07!22;UBERON:0005178!6.13e-07!34;UBERON:0002224!6.13e-07!34 | |ontology_enrichment_uberon=UBERON:0001004!2.71e-14!72;UBERON:0004119!1.66e-13!169;UBERON:0000925!1.66e-13!169;UBERON:0006595!1.66e-13!169;UBERON:0000065!2.27e-11!53;UBERON:0001007!4.17e-11!155;UBERON:0001555!4.17e-11!155;UBERON:0007026!4.17e-11!155;UBERON:0008947!7.39e-11!38;UBERON:0003258!7.39e-11!38;UBERON:0000464!9.54e-11!104;UBERON:0000077!1.71e-09!130;UBERON:0005153!3.25e-09!37;UBERON:0004921!5.93e-09!129;UBERON:0004185!5.93e-09!129;UBERON:0000072!7.84e-09!46;UBERON:0000064!1.20e-08!219;UBERON:0000466!2.77e-08!126;UBERON:0000915!3.99e-08!52;UBERON:0000062!4.18e-08!511;UBERON:0001041!5.01e-08!98;UBERON:0000481!7.29e-08!347;UBERON:0005157!1.45e-07!51;UBERON:0000475!1.46e-07!365;UBERON:0009569!2.12e-07!113;UBERON:0000063!4.00e-07!97;UBERON:0002048!4.14e-07!22;UBERON:0000117!4.14e-07!22;UBERON:0000171!4.14e-07!22;UBERON:0000170!4.14e-07!22;UBERON:0005597!4.14e-07!22;UBERON:0000118!4.14e-07!22;UBERON:0005178!6.13e-07!34;UBERON:0002224!6.13e-07!34 | ||
|ontology_enrichment_uberon_v019=UBERON:0002048;1.24e-12;22!UBERON:0000117;1.24e-12;22!UBERON:0000171;1.24e-12;22!UBERON:0000170;1.24e-12;22!UBERON:0000065;4.08e-11;44!UBERON:0000305;4.60e-09;7!UBERON:0000072;7.19e-09;37!UBERON:0005631;8.15e-09;10!UBERON:0000158;8.15e-09;10!UBERON:0005178;1.02e-08;34!UBERON:0002224;1.02e-08;34!UBERON:0004802;2.25e-08;19!UBERON:0000115;2.25e-08;19!UBERON:0000915;7.61e-08;52!UBERON:0001004;7.72e-08;65!UBERON:0005181;8.66e-08;35!UBERON:0004807;5.36e-07;22 | |ontology_enrichment_uberon_v019=UBERON:0002048;1.24e-12;22!UBERON:0000117;1.24e-12;22!UBERON:0000171;1.24e-12;22!UBERON:0000170;1.24e-12;22!UBERON:0000065;4.08e-11;44!UBERON:0000305;4.60e-09;7!UBERON:0000072;7.19e-09;37!UBERON:0005631;8.15e-09;10!UBERON:0000158;8.15e-09;10!UBERON:0005178;1.02e-08;34!UBERON:0002224;1.02e-08;34!UBERON:0004802;2.25e-08;19!UBERON:0000115;2.25e-08;19!UBERON:0000915;7.61e-08;52!UBERON:0001004;7.72e-08;65!UBERON:0005181;8.66e-08;35!UBERON:0004807;5.36e-07;22 | ||
|ontology_enrichment_uberon_v019_2=UBERON:0008947,2.81e-15,38;UBERON:0003258,2.81e-15,38;UBERON:0000065,5.07e-15,54;UBERON:0001004,1.83e-14,74;UBERON:0002048,3.36e-13,22;UBERON:0000117,3.36e-13,22;UBERON:0000171,3.36e-13,22;UBERON:0000170,3.36e-13,22;UBERON:0005597,3.36e-13,22;UBERON:0000118,3.36e-13,22;UBERON:0005153,8.15e-13,37;UBERON:0000915,5.50e-12,52;UBERON:0005178,1.25e-10,34;UBERON:0002224,1.25e-10,34;UBERON:0005157,1.74e-10,47;UBERON:0005181,3.15e-10,35;UBERON:0000305,5.82e-09,7;UBERON:0000072,1.09e-08,47;UBERON:0004802,1.17e-08,19;UBERON:0000115,1.17e-08,19;UBERON:0001041,2.95e-08,87;UBERON:0005631,5.26e-08,14;UBERON:0000158,5.26e-08,14;UBERON:0004119,7.93e-08,160;UBERON:0000925,7.93e-08,160;UBERON:0006595,7.93e-08,160;UBERON:0004871,8.85e-08,8;UBERON:0009569,6.70e-07,112 | |||
|phase1_expression=0.908391896352783,1.2846031433459,0.140954404095971,2.00146596706261,0.446961094427288,0,0,0,0,1.22866968250754,2.09340350391728,1.52908960491121,1.05506791291381,0.123766352960047,0,0,0,0,0,0.123121058076788,0.408001382488506,0,0,0.273748850145768,0.125542639594803,0,0,0,0,0,0,1.83884244895785,0.30120591877825,1.84877005083394,0.0774672005803016,0.142169232487422,0,0,0.200544447470142,0.217010870715852,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.205601498999509,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.34362744548263,0.253019692019503,0,0,0,0,0,0,0,0,0.201606743224732,0,0.144824403882799,0,0,0,0.361439152384566,1.50401373190767,0,0,0.486634870302636,0.189069634328136,0.221729397462564,0.43917392846563,0.458426764241994,0.364295288292542,1.11235332835329,0,0,0,0.238490624305342,0,0,0.198762407366705,0,0,0,0.419499436209906,0,0.208994966536811,0,0,0,0,0,0,0,0.81014194788176,0,0.22452937262617,0,0,0,0,0,0,2.18047026071267,0,0,0,0,0,1.12135520028461,0,0.24666754841716,0,0,0,0,0,0,0,0,0.149448680551801,0.117434498643765,0.161872944368132,0.140450806702248,0.204154171254893,0,0.103325781175765,0,0,0,0,0,0.125118519871964,0,0,0.919463387397059,0.45071417671979,0.113432183160021,0.179389635688862,0.213557388818567,0.211931901159562,0.300091096084402,0.206105058476878,0.257640540045629,0.558350568994769,0.337552664482532,0.194874010322397,0,0.0920498986422993,0,0,0.201504196455281,0,0.386521706326594,0.818238361772504,0.573609190778008,0.609868530647977,0.265059536642971,0.464775771478074,0.310983165046111,1.00928340350251,0,0,0,0,0,0,1.0647612003586,1.18009283054671,1.20505514941741,0.661763836394364,0.653638332277218,0.71181185733329,1.21348177344148,0.784885860501384,1.15424147083917,0,0,0,0,0,0,0,0,0.860919069801795,0.171567810298526,1.86575485194663,0,0.804231779293047,0.833296006426766,0,0,0,0.115930404975077,0.352226082707465,0,0,0,0,2.57545848628462,0,0.234004265139238,0,0.93733833986777,1.84780341018745,0.850650583454319,0.447792613514241,1.45316969256981,1.53353071666084,0,0.088048434013226,0.207328115540772,0.144119953416961,0,0,0,0,0,0,0.300343057843917,0.285826432630578,0.112131084345361,0.43596006883328,0.07333828582095,0.258543431515556,0,0.845302752556,0.26593811658487,0,0,0,0.532844358032199,0.142977993658148,0,0,0,0,0,0.301439377059586,0,0.599837947092342,0,0,0,0.239624855491583,1.14861935834114,0,0.144781306667579,0.205476322550383,0.179060963239896,0.112085143993527,0,0.215627574859517,0,0.254094624222463,0,0,0,0,0,0,0,0.36807447515742,0.500170521059677,0,0.623912584592421,0.356857977594324,0.315404830067869,0,0,0,0,0,0.368738337083406,0.260650843404249,0.195801157462741,0,0,0,0,0,1.66435439510497,0.907170879989041,1.24053903909388,0.306923946576125,0.561320188866147,0.384417447767103,0.511707249066704,0.321707842287215,1.48418066444991,0.308419387605311,0.177561725313127,0,0.519254429183621,0,0.362578348774867,1.80455823272956,0.276242966807689,0.229628896329213,0,0.131124414959424,0.451199612907412,0.231046011313244,1.56869953835371,0,0.422206515571503,0,0.170093705276516,0.431831832204279,0,0.812839312631559,0,0,0.831076008928724,0.223874754722178,0,0,0.512900250232778,0.656029291399411,0.976135183992909,0.206082023295445,0.27470839445503,0.165018999841176,0,1.95018073810956,0,0.096670718292122,0.308097234229289,0,0,0,0.290033387828457,0.0852266274161009,0.0890320356467374,1.15699440752685,1.53752053892085,0,1.4162089319777,0.464845549297286,0,0,0,0,0.869932992075073,0,0.715624433709956,0,0,1.14378116354295,0.255897791311334,0,0,0,0,0.274537029736055,0,0.202182481573316,0,0.842516912477962,0,0,0,0.136499911407986,0,0,0,0,0.876901770507525,0.578775534266688,0,0.405820753925408,0,0.281695602532241,0.143411352204052,0.392996164052485,0,0,0,0,0,0,0.962221127255121,0.670302275535787,0,0.564862804660675,1.72202149068492,0,1.33029046061003,0.689170200620878,0,0,0,0,0,0,0,0,0.106824071127473,0,1.96032172784825,0,0,0,0,0,0.191505370132367,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.835218521685727,0,0.270455678475983,0,0,0.18714054040822,0,0.121360521749513,0.111443384277478,0,2.3874448473769,2.37571744666111,3.99308912729002,0.994147647766298,0,0.111308705022906,0.16480387422676,0.422250816255987,1.19548792950642,0,1.76352923497993,0.20453736500431,0.123084805461069,0,1.07842021376792,0.179021174675609,0,0.493217028184668,0,1.11136990144637,0,0.0927680981618513,0,2.3438498497671,2.0115799999125,0.724999575434793,0.910347586283997,1.01701460117107,1.89110145414349,0,0.291604613383254,0.347249989866585,0,0.120596438625408,0,0.110579259931225,0,0.219385397153973,0.21787692703798,0.83654246567162,0.384751292518985,0.227884111694002,0.23056390438806,0.628303510868405,0.54323685961004,2.23300811812344,0.457987967009312,0,1.02193298195737,0,0,0,0,0,0.189753732724185,0,0.843992258112108,1.30586246527318,0.848118428603645,0.216388639742091,0,0.265372693510018,0,0,0,0.104421949505455,0.067401132980677,0,0,0,1.17398771359254,0,0.789168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|phase1_expression=0.908391896352783,1.2846031433459,0.140954404095971,2.00146596706261,0.446961094427288,0,0,0,0,1.22866968250754,2.09340350391728,1.52908960491121,1.05506791291381,0.123766352960047,0,0,0,0,0,0.123121058076788,0.408001382488506,0,0,0.273748850145768,0.125542639594803,0,0,0,0,0,0,1.83884244895785,0.30120591877825,1.84877005083394,0.0774672005803016,0.142169232487422,0,0,0.200544447470142,0.217010870715852,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.205601498999509,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.34362744548263,0.253019692019503,0,0,0,0,0,0,0,0,0.201606743224732,0,0.144824403882799,0,0,0,0.361439152384566,1.50401373190767,0,0,0.486634870302636,0.189069634328136,0.221729397462564,0.43917392846563,0.458426764241994,0.364295288292542,1.11235332835329,0,0,0,0.238490624305342,0,0,0.198762407366705,0,0,0,0.419499436209906,0,0.208994966536811,0,0,0,0,0,0,0,0.81014194788176,0,0.22452937262617,0,0,0,0,0,0,2.18047026071267,0,0,0,0,0,1.12135520028461,0,0.24666754841716,0,0,0,0,0,0,0,0,0.149448680551801,0.117434498643765,0.161872944368132,0.140450806702248,0.204154171254893,0,0.103325781175765,0,0,0,0,0,0.125118519871964,0,0,0.919463387397059,0.45071417671979,0.113432183160021,0.179389635688862,0.213557388818567,0.211931901159562,0.300091096084402,0.206105058476878,0.257640540045629,0.558350568994769,0.337552664482532,0.194874010322397,0,0.0920498986422993,0,0,0.201504196455281,0,0.386521706326594,0.818238361772504,0.573609190778008,0.609868530647977,0.265059536642971,0.464775771478074,0.310983165046111,1.00928340350251,0,0,0,0,0,0,1.0647612003586,1.18009283054671,1.20505514941741,0.661763836394364,0.653638332277218,0.71181185733329,1.21348177344148,0.784885860501384,1.15424147083917,0,0,0,0,0,0,0,0,0.860919069801795,0.171567810298526,1.86575485194663,0,0.804231779293047,0.833296006426766,0,0,0,0.115930404975077,0.352226082707465,0,0,0,0,2.57545848628462,0,0.234004265139238,0,0.93733833986777,1.84780341018745,0.850650583454319,0.447792613514241,1.45316969256981,1.53353071666084,0,0.088048434013226,0.207328115540772,0.144119953416961,0,0,0,0,0,0,0.300343057843917,0.285826432630578,0.112131084345361,0.43596006883328,0.07333828582095,0.258543431515556,0,0.845302752556,0.26593811658487,0,0,0,0.532844358032199,0.142977993658148,0,0,0,0,0,0.301439377059586,0,0.599837947092342,0,0,0,0.239624855491583,1.14861935834114,0,0.144781306667579,0.205476322550383,0.179060963239896,0.112085143993527,0,0.215627574859517,0,0.254094624222463,0,0,0,0,0,0,0,0.36807447515742,0.500170521059677,0,0.623912584592421,0.356857977594324,0.315404830067869,0,0,0,0,0,0.368738337083406,0.260650843404249,0.195801157462741,0,0,0,0,0,1.66435439510497,0.907170879989041,1.24053903909388,0.306923946576125,0.561320188866147,0.384417447767103,0.511707249066704,0.321707842287215,1.48418066444991,0.308419387605311,0.177561725313127,0,0.519254429183621,0,0.362578348774867,1.80455823272956,0.276242966807689,0.229628896329213,0,0.131124414959424,0.451199612907412,0.231046011313244,1.56869953835371,0,0.422206515571503,0,0.170093705276516,0.431831832204279,0,0.812839312631559,0,0,0.831076008928724,0.223874754722178,0,0,0.512900250232778,0.656029291399411,0.976135183992909,0.206082023295445,0.27470839445503,0.165018999841176,0,1.95018073810956,0,0.096670718292122,0.308097234229289,0,0,0,0.290033387828457,0.0852266274161009,0.0890320356467374,1.15699440752685,1.53752053892085,0,1.4162089319777,0.464845549297286,0,0,0,0,0.869932992075073,0,0.715624433709956,0,0,1.14378116354295,0.255897791311334,0,0,0,0,0.274537029736055,0,0.202182481573316,0,0.842516912477962,0,0,0,0.136499911407986,0,0,0,0,0.876901770507525,0.578775534266688,0,0.405820753925408,0,0.281695602532241,0.143411352204052,0.392996164052485,0,0,0,0,0,0,0.962221127255121,0.670302275535787,0,0.564862804660675,1.72202149068492,0,1.33029046061003,0.689170200620878,0,0,0,0,0,0,0,0,0.106824071127473,0,1.96032172784825,0,0,0,0,0,0.191505370132367,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.835218521685727,0,0.270455678475983,0,0,0.18714054040822,0,0.121360521749513,0.111443384277478,0,2.3874448473769,2.37571744666111,3.99308912729002,0.994147647766298,0,0.111308705022906,0.16480387422676,0.422250816255987,1.19548792950642,0,1.76352923497993,0.20453736500431,0.123084805461069,0,1.07842021376792,0.179021174675609,0,0.493217028184668,0,1.11136990144637,0,0.0927680981618513,0,2.3438498497671,2.0115799999125,0.724999575434793,0.910347586283997,1.01701460117107,1.89110145414349,0,0.291604613383254,0.347249989866585,0,0.120596438625408,0,0.110579259931225,0,0.219385397153973,0.21787692703798,0.83654246567162,0.384751292518985,0.227884111694002,0.23056390438806,0.628303510868405,0.54323685961004,2.23300811812344,0.457987967009312,0,1.02193298195737,0,0,0,0,0,0.189753732724185,0,0.843992258112108,1.30586246527318,0.848118428603645,0.216388639742091,0,0.265372693510018,0,0,0,0.104421949505455,0.067401132980677,0,0,0,1.17398771359254,0,0.789168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| ||
|short_description=p7@DSTN | |short_description=p7@DSTN | ||
}} | }} |
Revision as of 06:44, 18 November 2012
Short description: | p7@DSTN |
---|---|
Species: | Human (Homo sapiens) |
DPI dataset: | NA |
TSS-like-by-RIKEN-classifier(Yes/No): | NA |
DHS support(Yes/No): | NA |
Description: | CAGE_peak_7_at_DSTN_5end |
Coexpression cluster: | NA |
Association with transcript: | -31bp_to_ENST00000246069_5end |
EntrezGene: | DSTN |
HGNC: | 15750 |
UniProt: | P60981 |
Genome view: | ZENBU |
View on UCSC genome browser
CAGE Expression
- Click each plot point to find sample in table
Ontology-based sample term enrichment analysis<b>Summary:</b>This analysis has been performed by utilizing wilcoxon rank sum test.When the number of associated cells/tissues are > n , randomly sampled n cells/tissues are used for P value calculation with rank sum test. this process are repeated several times, and the P values are averaged on the log space <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source dataset<br>data
Ontology term | p-value | n |
---|---|---|
epithelial cell | 6.48e-15 | 253 |
endo-epithelial cell | 4.79e-12 | 42 |
epithelial cell of lung | 1.17e-08 | 19 |
endodermal cell | 1.30e-08 | 58 |
respiratory epithelial cell | 7.25e-08 | 13 |
extraembryonic cell | 4.19e-07 | 19 |
Ontology term | p-value | n |
---|---|---|
respiratory primordium | 2.81e-15 | 38 |
endoderm of foregut | 2.81e-15 | 38 |
respiratory tract | 5.07e-15 | 54 |
respiratory system | 1.83e-14 | 74 |
lung | 3.36e-13 | 22 |
respiratory tube | 3.36e-13 | 22 |
respiration organ | 3.36e-13 | 22 |
pair of lungs | 3.36e-13 | 22 |
lung primordium | 3.36e-13 | 22 |
lung bud | 3.36e-13 | 22 |
epithelial bud | 8.15e-13 | 37 |
thoracic segment of trunk | 5.50e-12 | 52 |
thoracic cavity element | 1.25e-10 | 34 |
thoracic cavity | 1.25e-10 | 34 |
epithelial fold | 1.74e-10 | 47 |
thoracic segment organ | 3.15e-10 | 35 |
amnion | 5.82e-09 | 7 |
segment of respiratory tract | 1.09e-08 | 47 |
respiratory tract epithelium | 1.17e-08 | 19 |
lung epithelium | 1.17e-08 | 19 |
foregut | 2.95e-08 | 87 |
extraembryonic membrane | 5.26e-08 | 14 |
membranous layer | 5.26e-08 | 14 |
endoderm-derived structure | 7.93e-08 | 160 |
endoderm | 7.93e-08 | 160 |
presumptive endoderm | 7.93e-08 | 160 |
somatic layer of lateral plate mesoderm | 8.85e-08 | 8 |
subdivision of trunk | 6.70e-07 | 112 |
Ontology term | p-value | n |
---|---|---|
carcinoma | 6.49e-14 | 106 |
cell type cancer | 3.05e-08 | 143 |
squamous cell carcinoma | 1.19e-07 | 14 |
thoracic cancer | 9.94e-07 | 4 |
breast cancer | 9.94e-07 | 4 |
Property "Dpi dataset" (as page type) with input value "{{{DPIdataset}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Property "TSS like by RIKEN classifier" (as page type) with input value "{{{TSSclassifier}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Property "DHS support" (as page type) with input value "{{{DHSsupport}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.