MCL coexpression mm9:2852

Phase1 CAGE Peaks

	Short description
Mm9::chr13:48356475..48356492,+	p1@Id4
Mm9::chr2:20890358..20890371,+	p3@Gm13375
Mm9::chr4:41587355..41587377,-	p1@ENSMUST00000127306

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048712	negative regulation of astrocyte differentiation	0.00405412808853339
GO:0048710	regulation of astrocyte differentiation	0.00405412808853339
GO:0021766	hippocampus development	0.00405412808853339
GO:0014014	negative regulation of gliogenesis	0.00405412808853339
GO:0045686	negative regulation of glial cell differentiation	0.00405412808853339
GO:0048708	astrocyte differentiation	0.00405412808853339
GO:0045685	regulation of glial cell differentiation	0.00405412808853339
GO:0021895	cerebral cortex neuron differentiation	0.00405412808853339
GO:0014013	regulation of gliogenesis	0.00405412808853339
GO:0021761	limbic system development	0.00405412808853339
GO:0021543	pallium development	0.00515979938540614
GO:0045665	negative regulation of neuron differentiation	0.00540550411804453
GO:0021537	telencephalon development	0.0068413411494001
GO:0000082	G1/S transition of mitotic cell cycle	0.0068413411494001
GO:0007405	neuroblast proliferation	0.0068413411494001
GO:0045664	regulation of neuron differentiation	0.0068413411494001
GO:0010001	glial cell differentiation	0.00831096258149346
GO:0042063	gliogenesis	0.00831096258149346
GO:0051325	interphase	0.00831096258149346
GO:0051329	interphase of mitotic cell cycle	0.00831096258149346
GO:0045596	negative regulation of cell differentiation	0.0164095660726352
GO:0030900	forebrain development	0.0183317096177162
GO:0051093	negative regulation of developmental process	0.0183317096177162
GO:0045595	regulation of cell differentiation	0.0258450665644004
GO:0008284	positive regulation of cell proliferation	0.0285410617432751
GO:0007420	brain development	0.028690752626544
GO:0000278	mitotic cell cycle	0.0334465567304005
GO:0007417	central nervous system development	0.0334465567304005
GO:0050793	regulation of developmental process	0.0357881651953293
GO:0022403	cell cycle phase	0.0362255961459274
GO:0030182	neuron differentiation	0.0362255961459274
GO:0048699	generation of neurons	0.0389442001231844
GO:0042127	regulation of cell proliferation	0.0389442001231844
GO:0022008	neurogenesis	0.040302802762479

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
ectodermal cell	4.34e-19	44
neurectodermal cell	4.34e-19	44
neural cell	2.01e-18	43
CNS neuron (sensu Vertebrata)	2.81e-15	23
neuroblast (sensu Vertebrata)	2.81e-15	23
neuron	1.44e-14	33
neuronal stem cell	1.44e-14	33
neuroblast	1.44e-14	33
electrically signaling cell	1.44e-14	33
non-terminally differentiated cell	3.36e-14	49
electrically responsive cell	1.78e-10	39
electrically active cell	1.78e-10	39

Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	1.11e-30	95
ectoderm	1.11e-30	95
presumptive ectoderm	1.11e-30	95
central nervous system	3.82e-30	73
nervous system	4.16e-30	75
neurectoderm	7.97e-27	64
neural plate	7.97e-27	64
presumptive neural plate	7.97e-27	64
ecto-epithelium	4.82e-25	73
regional part of nervous system	9.07e-24	54
neural tube	9.44e-23	52
neural rod	9.44e-23	52
future spinal cord	9.44e-23	52
neural keel	9.44e-23	52
brain	3.72e-19	47
future brain	3.72e-19	47
pre-chordal neural plate	5.37e-19	49
regional part of brain	9.67e-19	46
structure with developmental contribution from neural crest	6.51e-17	92
anterior neural tube	5.45e-16	40
gray matter	7.44e-16	34
regional part of forebrain	1.60e-15	39
forebrain	1.60e-15	39
future forebrain	1.60e-15	39
brain grey matter	1.04e-12	29
regional part of telencephalon	1.04e-12	29
telencephalon	1.04e-12	29
embryo	2.74e-09	320
cerebral cortex	2.51e-08	21
cerebral hemisphere	2.51e-08	21
pallium	2.51e-08	21
multi-cellular organism	6.04e-08	333
posterior neural tube	1.68e-07	12
chordal neural plate	1.68e-07	12

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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