MCL coexpression mm9:1402

Phase1 CAGE Peaks

	Short description
Mm9::chr17:56601566..56601666,-	p2@Ptprs
Mm9::chr4:134108037..134108115,-	p1@Sepn1
Mm9::chr6:29685471..29685547,+	p1@Smo
Mm9::chr6:29685631..29685663,+	p2@Smo
Mm9::chr6:29685667..29685680,+	p3@Smo
Mm9::chr7:86860574..86860635,-	p@chr7:86860574..86860635 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0051100	negative regulation of binding	0.0183440988746465
GO:0043392	negative regulation of DNA binding	0.0183440988746465
GO:0021938	smoothened signaling pathway in regulation of granule cell precursor cell proliferation	0.0183440988746465
GO:0021937	Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation	0.0183440988746465
GO:0002052	positive regulation of neuroblast proliferation	0.0183440988746465
GO:0004727	prenylated protein tyrosine phosphatase activity	0.0183440988746465
GO:0021940	positive regulation of granule cell precursor proliferation	0.0183440988746465
GO:0021936	regulation of granule cell precursor proliferation	0.0183440988746465
GO:0021534	cell proliferation in hindbrain	0.0183440988746465
GO:0021924	cell proliferation in the external granule layer	0.0183440988746465
GO:0021930	granule cell precursor proliferation	0.0183440988746465
GO:0051101	regulation of DNA binding	0.0183440988746465
GO:0004926	non-G-protein coupled 7TM receptor activity	0.0186252951044767
GO:0021696	cerebellar cortex morphogenesis	0.0220056817904624
GO:0021587	cerebellum morphogenesis	0.0220056817904624
GO:0021575	hindbrain morphogenesis	0.0220056817904624
GO:0021695	cerebellar cortex development	0.0229523844659907
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	0.0229523844659907
GO:0051098	regulation of binding	0.0229523844659907
GO:0001755	neural crest cell migration	0.0229523844659907
GO:0022037	metencephalon development	0.0229523844659907
GO:0021549	cerebellum development	0.0229523844659907
GO:0021953	central nervous system neuron differentiation	0.0229523844659907
GO:0007405	neuroblast proliferation	0.0231659527747764
GO:0001649	osteoblast differentiation	0.0231659527747764
GO:0007224	smoothened signaling pathway	0.0231659527747764
GO:0001570	vasculogenesis	0.0231659527747764
GO:0014032	neural crest cell development	0.0231659527747764
GO:0014033	neural crest cell differentiation	0.0231659527747764
GO:0007368	determination of left/right symmetry	0.0231659527747764
GO:0003007	heart morphogenesis	0.0231659527747764
GO:0009799	determination of symmetry	0.0231659527747764
GO:0009855	determination of bilateral symmetry	0.0231659527747764
GO:0042475	odontogenesis of dentine-containing teeth	0.0231659527747764
GO:0042476	odontogenesis	0.0231659527747764
GO:0048762	mesenchymal cell differentiation	0.0231659527747764
GO:0014031	mesenchymal cell development	0.0231659527747764
GO:0030902	hindbrain development	0.0242267904896349
GO:0009953	dorsal/ventral pattern formation	0.0242267904896349
GO:0048589	developmental growth	0.0263605344081711
GO:0005929	cilium	0.0358600873421324
GO:0004725	protein tyrosine phosphatase activity	0.0448866127346977
GO:0001503	ossification	0.0468114595328525
GO:0031214	biomineral formation	0.0468114595328525

Relative expression of the co-expression cluster over median <br>Analyst:

---

"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}