MCL coexpression mm9:499

Phase1 CAGE Peaks

	Short description
Mm9::chr15:33790939..33790943,+	p@chr15:33790939..33790943 +
Mm9::chr4:138387772..138387783,+	p1@Pla2g2a
Mm9::chr4:138388571..138388598,+	p@chr4:138388571..138388598 +
Mm9::chr4:138388796..138388811,+	p3@ENSMUST00000147728
Mm9::chr4:138388841..138388850,+	p5@ENSMUST00000147728
Mm9::chr4:138388852..138388863,+	p4@ENSMUST00000147728
Mm9::chr4:138388869..138388884,+	p2@ENSMUST00000147728
Mm9::chr4:138388916..138388925,+	p7@ENSMUST00000147728
Mm9::chr4:138389179..138389192,+	p1@ENSMUST00000147728
Mm9::chr4:138390835..138390853,+	p@chr4:138390835..138390853 +
Mm9::chr4:138390983..138390988,+	p@chr4:138390983..138390988 +
Mm9::chr6:56075077..56075082,+	p@chr6:56075077..56075082 +
Mm9::chr7:134194033..134194045,+	p@chr7:134194033..134194045 +
Mm9::chr7:134195225..134195237,+	p@chr7:134195225..134195237 +
Mm9::chr7:28876815..28876836,+	p@chr7:28876815..28876836 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007339	binding of sperm to zona pellucida	0.0312114896282304
GO:0035036	sperm-egg recognition	0.0312114896282304
GO:0009988	cell-cell recognition	0.0312114896282304
GO:0004623	phospholipase A2 activity	0.0312114896282304
GO:0007338	single fertilization	0.0382036845473835
GO:0008037	cell recognition	0.0382036845473835
GO:0004620	phospholipase activity	0.0382036845473835
GO:0009566	fertilization	0.0382036845473835
GO:0016298	lipase activity	0.0429529941524457
GO:0001558	regulation of cell growth	0.047595227214805
GO:0016042	lipid catabolic process	0.047595227214805
GO:0016049	cell growth	0.047595227214805
GO:0004091	carboxylesterase activity	0.047595227214805
GO:0008361	regulation of cell size	0.047595227214805
GO:0006644	phospholipid metabolic process	0.0481467517958884

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
brush border epithelial cell	1.46e-30	6
gut absorptive cell	1.46e-30	6
absorptive cell	1.46e-30	6
enterocyte	1.46e-30	6
columnar/cuboidal epithelial cell	3.67e-26	7
intestinal epithelial cell	2.74e-20	9
epithelial cell of alimentary canal	2.74e-20	9
transporting cell	2.19e-16	3
M cell of gut	2.19e-16	3
epithelial cell	1.01e-15	25
endo-epithelial cell	4.87e-12	15
endodermal cell	6.25e-09	20
defensive cell	2.54e-07	7

Uber Anatomy

Ontology term	p-value	n
mucosa	4.78e-41	15
intestinal mucosa	9.09e-32	13
anatomical wall	9.09e-32	13
wall of intestine	9.09e-32	13
gastrointestinal system mucosa	9.09e-32	13
organ component layer	3.85e-25	24
epithelium of mucosa	2.74e-20	9
gastrointestinal system epithelium	2.74e-20	9
intestinal epithelium	2.74e-20	9
intestine	5.66e-19	31
ileal mucosa	3.12e-17	3
ileum	3.12e-17	3
mucosa of small intestine	3.12e-17	3
wall of small intestine	3.12e-17	3
simple columnar epithelium	1.52e-16	11
small intestine	4.58e-13	4
gastrointestinal system	5.28e-12	47
gut-associated lymphoid tissue	1.48e-11	2
mucosa-associated lymphoid tissue	1.48e-11	2
lymphoid tissue	1.48e-11	2
lymphoid system	5.43e-08	3

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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