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Coexpression cluster:C1163

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Full id: C1163_Eosinophils_Neutrophils_CD14_Basophils_CD14CD16_Peripheral_Whole



Phase1 CAGE Peaks

Hg19::chr12:116971076..116971098,-p@chr12:116971076..116971098
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Hg19::chr12:6248302..6248322,+p@chr12:6248302..6248322
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Hg19::chr15:70046791..70046807,+p@chr15:70046791..70046807
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Hg19::chr17:72524933..72524943,+p@chr17:72524933..72524943
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Hg19::chr3:195627624..195627639,-p@chr3:195627624..195627639
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Hg19::chr6:14728163..14728174,-p@chr6:14728163..14728174
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Hg19::chr6:166755214..166755237,+p@chr6:166755214..166755237
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte6.61e-9642
CD14-positive, CD16-negative classical monocyte6.61e-9642
myeloid leukocyte4.54e-8472
defensive cell6.27e-8348
phagocyte6.27e-8348
monopoietic cell9.28e-6559
monocyte9.28e-6559
monoblast9.28e-6559
promonocyte9.28e-6559
macrophage dendritic cell progenitor2.05e-6261
myeloid lineage restricted progenitor cell8.13e-6166
granulocyte monocyte progenitor cell8.38e-6067
myeloid cell2.62e-53108
common myeloid progenitor2.62e-53108
leukocyte7.66e-53136
stuff accumulating cell3.36e-4287
nongranular leukocyte4.64e-41115
hematopoietic stem cell5.00e-41168
angioblastic mesenchymal cell5.00e-41168
hematopoietic cell1.81e-38177
hematopoietic oligopotent progenitor cell1.05e-36161
hematopoietic multipotent progenitor cell1.05e-36161
intermediate monocyte1.98e-369
CD14-positive, CD16-positive monocyte1.98e-369
hematopoietic lineage restricted progenitor cell3.41e-34120
granulocyte2.67e-258
blood cell4.07e-1811
mesenchymal cell1.91e-14354
connective tissue cell5.62e-14361
neutrophil1.11e-133
basophil4.15e-133
single nucleate cell5.98e-133
mononuclear cell5.98e-133
non-classical monocyte1.05e-123
CD14-low, CD16-positive monocyte1.05e-123
motile cell2.53e-12386
stem cell1.95e-10441
multi fate stem cell2.65e-10427
somatic stem cell5.04e-10433
Uber Anatomy
Ontology termp-valuen
hematopoietic system9.88e-5998
blood island9.88e-5998
hemolymphoid system1.64e-52108
bone marrow7.24e-5276
bone element1.56e-4782
skeletal element1.22e-4290
immune system5.06e-4193
skeletal system1.28e-37100
lateral plate mesoderm8.19e-24203
musculoskeletal system2.07e-19167
connective tissue2.45e-13371
mesoderm3.83e-12315
mesoderm-derived structure3.83e-12315
presumptive mesoderm3.83e-12315
blood4.61e-1215
haemolymphatic fluid4.61e-1215
organism substance4.61e-1215


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.