MCL coexpression mm9:2597

Phase1 CAGE Peaks

	Short description
Mm9::chr10:86195163..86195174,-	p1@ENSMUST00000070435
Mm9::chr4:129985975..129985996,+	p1@Fabp3
Mm9::chr4:148829080..148829095,-	p1@Rbp7

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008289	lipid binding	0.00569582052078081
GO:0006656	phosphatidylcholine biosynthetic process	0.00569582052078081
GO:0019841	retinol binding	0.00569582052078081
GO:0046470	phosphatidylcholine metabolic process	0.00569582052078081
GO:0016918	retinal binding	0.00569582052078081
GO:0005501	retinoid binding	0.00569582052078081
GO:0019840	isoprenoid binding	0.00569582052078081
GO:0046474	glycerophospholipid biosynthetic process	0.0114958181651117
GO:0008654	phospholipid biosynthetic process	0.0177665498089116
GO:0006650	glycerophospholipid metabolic process	0.0177665498089116
GO:0046467	membrane lipid biosynthetic process	0.0200423232590758
GO:0019842	vitamin binding	0.0267684210049848
GO:0006644	phospholipid metabolic process	0.0272896568883578
GO:0006810	transport	0.028835167927688
GO:0051234	establishment of localization	0.028835167927688
GO:0006643	membrane lipid metabolic process	0.028835167927688
GO:0051179	localization	0.0338976457464883
GO:0008610	lipid biosynthetic process	0.0399657895163844

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	1.20e-08	18
heart	1.20e-08	18
primitive heart tube	1.20e-08	18
primary heart field	1.20e-08	18
anterior lateral plate mesoderm	1.20e-08	18
heart tube	1.20e-08	18
heart primordium	1.20e-08	18
cardiac mesoderm	1.20e-08	18
cardiogenic plate	1.20e-08	18
heart rudiment	1.20e-08	18
multi-cellular organism	1.88e-07	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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