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UBERON:0002106

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Name:spleen
Definition:"Organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system.[1] In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron.[2] It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells." [Wikipedia:Spleen]
Xrefs:
links:

AAO:0010395
BTO:0001281
EFO:0000869
EMAPA:18767
EV:0100055
FMA:7196
GAID:1289
galen:Spleen
[1]
[2]
MA:0000141
MAT:0000085
MESH:A.15.382.520.604.713
MIAA:0000085
ncithesaurus:Spleen
OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA
SCTID:181279003
TAO:0000436
VHOG:0000120
XAO:0000328

ZFA:0000436
Synonyms: "splen, lien" RELATED LATIN [Wikipedia:Spleen]
Comments:Taxon notes: Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96) [PMID:20959416]
Alt_id: UBERON:FMA_7196-MA_0000141-MIAA_0000085-XAO_0000328-ZFA_0000436
Subset: organ_slim
uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0004177(hemopoietic organ),UBERON:0005057(immune organ),UBERON:0013765(digestive system element),UBERON:0017672(abdominal viscera)
develops_from:UBERON:0006293(spleen primordium)
part_of:UBERON:0000916(abdomen),UBERON:0001007(digestive system),UBERON:0002390(hematopoietic system),UBERON:0002405(immune system)



Children

is a:FF:10424-106D1 (splenic lymphoma with villous lymphocytes cell line:SLVL)
derives from:FF:0010025 (human spleen - adult sample),FF:0010044 (human spleen - fetal sample),FF:0011306 (mouse spleen- adult sample),FF:0011360 (mouse spleen- embryo E16 sample),FF:0011417 (mouse spleen- neonate N10 sample),FF:0011430 (mouse spleen- neonate N20 sample),FF:0011491 (mouse spleen- neonate N25 sample),FF:0011517 (mouse spleen-, embryo E18 sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002106 (spleen), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
8.98e-131FFCP PHASE2:Hg19::chr6:119812455..119812476,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@uc003pyn.1
8.98e-131FFCP PHASE1:Hg19::chr11:56859608..56859619,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859608..56859619, -
8.98e-131FFCP PHASE1:Hg19::chr9:79894790..79894797,+#_736a17cfbd40f566fd6df9e82ed4ec5ep10@VPS13A
8.98e-131FFCP PHASE1:Hg19::chr4:76901930..76901942,+#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000501239
8.98e-131FFCP PHASE1:Hg19::chr8:22436248..22436259,+#_736a17cfbd40f566fd6df9e82ed4ec5ep11@PDLIM2
8.98e-131FFCP PHASE1:Hg19::chr1:159172187..159172197,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@uc001ftm.1
8.98e-131FFCP PHASE2:Hg19::chr10:98014908..98014919,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr10:98014908..98014919, -
8.98e-131FFCP PHASE2:Hg19::chr1:28520450..28520453,-#_736a17cfbd40f566fd6df9e82ed4ec5ep21@PTAFR
8.98e-131FFCP PHASE2:Hg19::chr11:56859608..56859619,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859608..56859619, -
8.98e-131FFCP PHASE1:Hg19::chr9:127269434..127269438,-#_736a17cfbd40f566fd6df9e82ed4ec5ep8@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr21:28820941..28820952,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@ENST00000420186, p2@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr15:95561320..95561328,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr15:95561320..95561328, -
8.98e-131FFCP PHASE2:Hg19::chr8:22424709..22424716,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@ENST00000517384
8.98e-131FFCP PHASE1:Hg19::chr10:98014943..98014960,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr10:98014943..98014960, -
8.98e-131FFCP PHASE2:Hg19::chr1:157811772..157811796,-#_736a17cfbd40f566fd6df9e82ed4ec5ep7@CD5L
8.98e-131FFCP PHASE1:Hg19::chr11:56859638..56859643,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859638..56859643, -
8.98e-131FFCP PHASE2:Hg19::chr21:28820892..28820899,-#_736a17cfbd40f566fd6df9e82ed4ec5ep4@ENST00000420186, p4@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr11:1891326..1891337,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:1891326..1891337, -
8.98e-131FFCP PHASE1:Hg19::chr9:127260615..127260651,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr9:127260615..127260651, -
8.98e-131FFCP PHASE2:Hg19::chr16:84218794..84218800,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr16:84218794..84218800, +
8.98e-131FFCP PHASE1:Hg19::chr6:152639579..152639586,-#_736a17cfbd40f566fd6df9e82ed4ec5ep60@SYNE1
8.98e-131FFCP PHASE1:Hg19::chr9:133973310..133973321,+#_736a17cfbd40f566fd6df9e82ed4ec5ep18@AIF1L
8.98e-131FFCP PHASE2:Hg19::chr15:95561320..95561328,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr15:95561320..95561328, -
8.98e-131FFCP PHASE2:Hg19::chr10:98014943..98014960,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr10:98014943..98014960, -
8.98e-131FFCP PHASE1:Hg19::chr14:75904485..75904519,+#_736a17cfbd40f566fd6df9e82ed4ec5ep12@JDP2
8.98e-131FFCP PHASE1:Hg19::chr8:47834174..47834213,+#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000524012
8.98e-131FFCP PHASE2:Hg19::chr11:56859638..56859643,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859638..56859643, -
8.98e-131FFCP PHASE2:Hg19::chr19:32401253..32401271,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr19:32401253..32401271, -
8.98e-131FFCP PHASE1:Hg19::chr9:127269462..127269484,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr21:28820954..28820963,-#_736a17cfbd40f566fd6df9e82ed4ec5ep3@ENST00000420186, p3@uc002ymh.2
8.98e-131FFCP PHASE2:Hg19::chr8:22424743..22424759,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000517384
8.98e-131FFCP PHASE2:Hg19::chrX:69645652..69645664,+#_736a17cfbd40f566fd6df9e82ed4ec5ep7@GDPD2
8.98e-131FFCP PHASE2:Hg19::chr11:1891326..1891337,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:1891326..1891337, -
8.98e-131FFCP PHASE1:Hg19::chr11:56859693..56859701,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859693..56859701, -
8.98e-131FFCP PHASE2:Hg19::chr11:925449..925458,+#_736a17cfbd40f566fd6df9e82ed4ec5ep17@AP2A2
8.98e-131FFCP PHASE2:Hg19::chr21:28820911..28820933,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000420186, p1@uc002ymh.2
8.98e-131FFCP PHASE2:Hg19::chr9:127269434..127269438,-#_736a17cfbd40f566fd6df9e82ed4ec5ep8@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr6:119812455..119812476,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@uc003pyn.1
8.98e-131FFCP PHASE2:Hg19::chr14:75904485..75904519,+#_736a17cfbd40f566fd6df9e82ed4ec5ep12@JDP2
8.98e-131FFCP PHASE2:Hg19::chr9:79894790..79894797,+#_736a17cfbd40f566fd6df9e82ed4ec5ep10@VPS13A
8.98e-131FFCP PHASE1:Hg19::chr11:56859584..56859589,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859584..56859589, -
8.98e-131FFCP PHASE1:Hg19::chr7:22259740..22259751,-#_736a17cfbd40f566fd6df9e82ed4ec5ep19@RAPGEF5
8.98e-131FFCP PHASE2:Hg19::chr4:76901930..76901942,+#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000501239
8.98e-131FFCP PHASE2:Hg19::chr11:56859693..56859701,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859693..56859701, -
8.98e-131FFCP PHASE1:Hg19::chr9:127269488..127269495,-#_736a17cfbd40f566fd6df9e82ed4ec5ep5@NR5A1
8.98e-131FFCP PHASE2:Hg19::chr9:127260615..127260651,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr9:127260615..127260651, -
8.98e-131FFCP PHASE2:Hg19::chr8:22436248..22436259,+#_736a17cfbd40f566fd6df9e82ed4ec5ep11@PDLIM2
8.98e-131FFCP PHASE1:Hg19::chr9:124516729..124516752,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr9:124516729..124516752, +
8.98e-131FFCP PHASE2:Hg19::chr1:159172187..159172197,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@uc001ftm.1
8.98e-131FFCP PHASE1:Hg19::chr1:28520450..28520453,-#_736a17cfbd40f566fd6df9e82ed4ec5ep21@PTAFR
8.98e-131FFCP PHASE1:Hg19::chr1:157811772..157811796,-#_736a17cfbd40f566fd6df9e82ed4ec5ep7@CD5L
8.98e-131FFCP PHASE2:Hg19::chr9:133973310..133973321,+#_736a17cfbd40f566fd6df9e82ed4ec5ep18@AIF1L
8.98e-131FFCP PHASE2:Hg19::chr21:28820941..28820952,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@ENST00000420186, p2@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr8:22424709..22424716,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@ENST00000517384
8.98e-131FFCP PHASE2:Hg19::chr17:78171885..78171900,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr17:78171885..78171900, +
8.98e-131FFCP PHASE1:Hg19::chr16:84218794..84218800,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr16:84218794..84218800, +
8.98e-131FFCP PHASE2:Hg19::chr11:56859584..56859589,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859584..56859589, -
8.98e-131FFCP PHASE2:Hg19::chr9:127269462..127269484,-#_736a17cfbd40f566fd6df9e82ed4ec5ep2@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr21:28820892..28820899,-#_736a17cfbd40f566fd6df9e82ed4ec5ep4@ENST00000420186, p4@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr11:56859603..56859606,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859603..56859606, -
8.98e-131FFCP PHASE1:Hg19::chr11:925449..925458,+#_736a17cfbd40f566fd6df9e82ed4ec5ep17@AP2A2
8.98e-131FFCP PHASE2:Hg19::chr6:152639579..152639586,-#_736a17cfbd40f566fd6df9e82ed4ec5ep60@SYNE1
8.98e-131FFCP PHASE2:Hg19::chr8:47834174..47834213,+#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000524012
8.98e-131FFCP PHASE1:Hg19::chr19:32401253..32401271,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr19:32401253..32401271, -
8.98e-131FFCP PHASE1:Hg19::chrX:69645652..69645664,+#_736a17cfbd40f566fd6df9e82ed4ec5ep7@GDPD2
8.98e-131FFCP PHASE2:Hg19::chr7:22259740..22259751,-#_736a17cfbd40f566fd6df9e82ed4ec5ep19@RAPGEF5
8.98e-131FFCP PHASE2:Hg19::chr21:28820954..28820963,-#_736a17cfbd40f566fd6df9e82ed4ec5ep3@ENST00000420186, p3@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr8:22424743..22424759,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000517384
8.98e-131FFCP PHASE2:Hg19::chr11:56859603..56859606,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr11:56859603..56859606, -
8.98e-131FFCP PHASE2:Hg19::chr9:127269488..127269495,-#_736a17cfbd40f566fd6df9e82ed4ec5ep5@NR5A1
8.98e-131FFCP PHASE1:Hg19::chr21:28820911..28820933,-#_736a17cfbd40f566fd6df9e82ed4ec5ep1@ENST00000420186, p1@uc002ymh.2
8.98e-131FFCP PHASE1:Hg19::chr17:78171885..78171900,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr17:78171885..78171900, +
8.98e-131FFCP PHASE2:Hg19::chr9:124516729..124516752,+#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr9:124516729..124516752, +
8.98e-131FFCP PHASE1:Hg19::chr10:98014908..98014919,-#_736a17cfbd40f566fd6df9e82ed4ec5ep@chr10:98014908..98014919, -
6.24e-88FFCP PHASE1:Hg19::chr1:21011608..21011618,-#_ad33c80427af15cbdae05963c6c52f28p15@KIF17
6.24e-88FFCP PHASE2:Hg19::chr22:36718586..36718593,-#_ad33c80427af15cbdae05963c6c52f28p@chr22:36718586..36718593, -
6.24e-88FFCP PHASE1:Hg19::chr19:32401274..32401289,-#_ad33c80427af15cbdae05963c6c52f28p@chr19:32401274..32401289, -
6.24e-88FFCP PHASE1:Hg19::chr21:40459334..40459341,+#_ad33c80427af15cbdae05963c6c52f28p@chr21:40459334..40459341, +
6.24e-88FFCP PHASE2:Hg19::chr9:127267367..127267383,+#_ad33c80427af15cbdae05963c6c52f28p@chr9:127267367..127267383, +
6.24e-88FFCP PHASE2:Hg19::chr4:146461014..146461025,+#_ad33c80427af15cbdae05963c6c52f28p@chr4:146461014..146461025, +
6.24e-88FFCP PHASE2:Hg19::chr3:130267501..130267516,+#_ad33c80427af15cbdae05963c6c52f28p@chr3:130267501..130267516, +
6.24e-88FFCP PHASE2:Hg19::chr1:21011608..21011618,-#_ad33c80427af15cbdae05963c6c52f28p15@KIF17
6.24e-88FFCP PHASE2:Hg19::chr19:32401274..32401289,-#_ad33c80427af15cbdae05963c6c52f28p@chr19:32401274..32401289, -
6.24e-88FFCP PHASE1:Hg19::chr11:56859722..56859732,-#_ad33c80427af15cbdae05963c6c52f28p@chr11:56859722..56859732, -
6.24e-88FFCP PHASE1:Hg19::chr22:36718586..36718593,-#_ad33c80427af15cbdae05963c6c52f28p@chr22:36718586..36718593, -
6.24e-88FFCP PHASE2:Hg19::chr21:40459334..40459341,+#_ad33c80427af15cbdae05963c6c52f28p@chr21:40459334..40459341, +
6.24e-88FFCP PHASE2:Hg19::chr11:56859722..56859732,-#_ad33c80427af15cbdae05963c6c52f28p@chr11:56859722..56859732, -
6.24e-88FFCP PHASE1:Hg19::chr4:146461014..146461025,+#_ad33c80427af15cbdae05963c6c52f28p@chr4:146461014..146461025, +
6.24e-88FFCP PHASE1:Hg19::chr3:130267501..130267516,+#_ad33c80427af15cbdae05963c6c52f28p@chr3:130267501..130267516, +
6.24e-88FFCP PHASE1:Hg19::chr9:127267367..127267383,+#_ad33c80427af15cbdae05963c6c52f28p@chr9:127267367..127267383, +
9.74e-88FFCP PHASE2:Hg19::chr2:1508349..1508357,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr2:1508349..1508357, +
9.74e-88FFCP PHASE1:Hg19::chr7:151070957..151070988,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr7:151070957..151070988, +
9.74e-88FFCP PHASE1:Hg19::chr2:128321491..128321509,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr2:128321491..128321509, +
9.74e-88FFCP PHASE2:Hg19::chr16:70680361..70680370,+#_9d693fbafe05dbaa637fb69ee44aa626p6@IL34
9.74e-88FFCP PHASE1:Hg19::chr12:72481040..72481051,+#_9d693fbafe05dbaa637fb69ee44aa626p19@TRHDE
9.74e-88FFCP PHASE1:Hg19::chr14:24168655..24168686,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr14:24168655..24168686, +
9.74e-88FFCP PHASE1:Hg19::chr2:1508349..1508357,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr2:1508349..1508357, +
9.74e-88FFCP PHASE2:Hg19::chr12:72481040..72481051,+#_9d693fbafe05dbaa637fb69ee44aa626p19@TRHDE
9.74e-88FFCP PHASE1:Hg19::chr16:70680361..70680370,+#_9d693fbafe05dbaa637fb69ee44aa626p6@IL34
9.74e-88FFCP PHASE2:Hg19::chr2:128321491..128321509,+#_9d693fbafe05dbaa637fb69ee44aa626p@chr2:128321491..128321509, +










Property "Property value" (as page type) with input value "UBPROP:0000001 "An organ involved in red blood cell filtration and immune response.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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