MCL coexpression mm9:2752

Phase1 CAGE Peaks

	Short description
Mm9::chr11:98902551..98902568,+	p1@Igfbp4
Mm9::chr2:27532479..27532509,+	p3@Rxra
Mm9::chr2:27532513..27532525,+	p8@Rxra

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0055010	ventricular cardiac muscle morphogenesis	0.0138763356260445
GO:0055008	cardiac muscle morphogensis	0.0138763356260445
GO:0055012	ventricular cardiac muscle cell differentiation	0.0138763356260445
GO:0048644	muscle morphogenesis	0.0138763356260445
GO:0014855	striated muscle cell proliferation	0.0138763356260445
GO:0060038	cardiac muscle cell proliferation	0.0138763356260445
GO:0055007	cardiac muscle cell differentiation	0.0148666877318437
GO:0033002	muscle cell proliferation	0.0156078834662755
GO:0016439	tRNA-pseudouridine synthase activity	0.0156078834662755
GO:0035051	cardiac cell differentiation	0.0156078834662755
GO:0009982	pseudouridine synthase activity	0.0170253821181593
GO:0005520	insulin-like growth factor binding	0.018206203264297
GO:0051146	striated muscle cell differentiation	0.0215454743793604
GO:0016866	intramolecular transferase activity	0.0215454743793604
GO:0009653	anatomical structure morphogenesis	0.0233592523767514
GO:0005496	steroid binding	0.0268096031911463
GO:0003707	steroid hormone receptor activity	0.0268096031911463
GO:0004879	ligand-dependent nuclear receptor activity	0.0268096031911463
GO:0019838	growth factor binding	0.0268096031911463
GO:0042692	muscle cell differentiation	0.0327334400516259
GO:0001558	regulation of cell growth	0.0400619655199513
GO:0016049	cell growth	0.0443625672618589
GO:0048856	anatomical structure development	0.0449217625301017
GO:0008361	regulation of cell size	0.0462731375699493

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
liver	8.58e-12	22
epithelial sac	8.58e-12	22
digestive gland	8.58e-12	22
epithelium of foregut-midgut junction	8.58e-12	22
anatomical boundary	8.58e-12	22
hepatobiliary system	8.58e-12	22
foregut-midgut junction	8.58e-12	22
hepatic diverticulum	8.58e-12	22
liver primordium	8.58e-12	22
septum transversum	8.58e-12	22
liver bud	8.58e-12	22
digestive tract diverticulum	5.17e-11	23
sac	5.17e-11	23
exocrine gland	8.39e-10	25
exocrine system	8.39e-10	25
abdomen element	9.65e-09	49
abdominal segment element	9.65e-09	49
abdominal segment of trunk	9.65e-09	49
abdomen	9.65e-09	49
subdivision of trunk	3.28e-07	66
trunk region element	7.89e-07	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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