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Coexpression cluster:C4554

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Full id: C4554_rectal_small_gastric_hepatoblastoma_Intestinal_mesothelioma_colon



Phase1 CAGE Peaks

Hg19::chr6:125540884..125540897,+p9@TPD52L1
Hg19::chr6:125540901..125540910,+p15@TPD52L1
Hg19::chr6:125540951..125540969,+p8@TPD52L1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
atypical epithelium1.76e-284
pigment epithelium of eye1.26e-2211
ciliary epithelium8.29e-223
ciliary body8.29e-223
vasculature of eye4.37e-196
uvea4.37e-196
vasculature of head4.37e-196
anterior segment of eyeball1.96e-1214
camera-type eye3.05e-1220
simple eye3.05e-1220
immature eye3.05e-1220
ocular region3.05e-1220
eyeball of camera-type eye3.05e-1220
optic cup3.05e-1220
optic vesicle3.05e-1220
eye primordium3.05e-1220
eye1.23e-1121
visual system1.23e-1121
face4.37e-1122
vasculature of organ1.68e-1011
sense organ4.03e-1024
sensory system4.03e-1024
entire sense organ system4.03e-1024
medulla oblongata4.60e-103
myelencephalon4.60e-103
future myelencephalon4.60e-103
epithelium of female gonad1.71e-081
rectum1.84e-084
iris epithelium1.98e-081
iris1.98e-081
intestinal mucosa2.21e-084
wall of intestine2.21e-084
gastrointestinal system mucosa2.21e-084
gastrointestinal system epithelium2.21e-084
intestinal epithelium2.21e-084
corpus callosum3.79e-081
central nervous system cell part cluster3.79e-081
axon tract3.79e-081
intercerebral commissure3.79e-081
dorsal telencephalic commissure3.79e-081
brain white matter3.79e-081
brain commissure3.79e-081
white matter3.79e-081
nervous system commissure3.79e-081
cerebral hemisphere white matter3.79e-081
ectodermal placode1.01e-0731
gastrointestinal system6.29e-0725
lower digestive tract6.30e-075
organ segment6.90e-0798
neural plate8.63e-0782
presumptive neural plate8.63e-0782
Disease
Ontology termp-valuen
vascular disease1.18e-081
ischemia1.18e-081
extrinsic cardiomyopathy1.18e-081
myocardial ischemia1.18e-081
myocardial infarction1.18e-081
ovary epithelial cancer1.71e-081


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.