MCL coexpression mm9:318
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0002266 | follicular dendritic cell activation | 0.018015548174587 |
| GO:0002268 | follicular dendritic cell differentiation | 0.018015548174587 |
| GO:0016149 | translation release factor activity, codon specific | 0.018015548174587 |
| GO:0010467 | gene expression | 0.018015548174587 |
| GO:0008023 | transcription elongation factor complex | 0.018015548174587 |
| GO:0008079 | translation termination factor activity | 0.018015548174587 |
| GO:0006415 | translational termination | 0.018015548174587 |
| GO:0003747 | translation release factor activity | 0.018015548174587 |
| GO:0006355 | regulation of transcription, DNA-dependent | 0.0187493882502284 |
| GO:0003700 | transcription factor activity | 0.0187493882502284 |
| GO:0002467 | germinal center formation | 0.0187493882502284 |
| GO:0006351 | transcription, DNA-dependent | 0.0187493882502284 |
| GO:0032774 | RNA biosynthetic process | 0.0187493882502284 |
| GO:0045449 | regulation of transcription | 0.0187493882502284 |
| GO:0048536 | spleen development | 0.0187493882502284 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0187493882502284 |
| GO:0006350 | transcription | 0.0187493882502284 |
| GO:0010468 | regulation of gene expression | 0.0200238177225507 |
| GO:0031323 | regulation of cellular metabolic process | 0.0215902506335981 |
| GO:0043624 | cellular protein complex disassembly | 0.0215902506335981 |
| GO:0043241 | protein complex disassembly | 0.0217480607147832 |
| GO:0019222 | regulation of metabolic process | 0.0217480607147832 |
| GO:0032984 | macromolecular complex disassembly | 0.0218959546766158 |
| GO:0016070 | RNA metabolic process | 0.0219455121922195 |
| GO:0048535 | lymph node development | 0.0244488528490187 |
| GO:0051726 | regulation of cell cycle | 0.0261174403194484 |
| GO:0022411 | cellular component disassembly | 0.0292719506150735 |
| GO:0003676 | nucleic acid binding | 0.0394693602620986 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0498253690261291 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| hematopoietic cell | 3.06e-13 | 32 |
| hematopoietic oligopotent progenitor cell | 3.06e-13 | 32 |
| hematopoietic stem cell | 3.06e-13 | 32 |
| angioblastic mesenchymal cell | 3.06e-13 | 32 |
| hematopoietic multipotent progenitor cell | 3.06e-13 | 32 |
| connective tissue cell | 8.13e-11 | 46 |
| mesenchymal cell | 8.13e-11 | 46 |
| hematopoietic lineage restricted progenitor cell | 8.11e-10 | 25 |
| epithelial cell | 2.13e-09 | 25 |
| lymphoid lineage restricted progenitor cell | 3.34e-09 | 12 |
| leukocyte | 9.22e-09 | 17 |
| nongranular leukocyte | 9.22e-09 | 17 |
| nucleate cell | 1.08e-08 | 16 |
| lymphocyte | 1.75e-08 | 13 |
| common lymphoid progenitor | 1.75e-08 | 13 |
| T cell | 1.94e-08 | 11 |
| pro-T cell | 1.94e-08 | 11 |
| mature alpha-beta T cell | 6.19e-08 | 9 |
| alpha-beta T cell | 6.19e-08 | 9 |
| immature T cell | 6.19e-08 | 9 |
| mature T cell | 6.19e-08 | 9 |
| immature alpha-beta T cell | 6.19e-08 | 9 |
| motile cell | 6.52e-08 | 54 |
| CD4-positive, alpha-beta T cell | 3.18e-07 | 8 |
| endodermal cell | 8.82e-07 | 20 |
| Ontology term | p-value | n |
|---|---|---|
| connective tissue | 8.13e-11 | 46 |
| unilaminar epithelium | 5.69e-09 | 66 |
| mucosa | 3.48e-08 | 15 |
| simple columnar epithelium | 1.13e-07 | 11 |
| hemolymphoid system | 1.36e-07 | 48 |
| immune system | 1.36e-07 | 48 |
| intestinal mucosa | 2.72e-07 | 13 |
| anatomical wall | 2.72e-07 | 13 |
| wall of intestine | 2.72e-07 | 13 |
| gastrointestinal system mucosa | 2.72e-07 | 13 |
| endoderm-derived structure | 4.66e-07 | 118 |
| endoderm | 4.66e-07 | 118 |
| presumptive endoderm | 4.66e-07 | 118 |
| respiratory tract | 4.72e-07 | 41 |
| digestive system | 6.26e-07 | 116 |
| digestive tract | 6.26e-07 | 116 |
| primitive gut | 6.26e-07 | 116 |
| respiratory system | 7.38e-07 | 42 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
