Coexpression cluster:C2420

Full id: C2420_Smooth_osteosarcoma_Fibroblast_Preadipocyte_mesenchymal_thyroid_osteoclastoma

Phase1 CAGE Peaks

Hg19::chr17:4872260..4872292,-	p@chr17:4872260..4872292 -
Hg19::chr17:4872322..4872330,-	p@chr17:4872322..4872330 -
Hg19::chr17:4872340..4872347,-	p@chr17:4872340..4872347 -
Hg19::chr17:4872349..4872405,-	p@chr17:4872349..4872405 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
fibroblast	1.63e-17	76
non-terminally differentiated cell	3.67e-16	106
animal cell	1.34e-15	679
eukaryotic cell	1.34e-15	679
muscle precursor cell	1.40e-12	58
myoblast	1.40e-12	58
multi-potent skeletal muscle stem cell	1.40e-12	58
contractile cell	1.76e-12	59
somatic cell	1.06e-11	588
muscle cell	1.07e-11	55
electrically responsive cell	1.68e-11	61
electrically active cell	1.68e-11	61
embryonic cell	7.07e-11	250
native cell	2.40e-09	722
smooth muscle cell	3.10e-09	43
smooth muscle myoblast	3.10e-09	43
preadipocyte	2.63e-08	12
vascular associated smooth muscle cell	3.79e-07	32

Uber Anatomy

Ontology term	p-value	n
epithelial vesicle	9.16e-13	78
dense mesenchyme tissue	1.49e-12	73
somite	1.81e-12	71
presomitic mesoderm	1.81e-12	71
presumptive segmental plate	1.81e-12	71
dermomyotome	1.81e-12	71
trunk paraxial mesoderm	1.81e-12	71
paraxial mesoderm	3.29e-12	72
presumptive paraxial mesoderm	3.29e-12	72
multilaminar epithelium	2.48e-11	83
skeletal muscle tissue	2.58e-11	62
striated muscle tissue	2.58e-11	62
myotome	2.58e-11	62
muscle tissue	1.91e-10	64
musculature	1.91e-10	64
musculature of body	1.91e-10	64
mesenchyme	3.06e-10	160
entire embryonic mesenchyme	3.06e-10	160
organism subdivision	1.22e-09	264
multi-tissue structure	1.56e-09	342
trunk	2.27e-08	199
trunk mesenchyme	1.33e-07	122

Disease

Ontology term	p-value	n
ovarian cancer	8.81e-07	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CEBPB#1051	3	5.97836071936861	0.00715383248472697	0.029726231832275
EP300#2033	4	6.7739417262232	0.000474845982144264	0.00434069492596628
FOSL2#2355	3	12.6976504534213	0.00078756857297571	0.0061663448679069
GTF2F1#2962	4	12.7396608767577	3.79492332235515e-05	0.000717613610109451
JUN#3725	3	9.38462189425225	0.00191899450203047	0.0112847897971599
JUND#3727	3	5.24599795640327	0.0104343275174842	0.0386847970038528
STAT3#6774	3	7.88959874786568	0.00319076048168013	0.0167406728597504
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0322024201338585
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0244032471257009
TFAP2A#7020	4	16.518634373045	1.34240829060362e-05	0.000326425563358211
TFAP2C#7022	4	10.8092286098602	7.32289634782688e-05	0.00114507556770578

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.