Novel motif:74

name:	motif74_TTKAAAY

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0023052	signaling	1.695961e-14
GO:0002376	immune system process	2.009654e-14
GO:0032501	multicellular organismal process	1.710495e-13
GO:0042113	B cell activation	5.550000e-13
GO:0050896	response to stimulus	6.565129e-13
GO:0007154	cell communication	2.483492e-12
GO:0001775	cell activation	3.276586e-12
GO:0007165	signal transduction	8.856576e-12
GO:0032502	developmental process	1.960367e-11
GO:0007275	multicellular organismal development	3.524612e-11
GO:0048856	anatomical structure development	5.753049e-11
GO:0042060	wound healing	7.324925e-11
GO:0072358	cardiovascular system development	8.365398e-11
GO:0048513	organ development	1.307536e-10
GO:0051716	cellular response to stimulus	1.427296e-10
GO:0009888	tissue development	7.588341e-10
GO:0048731	system development	9.848092e-10
GO:0055013	cardiac muscle cell development	1.110977e-9
GO:0015705	iodide transport	2.747903e-9
GO:0002520	immune system development	4.470285e-9
GO:2000725	regulation of cardiac muscle cell differentiation	4.971151e-9
GO:0006590	thyroid hormone generation	6.360040e-9
GO:0048468	cell development	1.020601e-8
GO:0050794	regulation of cellular process	1.112367e-8
GO:0048534	hemopoietic or lymphoid organ development	1.125154e-8
GO:0019220	regulation of phosphate metabolic process	1.177083e-8
GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification	1.600054e-8
GO:0055003	cardiac myofibril assembly	1.827023e-8
GO:0035051	cardiac cell differentiation	2.209319e-8
GO:0046649	lymphocyte activation	3.044550e-8
GO:0050867	positive regulation of cell activation	3.162577e-8
GO:0045321	leukocyte activation	3.765529e-8
GO:0007507	heart development	3.860731e-8
GO:0045056	transcytosis	3.902775e-8
GO:0050870	positive regulation of T cell activation	3.989095e-8
GO:0051246	regulation of protein metabolic process	5.627643e-8
GO:0042221	response to chemical stimulus	5.855716e-8
GO:0055007	cardiac muscle cell differentiation	6.645848e-8
GO:0050789	regulation of biological process	7.210140e-8
GO:2001016	positive regulation of skeletal muscle cell differentiation	1.156741e-7
GO:0002696	positive regulation of leukocyte activation	1.236362e-7
GO:2000987	positive regulation of behavioral fear response	1.490120e-7
GO:2000727	positive regulation of cardiac muscle cell differentiation	1.490120e-7
GO:0003138	primary heart field specification	1.490120e-7
GO:0003185	sinoatrial valve morphogenesis	1.490120e-7
GO:0035984	cellular response to trichostatin A	1.490120e-7
GO:0007166	cell surface receptor linked signaling pathway	1.718734e-7
GO:0051251	positive regulation of lymphocyte activation	1.853651e-7
GO:0048869	cellular developmental process	1.980425e-7
GO:0065007	biological regulation	2.643497e-7
GO:0040007	growth	2.882504e-7
GO:0006880	intracellular sequestering of iron ion	3.053025e-7
GO:0060420	regulation of heart growth	3.058959e-7
GO:0042325	regulation of phosphorylation	3.246179e-7
GO:0030878	thyroid gland development	3.359476e-7
GO:0030098	lymphocyte differentiation	3.614293e-7
GO:0042551	neuron maturation	3.860991e-7
GO:0060045	positive regulation of cardiac muscle cell proliferation	4.033324e-7
GO:0065008	regulation of biological quality	4.128667e-7
GO:0002244	hemopoietic progenitor cell differentiation	4.339267e-7
GO:0051592	response to calcium ion	4.538535e-7
GO:0009611	response to wounding	4.541519e-7
GO:0032268	regulation of cellular protein metabolic process	4.565571e-7
GO:0003211	cardiac ventricle formation	4.681569e-7
GO:0030183	B cell differentiation	4.776844e-7
GO:0048608	reproductive structure development	5.015830e-7
GO:0044272	sulfur compound biosynthetic process	5.094468e-7
GO:0042264	peptidyl-aspartic acid hydroxylation	5.172684e-7
GO:0055021	regulation of cardiac muscle tissue growth	5.268908e-7
GO:0002262	myeloid cell homeostasis	5.618658e-7
GO:0030097	hemopoiesis	5.645878e-7
GO:0030154	cell differentiation	5.707844e-7
GO:0015012	heparan sulfate proteoglycan biosynthetic process	6.138481e-7
GO:0050777	negative regulation of immune response	6.303049e-7
GO:0009268	response to pH	6.456550e-7
GO:0002440	production of molecular mediator of immune response	6.983233e-7
GO:0003008	system process	7.716079e-7
GO:0002683	negative regulation of immune system process	9.302698e-7
GO:0003179	heart valve morphogenesis	9.791221e-7
GO:0007076	mitotic chromosome condensation	1.137359e-6
GO:0048769	sarcomerogenesis	1.194510e-6
GO:0051249	regulation of lymphocyte activation	1.203494e-6
GO:0001568	blood vessel development	1.273754e-6
GO:0010692	regulation of alkaline phosphatase activity	1.273907e-6
GO:0048729	tissue morphogenesis	1.290293e-6
GO:0055005	ventricular cardiac myofibril development	1.333540e-6
GO:0046485	ether lipid metabolic process	1.375967e-6
GO:0006887	exocytosis	1.399314e-6
GO:0001932	regulation of protein phosphorylation	1.420974e-6
GO:0042403	thyroid hormone metabolic process	1.564290e-6
GO:0046620	regulation of organ growth	1.575996e-6
GO:2000822	regulation of behavioral fear response	1.648775e-6
GO:0001933	negative regulation of protein phosphorylation	1.699703e-6
GO:0045161	neuronal ion channel clustering	1.843010e-6
GO:0001944	vasculature development	2.148287e-6
GO:0031399	regulation of protein modification process	2.315451e-6
GO:2000111	positive regulation of macrophage apoptosis	2.508063e-6
GO:0010694	positive regulation of alkaline phosphatase activity	2.725194e-6
GO:0003170	heart valve development	2.871300e-6
GO:0010033	response to organic substance	2.992738e-6
GO:0030001	metal ion transport	3.053371e-6
GO:0030240	skeletal muscle thin filament assembly	3.290918e-6
GO:0051450	myoblast proliferation	3.348095e-6
GO:0045666	positive regulation of neuron differentiation	3.532255e-6
GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	3.976521e-6
GO:0051179	localization	4.059547e-6
GO:0046883	regulation of hormone secretion	4.070907e-6
GO:0052547	regulation of peptidase activity	4.695500e-6
GO:0051155	positive regulation of striated muscle cell differentiation	4.830471e-6
GO:0009820	alkaloid metabolic process	4.841582e-6
GO:0060043	regulation of cardiac muscle cell proliferation	5.400326e-6
GO:0009790	embryo development	5.522867e-6
GO:0002320	lymphoid progenitor cell differentiation	5.586849e-6
GO:0014706	striated muscle tissue development	5.723126e-6
GO:0006955	immune response	5.752060e-6
GO:0000070	mitotic sister chromatid segregation	5.811705e-6
GO:0051238	sequestering of metal ion	7.196304e-6
GO:0060537	muscle tissue development	7.287402e-6
GO:0010646	regulation of cell communication	7.418527e-6
GO:0045727	positive regulation of translation	7.631086e-6
GO:0046427	positive regulation of JAK-STAT cascade	7.817404e-6
GO:0048066	developmental pigmentation	7.938827e-6
GO:2000109	regulation of macrophage apoptosis	7.993045e-6
GO:0002576	platelet degranulation	8.058041e-6
GO:0046635	positive regulation of alpha-beta T cell activation	8.309618e-6
GO:0006950	response to stress	9.845366e-6
GO:0050865	regulation of cell activation	9.906124e-6
GO:0007521	muscle cell fate determination	1.014181e-5
GO:0060025	regulation of synaptic activity	1.015338e-5
GO:0048738	cardiac muscle tissue development	1.016863e-5
GO:0002369	T cell cytokine production	1.150113e-5
GO:0007599	hemostasis	1.203233e-5
GO:0048585	negative regulation of response to stimulus	1.213681e-5
GO:0045769	negative regulation of asymmetric cell division	1.219663e-5
GO:2000409	positive regulation of T cell extravasation	1.219663e-5
GO:0043310	negative regulation of eosinophil degranulation	1.219663e-5
GO:0035705	T-helper 17 cell chemotaxis	1.219663e-5
GO:0035696	monocyte extravasation	1.219663e-5
GO:0050931	pigment cell differentiation	1.248660e-5
GO:0008406	gonad development	1.334921e-5
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	1.349644e-5
GO:0010737	protein kinase A signaling cascade	1.364027e-5
GO:0000819	sister chromatid segregation	1.405295e-5
GO:0050878	regulation of body fluid levels	1.443500e-5
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1.450100e-5
GO:0002694	regulation of leukocyte activation	1.499645e-5
GO:0050853	B cell receptor signaling pathway	1.514802e-5
GO:0007596	blood coagulation	1.663060e-5
GO:0055082	cellular chemical homeostasis	1.669091e-5
GO:0046638	positive regulation of alpha-beta T cell differentiation	1.774090e-5
GO:0046888	negative regulation of hormone secretion	1.776475e-5
GO:0031641	regulation of myelination	1.859255e-5
GO:0048863	stem cell differentiation	1.930480e-5
GO:0052548	regulation of endopeptidase activity	1.995664e-5
GO:0007517	muscle organ development	2.008018e-5
GO:0002820	negative regulation of adaptive immune response	2.026956e-5
GO:0055001	muscle cell development	2.027737e-5
GO:0003006	developmental process involved in reproduction	2.063343e-5
GO:0055024	regulation of cardiac muscle tissue development	2.150056e-5
GO:0048646	anatomical structure formation involved in morphogenesis	2.155605e-5
GO:0048536	spleen development	2.212326e-5
GO:0032940	secretion by cell	2.235820e-5
GO:0009893	positive regulation of metabolic process	2.381877e-5
GO:0051094	positive regulation of developmental process	2.836963e-5
GO:0002328	pro-B cell differentiation	2.860301e-5
GO:0016477	cell migration	2.870110e-5
GO:0007040	lysosome organization	3.036207e-5
GO:0048514	blood vessel morphogenesis	3.049953e-5
GO:0042327	positive regulation of phosphorylation	3.170878e-5
GO:0006556	S-adenosylmethionine biosynthetic process	3.176890e-5
GO:0007229	integrin-mediated signaling pathway	3.284713e-5
GO:0045937	positive regulation of phosphate metabolic process	3.314120e-5
GO:0060442	branching involved in prostate gland morphogenesis	3.353480e-5
GO:0030318	melanocyte differentiation	3.398563e-5
GO:0018126	protein hydroxylation	3.457028e-5
GO:0007417	central nervous system development	3.485080e-5
GO:0032095	regulation of response to food	3.666491e-5
GO:0030168	platelet activation	3.676501e-5
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	3.876885e-5
GO:0007059	chromosome segregation	3.917355e-5
GO:2000116	regulation of cysteine-type endopeptidase activity	4.061277e-5
GO:0009786	regulation of asymmetric cell division	4.611713e-5
GO:0009100	glycoprotein metabolic process	4.877375e-5
GO:0008343	adult feeding behavior	4.899129e-5
GO:0050863	regulation of T cell activation	4.962076e-5
GO:0030003	cellular cation homeostasis	4.997202e-5
GO:0071374	cellular response to parathyroid hormone stimulus	5.104313e-5
GO:0061061	muscle structure development	5.195242e-5
GO:0008584	male gonad development	5.301135e-5
GO:0050793	regulation of developmental process	5.305215e-5
GO:0016192	vesicle-mediated transport	5.501422e-5
GO:0006875	cellular metal ion homeostasis	5.585432e-5
GO:0002467	germinal center formation	5.587566e-5
GO:0045621	positive regulation of lymphocyte differentiation	5.629826e-5
GO:0045927	positive regulation of growth	5.645196e-5
GO:0030166	proteoglycan biosynthetic process	5.668223e-5
GO:0001821	histamine secretion	5.675358e-5
GO:0048598	embryonic morphogenesis	5.730100e-5
GO:0055080	cation homeostasis	5.901977e-5
GO:0051240	positive regulation of multicellular organismal process	5.989145e-5
GO:0019725	cellular homeostasis	6.313691e-5
GO:0006936	muscle contraction	6.342420e-5
GO:0040008	regulation of growth	6.354211e-5
GO:0045582	positive regulation of T cell differentiation	6.363779e-5
GO:0031032	actomyosin structure organization	6.542491e-5
GO:0042246	tissue regeneration	6.569913e-5
GO:0050900	leukocyte migration	6.570110e-5
GO:0019226	transmission of nerve impulse	6.756302e-5
GO:0045663	positive regulation of myoblast differentiation	6.826519e-5
GO:0007155	cell adhesion	6.902149e-5
GO:0006811	ion transport	7.161640e-5
GO:0090073	positive regulation of protein homodimerization activity	7.490889e-5
GO:0002250	adaptive immune response	7.501790e-5
GO:0030182	neuron differentiation	7.717288e-5
GO:0061337	cardiac conduction	7.763301e-5
GO:0032989	cellular component morphogenesis	7.871043e-5
GO:0060711	labyrinthine layer development	7.890323e-5
GO:0007495	visceral mesoderm-endoderm interaction involved in midgut development	8.109170e-5
GO:0045137	development of primary sexual characteristics	8.215821e-5
GO:0045597	positive regulation of cell differentiation	8.521294e-5
GO:0050877	neurological system process	8.671642e-5
GO:0030241	skeletal muscle myosin thick filament assembly	8.744418e-5
GO:0007219	Notch signaling pathway	8.780763e-5
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	9.003927e-5
GO:0006873	cellular ion homeostasis	9.096763e-5
GO:0030239	myofibril assembly	9.100488e-5
GO:0048762	mesenchymal cell differentiation	9.247451e-5
GO:0006928	cellular component movement	9.490054e-5
GO:0002521	leukocyte differentiation	9.885578e-5
GO:0042063	gliogenesis	9.902415e-5
GO:0019674	NAD metabolic process	9.981395e-5
GO:0046546	development of primary male sexual characteristics	1.018712e-4
GO:0031325	positive regulation of cellular metabolic process	1.037935e-4
GO:0042127	regulation of cell proliferation	1.075542e-4
GO:0006790	sulfur compound metabolic process	1.076236e-4
GO:2001013	epithelial cell proliferation involve in renal tubule morphogenesis	1.080490e-4
GO:0071498	cellular response to fluid shear stress	1.080490e-4
GO:0051608	histamine transport	1.081822e-4
GO:0055065	metal ion homeostasis	1.092592e-4
GO:0032879	regulation of localization	1.095512e-4
GO:0048589	developmental growth	1.104388e-4
GO:0006417	regulation of translation	1.115547e-4
GO:0055015	ventricular cardiac muscle cell development	1.119038e-4
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	1.159486e-4
GO:0006940	regulation of smooth muscle contraction	1.162389e-4
GO:0071840	cellular component organization or biogenesis	1.169346e-4
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	1.183036e-4
GO:0019227	neuronal action potential propagation	1.187181e-4
GO:0002819	regulation of adaptive immune response	1.190722e-4
GO:0051797	regulation of hair follicle development	1.237399e-4
GO:0051641	cellular localization	1.277768e-4
GO:0010092	specification of organ identity	1.316691e-4
GO:0045667	regulation of osteoblast differentiation	1.330165e-4
GO:0045055	regulated secretory pathway	1.333403e-4
GO:0035690	cellular response to drug	1.338982e-4
GO:0042534	regulation of tumor necrosis factor biosynthetic process	1.344752e-4
GO:0030521	androgen receptor signaling pathway	1.348480e-4
GO:0030201	heparan sulfate proteoglycan metabolic process	1.428128e-4
GO:0002443	leukocyte mediated immunity	1.433766e-4
GO:0080090	regulation of primary metabolic process	1.442476e-4
GO:0001816	cytokine production	1.448092e-4
GO:0048634	regulation of muscle organ development	1.481128e-4
GO:0046496	nicotinamide nucleotide metabolic process	1.522339e-4
GO:0050801	ion homeostasis	1.537925e-4
GO:0010820	positive regulation of T cell chemotaxis	1.597147e-4
GO:0046637	regulation of alpha-beta T cell differentiation	1.619908e-4
GO:0046661	male sex differentiation	1.631551e-4
GO:0051661	maintenance of centrosome location	1.632983e-4
GO:0051146	striated muscle cell differentiation	1.661147e-4
GO:0045844	positive regulation of striated muscle tissue development	1.663329e-4
GO:0070253	somatostatin secretion	1.676527e-4
GO:0032812	positive regulation of epinephrine secretion	1.676527e-4
GO:0010604	positive regulation of macromolecule metabolic process	1.692841e-4
GO:0021872	forebrain generation of neurons	1.731754e-4
GO:0060255	regulation of macromolecule metabolic process	1.732796e-4
GO:0006959	humoral immune response	1.755610e-4
GO:0002367	cytokine production involved in immune response	1.756488e-4
GO:0042326	negative regulation of phosphorylation	1.778052e-4
GO:0009617	response to bacterium	1.792788e-4
GO:0048643	positive regulation of skeletal muscle tissue development	1.798835e-4
GO:0046903	secretion	1.805442e-4
GO:0019222	regulation of metabolic process	1.810785e-4
GO:0048878	chemical homeostasis	1.815009e-4
GO:0001890	placenta development	1.817297e-4
GO:0042100	B cell proliferation	1.872268e-4
GO:0003007	heart morphogenesis	1.876957e-4
GO:0010666	positive regulation of cardiac muscle cell apoptosis	1.886243e-4
GO:0001655	urogenital system development	1.924653e-4
GO:0014866	skeletal myofibril assembly	1.961756e-4
GO:0002377	immunoglobulin production	1.963600e-4
GO:0072160	nephron tubule epithelial cell differentiation	1.974096e-4
GO:0031295	T cell costimulation	1.985131e-4
GO:0010038	response to metal ion	2.048904e-4
GO:0006029	proteoglycan metabolic process	2.054100e-4
GO:0009791	post-embryonic development	2.064957e-4
GO:0001543	ovarian follicle rupture	2.080892e-4
GO:0051495	positive regulation of cytoskeleton organization	2.133574e-4
GO:0071107	response to parathyroid hormone stimulus	2.143568e-4
GO:0010613	positive regulation of cardiac muscle hypertrophy	2.144971e-4
GO:0042634	regulation of hair cycle	2.207053e-4
GO:0051234	establishment of localization	2.222446e-4
GO:0010647	positive regulation of cell communication	2.226046e-4
GO:0001967	suckling behavior	2.261730e-4
GO:0050790	regulation of catalytic activity	2.263702e-4
GO:0021629	olfactory nerve structural organization	2.277585e-4
GO:0072503	cellular divalent inorganic cation homeostasis	2.312881e-4
GO:0003139	secondary heart field specification	2.325512e-4
GO:0045787	positive regulation of cell cycle	2.384133e-4
GO:0051093	negative regulation of developmental process	2.399612e-4
GO:0009967	positive regulation of signal transduction	2.435196e-4
GO:0048864	stem cell development	2.442175e-4
GO:0030534	adult behavior	2.447856e-4
GO:0050435	beta-amyloid metabolic process	2.489169e-4
GO:2000534	positive regulation of renal albumin absorption	2.514746e-4
GO:2000481	positive regulation of cAMP-dependent protein kinase activity	2.514746e-4
GO:0070994	detection of oxidative stress	2.514746e-4
GO:2000461	negative regulation of eukaryotic cell surface binding	2.514746e-4
GO:2000478	positive regulation of metanephric glomerular visceral epithelial cell development	2.514746e-4
GO:0035108	limb morphogenesis	2.519084e-4
GO:0065009	regulation of molecular function	2.519669e-4
GO:0000962	positive regulation of mitochondrial RNA catabolic process	2.545470e-4
GO:0000965	mitochondrial RNA 3'-end processing	2.545470e-4
GO:0000958	mitochondrial mRNA catabolic process	2.545470e-4
GO:0008283	cell proliferation	2.549634e-4
GO:0006911	phagocytosis, engulfment	2.549960e-4
GO:0014853	regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction	2.607102e-4
GO:0010557	positive regulation of macromolecule biosynthetic process	2.620247e-4
GO:0030199	collagen fibril organization	2.632822e-4
GO:0032269	negative regulation of cellular protein metabolic process	2.676761e-4
GO:2000026	regulation of multicellular organismal development	2.731212e-4
GO:0001960	negative regulation of cytokine-mediated signaling pathway	2.754537e-4
GO:0015820	leucine transport	2.836037e-4
GO:0007389	pattern specification process	2.938886e-4
GO:0034765	regulation of ion transmembrane transport	2.958098e-4
GO:0006874	cellular calcium ion homeostasis	2.968806e-4
GO:0010952	positive regulation of peptidase activity	2.972895e-4
GO:0055002	striated muscle cell development	2.990749e-4
GO:0007033	vacuole organization	3.009632e-4
GO:0042522	regulation of tyrosine phosphorylation of Stat5 protein	3.009684e-4
GO:2000761	positive regulation of N-terminal peptidyl-lysine acetylation	3.017435e-4
GO:0035910	ascending aorta morphogenesis	3.017435e-4
GO:0051798	positive regulation of hair follicle development	3.079250e-4
GO:0023056	positive regulation of signaling	3.089308e-4
GO:0006518	peptide metabolic process	3.107151e-4
GO:0048666	neuron development	3.207009e-4
GO:0002009	morphogenesis of an epithelium	3.304229e-4
GO:0051893	regulation of focal adhesion assembly	3.409415e-4
GO:0016198	axon choice point recognition	3.462902e-4
GO:0006878	cellular copper ion homeostasis	3.477869e-4
GO:0032098	regulation of appetite	3.483343e-4
GO:0045214	sarcomere organization	3.518972e-4
GO:0000296	spermine transport	3.555896e-4
GO:0001889	liver development	3.642446e-4
GO:0010740	positive regulation of intracellular protein kinase cascade	3.682021e-4
GO:0007548	sex differentiation	3.698233e-4
GO:0061008	hepaticobiliary system development	3.705390e-4
GO:0042180	cellular ketone metabolic process	3.708115e-4
GO:0055108	Golgi to transport vesicle transport	3.743006e-4
GO:0001822	kidney development	3.795217e-4
GO:0000002	mitochondrial genome maintenance	3.801037e-4
GO:0060173	limb development	3.815541e-4
GO:0048732	gland development	3.830588e-4
GO:0016049	cell growth	3.830751e-4
GO:0009653	anatomical structure morphogenesis	3.866856e-4
GO:0030278	regulation of ossification	3.878158e-4
GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	3.984842e-4
GO:0055074	calcium ion homeostasis	4.000454e-4
GO:0006633	fatty acid biosynthetic process	4.023715e-4
GO:0006769	nicotinamide metabolic process	4.052626e-4
GO:0019752	carboxylic acid metabolic process	4.086171e-4
GO:0072507	divalent inorganic cation homeostasis	4.151885e-4
GO:0002456	T cell mediated immunity	4.229781e-4
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	4.299310e-4
GO:0030261	chromosome condensation	4.346052e-4
GO:0046425	regulation of JAK-STAT cascade	4.383251e-4
GO:0033032	regulation of myeloid cell apoptosis	4.450363e-4
GO:0060548	negative regulation of cell death	4.572756e-4
GO:0060538	skeletal muscle organ development	4.591787e-4
GO:0008585	female gonad development	4.591956e-4
GO:0010922	positive regulation of phosphatase activity	4.628651e-4
GO:0021953	central nervous system neuron differentiation	4.675881e-4
GO:0006812	cation transport	4.723393e-4
GO:0060485	mesenchyme development	4.756801e-4
GO:0040011	locomotion	4.931885e-4
GO:0003012	muscle system process	4.939254e-4
GO:0048870	cell motility	4.944650e-4
GO:0046880	regulation of follicle-stimulating hormone secretion	4.947651e-4
GO:0008038	neuron recognition	5.004455e-4
GO:0031323	regulation of cellular metabolic process	5.025862e-4
GO:0009891	positive regulation of biosynthetic process	5.092413e-4
GO:0008284	positive regulation of cell proliferation	5.146286e-4
GO:0042692	muscle cell differentiation	5.165499e-4
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	5.261220e-4
GO:0051707	response to other organism	5.302730e-4
GO:0032733	positive regulation of interleukin-10 production	5.312415e-4
GO:0071236	cellular response to antibiotic	5.438222e-4
GO:0016202	regulation of striated muscle tissue development	5.445376e-4
GO:0016446	somatic hypermutation of immunoglobulin genes	5.477024e-4
GO:0001101	response to acid	5.519355e-4
GO:0070887	cellular response to chemical stimulus	5.704325e-4
GO:0007186	G-protein coupled receptor protein signaling pathway	5.718837e-4
GO:0055008	cardiac muscle tissue morphogenesis	5.721765e-4
GO:0071345	cellular response to cytokine stimulus	5.733898e-4
GO:0001657	ureteric bud development	5.750530e-4
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway	5.771428e-4
GO:0016447	somatic recombination of immunoglobulin gene segments	5.820851e-4
GO:0051769	regulation of nitric-oxide synthase biosynthetic process	5.847641e-4
GO:0044036	cell wall macromolecule metabolic process	5.945487e-4
GO:0016043	cellular component organization	6.049178e-4
GO:0014033	neural crest cell differentiation	6.056405e-4
GO:0070093	negative regulation of glucagon secretion	6.098228e-4
GO:0032835	glomerulus development	6.128779e-4
GO:0007292	female gamete generation	6.218317e-4
GO:0061005	cell differentiation involved in kidney development	6.296232e-4
GO:0045358	negative regulation of interferon-beta biosynthetic process	6.319456e-4
GO:0016358	dendrite development	6.406481e-4
GO:0007631	feeding behavior	6.419542e-4
GO:0050774	negative regulation of dendrite morphogenesis	6.438784e-4
GO:0033034	positive regulation of myeloid cell apoptosis	6.438784e-4
GO:0050776	regulation of immune response	6.527996e-4
GO:0006810	transport	6.608080e-4
GO:0002366	leukocyte activation involved in immune response	6.616299e-4
GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway	6.639978e-4
GO:0048520	positive regulation of behavior	6.735987e-4
GO:0010939	regulation of necrotic cell death	6.819290e-4
GO:0042537	benzene-containing compound metabolic process	6.830481e-4
GO:0008611	ether lipid biosynthetic process	6.835320e-4
GO:0032270	positive regulation of cellular protein metabolic process	6.840675e-4
GO:0060412	ventricular septum morphogenesis	6.926296e-4
GO:0007610	behavior	6.931889e-4
GO:0002553	histamine secretion by mast cell	7.087330e-4
GO:0009435	NAD biosynthetic process	7.180531e-4
GO:0051649	establishment of localization in cell	7.307314e-4
GO:0006627	protein processing involved in protein targeting to mitochondrion	7.337192e-4
GO:0060761	negative regulation of response to cytokine stimulus	7.351353e-4
GO:0050671	positive regulation of lymphocyte proliferation	7.412718e-4
GO:0010921	regulation of phosphatase activity	7.445985e-4
GO:0001525	angiogenesis	7.470526e-4
GO:0055070	copper ion homeostasis	7.504394e-4
GO:0090257	regulation of muscle system process	7.524537e-4
GO:0030901	midbrain development	7.607722e-4
GO:0045936	negative regulation of phosphate metabolic process	7.620279e-4
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	7.655634e-4
GO:0035850	epithelial cell differentiation involved in kidney development	7.655634e-4
GO:0030334	regulation of cell migration	7.696007e-4
GO:0032276	regulation of gonadotropin secretion	7.722519e-4
GO:0002682	regulation of immune system process	7.727431e-4
GO:0010466	negative regulation of peptidase activity	7.745971e-4
GO:0048638	regulation of developmental growth	7.851741e-4
GO:0010660	regulation of muscle cell apoptosis	7.856024e-4
GO:0043200	response to amino acid stimulus	8.032718e-4
GO:0007399	nervous system development	8.091502e-4
GO:0060547	negative regulation of necrotic cell death	8.094094e-4
GO:0007267	cell-cell signaling	8.184435e-4
GO:0048285	organelle fission	8.415024e-4
GO:2000021	regulation of ion homeostasis	8.601555e-4
GO:0007176	regulation of epidermal growth factor-activated receptor activity	8.656869e-4
GO:0048644	muscle organ morphogenesis	8.658432e-4
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	8.704342e-4
GO:0045162	clustering of voltage-gated sodium channels	8.914550e-4
GO:0060638	mesenchymal-epithelial cell signaling	9.092296e-4
GO:0007519	skeletal muscle tissue development	9.123526e-4
GO:0045190	isotype switching	9.221837e-4
GO:0051248	negative regulation of protein metabolic process	9.243032e-4
GO:0003183	mitral valve morphogenesis	9.268703e-4
GO:0072111	cell proliferation involved in kidney development	9.290486e-4
GO:0035295	tube development	9.316409e-4
GO:0050864	regulation of B cell activation	9.376491e-4
GO:0003289	atrial septum primum morphogenesis	9.380460e-4
GO:0046634	regulation of alpha-beta T cell activation	9.498865e-4
GO:0000087	M phase of mitotic cell cycle	9.587199e-4
GO:0051247	positive regulation of protein metabolic process	9.664376e-4
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	9.784954e-4
GO:0051795	positive regulation of catagen	9.811940e-4
GO:0043031	negative regulation of macrophage activation	9.928552e-4
GO:0046394	carboxylic acid biosynthetic process	9.940303e-4
GO:0048522	positive regulation of cellular process	9.962207e-4
GO:0007160	cell-matrix adhesion	9.986946e-4
GO:0021860	pyramidal neuron development	1.000428e-3
GO:0051480	cytosolic calcium ion homeostasis	1.001547e-3
GO:0043066	negative regulation of apoptosis	1.009337e-3
GO:0019221	cytokine-mediated signaling pathway	1.020748e-3
GO:0008152	metabolic process	1.039698e-3
GO:0045189	connective tissue growth factor biosynthetic process	1.039795e-3
GO:0043069	negative regulation of programmed cell death	1.044184e-3
GO:0050880	regulation of blood vessel size	1.047492e-3
GO:0072659	protein localization in plasma membrane	1.054900e-3
GO:0045132	meiotic chromosome segregation	1.054900e-3
GO:0042693	muscle cell fate commitment	1.054900e-3
GO:0030279	negative regulation of ossification	1.058281e-3
GO:0010628	positive regulation of gene expression	1.064008e-3
GO:0045665	negative regulation of neuron differentiation	1.071019e-3
GO:0031401	positive regulation of protein modification process	1.084348e-3
GO:0070665	positive regulation of leukocyte proliferation	1.085347e-3
GO:0009607	response to biotic stimulus	1.085530e-3
GO:0008037	cell recognition	1.103706e-3
GO:0070340	detection of bacterial lipopeptide	1.118048e-3
GO:0021700	developmental maturation	1.118256e-3
GO:0021680	cerebellar Purkinje cell layer development	1.129062e-3
GO:0001658	branching involved in ureteric bud morphogenesis	1.134491e-3

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0032501	multicellular organismal process	9.351642e-11
GO:0048856	anatomical structure development	1.037442e-8
GO:0021700	developmental maturation	3.723336e-8
GO:0042759	long-chain fatty acid biosynthetic process	4.418141e-8
GO:0001676	long-chain fatty acid metabolic process	8.955716e-8
GO:0048731	system development	1.405424e-7
GO:0060537	muscle tissue development	1.805210e-7
GO:0032502	developmental process	4.049303e-7
GO:0048469	cell maturation	5.432597e-7
GO:0030203	glycosaminoglycan metabolic process	7.753606e-7
GO:0007275	multicellular organismal development	9.449304e-7
GO:0048240	sperm capacitation	1.010439e-6
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	1.399546e-6
GO:0035051	cardiac cell differentiation	1.722638e-6
GO:0048738	cardiac muscle tissue development	1.947586e-6
GO:0035458	cellular response to interferon-beta	1.979054e-6
GO:0050654	chondroitin sulfate proteoglycan metabolic process	2.334190e-6
GO:0014706	striated muscle tissue development	2.564049e-6
GO:0018149	peptide cross-linking	3.562278e-6
GO:0001568	blood vessel development	4.181830e-6
GO:0022010	central nervous system myelination	4.202100e-6
GO:0032929	negative regulation of superoxide anion generation	4.433240e-6
GO:0006022	aminoglycan metabolic process	5.098925e-6
GO:0030204	chondroitin sulfate metabolic process	5.211195e-6
GO:0045605	negative regulation of epidermal cell differentiation	1.056174e-5
GO:0045844	positive regulation of striated muscle tissue development	1.090058e-5
GO:0055007	cardiac muscle cell differentiation	1.173373e-5
GO:0042060	wound healing	1.212643e-5
GO:0001944	vasculature development	1.391321e-5
GO:0043519	regulation of myosin II filament organization	1.406579e-5
GO:0048013	ephrin receptor signaling pathway	1.627997e-5
GO:0072358	cardiovascular system development	1.644862e-5
GO:0048514	blood vessel morphogenesis	1.739894e-5
GO:0043496	regulation of protein homodimerization activity	1.784116e-5
GO:0030574	collagen catabolic process	1.813923e-5
GO:0042100	B cell proliferation	1.899005e-5
GO:0014003	oligodendrocyte development	1.942088e-5
GO:0008038	neuron recognition	1.995514e-5
GO:0048468	cell development	2.101632e-5
GO:0070167	regulation of biomineral tissue development	2.793576e-5
GO:0002062	chondrocyte differentiation	3.136674e-5
GO:0009611	response to wounding	3.174737e-5
GO:0030500	regulation of bone mineralization	3.235202e-5
GO:2000111	positive regulation of macrophage apoptosis	3.308231e-5
GO:0048643	positive regulation of skeletal muscle tissue development	3.516992e-5
GO:0043473	pigmentation	4.300525e-5
GO:0031424	keratinization	4.387039e-5
GO:0045617	negative regulation of keratinocyte differentiation	5.191858e-5
GO:0050896	response to stimulus	5.355947e-5
GO:0050803	regulation of synapse structure and activity	5.456986e-5
GO:0006029	proteoglycan metabolic process	5.803350e-5
GO:0016198	axon choice point recognition	6.048850e-5
GO:0030318	melanocyte differentiation	7.386169e-5
GO:0048513	organ development	7.421106e-5
GO:0006952	defense response	7.767435e-5
GO:0060025	regulation of synaptic activity	8.039457e-5
GO:2000987	positive regulation of behavioral fear response	8.039457e-5
GO:0003185	sinoatrial valve morphogenesis	8.039457e-5
GO:0035984	cellular response to trichostatin A	8.039457e-5
GO:0003138	primary heart field specification	8.039457e-5
GO:0003006	developmental process involved in reproduction	8.547604e-5
GO:0016553	base conversion or substitution editing	8.716674e-5
GO:0061061	muscle structure development	9.162736e-5
GO:0045683	negative regulation of epidermis development	9.583923e-5
GO:0016554	cytidine to uridine editing	1.021540e-4
GO:0050931	pigment cell differentiation	1.029213e-4
GO:0045666	positive regulation of neuron differentiation	1.046615e-4
GO:0007281	germ cell development	1.069055e-4
GO:0010694	positive regulation of alkaline phosphatase activity	1.081624e-4
GO:0001542	ovulation from ovarian follicle	1.129755e-4
GO:0016043	cellular component organization	1.272422e-4
GO:0051149	positive regulation of muscle cell differentiation	1.277439e-4
GO:0050878	regulation of body fluid levels	1.464534e-4
GO:0048703	embryonic viscerocranium morphogenesis	1.471915e-4
GO:0014898	cardiac muscle hypertrophy in response to stress	1.568653e-4
GO:0030279	negative regulation of ossification	1.721949e-4
GO:0035112	genitalia morphogenesis	1.783798e-4
GO:0001525	angiogenesis	1.793158e-4
GO:0031214	biomineral tissue development	1.804486e-4
GO:0045652	regulation of megakaryocyte differentiation	1.930743e-4
GO:0009888	tissue development	1.943209e-4
GO:2000109	regulation of macrophage apoptosis	1.944547e-4
GO:0045604	regulation of epidermal cell differentiation	1.996314e-4
GO:0031341	regulation of cell killing	2.076198e-4
GO:0001910	regulation of leukocyte mediated cytotoxicity	2.126782e-4
GO:0000245	spliceosome assembly	2.161116e-4
GO:0030278	regulation of ossification	2.170920e-4
GO:0014896	muscle hypertrophy	2.222110e-4
GO:0071840	cellular component organization or biogenesis	2.274789e-4
GO:0051155	positive regulation of striated muscle cell differentiation	2.489418e-4
GO:0010592	positive regulation of lamellipodium assembly	2.560658e-4
GO:0042640	anagen	2.587078e-4
GO:0060035	notochord cell development	2.634635e-4
GO:0042475	odontogenesis of dentine-containing tooth	2.683017e-4
GO:0033364	mast cell secretory granule organization	2.711687e-4
GO:0070189	kynurenine metabolic process	2.878187e-4
GO:0019441	tryptophan catabolic process to kynurenine	2.912703e-4
GO:0008037	cell recognition	3.033666e-4
GO:0071277	cellular response to calcium ion	3.036705e-4
GO:0051146	striated muscle cell differentiation	3.039350e-4
GO:2000727	positive regulation of cardiac muscle cell differentiation	3.166102e-4
GO:2000278	regulation of DNA biosynthetic process	3.199380e-4
GO:0001974	blood vessel remodeling	3.382230e-4
GO:0097117	guanylate kinase-associated protein clustering	3.637698e-4
GO:0097114	N-methyl-D-aspartate receptor clustering	3.637698e-4
GO:0097112	gamma-aminobutyric acid receptor clustering	3.637698e-4
GO:0003151	outflow tract morphogenesis	3.838467e-4
GO:0065008	regulation of biological quality	3.864824e-4
GO:0009653	anatomical structure morphogenesis	3.894692e-4
GO:0021782	glial cell development	3.959702e-4
GO:0010811	positive regulation of cell-substrate adhesion	4.164282e-4
GO:0030719	P granule organization	4.172025e-4
GO:0070166	enamel mineralization	4.172025e-4
GO:0016199	axon midline choice point recognition	4.227123e-4
GO:0010591	regulation of lamellipodium assembly	4.321702e-4
GO:0048066	developmental pigmentation	4.397246e-4
GO:0035058	nonmotile primary cilium assembly	4.499958e-4
GO:0050890	cognition	4.515476e-4
GO:0006968	cellular defense response	4.561140e-4
GO:0046620	regulation of organ growth	4.755763e-4
GO:0014028	notochord formation	4.773045e-4
GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly	4.773045e-4
GO:0016082	synaptic vesicle priming	4.981750e-4
GO:2000822	regulation of behavioral fear response	5.007704e-4
GO:0033373	maintenance of protease location in mast cell secretory granule	5.521048e-4
GO:0033382	maintenance of granzyme B location in T cell secretory granule	5.521048e-4
GO:0048771	tissue remodeling	5.549643e-4
GO:0048589	developmental growth	5.769608e-4
GO:0006508	proteolysis	6.028225e-4
GO:0048762	mesenchymal cell differentiation	6.079616e-4
GO:0060914	heart formation	6.103947e-4
GO:0007586	digestion	6.114863e-4
GO:0071374	cellular response to parathyroid hormone stimulus	6.166870e-4
GO:0048869	cellular developmental process	6.219284e-4
GO:0060840	artery development	6.346059e-4
GO:0007166	cell surface receptor linked signaling pathway	6.364707e-4
GO:0042692	muscle cell differentiation	6.573022e-4
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	6.719571e-4
GO:0006955	immune response	6.814286e-4
GO:0090073	positive regulation of protein homodimerization activity	6.825333e-4
GO:0007341	penetration of zona pellucida	6.825333e-4
GO:0042476	odontogenesis	6.948505e-4
GO:0035690	cellular response to drug	7.033173e-4
GO:0007269	neurotransmitter secretion	7.358782e-4
GO:0045667	regulation of osteoblast differentiation	8.108142e-4
GO:2001013	epithelial cell proliferation involve in renal tubule morphogenesis	8.318212e-4
GO:0072160	nephron tubule epithelial cell differentiation	8.318212e-4
GO:0050778	positive regulation of immune response	8.643976e-4
GO:0007286	spermatid development	8.853314e-4
GO:0043486	histone exchange	8.871229e-4
GO:0042113	B cell activation	8.890389e-4
GO:0070168	negative regulation of biomineral tissue development	8.897537e-4
GO:0032816	positive regulation of natural killer cell activation	9.646858e-4
GO:0030154	cell differentiation	9.667038e-4
GO:0007499	ectoderm and mesoderm interaction	9.729378e-4
GO:0030220	platelet formation	9.821527e-4
GO:0051239	regulation of multicellular organismal process	9.908448e-4
GO:0006659	phosphatidylserine biosynthetic process	1.004810e-3
GO:0003300	cardiac muscle hypertrophy	1.007180e-3
GO:0060271	cilium morphogenesis	1.020041e-3
GO:0006568	tryptophan metabolic process	1.035199e-3
GO:0035880	embryonic nail plate morphogenesis	1.047261e-3
GO:0044259	multicellular organismal macromolecule metabolic process	1.068018e-3
GO:0008285	negative regulation of cell proliferation	1.082568e-3
GO:0046651	lymphocyte proliferation	1.097135e-3
GO:0034337	RNA folding	1.121115e-3
GO:0032989	cellular component morphogenesis	1.138673e-3
GO:0000902	cell morphogenesis	1.154946e-3
GO:0007616	long-term memory	1.155443e-3
GO:0048610	cellular process involved in reproduction	1.198697e-3
GO:0045597	positive regulation of cell differentiation	1.234775e-3
GO:0001879	detection of yeast	1.238199e-3
GO:0061312	BMP signaling pathway involved in heart development	1.244593e-3
GO:0051795	positive regulation of catagen	1.244593e-3
GO:0048820	hair follicle maturation	1.251375e-3
GO:0001911	negative regulation of leukocyte mediated cytotoxicity	1.251375e-3
GO:2000279	negative regulation of DNA biosynthetic process	1.281909e-3
GO:0035050	embryonic heart tube development	1.312174e-3
GO:0031342	negative regulation of cell killing	1.318924e-3
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	1.328562e-3
GO:0017121	phospholipid scrambling	1.328562e-3
GO:0009913	epidermal cell differentiation	1.342656e-3
GO:0065007	biological regulation	1.352015e-3
GO:0007276	gamete generation	1.352566e-3
GO:0002684	positive regulation of immune system process	1.390113e-3
GO:0033363	secretory granule organization	1.437606e-3
GO:0030510	regulation of BMP signaling pathway	1.437800e-3
GO:0051216	cartilage development	1.439065e-3
GO:0048818	positive regulation of hair follicle maturation	1.441420e-3
GO:0042742	defense response to bacterium	1.447772e-3
GO:0034509	centromeric core chromatin assembly	1.472675e-3
GO:0034080	CenH3-containing nucleosome assembly at centromere	1.472675e-3
GO:0048515	spermatid differentiation	1.474200e-3
GO:0048585	negative regulation of response to stimulus	1.490318e-3
GO:0045682	regulation of epidermis development	1.508198e-3
GO:0019953	sexual reproduction	1.536202e-3
GO:0032943	mononuclear cell proliferation	1.575751e-3
GO:0033762	response to glucagon stimulus	1.576089e-3
GO:0071498	cellular response to fluid shear stress	1.582296e-3
GO:0014888	striated muscle adaptation	1.627155e-3
GO:0048609	multicellular organismal reproductive process	1.654730e-3
GO:2000026	regulation of multicellular organismal development	1.663153e-3
GO:0010106	cellular response to iron ion starvation	1.665420e-3
GO:0006393	termination of mitochondrial transcription	1.665420e-3
GO:0032655	regulation of interleukin-12 production	1.695136e-3
GO:2000725	regulation of cardiac muscle cell differentiation	1.723991e-3
GO:0097118	neuroligin clustering	1.743971e-3
GO:0001501	skeletal system development	1.746861e-3
GO:0032963	collagen metabolic process	1.767380e-3
GO:0048619	embryonic hindgut morphogenesis	1.792611e-3
GO:0030502	negative regulation of bone mineralization	1.793004e-3
GO:0044029	hypomethylation of CpG island	1.824377e-3
GO:0045453	bone resorption	1.824535e-3
GO:0071107	response to parathyroid hormone stimulus	1.877021e-3
GO:0007611	learning or memory	1.899457e-3
GO:0048858	cell projection morphogenesis	1.900614e-3
GO:0046835	carbohydrate phosphorylation	1.933976e-3
GO:0071844	cellular component assembly at cellular level	1.937016e-3
GO:0032252	secretory granule localization	1.970826e-3
GO:0003139	secondary heart field specification	1.970826e-3
GO:0048844	artery morphogenesis	2.003527e-3
GO:0031000	response to caffeine	2.003797e-3
GO:0007521	muscle cell fate determination	2.040306e-3
GO:0090074	negative regulation of protein homodimerization activity	2.052659e-3
GO:0007167	enzyme linked receptor protein signaling pathway	2.073059e-3
GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	2.097730e-3
GO:0006666	3-keto-sphinganine metabolic process	2.100980e-3
GO:0060197	cloacal septation	2.122247e-3
GO:0050793	regulation of developmental process	2.124738e-3
GO:0042384	cilium assembly	2.141183e-3
GO:0070373	negative regulation of ERK1 and ERK2 cascade	2.163089e-3
GO:0042634	regulation of hair cycle	2.163485e-3
GO:0022607	cellular component assembly	2.168755e-3
GO:0010886	positive regulation of cholesterol storage	2.178915e-3
GO:0070661	leukocyte proliferation	2.179291e-3
GO:0061039	ovum-producing ovary development	2.179291e-3
GO:0044087	regulation of cellular component biogenesis	2.189013e-3
GO:0046649	lymphocyte activation	2.226102e-3
GO:0003008	system process	2.264677e-3
GO:0001782	B cell homeostasis	2.320947e-3
GO:0030216	keratinocyte differentiation	2.403117e-3
GO:0048709	oligodendrocyte differentiation	2.436234e-3
GO:0006658	phosphatidylserine metabolic process	2.438899e-3
GO:0050789	regulation of biological process	2.446668e-3
GO:0070098	chemokine-mediated signaling pathway	2.506416e-3
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	2.595899e-3
GO:0071842	cellular component organization at cellular level	2.617121e-3
GO:0032814	regulation of natural killer cell activation	2.643277e-3
GO:0048806	genitalia development	2.706123e-3
GO:0043065	positive regulation of apoptosis	2.721139e-3
GO:0046545	development of primary female sexual characteristics	2.764127e-3
GO:0032990	cell part morphogenesis	2.770454e-3
GO:0048485	sympathetic nervous system development	2.806372e-3
GO:0016525	negative regulation of angiogenesis	2.843635e-3
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2.881953e-3
GO:0010033	response to organic substance	2.900442e-3
GO:0051240	positive regulation of multicellular organismal process	2.902522e-3
GO:0043500	muscle adaptation	2.909820e-3
GO:0090287	regulation of cellular response to growth factor stimulus	2.951581e-3
GO:0060536	cartilage morphogenesis	2.988112e-3
GO:0071864	positive regulation of cell proliferation in bone marrow	3.085379e-3
GO:0045019	negative regulation of nitric oxide biosynthetic process	3.180977e-3
GO:0009074	aromatic amino acid family catabolic process	3.287661e-3
GO:0048518	positive regulation of biological process	3.322496e-3
GO:0060986	endocrine hormone secretion	3.354985e-3
GO:0030224	monocyte differentiation	3.413256e-3
GO:0048646	anatomical structure formation involved in morphogenesis	3.431512e-3
GO:0070848	response to growth factor stimulus	3.515228e-3
GO:0031349	positive regulation of defense response	3.569642e-3
GO:0002429	immune response-activating cell surface receptor signaling pathway	3.586047e-3
GO:0071603	endothelial cell-cell adhesion	3.625153e-3
GO:0010232	vascular transport	3.625153e-3
GO:0043049	otic placode formation	3.625153e-3
GO:0006950	response to stress	3.626385e-3
GO:0014033	neural crest cell differentiation	3.640486e-3
GO:0060415	muscle tissue morphogenesis	3.657648e-3
GO:0010634	positive regulation of epithelial cell migration	3.675776e-3
GO:0071695	anatomical structure maturation	3.696728e-3
GO:0050775	positive regulation of dendrite morphogenesis	3.699534e-3
GO:0097116	gephyrin clustering	3.771741e-3
GO:2000821	regulation of grooming behavior	3.771741e-3
GO:2000677	regulation of transcription regulatory region DNA binding	3.798451e-3
GO:0048251	elastic fiber assembly	3.804876e-3
GO:0055012	ventricular cardiac muscle cell differentiation	3.824370e-3
GO:0030282	bone mineralization	3.833286e-3
GO:0042147	retrograde transport, endosome to Golgi	3.863605e-3
GO:0048743	positive regulation of skeletal muscle fiber development	3.894143e-3
GO:0003416	endochondral bone growth	3.894143e-3
GO:0051053	negative regulation of DNA metabolic process	3.908489e-3
GO:0042063	gliogenesis	3.914780e-3
GO:0007599	hemostasis	3.945893e-3
GO:0050795	regulation of behavior	4.019645e-3
GO:0043068	positive regulation of programmed cell death	4.100925e-3
GO:0071841	cellular component organization or biogenesis at cellular level	4.217552e-3
GO:0007062	sister chromatid cohesion	4.268711e-3
GO:0050830	defense response to Gram-positive bacterium	4.292744e-3
GO:0010912	positive regulation of isomerase activity	4.301284e-3
GO:0070349	positive regulation of brown fat cell proliferation	4.301780e-3
GO:0010810	regulation of cell-substrate adhesion	4.307812e-3
GO:0001915	negative regulation of T cell mediated cytotoxicity	4.312838e-3
GO:0035411	catenin import into nucleus	4.351045e-3
GO:0014031	mesenchymal cell development	4.405699e-3
GO:0006953	acute-phase response	4.436357e-3
GO:0010921	regulation of phosphatase activity	4.463758e-3
GO:0090288	negative regulation of cellular response to growth factor stimulus	4.581554e-3
GO:0042269	regulation of natural killer cell mediated cytotoxicity	4.651578e-3
GO:0042221	response to chemical stimulus	4.692868e-3
GO:0060043	regulation of cardiac muscle cell proliferation	4.764747e-3
GO:0007517	muscle organ development	4.770077e-3
GO:0070407	oxidation-dependent protein catabolic process	4.860371e-3
GO:0061042	vascular wound healing	4.860371e-3
GO:0051798	positive regulation of hair follicle development	4.888582e-3
GO:0090322	regulation of superoxide metabolic process	4.913644e-3
GO:0002833	positive regulation of response to biotic stimulus	4.919449e-3
GO:0002757	immune response-activating signal transduction	4.976621e-3
GO:0006954	inflammatory response	5.009901e-3
GO:0043476	pigment accumulation	5.019342e-3
GO:0008585	female gonad development	5.042054e-3
GO:0007507	heart development	5.091858e-3
GO:0044085	cellular component biogenesis	5.096161e-3
GO:0051493	regulation of cytoskeleton organization	5.118591e-3
GO:0070206	protein trimerization	5.121934e-3
GO:0051491	positive regulation of filopodium assembly	5.182292e-3
GO:0010942	positive regulation of cell death	5.324937e-3
GO:0032928	regulation of superoxide anion generation	5.344350e-3
GO:0000003	reproduction	5.354455e-3
GO:0030838	positive regulation of actin filament polymerization	5.371265e-3
GO:0007596	blood coagulation	5.373613e-3
GO:0060297	regulation of sarcomere organization	5.417569e-3
GO:0010922	positive regulation of phosphatase activity	5.437238e-3
GO:0001952	regulation of cell-matrix adhesion	5.495564e-3
GO:0016202	regulation of striated muscle tissue development	5.525878e-3
GO:0016197	endosome transport	5.552261e-3
GO:0003206	cardiac chamber morphogenesis	5.563526e-3
GO:2000831	regulation of steroid hormone secretion	5.583131e-3
GO:0010885	regulation of cholesterol storage	5.626038e-3
GO:0008354	germ cell migration	5.626038e-3
GO:0048644	muscle organ morphogenesis	5.658761e-3
GO:0045746	negative regulation of Notch signaling pathway	5.660771e-3
GO:0051094	positive regulation of developmental process	5.720014e-3
GO:0030514	negative regulation of BMP signaling pathway	5.745884e-3
GO:0003205	cardiac chamber development	5.754330e-3
GO:0030011	maintenance of cell polarity	5.765054e-3
GO:0051172	negative regulation of nitrogen compound metabolic process	5.772253e-3
GO:0002768	immune response-regulating cell surface receptor signaling pathway	5.841580e-3
GO:0048846	axon extension involved in axon guidance	5.856236e-3
GO:0045089	positive regulation of innate immune response	5.885787e-3
GO:0045445	myoblast differentiation	5.894614e-3
GO:0008544	epidermis development	6.011202e-3
GO:0043589	skin morphogenesis	6.081306e-3
GO:0042402	cellular biogenic amine catabolic process	6.160537e-3
GO:0032274	gonadotropin secretion	6.160537e-3
GO:0007413	axonal fasciculation	6.160537e-3
GO:0045321	leukocyte activation	6.180573e-3
GO:0050680	negative regulation of epithelial cell proliferation	6.183838e-3
GO:0030252	growth hormone secretion	6.192972e-3
GO:0006691	leukotriene metabolic process	6.249870e-3
GO:0046660	female sex differentiation	6.276271e-3
GO:0051093	negative regulation of developmental process	6.383011e-3
GO:0009124	nucleoside monophosphate biosynthetic process	6.398647e-3
GO:0060600	dichotomous subdivision of an epithelial terminal unit	6.500026e-3
GO:0030104	water homeostasis	6.500026e-3
GO:0002710	negative regulation of T cell mediated immunity	6.500026e-3
GO:0007267	cell-cell signaling	6.525630e-3
GO:0043480	pigment accumulation in tissues	6.568899e-3
GO:0032023	trypsinogen activation	6.568899e-3
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	6.597661e-3
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	6.656638e-3
GO:0048634	regulation of muscle organ development	6.768255e-3
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	6.851070e-3
GO:0070943	neutrophil mediated killing of symbiont cell	6.862694e-3
GO:0030501	positive regulation of bone mineralization	6.894201e-3
GO:0035295	tube development	6.910746e-3
GO:0007399	nervous system development	6.918493e-3
GO:0046621	negative regulation of organ growth	6.926921e-3
GO:0060395	SMAD protein signal transduction	7.002548e-3
GO:0045663	positive regulation of myoblast differentiation	7.009321e-3
GO:0045892	negative regulation of transcription, DNA-dependent	7.055339e-3
GO:0045668	negative regulation of osteoblast differentiation	7.111356e-3
GO:0044243	multicellular organismal catabolic process	7.133285e-3
GO:0014074	response to purine-containing compound	7.138211e-3
GO:2000058	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	7.223760e-3
GO:0072102	glomerulus morphogenesis	7.223760e-3
GO:0048583	regulation of response to stimulus	7.238894e-3
GO:0022414	reproductive process	7.261047e-3
GO:0045616	regulation of keratinocyte differentiation	7.288520e-3
GO:0060485	mesenchyme development	7.387747e-3
GO:0002562	somatic diversification of immune receptors via germline recombination within a single locus	7.391455e-3
GO:2001054	negative regulation of mesenchymal cell apoptosis	7.559633e-3
GO:0048625	myoblast cell fate commitment	7.608893e-3
GO:0009072	aromatic amino acid family metabolic process	7.654976e-3
GO:0033133	positive regulation of glucokinase activity	7.683505e-3
GO:0030728	ovulation	7.695865e-3
GO:0003007	heart morphogenesis	7.730695e-3
GO:0050851	antigen receptor-mediated signaling pathway	7.766317e-3
GO:0006367	transcription initiation from RNA polymerase II promoter	7.793240e-3
GO:0048745	smooth muscle tissue development	7.819671e-3
GO:0032695	negative regulation of interleukin-12 production	7.862306e-3
GO:0001967	suckling behavior	7.862306e-3
GO:0001887	selenium compound metabolic process	7.911974e-3
GO:0070169	positive regulation of biomineral tissue development	7.913110e-3
GO:0060244	negative regulation of cell proliferation involved in contact inhibition	7.944216e-3
GO:0032231	regulation of actin filament bundle assembly	7.983012e-3
GO:0035850	epithelial cell differentiation involved in kidney development	8.010138e-3
GO:0042127	regulation of cell proliferation	8.013112e-3
GO:0002839	positive regulation of immune response to tumor cell	8.035969e-3
GO:0009914	hormone transport	8.209169e-3
GO:0008593	regulation of Notch signaling pathway	8.217861e-3
GO:0002820	negative regulation of adaptive immune response	8.303827e-3
GO:0003208	cardiac ventricle morphogenesis	8.325916e-3
GO:0030538	embryonic genitalia morphogenesis	8.427950e-3
GO:0060134	prepulse inhibition	8.489695e-3
GO:0051883	killing of cells in other organism involved in symbiotic interaction	8.489695e-3
GO:0050776	regulation of immune response	8.497807e-3
GO:0007268	synaptic transmission	8.648215e-3
GO:0001964	startle response	8.655760e-3
GO:0045669	positive regulation of osteoblast differentiation	8.705108e-3
GO:0006376	mRNA splice site selection	8.728287e-3
GO:0048584	positive regulation of response to stimulus	8.738507e-3
GO:0048320	axial mesoderm formation	8.760065e-3
GO:0002837	regulation of immune response to tumor cell	8.843145e-3
GO:0031640	killing of cells of other organism	8.987460e-3
GO:0051253	negative regulation of RNA metabolic process	9.060602e-3
GO:0085029	extracellular matrix assembly	9.068357e-3
GO:0000301	retrograde transport, vesicle recycling within Golgi	9.068357e-3
GO:0048333	mesodermal cell differentiation	9.129703e-3
GO:0010884	positive regulation of lipid storage	9.129703e-3
GO:0030857	negative regulation of epithelial cell differentiation	9.395505e-3
GO:0007442	hindgut morphogenesis	9.395505e-3
GO:0002764	immune response-regulating signaling pathway	9.415041e-3
GO:0002707	negative regulation of lymphocyte mediated immunity	9.449088e-3
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	9.500840e-3
GO:0060678	dichotomous subdivision of terminal units involved in ureteric bud branching	9.500840e-3
GO:0071236	cellular response to antibiotic	9.507638e-3
GO:0042984	regulation of amyloid precursor protein biosynthetic process	9.582559e-3
GO:0001954	positive regulation of cell-matrix adhesion	9.783873e-3
GO:0010629	negative regulation of gene expression	9.954427e-3
GO:0042832	defense response to protozoan	1.005088e-2
GO:0007519	skeletal muscle tissue development	1.010812e-2
GO:0042554	superoxide anion generation	1.017845e-2
GO:0055021	regulation of cardiac muscle tissue growth	1.030920e-2
GO:0034755	iron ion transmembrane transport	1.054823e-2
GO:0019370	leukotriene biosynthetic process	1.064951e-2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	1.071972e-2
GO:0010744	positive regulation of macrophage derived foam cell differentiation	1.078552e-2
GO:0002200	somatic diversification of immune receptors	1.078774e-2
GO:0050807	regulation of synapse organization	1.093105e-2
GO:0009968	negative regulation of signal transduction	1.120957e-2
GO:0070869	heterochromatin formation involved in chromatin silencing	1.124283e-2
GO:0009992	cellular water homeostasis	1.124283e-2
GO:0071559	response to transforming growth factor beta stimulus	1.125587e-2
GO:0071625	vocalization behavior	1.128874e-2
GO:0051937	catecholamine transport	1.130874e-2
GO:0048633	positive regulation of skeletal muscle tissue growth	1.132891e-2
GO:0035129	post-embryonic hindlimb morphogenesis	1.132891e-2
GO:0006426	glycyl-tRNA aminoacylation	1.132891e-2
GO:0010743	regulation of macrophage derived foam cell differentiation	1.136189e-2
GO:0030865	cortical cytoskeleton organization	1.146893e-2
GO:0050911	detection of chemical stimulus involved in sensory perception of smell	1.169598e-2
GO:0006072	glycerol-3-phosphate metabolic process	1.179394e-2
GO:0015867	ATP transport	1.179394e-2
GO:0030888	regulation of B cell proliferation	1.211047e-2
GO:0040011	locomotion	1.221811e-2
GO:0048729	tissue morphogenesis	1.227598e-2
GO:0006003	fructose 2,6-bisphosphate metabolic process	1.229303e-2
GO:0032956	regulation of actin cytoskeleton organization	1.235953e-2
GO:0055008	cardiac muscle tissue morphogenesis	1.242418e-2
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.254562e-2
GO:0002456	T cell mediated immunity	1.273372e-2
GO:0043620	regulation of DNA-dependent transcription in response to stress	1.273372e-2
GO:0031343	positive regulation of cell killing	1.285359e-2
GO:0015986	ATP synthesis coupled proton transport	1.287301e-2
GO:0071320	cellular response to cAMP	1.287419e-2
GO:0032825	positive regulation of natural killer cell differentiation	1.292504e-2
GO:0022618	ribonucleoprotein complex assembly	1.306800e-2
GO:0001505	regulation of neurotransmitter levels	1.315307e-2
GO:0006419	alanyl-tRNA aminoacylation	1.317760e-2
GO:0016560	protein import into peroxisome matrix, docking	1.317760e-2
GO:0048343	paraxial mesodermal cell fate commitment	1.317760e-2
GO:0009051	pentose-phosphate shunt, oxidative branch	1.317760e-2
GO:0044236	multicellular organismal metabolic process	1.320860e-2
GO:0032861	activation of Rap GTPase activity	1.322039e-2
GO:0034109	homotypic cell-cell adhesion	1.330131e-2
GO:0007059	chromosome segregation	1.335555e-2
GO:0001937	negative regulation of endothelial cell proliferation	1.337224e-2
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	1.343949e-2
GO:0040019	positive regulation of embryonic development	1.343949e-2
GO:0044344	cellular response to fibroblast growth factor stimulus	1.370358e-2
GO:0048608	reproductive structure development	1.382811e-2
GO:0046879	hormone secretion	1.405042e-2
GO:0008090	retrograde axon cargo transport	1.424069e-2
GO:0015938	coenzyme A catabolic process	1.428578e-2
GO:0022008	neurogenesis	1.428675e-2
GO:0045778	positive regulation of ossification	1.432857e-2
GO:0001912	positive regulation of leukocyte mediated cytotoxicity	1.432963e-2
GO:2000833	positive regulation of steroid hormone secretion	1.434185e-2
GO:0060513	prostatic bud formation	1.434185e-2
GO:0001755	neural crest cell migration	1.450586e-2
GO:0001736	establishment of planar polarity	1.455441e-2
GO:0048520	positive regulation of behavior	1.461272e-2