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{{Coexpression_clusters
{
|full_id=C4304_iPS_H9_Lens_HES3GFP_Ciliary_renal_Fibroblast
 

Latest revision as of 12:43, 17 September 2013


Full id: C4304_iPS_H9_Lens_HES3GFP_Ciliary_renal_Fibroblast



Phase1 CAGE Peaks

Hg19::chr3:170076223..170076242,+p6@SKIL
Hg19::chr3:170076246..170076261,+p8@SKIL
Hg19::chr3:170076314..170076334,+p2@SKIL


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
animal cell2.09e-13679
eukaryotic cell2.09e-13679
mesodermal cell3.42e-10121
embryonic cell1.78e-09250
non-terminally differentiated cell2.32e-09106
somatic cell8.25e-09588
electrically responsive cell3.11e-0861
electrically active cell3.11e-0861
muscle precursor cell6.06e-0858
myoblast6.06e-0858
multi-potent skeletal muscle stem cell6.06e-0858
contractile cell2.97e-0759
muscle cell3.92e-0755
Uber Anatomy
Ontology termp-valuen
artery9.00e-1242
arterial blood vessel9.00e-1242
arterial system9.00e-1242
systemic artery5.15e-1133
systemic arterial system5.15e-1133
epithelial tube7.31e-11117
epithelial tube open at both ends1.59e-0859
blood vessel1.59e-0859
blood vasculature1.59e-0859
vascular cord1.59e-0859
vasculature1.73e-0878
vascular system1.73e-0878
aorta1.84e-0821
aortic system1.84e-0821
splanchnic layer of lateral plate mesoderm3.40e-0883
cardiovascular system1.48e-07109
circulatory system2.84e-07112
vessel3.84e-0768


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.05336
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.12.01615
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.13.76647
MA0069.11.31207
MA0070.11.30033
MA0071.13.42881
MA0072.11.29561
MA0073.115.8256
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.11.55947
MA0103.10.628063
MA0105.17.43664
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.96087
MA0140.12.07172
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.838867
MA0155.12.83144
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.15.21222
MA0163.15.63764
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.23.61229
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.019061317870885
CEBPB#105137.971147625824820.001974187055288560.0115540555823638
CTCF#1066435.360256373075030.0064925092527670.0280449654168969
E2F1#186934.907389214879320.008460985347239390.0326614987499662
EGR1#195834.988179094810140.008056488137383440.0321640506337993
ELF1#199734.258097958807540.01295179875054610.0463815975074847
EP300#203336.77394172622320.003216880500103790.0167950301214927
ESR1#2099330.76860329615453.43136389821584e-050.000678342256607541
HMGN3#932438.178547723350590.001827766942164210.0108955566023224
JUND#372736.994663941871030.002921845042734990.0157198935925304
NFKB1#479035.488063424193840.006049381815655430.0270296649031076
PAX5#507936.669565531177830.003370290999677260.0173394000844972
RAD21#5885310.35503389545630.0009004912073565420.0066633414485695
REST#597839.650028716128020.001112636247114590.0076970667690535
RXRA#6256320.07461713913330.0001235730348432220.00165629417171346
SMARCB1#6598318.25271578115740.000164397760679890.00203502876942599
SMC3#9126315.04493284493280.0002935825420371870.00309962263524279
TFAP2C#7022310.80922860986020.0007916746575753130.00617488495612458
YY1#752834.911170749853860.008441455341808260.0330428827421428
ZBTB7A#5134137.35190930787590.002516255860282270.014059988539512



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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