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{{CL
{{CL
|id=CL:0000771
|alt_id=
|name=eosinophil
|namespace=cell;;efo
|def="Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMCID:PMC2626675, PMID:10914487, PMID:1662676]
|xref=BTO:0000399;;FMA:62861
|is_a=CL:0000094
|synonym="eosinocyte" EXACT [];;"eosinophilic granulocyte" EXACT [];;"eosinophilic leucocyte" EXACT [];;"eosinophilic leukocyte" EXACT [];;"polymorphonuclear leucocyte" BROAD [];;"polymorphonuclear leukocyte" BROAD []
|comment=Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte.
|comment=Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMCID:PMC2626675, PMID:10914487, PMID:1662676]
|subset=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000771
|is_a=CL:0000094
|is_obsolete=
|located_in=
|located_in=
|name=eosinophil
|namespace=cell;;efo
|obo_creation_date=
|part_of=
|part_of=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="eosinocyte" EXACT [];;"eosinophilic granulocyte" EXACT [];;"eosinophilic leucocyte" EXACT [];;"eosinophilic leukocyte" EXACT [];;"polymorphonuclear leucocyte" BROAD [];;"polymorphonuclear leukocyte" BROAD []
|union_of=
|xref=BTO:0000399;;FMA:62861
}}
}}

Revision as of 10:20, 12 September 2014

Name:eosinophil
Namespace:cell;;efo
Definition:"Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMCID:PMC2626675, PMID:10914487, PMID:1662676]
Xrefs:
links:

BTO:0000399

FMA:62861
Synonyms: "eosinocyte" EXACT []
"eosinophilic granulocyte" EXACT []
"eosinophilic leucocyte" EXACT []
"eosinophilic leukocyte" EXACT []
"polymorphonuclear leucocyte" BROAD []
"polymorphonuclear leukocyte" BROAD []
Comments:Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000094(granulocyte)



Children


derives from:FF:0000054 (human eosinophil sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000771 (eosinophil), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.29e-195FFCP PHASE1:Hg19::chr20:58583854..58583859,+#_54590defd6044dd13ceebdd2a61e1ecfp@chr20:58583854..58583859, +
3.29e-195FFCP PHASE2:Hg19::chr20:58583854..58583859,+#_54590defd6044dd13ceebdd2a61e1ecfp@chr20:58583854..58583859, +
8.99e-131FFCP PHASE1:Hg19::chr12:78398581..78398586,-#_cf17571beecb4a14331c919d98545880p@chr12:78398581..78398586, -
8.99e-131FFCP PHASE2:Hg19::chr17:7254317..7254321,+#_cf17571beecb4a14331c919d98545880p@chr17:7254317..7254321, +
8.99e-131FFCP PHASE1:Hg19::chr6:2523125..2523129,+#_cf17571beecb4a14331c919d98545880p@chr6:2523125..2523129, +
8.99e-131FFCP PHASE1:Hg19::chr17:7254317..7254321,+#_cf17571beecb4a14331c919d98545880p@chr17:7254317..7254321, +
8.99e-131FFCP PHASE2:Hg19::chr12:78398581..78398586,-#_cf17571beecb4a14331c919d98545880p@chr12:78398581..78398586, -
8.99e-131FFCP PHASE2:Hg19::chr6:2523125..2523129,+#_cf17571beecb4a14331c919d98545880p@chr6:2523125..2523129, +
1.75e-130FFCP PHASE1:Hg19::chr1:94181180..94181200,-#_98efd0bb17207eee7587d867b161066cp@chr1:94181180..94181200, -
1.75e-130FFCP PHASE1:Hg19::chr20:61317566..61317586,-#_98efd0bb17207eee7587d867b161066cp@chr20:61317566..61317586, -
1.75e-130FFCP PHASE2:Hg19::chr1:94181180..94181200,-#_98efd0bb17207eee7587d867b161066cp@chr1:94181180..94181200, -
1.75e-130FFCP PHASE2:Hg19::chr20:61317566..61317586,-#_98efd0bb17207eee7587d867b161066cp@chr20:61317566..61317586, -
5.68e-99FFCP PHASE2:Hg19::chr12:66562929..66562938,-#_3067e9586a01faeaa652da522b258007p12@TMBIM4
5.68e-99FFCP PHASE1:Hg19::chr2:70205032..70205037,+#_3067e9586a01faeaa652da522b258007p@chr2:70205032..70205037, +
5.68e-99FFCP PHASE1:Hg19::chr12:66562929..66562938,-#_3067e9586a01faeaa652da522b258007p12@TMBIM4
5.68e-99FFCP PHASE2:Hg19::chr2:70205032..70205037,+#_3067e9586a01faeaa652da522b258007p@chr2:70205032..70205037, +
5.68e-99FFCP PHASE1:Hg19::chr11:325899..325904,-#_3067e9586a01faeaa652da522b258007p@chr11:325899..325904, -
5.68e-99FFCP PHASE2:Hg19::chr11:325899..325904,-#_3067e9586a01faeaa652da522b258007p@chr11:325899..325904, -
9.38e-99FFCP PHASE1:Hg19::chr1:36825695..36825702,+#_93917df58d355404d75d7d847647c8e4p@chr1:36825695..36825702, +
9.38e-99FFCP PHASE2:Hg19::chr12:106697974..106697990,-#_93917df58d355404d75d7d847647c8e4p31@CKAP4
9.38e-99FFCP PHASE2:Hg19::chr1:36825695..36825702,+#_93917df58d355404d75d7d847647c8e4p@chr1:36825695..36825702, +
9.38e-99FFCP PHASE1:Hg19::chr2:70246173..70246174,-#_93917df58d355404d75d7d847647c8e4p@chr2:70246173..70246174, -
9.38e-99FFCP PHASE2:Hg19::chr2:70246173..70246174,-#_93917df58d355404d75d7d847647c8e4p@chr2:70246173..70246174, -
9.38e-99FFCP PHASE1:Hg19::chr12:106697974..106697990,-#_93917df58d355404d75d7d847647c8e4p31@CKAP4
9.38e-99FFCP PHASE1:Hg19::chr10:6437802..6437809,+#_93917df58d355404d75d7d847647c8e4p@chr10:6437802..6437809, +
9.38e-99FFCP PHASE2:Hg19::chr10:6437802..6437809,+#_93917df58d355404d75d7d847647c8e4p@chr10:6437802..6437809, +
1.55e-98FFCP PHASE2:Hg19::chr5:126147844..126147847,+#_31496fd395bf59391fdb1b33884fc25dp@chr5:126147844..126147847, +
1.55e-98FFCP PHASE1:Hg19::chr19:21860925..21860945,-#_31496fd395bf59391fdb1b33884fc25dp@chr19:21860925..21860945, -
1.55e-98FFCP PHASE2:Hg19::chr10:125797517..125797522,-#_31496fd395bf59391fdb1b33884fc25dp@chr10:125797517..125797522, -
1.55e-98FFCP PHASE2:Hg19::chr17:7835843..7835845,-#_31496fd395bf59391fdb1b33884fc25dp@chr17:7835843..7835845, -
1.55e-98FFCP PHASE1:Hg19::chr14:62035649..62035652,+#_31496fd395bf59391fdb1b33884fc25dp@chr14:62035649..62035652, +
1.55e-98FFCP PHASE1:Hg19::chr17:7835843..7835845,-#_31496fd395bf59391fdb1b33884fc25dp@chr17:7835843..7835845, -
1.55e-98FFCP PHASE2:Hg19::chr12:132345733..132345736,+#_31496fd395bf59391fdb1b33884fc25dp@chr12:132345733..132345736, +
1.55e-98FFCP PHASE2:Hg19::chr8:6875818..6875822,-#_31496fd395bf59391fdb1b33884fc25dp1@DEFA1B, p1@DEFA1, p1@DEFA3
1.55e-98FFCP PHASE1:Hg19::chr8:6875818..6875822,-#_31496fd395bf59391fdb1b33884fc25dp1@DEFA1B, p1@DEFA1, p1@DEFA3
1.55e-98FFCP PHASE1:Hg19::chr10:125797517..125797522,-#_31496fd395bf59391fdb1b33884fc25dp@chr10:125797517..125797522, -
1.55e-98FFCP PHASE2:Hg19::chr14:62035649..62035652,+#_31496fd395bf59391fdb1b33884fc25dp@chr14:62035649..62035652, +
1.55e-98FFCP PHASE1:Hg19::chr12:132345733..132345736,+#_31496fd395bf59391fdb1b33884fc25dp@chr12:132345733..132345736, +
1.55e-98FFCP PHASE1:Hg19::chr5:126147844..126147847,+#_31496fd395bf59391fdb1b33884fc25dp@chr5:126147844..126147847, +
1.55e-98FFCP PHASE2:Hg19::chr19:21860925..21860945,-#_31496fd395bf59391fdb1b33884fc25dp@chr19:21860925..21860945, -
2.56e-98FFCP PHASE1:Hg19::chr1:28453609..28453619,+#_acf1cfc773444e45495387ec9e7ebd59p@chr1:28453609..28453619, +
2.56e-98FFCP PHASE1:Hg19::chr1:208712314..208712317,+#_acf1cfc773444e45495387ec9e7ebd59p@chr1:208712314..208712317, +
2.56e-98FFCP PHASE2:Hg19::chr1:28453609..28453619,+#_acf1cfc773444e45495387ec9e7ebd59p@chr1:28453609..28453619, +
2.56e-98FFCP PHASE2:Hg19::chr1:208712314..208712317,+#_acf1cfc773444e45495387ec9e7ebd59p@chr1:208712314..208712317, +
2.56e-98FFCP PHASE1:Hg19::chr10:129052667..129052672,-#_acf1cfc773444e45495387ec9e7ebd59p@chr10:129052667..129052672, -
2.56e-98FFCP PHASE2:Hg19::chr19:47885192..47885197,-#_acf1cfc773444e45495387ec9e7ebd59p@chr19:47885192..47885197, -
2.56e-98FFCP PHASE1:Hg19::chr19:47885192..47885197,-#_acf1cfc773444e45495387ec9e7ebd59p@chr19:47885192..47885197, -
2.56e-98FFCP PHASE2:Hg19::chr10:129052667..129052672,-#_acf1cfc773444e45495387ec9e7ebd59p@chr10:129052667..129052672, -
1.05e-79FFCP PHASE2:Hg19::chr8:133774199..133774210,-#_3e70302a07f2e1fbba9b582277365dc6p@chr8:133774199..133774210, -
1.05e-79FFCP PHASE2:Hg19::chr4:74581933..74581937,+#_3e70302a07f2e1fbba9b582277365dc6p@chr4:74581933..74581937, +
1.05e-79FFCP PHASE1:Hg19::chr1:182367189..182367199,+#_3e70302a07f2e1fbba9b582277365dc6p@chr1:182367189..182367199, +
1.05e-79FFCP PHASE1:Hg19::chr4:74581933..74581937,+#_3e70302a07f2e1fbba9b582277365dc6p@chr4:74581933..74581937, +
1.05e-79FFCP PHASE1:Hg19::chr8:133774199..133774210,-#_3e70302a07f2e1fbba9b582277365dc6p@chr8:133774199..133774210, -
1.05e-79FFCP PHASE2:Hg19::chr5:142384316..142384325,-#_3e70302a07f2e1fbba9b582277365dc6p@chr5:142384316..142384325, -
1.05e-79FFCP PHASE1:Hg19::chr5:142384316..142384325,-#_3e70302a07f2e1fbba9b582277365dc6p@chr5:142384316..142384325, -
1.05e-79FFCP PHASE2:Hg19::chr15:75370087..75370094,-#_3e70302a07f2e1fbba9b582277365dc6p@chr15:75370087..75370094, -
1.05e-79FFCP PHASE2:Hg19::chr17:34617878..34617880,-#_3e70302a07f2e1fbba9b582277365dc6p@chr17:34617878..34617880, -
1.05e-79FFCP PHASE2:Hg19::chr1:185389704..185389711,+#_3e70302a07f2e1fbba9b582277365dc6p@chr1:185389704..185389711, +
1.05e-79FFCP PHASE1:Hg19::chr17:34617878..34617880,-#_3e70302a07f2e1fbba9b582277365dc6p@chr17:34617878..34617880, -
1.05e-79FFCP PHASE1:Hg19::chr1:235099440..235099448,+#_3e70302a07f2e1fbba9b582277365dc6p@chr1:235099440..235099448, +
1.05e-79FFCP PHASE2:Hg19::chr15:90579320..90579331,-#_3e70302a07f2e1fbba9b582277365dc6p@chr15:90579320..90579331, -
1.05e-79FFCP PHASE1:Hg19::chr15:90579320..90579331,-#_3e70302a07f2e1fbba9b582277365dc6p@chr15:90579320..90579331, -
1.05e-79FFCP PHASE1:Hg19::chr9:129233326..129233330,-#_3e70302a07f2e1fbba9b582277365dc6p@chr9:129233326..129233330, -
1.05e-79FFCP PHASE1:Hg19::chr11:1865720..1865724,+#_3e70302a07f2e1fbba9b582277365dc6p@chr11:1865720..1865724, +
1.05e-79FFCP PHASE1:Hg19::chr1:185389704..185389711,+#_3e70302a07f2e1fbba9b582277365dc6p@chr1:185389704..185389711, +
1.05e-79FFCP PHASE2:Hg19::chr9:129233326..129233330,-#_3e70302a07f2e1fbba9b582277365dc6p@chr9:129233326..129233330, -
1.05e-79FFCP PHASE2:Hg19::chr11:1865720..1865724,+#_3e70302a07f2e1fbba9b582277365dc6p@chr11:1865720..1865724, +
1.05e-79FFCP PHASE2:Hg19::chr1:235099440..235099448,+#_3e70302a07f2e1fbba9b582277365dc6p@chr1:235099440..235099448, +
1.05e-79FFCP PHASE2:Hg19::chr1:182367189..182367199,+#_3e70302a07f2e1fbba9b582277365dc6p@chr1:182367189..182367199, +
1.05e-79FFCP PHASE1:Hg19::chr15:75370087..75370094,-#_3e70302a07f2e1fbba9b582277365dc6p@chr15:75370087..75370094, -
1.56e-79FFCP PHASE2:Hg19::chr15:89672367..89672372,+#_d2cf605625a135a61524fbd83f9f30acp@chr15:89672367..89672372, +
1.56e-79FFCP PHASE2:Hg19::chr1:206731759..206731770,+#_d2cf605625a135a61524fbd83f9f30acp@chr1:206731759..206731770, +
1.56e-79FFCP PHASE2:Hg19::chr1:198571112..198571115,-#_d2cf605625a135a61524fbd83f9f30acp@chr1:198571112..198571115, -
1.56e-79FFCP PHASE2:Hg19::chr2:68613090..68613098,+#_d2cf605625a135a61524fbd83f9f30acp@chr2:68613090..68613098, +
1.56e-79FFCP PHASE2:Hg19::chr11:15647581..15647597,+#_d2cf605625a135a61524fbd83f9f30acp@chr11:15647581..15647597, +
1.56e-79FFCP PHASE1:Hg19::chr15:101662027..101662033,+#_d2cf605625a135a61524fbd83f9f30acp@chr15:101662027..101662033, +
1.56e-79FFCP PHASE1:Hg19::chr1:198571112..198571115,-#_d2cf605625a135a61524fbd83f9f30acp@chr1:198571112..198571115, -
1.56e-79FFCP PHASE1:Hg19::chr11:15647581..15647597,+#_d2cf605625a135a61524fbd83f9f30acp@chr11:15647581..15647597, +
1.56e-79FFCP PHASE2:Hg19::chr7:128048285..128048310,-#_d2cf605625a135a61524fbd83f9f30acp@chr7:128048285..128048310, -
1.56e-79FFCP PHASE1:Hg19::chr7:128048285..128048310,-#_d2cf605625a135a61524fbd83f9f30acp@chr7:128048285..128048310, -
1.56e-79FFCP PHASE1:Hg19::chr1:206731759..206731770,+#_d2cf605625a135a61524fbd83f9f30acp@chr1:206731759..206731770, +
1.56e-79FFCP PHASE1:Hg19::chr2:68613090..68613098,+#_d2cf605625a135a61524fbd83f9f30acp@chr2:68613090..68613098, +
1.56e-79FFCP PHASE1:Hg19::chr15:89672367..89672372,+#_d2cf605625a135a61524fbd83f9f30acp@chr15:89672367..89672372, +
1.56e-79FFCP PHASE2:Hg19::chr15:101662027..101662033,+#_d2cf605625a135a61524fbd83f9f30acp@chr15:101662027..101662033, +
2.34e-79FFCP PHASE1:Hg19::chr2:70246139..70246146,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr2:70246139..70246146, -
2.34e-79FFCP PHASE1:Hg19::chr22:43288684..43288705,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr22:43288684..43288705, -
2.34e-79FFCP PHASE2:Hg19::chr2:103106370..103106380,+#_4cf74f1f3726f3f3669a9e6ec51495abp@chr2:103106370..103106380, +
2.34e-79FFCP PHASE2:Hg19::chr2:70246139..70246146,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr2:70246139..70246146, -
2.34e-79FFCP PHASE1:Hg19::chr1:208712347..208712354,+#_4cf74f1f3726f3f3669a9e6ec51495abp@chr1:208712347..208712354, +
2.34e-79FFCP PHASE1:Hg19::chr2:28823344..28823354,+#_4cf74f1f3726f3f3669a9e6ec51495abp@chr2:28823344..28823354, +
2.34e-79FFCP PHASE2:Hg19::chr22:43288684..43288705,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr22:43288684..43288705, -
2.34e-79FFCP PHASE1:Hg19::chr2:120967889..120967892,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr2:120967889..120967892, -
2.34e-79FFCP PHASE2:Hg19::chr7:75268487..75268499,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr7:75268487..75268499, -
2.34e-79FFCP PHASE1:Hg19::chr7:75268487..75268499,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr7:75268487..75268499, -
2.34e-79FFCP PHASE2:Hg19::chr1:208712347..208712354,+#_4cf74f1f3726f3f3669a9e6ec51495abp@chr1:208712347..208712354, +
2.34e-79FFCP PHASE2:Hg19::chr2:28823344..28823354,+#_4cf74f1f3726f3f3669a9e6ec51495abp@chr2:28823344..28823354, +
2.34e-79FFCP PHASE2:Hg19::chr9:140501563..140501569,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr9:140501563..140501569, -
2.34e-79FFCP PHASE1:Hg19::chr2:103106370..103106380,+#_4cf74f1f3726f3f3669a9e6ec51495abp@chr2:103106370..103106380, +
2.34e-79FFCP PHASE1:Hg19::chr9:140501563..140501569,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr9:140501563..140501569, -
2.34e-79FFCP PHASE2:Hg19::chr2:120967889..120967892,-#_4cf74f1f3726f3f3669a9e6ec51495abp@chr2:120967889..120967892, -

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