Coexpression cluster:C255: Difference between revisions
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{{Coexpression_clusters | 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regulation of cellular catabolic process!0.0243337650614231!147$GO:0045818!negative regulation of glycogen catabolic process!0.0243337650614231!147$GO:0045819!positive regulation of glycogen catabolic process!0.0243337650614231!147$GO:0031329!regulation of cellular catabolic process!0.0243337650614231!147$GO:0005981!regulation of glycogen catabolic process!0.0243337650614231!147$GO:0001987!vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure!0.0243337650614231!147$GO:0043278!response to morphine!0.0243337650614231!147$GO:0031331!positive regulation of cellular catabolic process!0.0243337650614231!147$GO:0014072!response to isoquinoline alkaloid!0.0243337650614231!147$GO:0001982!baroreceptor response to decreased systemic arterial blood pressure!0.0291923521403618!147$GO:0003099!positive regulation of the force of heart contraction by chemical signal!0.0291923521403618!147$GO:0001996!positive regulation of heart rate by epinephrine-norepinephrine!0.0291923521403618!147$GO:0048148!behavioral response to cocaine!0.0291923521403618!147$GO:0003057!regulation of the force of heart contraction by chemical signal!0.0291923521403618!147$GO:0001997!positive regulation of the force of heart contraction by epinephrine-norepinephrine!0.0291923521403618!147$GO:0004813!alanine-tRNA ligase activity!0.0298474661164654!80755$GO:0045912!negative regulation of carbohydrate metabolic process!0.0298474661164654!147$GO:0010460!positive regulation of heart rate!0.0298474661164654!147$GO:0006419!alanyl-tRNA aminoacylation!0.0298474661164654!80755$GO:0000309!nicotinamide-nucleotide adenylyltransferase activity!0.0298474661164654!23057$GO:0042220!response to cocaine!0.0298474661164654!147$GO:0014073!response to tropane!0.0298474661164654!147$GO:0004714!transmembrane receptor protein tyrosine kinase activity!0.030184957028829!4916;285220$GO:0001978!carotid sinus baroreceptor feedback regulation of systemic arterial blood 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,0.902417,0.945538|tfbs_overrepresentation_for_novel_motifs=0.481682,0.24193,0.129135,0.0352482,0.346819,0.930217,0.800478,0.316884,0.188904,0.0424525,1.62077,0.256585,1.56536,0.439327,0.0291717,0.230197,0.48452,0.558757,0.217236,0.307217,0.266546,0.42954,0.313076,0.18453,0.182796,0.0829608,1.32483,0.309568,0.1978,0.174587,0.461914,0.182397,0.855791,0.29989,1.20129,0.63573,0.631899,0.59473,0.532811,1.54653,0.26038,0.0881102,0.0988443,0.0286566,0.372808,0.327431,0.462982,0.261018,0.182027,0.355091,0.0890171,0.485536,0.318527,0.231144,0.3402,0.201607,0.20506,0.684497,0.174273,0.681743,1.12906,0.810437,0.31025,0.875041,0.862736,0.399312,0.409209,0.727856,0.176167,0.58255,0.203487,0.336077,1.13495,0.338683,0.571037,1.10888,0.0114078,0.136087,0.517685,0.0665908,0.356801,0.444341,0.065229,0.201092,0.300427,1.66555,0.411529,0.252137,0.330571,0.819547,0.485902,0.280966,0.562326,0.0340674,0.807344,0.194711,0.124517,0.62667,0.102812,0.0693411,0.538347,0.55395,0.618126,0.948857,0.384166,0.111808,0.153835,0.195261,1.24693,0.0752699,0.141419,0.214289,0.256068,0.538506,0.446027,0.134123,0.740708,0.0227223,0.396218,0.467564,0.332425,0.327579,0.920211,0.244408,0.539181,0.423787,0.203834,0.19576,0.956872,0.196584,0.281458,0.46874,0.376217,0.240788,0.496746,0.0432911,1.06717,0.310482,0.461248,1.25501,0.868564,0.430601,0.452197,0.217405,0.386463,0.370366,0.736749,1.10041,0.216868,0.0814693,0.808946,1.11128,0.770319,0.283234,0.213312,0.609476,0.0933429,0.17073,0.359306,2.32995,0.429612,0.268633,0.17377,0.30594,0.81035,0.231403,0.583406,0.0572615,1.47727|tfbs_overrepresentation_jaspar=MA0003.1;2.65757,MA0004.1;0.0287532,MA0006.1;0.0290142,MA0007.1;0.105058,MA0009.1;0.252434,MA0014.1;2.20334,MA0017.1;0.259054,MA0019.1;0.555905,MA0024.1;0.183969,MA0025.1;1.65237,MA0027.1;1.73105,MA0028.1;0.38452,MA0029.1;0.195946,MA0030.1;0.188804,MA0031.1;0.150659,MA0038.1;0.466212,MA0040.1;0.579034,MA0041.1;0.134241,MA0042.1;0.264815,MA0043.1;0.703596,MA0046.1;0.24494,MA0048.1;0.152472,MA0050.1;0.0259441,MA0051.1;0.0572096,MA0052.1;0.202085,MA0055.1;0.398929,MA0056.1;0,MA0057.1;0.570587,MA0058.1;0.0568651,MA0059.1;0.151766,MA0060.1;1.42636,MA0061.1;0.0300898,MA0063.1;0,MA0066.1;0.213568,MA0067.1;0.49981,MA0068.1;0.322801,MA0069.1;0.242306,MA0070.1;0.234718,MA0071.1;0.174636,MA0072.1;0.231695,MA0073.1;2.11352,MA0074.1;2.23582,MA0076.1;0.0138475,MA0077.1;1.20132,MA0078.1;1.09854,MA0081.1;0.151958,MA0083.1;0.715135,MA0084.1;0.664025,MA0087.1;0.230056,MA0088.1;0.148712,MA0089.1;0,MA0090.1;0.0160524,MA0091.1;0.534615,MA0092.1;0.441881,MA0093.1;0.00542575,MA0095.1;0,MA0098.1;0,MA0100.1;0.849289,MA0101.1;0.0312519,MA0103.1;0.751317,MA0105.1;0.472232,MA0106.1;0.547964,MA0107.1;0.0392752,MA0108.2;0.45517,MA0109.1;0,MA0111.1;0.209449,MA0113.1;0.0808928,MA0114.1;0.932237,MA0115.1;0.436009,MA0116.1;1.28368,MA0117.1;0.27892,MA0119.1;0.0482372,MA0122.1;0.806534,MA0124.1;0.402329,MA0125.1;0.8938,MA0130.1;0,MA0131.1;0.10574,MA0132.1;0,MA0133.1;0,MA0135.1;0.27375,MA0136.1;0.220509,MA0139.1;4.74703,MA0140.1;0.389168,MA0141.1;0.149727,MA0142.1;0.133251,MA0143.1;0.27686,MA0144.1;0.0751841,MA0145.1;0.79868,MA0146.1;0.289936,MA0147.1;0.012723,MA0148.1;0.0348816,MA0149.1;0.0422402,MA0062.2;0.122451,MA0035.2;0.387901,MA0039.2;3.32036,MA0138.2;0.0978028,MA0002.2;0.0875896,MA0137.2;0.402158,MA0104.2;0.00442204,MA0047.2;0.244302,MA0112.2;1.99723,MA0065.2;0.667807,MA0150.1;0.0704527,MA0151.1;0,MA0152.1;0.401045,MA0153.1;0.323801,MA0154.1;1.62697,MA0155.1;0.810786,MA0156.1;0.110132,MA0157.1;0.119034,MA0158.1;0,MA0159.1;0.751731,MA0160.1;0.152819,MA0161.1;0,MA0162.1;0.210045,MA0163.1;1.71766,MA0164.1;0.0861719,MA0080.2;0.0301046,MA0018.2;0.550787,MA0099.2;0.178704,MA0079.2;3.98856,MA0102.2;0.697711,MA0258.1;0.56487,MA0259.1;0.220187,MA0442.1;0}} | ||
|full_id=C255_Wilms_leiomyoblastoma_kidney_adrenal_MCF7_epithelioid_Mast | |||
|id=C255 | |||
}} |
Latest revision as of 11:07, 17 September 2013
Full id: C255_Wilms_leiomyoblastoma_kidney_adrenal_MCF7_epithelioid_Mast
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0031330 | negative regulation of cellular catabolic process | 0.0243337650614231 |
GO:0045818 | negative regulation of glycogen catabolic process | 0.0243337650614231 |
GO:0045819 | positive regulation of glycogen catabolic process | 0.0243337650614231 |
GO:0031329 | regulation of cellular catabolic process | 0.0243337650614231 |
GO:0005981 | regulation of glycogen catabolic process | 0.0243337650614231 |
GO:0001987 | vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure | 0.0243337650614231 |
GO:0043278 | response to morphine | 0.0243337650614231 |
GO:0031331 | positive regulation of cellular catabolic process | 0.0243337650614231 |
GO:0014072 | response to isoquinoline alkaloid | 0.0243337650614231 |
GO:0001982 | baroreceptor response to decreased systemic arterial blood pressure | 0.0291923521403618 |
GO:0003099 | positive regulation of the force of heart contraction by chemical signal | 0.0291923521403618 |
GO:0001996 | positive regulation of heart rate by epinephrine-norepinephrine | 0.0291923521403618 |
GO:0048148 | behavioral response to cocaine | 0.0291923521403618 |
GO:0003057 | regulation of the force of heart contraction by chemical signal | 0.0291923521403618 |
GO:0001997 | positive regulation of the force of heart contraction by epinephrine-norepinephrine | 0.0291923521403618 |
GO:0004813 | alanine-tRNA ligase activity | 0.0298474661164654 |
GO:0045912 | negative regulation of carbohydrate metabolic process | 0.0298474661164654 |
GO:0010460 | positive regulation of heart rate | 0.0298474661164654 |
GO:0006419 | alanyl-tRNA aminoacylation | 0.0298474661164654 |
GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity | 0.0298474661164654 |
GO:0042220 | response to cocaine | 0.0298474661164654 |
GO:0014073 | response to tropane | 0.0298474661164654 |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 0.030184957028829 |
GO:0001978 | carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure | 0.0312600309926838 |
GO:0003025 | baroreceptor regulation of systemic arterial blood pressure | 0.0312600309926838 |
GO:0001975 | response to amphetamine | 0.0312600309926838 |
GO:0014075 | response to amine stimulus | 0.0312600309926838 |
GO:0043526 | neuroprotection | 0.0312600309926838 |
GO:0019199 | transmembrane receptor protein kinase activity | 0.0321704466659882 |
GO:0004937 | alpha1-adrenergic receptor activity | 0.0321704466659882 |
GO:0043121 | neurotrophin binding | 0.0321704466659882 |
GO:0035265 | organ growth | 0.0321704466659882 |
GO:0045823 | positive regulation of heart contraction | 0.0321704466659882 |
GO:0001993 | regulation of systemic arterial blood pressure by norepinephrine-epinephrine | 0.0321704466659882 |
GO:0002027 | regulation of heart rate | 0.0347831181905141 |
GO:0005980 | glycogen catabolic process | 0.0347831181905141 |
GO:0009251 | glucan catabolic process | 0.0347831181905141 |
GO:0045913 | positive regulation of carbohydrate metabolic process | 0.0347831181905141 |
GO:0007512 | adult heart development | 0.0347831181905141 |
GO:0002026 | regulation of the force of heart contraction | 0.0347831181905141 |
GO:0009896 | positive regulation of catabolic process | 0.0347831181905141 |
GO:0001974 | blood vessel remodeling | 0.0347831181905141 |
GO:0003084 | positive regulation of systemic arterial blood pressure | 0.0347831181905141 |
GO:0008542 | visual learning | 0.0347831181905141 |
GO:0001976 | regulation of systemic arterial blood pressure by neurological process | 0.0364292713497891 |
GO:0006109 | regulation of carbohydrate metabolic process | 0.0364292713497891 |
GO:0000299 | integral to membrane of membrane fraction | 0.0364292713497891 |
GO:0043279 | response to alkaloid | 0.0364292713497891 |
GO:0009895 | negative regulation of catabolic process | 0.0393326162769219 |
GO:0004936 | alpha-adrenergic receptor activity | 0.0393326162769219 |
GO:0007632 | visual behavior | 0.0420102813890101 |
GO:0045777 | positive regulation of blood pressure | 0.0420102813890101 |
GO:0014070 | response to organic cyclic substance | 0.0444873434181894 |
GO:0001837 | epithelial to mesenchymal transition | 0.0444873434181894 |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 0.0454180426281821 |
GO:0003044 | regulation of systemic arterial blood pressure mediated by a chemical signal | 0.0467852967057092 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br><br>
Ontology term | p-value | n |
---|---|---|
embryonic stem cell | 2.94e-11 | 5 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 2.65757 |
MA0004.1 | 0.0287532 |
MA0006.1 | 0.0290142 |
MA0007.1 | 0.105058 |
MA0009.1 | 0.252434 |
MA0014.1 | 2.20334 |
MA0017.1 | 0.259054 |
MA0019.1 | 0.555905 |
MA0024.1 | 0.183969 |
MA0025.1 | 1.65237 |
MA0027.1 | 1.73105 |
MA0028.1 | 0.38452 |
MA0029.1 | 0.195946 |
MA0030.1 | 0.188804 |
MA0031.1 | 0.150659 |
MA0038.1 | 0.466212 |
MA0040.1 | 0.579034 |
MA0041.1 | 0.134241 |
MA0042.1 | 0.264815 |
MA0043.1 | 0.703596 |
MA0046.1 | 0.24494 |
MA0048.1 | 0.152472 |
MA0050.1 | 0.0259441 |
MA0051.1 | 0.0572096 |
MA0052.1 | 0.202085 |
MA0055.1 | 0.398929 |
MA0056.1 | 0 |
MA0057.1 | 0.570587 |
MA0058.1 | 0.0568651 |
MA0059.1 | 0.151766 |
MA0060.1 | 1.42636 |
MA0061.1 | 0.0300898 |
MA0063.1 | 0 |
MA0066.1 | 0.213568 |
MA0067.1 | 0.49981 |
MA0068.1 | 0.322801 |
MA0069.1 | 0.242306 |
MA0070.1 | 0.234718 |
MA0071.1 | 0.174636 |
MA0072.1 | 0.231695 |
MA0073.1 | 2.11352 |
MA0074.1 | 2.23582 |
MA0076.1 | 0.0138475 |
MA0077.1 | 1.20132 |
MA0078.1 | 1.09854 |
MA0081.1 | 0.151958 |
MA0083.1 | 0.715135 |
MA0084.1 | 0.664025 |
MA0087.1 | 0.230056 |
MA0088.1 | 0.148712 |
MA0089.1 | 0 |
MA0090.1 | 0.0160524 |
MA0091.1 | 0.534615 |
MA0092.1 | 0.441881 |
MA0093.1 | 0.00542575 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.849289 |
MA0101.1 | 0.0312519 |
MA0103.1 | 0.751317 |
MA0105.1 | 0.472232 |
MA0106.1 | 0.547964 |
MA0107.1 | 0.0392752 |
MA0108.2 | 0.45517 |
MA0109.1 | 0 |
MA0111.1 | 0.209449 |
MA0113.1 | 0.0808928 |
MA0114.1 | 0.932237 |
MA0115.1 | 0.436009 |
MA0116.1 | 1.28368 |
MA0117.1 | 0.27892 |
MA0119.1 | 0.0482372 |
MA0122.1 | 0.806534 |
MA0124.1 | 0.402329 |
MA0125.1 | 0.8938 |
MA0130.1 | 0 |
MA0131.1 | 0.10574 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.27375 |
MA0136.1 | 0.220509 |
MA0139.1 | 4.74703 |
MA0140.1 | 0.389168 |
MA0141.1 | 0.149727 |
MA0142.1 | 0.133251 |
MA0143.1 | 0.27686 |
MA0144.1 | 0.0751841 |
MA0145.1 | 0.79868 |
MA0146.1 | 0.289936 |
MA0147.1 | 0.012723 |
MA0148.1 | 0.0348816 |
MA0149.1 | 0.0422402 |
MA0062.2 | 0.122451 |
MA0035.2 | 0.387901 |
MA0039.2 | 3.32036 |
MA0138.2 | 0.0978028 |
MA0002.2 | 0.0875896 |
MA0137.2 | 0.402158 |
MA0104.2 | 0.00442204 |
MA0047.2 | 0.244302 |
MA0112.2 | 1.99723 |
MA0065.2 | 0.667807 |
MA0150.1 | 0.0704527 |
MA0151.1 | 0 |
MA0152.1 | 0.401045 |
MA0153.1 | 0.323801 |
MA0154.1 | 1.62697 |
MA0155.1 | 0.810786 |
MA0156.1 | 0.110132 |
MA0157.1 | 0.119034 |
MA0158.1 | 0 |
MA0159.1 | 0.751731 |
MA0160.1 | 0.152819 |
MA0161.1 | 0 |
MA0162.1 | 0.210045 |
MA0163.1 | 1.71766 |
MA0164.1 | 0.0861719 |
MA0080.2 | 0.0301046 |
MA0018.2 | 0.550787 |
MA0099.2 | 0.178704 |
MA0079.2 | 3.98856 |
MA0102.2 | 0.697711 |
MA0258.1 | 0.56487 |
MA0259.1 | 0.220187 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
CTCF#10664 | 17 | 1.78675212435834 | 0.00900219480913783 | 0.0341300404280519 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data