Coexpression cluster:C367: Difference between revisions
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{{Coexpression_clusters | {{Coexpression_clusters|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0521599633818348,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.11851967913857,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0405993330353711,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0334876163089719,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0406607636248659,0,0,0,0,0,0,0,0,0,0,0,1.08611067218035,0,0,0,0,0,0,0,0,0.026108810802436,0,0,0,0,0,0,0,0,0,0,0.0458045054759181,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.016760402053431,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0802005422252233,0,0,0,0,0,0,0,0,0|full_id=C367_papillotubular_Macrophage_clear_pharyngeal_Renal_endometrial_tubular|gostat_on_coexpression_clusters=GO:0030574!collagen catabolic process!3.49113901529097e-05!4316;5653$GO:0044256!protein digestion!3.49113901529097e-05!4316;5653$GO:0044254!multicellular organismal protein catabolic process!3.49113901529097e-05!4316;5653$GO:0044266!multicellular organismal macromolecule catabolic process!3.49113901529097e-05!4316;5653$GO:0044259!multicellular organismal macromolecule metabolic process!3.49113901529097e-05!4316;5653$GO:0044268!multicellular organismal protein metabolic process!3.49113901529097e-05!4316;5653$GO:0044243!multicellular organismal catabolic process!3.49113901529097e-05!4316;5653$GO:0032963!collagen metabolic process!3.49113901529097e-05!4316;5653$GO:0044236!multicellular organismal metabolic process!3.738365344664e-05!4316;5653$GO:0007586!digestion!0.000592102168167378!4316;5653$GO:0004235!matrilysin activity!0.00137011228498335!4316$GO:0016316!phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity!0.00251176160996224!8821$GO:0004293!tissue kallikrein activity!0.00579560515052357!5653$GO:0030163!protein catabolic process!0.00592419392120253!4316;5653$GO:0007130!synaptonemal complex assembly!0.00602716320831794!10734$GO:0007129!synapsis!0.00659191867090141!10734$GO:0043285!biopolymer catabolic process!0.00790864191242954!4316;5653$GO:0042577!lipid phosphatase activity!0.0100426108972329!8821$GO:0000795!synaptonemal complex!0.0103064350029073!10734$GO:0042982!amyloid precursor protein metabolic process!0.0105438101975185!5653$GO:0042246!tissue regeneration!0.0111317409286778!5653$GO:0009057!macromolecule catabolic process!0.0111317409286778!4316;5653$GO:0050435!beta-amyloid metabolic process!0.0111317409286778!5653$GO:0031099!regeneration!0.0112949442082651!5653$GO:0042552!myelination!0.015656790337173!5653$GO:0004175!endopeptidase activity!0.0159698035176525!4316;5653$GO:0000794!condensed nuclear chromosome!0.0165549481747521!10734$GO:0007272!ensheathment of neurons!0.0165549481747521!5653$GO:0008366!axon 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Latest revision as of 11:21, 17 September 2013
Full id: C367_papillotubular_Macrophage_clear_pharyngeal_Renal_endometrial_tubular
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0030574 | collagen catabolic process | 3.49113901529097e-05 |
GO:0044256 | protein digestion | 3.49113901529097e-05 |
GO:0044254 | multicellular organismal protein catabolic process | 3.49113901529097e-05 |
GO:0044266 | multicellular organismal macromolecule catabolic process | 3.49113901529097e-05 |
GO:0044259 | multicellular organismal macromolecule metabolic process | 3.49113901529097e-05 |
GO:0044268 | multicellular organismal protein metabolic process | 3.49113901529097e-05 |
GO:0044243 | multicellular organismal catabolic process | 3.49113901529097e-05 |
GO:0032963 | collagen metabolic process | 3.49113901529097e-05 |
GO:0044236 | multicellular organismal metabolic process | 3.738365344664e-05 |
GO:0007586 | digestion | 0.000592102168167378 |
GO:0004235 | matrilysin activity | 0.00137011228498335 |
GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity | 0.00251176160996224 |
GO:0004293 | tissue kallikrein activity | 0.00579560515052357 |
GO:0030163 | protein catabolic process | 0.00592419392120253 |
GO:0007130 | synaptonemal complex assembly | 0.00602716320831794 |
GO:0007129 | synapsis | 0.00659191867090141 |
GO:0043285 | biopolymer catabolic process | 0.00790864191242954 |
GO:0042577 | lipid phosphatase activity | 0.0100426108972329 |
GO:0000795 | synaptonemal complex | 0.0103064350029073 |
GO:0042982 | amyloid precursor protein metabolic process | 0.0105438101975185 |
GO:0042246 | tissue regeneration | 0.0111317409286778 |
GO:0009057 | macromolecule catabolic process | 0.0111317409286778 |
GO:0050435 | beta-amyloid metabolic process | 0.0111317409286778 |
GO:0031099 | regeneration | 0.0112949442082651 |
GO:0042552 | myelination | 0.015656790337173 |
GO:0004175 | endopeptidase activity | 0.0159698035176525 |
GO:0000794 | condensed nuclear chromosome | 0.0165549481747521 |
GO:0007272 | ensheathment of neurons | 0.0165549481747521 |
GO:0008366 | axon ensheathment | 0.0165549481747521 |
GO:0007127 | meiosis I | 0.0165549481747521 |
GO:0048589 | developmental growth | 0.0179596740625052 |
GO:0001508 | regulation of action potential | 0.0183529399737562 |
GO:0009056 | catabolic process | 0.0183529399737562 |
GO:0016540 | protein autoprocessing | 0.0203500138822008 |
GO:0016787 | hydrolase activity | 0.0207309052081313 |
GO:0000793 | condensed chromosome | 0.0217205866203829 |
GO:0004437 | inositol or phosphatidylinositol phosphatase activity | 0.0231604999529081 |
GO:0007059 | chromosome segregation | 0.0233402148347696 |
GO:0008233 | peptidase activity | 0.0246856409289252 |
GO:0044454 | nuclear chromosome part | 0.0246856409289252 |
GO:0051327 | M phase of meiotic cell cycle | 0.0246856409289252 |
GO:0007126 | meiosis | 0.0246856409289252 |
GO:0051321 | meiotic cell cycle | 0.0248082502336922 |
GO:0006508 | proteolysis | 0.0248798947491532 |
GO:0042445 | hormone metabolic process | 0.0293596090777808 |
GO:0016485 | protein processing | 0.0316086834367993 |
GO:0000228 | nuclear chromosome | 0.0316086834367993 |
GO:0042060 | wound healing | 0.0408964047267248 |
GO:0045595 | regulation of cell differentiation | 0.0440120927780186 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
bladder cell | 2.30e-21 | 1 |
lower urinary tract cell | 2.30e-21 | 1 |
epithelial cell of gall bladder | 3.70e-11 | 2 |
epithelial cell | 2.35e-07 | 253 |
Ontology term | p-value | n |
---|---|---|
hepatopancreatic ampulla | 1.53e-21 | 1 |
extrahepatic bile duct | 1.53e-21 | 1 |
common bile duct | 1.53e-21 | 1 |
duodenal papilla | 1.53e-21 | 1 |
urinary bladder urothelium | 2.30e-21 | 1 |
wall of urinary bladder | 2.30e-21 | 1 |
mucosa of urinary bladder | 2.30e-21 | 1 |
mammalian vulva | 5.16e-21 | 1 |
external female genitalia | 5.16e-21 | 1 |
biliary system | 1.24e-20 | 9 |
biliary tree | 1.24e-20 | 9 |
biliary bud | 1.24e-20 | 9 |
bile duct | 1.90e-14 | 6 |
digestive system duct | 1.90e-14 | 6 |
urinary bladder | 2.23e-11 | 2 |
lower urinary tract | 2.23e-11 | 2 |
endoderm-derived structure | 1.47e-09 | 160 |
endoderm | 1.47e-09 | 160 |
presumptive endoderm | 1.47e-09 | 160 |
endo-epithelium | 1.16e-08 | 82 |
digestive system | 2.47e-08 | 145 |
digestive tract | 2.47e-08 | 145 |
primitive gut | 2.47e-08 | 145 |
duodenum | 4.52e-08 | 2 |
gallbladder | 7.26e-08 | 3 |
gall bladder primordium | 7.26e-08 | 3 |
epithelium of foregut-midgut junction | 7.66e-08 | 25 |
anatomical boundary | 7.66e-08 | 25 |
hepatobiliary system | 7.66e-08 | 25 |
foregut-midgut junction | 7.66e-08 | 25 |
septum transversum | 7.66e-08 | 25 |
Ontology term | p-value | n |
---|---|---|
carcinoma | 9.81e-15 | 106 |
squamous cell carcinoma | 2.67e-13 | 14 |
tubular adenocarcinoma | 1.82e-11 | 2 |
cell type cancer | 8.27e-11 | 143 |
disease of anatomical entity | 1.65e-08 | 39 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.0907022 |
MA0004.1 | 0.0961566 |
MA0006.1 | 0.0332857 |
MA0007.1 | 0.293913 |
MA0009.1 | 1.07184 |
MA0014.1 | 0.0731518 |
MA0017.1 | 0.173605 |
MA0019.1 | 0.533378 |
MA0024.1 | 0.332558 |
MA0025.1 | 0.531977 |
MA0027.1 | 1.95983 |
MA0028.1 | 0.0380705 |
MA0029.1 | 0.347825 |
MA0030.1 | 0.898657 |
MA0031.1 | 0.288912 |
MA0038.1 | 0.15256 |
MA0040.1 | 0.352485 |
MA0041.1 | 0.105506 |
MA0042.1 | 0.300789 |
MA0043.1 | 0.417784 |
MA0046.1 | 0.408463 |
MA0048.1 | 0.0261535 |
MA0050.1 | 0.0900741 |
MA0051.1 | 0.150026 |
MA0052.1 | 0.936014 |
MA0055.1 | 0.790605 |
MA0056.1 | 0 |
MA0057.1 | 0.227938 |
MA0058.1 | 0.0546193 |
MA0059.1 | 0.0541371 |
MA0060.1 | 0.705082 |
MA0061.1 | 0.205567 |
MA0063.1 | 0 |
MA0066.1 | 2.79646 |
MA0067.1 | 0.697961 |
MA0068.1 | 1.86673 |
MA0069.1 | 0.405267 |
MA0070.1 | 0.396023 |
MA0071.1 | 0.12997 |
MA0072.1 | 0.392323 |
MA0073.1 | 0.000699327 |
MA0074.1 | 0.89351 |
MA0076.1 | 0.060743 |
MA0077.1 | 0.386 |
MA0078.1 | 2.54007 |
MA0081.1 | 0.441387 |
MA0083.1 | 0.423797 |
MA0084.1 | 0.873335 |
MA0087.1 | 0.390315 |
MA0088.1 | 0.384887 |
MA0089.1 | 0 |
MA0090.1 | 0.508642 |
MA0091.1 | 0.0974512 |
MA0092.1 | 0.272882 |
MA0093.1 | 0.0341631 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.161006 |
MA0101.1 | 0.327739 |
MA0103.1 | 1.69832 |
MA0105.1 | 0.103391 |
MA0106.1 | 0.178189 |
MA0107.1 | 0.387848 |
MA0108.2 | 0.781414 |
MA0109.1 | 0 |
MA0111.1 | 0.252572 |
MA0113.1 | 1.05411 |
MA0114.1 | 0.0161389 |
MA0115.1 | 0.62811 |
MA0116.1 | 0.0805087 |
MA0117.1 | 0.449155 |
MA0119.1 | 1.10716 |
MA0122.1 | 0.471243 |
MA0124.1 | 0.590699 |
MA0125.1 | 0.516292 |
MA0130.1 | 0 |
MA0131.1 | 0.226279 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.443024 |
MA0136.1 | 0.156833 |
MA0139.1 | 1.05851 |
MA0140.1 | 0.403323 |
MA0141.1 | 0.197657 |
MA0142.1 | 0.265252 |
MA0143.1 | 0.553308 |
MA0144.1 | 0.338277 |
MA0145.1 | 0.833844 |
MA0146.1 | 0.0820453 |
MA0147.1 | 0.0184972 |
MA0148.1 | 0.1088 |
MA0149.1 | 0.123091 |
MA0062.2 | 0.00542453 |
MA0035.2 | 0.402308 |
MA0039.2 | 0.379307 |
MA0138.2 | 0.214585 |
MA0002.2 | 1.26293 |
MA0137.2 | 0.156367 |
MA0104.2 | 0.00891586 |
MA0047.2 | 0.508505 |
MA0112.2 | 1.52564 |
MA0065.2 | 0.00887985 |
MA0150.1 | 0.229194 |
MA0151.1 | 0 |
MA0152.1 | 0.412817 |
MA0153.1 | 0.501603 |
MA0154.1 | 1.10983 |
MA0155.1 | 0.253174 |
MA0156.1 | 0.15867 |
MA0157.1 | 0.686763 |
MA0158.1 | 0 |
MA0159.1 | 0.991097 |
MA0160.1 | 0.116872 |
MA0161.1 | 0 |
MA0162.1 | 2.4905e-05 |
MA0163.1 | 0.00234709 |
MA0164.1 | 0.572716 |
MA0080.2 | 0.321686 |
MA0018.2 | 0.179075 |
MA0099.2 | 0.413335 |
MA0079.2 | 0.000269655 |
MA0102.2 | 0.908736 |
MA0258.1 | 0.0584056 |
MA0259.1 | 0.0202561 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
ESR1#2099 | 6 | 6.1537206592309 | 0.00035632148641039 | 0.00356591220000141 |
NR3C1#2908 | 6 | 2.99460466623461 | 0.0130939800352426 | 0.0464480056008663 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.