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{{CL
{{CL
|id=CL:0000825
|alt_id=
|name=pro-NK cell
|namespace=cell;;efo
|def="A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674]
|xref=
|is_a=CL:0000838
|synonym="natural killer cell progenitor" EXACT [];;"NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674];;"null cell" RELATED [PMID:11532393];;"preNK cell" RELATED [PMID:11532393];;"pro-natural killer cell" EXACT []
|comment=Most markers only described for human pro NK cells.
|comment=Most markers only described for human pro NK cells.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674]
|subset=
|derives_from=
|derives_from=
|develops_from=CL:0000051
|develops_from=CL:0000051
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000825
|is_a=CL:0000838
|is_obsolete=
|located_in=
|located_in=
|name=pro-NK cell
|namespace=FANTOM
|obo_creation_date=
|part_of=
|part_of=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="natural killer cell progenitor" EXACT [];;"NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674];;"null cell" RELATED [PMID:11532393];;"preNK cell" RELATED [PMID:11532393];;"pro-natural killer cell" EXACT []
|union_of=
|xref=
}}
}}

Latest revision as of 16:37, 12 September 2014

Name:pro-NK cell
Namespace:FANTOM
Definition:"A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674]
Synonyms: "natural killer cell progenitor" EXACT []
"NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674]
"null cell" RELATED [PMID:11532393]
"preNK cell" RELATED [PMID:11532393]
"pro-natural killer cell" EXACT []
Comments:Most markers only described for human pro NK cells.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000838(lymphoid lineage restricted progenitor cell)
develops_from:CL:0000051(common lymphoid progenitor)



Children


develops from:CL:0000623 (natural killer cell)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.



Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000825 (pro-NK cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
2.79e-195FFCP PHASE1:Hg19::chr11:115085875..115085888,+#_f651adbf48390d1d48047a470d20b153p@chr11:115085875..115085888, +
2.79e-195FFCP PHASE1:Hg19::chr3:4892090..4892095,-#_f651adbf48390d1d48047a470d20b153p@chr3:4892090..4892095, -
2.79e-195FFCP PHASE1:Hg19::chr8:103110281..103110286,+#_f651adbf48390d1d48047a470d20b153p@chr8:103110281..103110286, +
2.79e-195FFCP PHASE2:Hg19::chr11:115085875..115085888,+#_f651adbf48390d1d48047a470d20b153p@chr11:115085875..115085888, +
2.79e-195FFCP PHASE2:Hg19::chr3:4892090..4892095,-#_f651adbf48390d1d48047a470d20b153p@chr3:4892090..4892095, -
2.79e-195FFCP PHASE2:Hg19::chr8:103110281..103110286,+#_f651adbf48390d1d48047a470d20b153p@chr8:103110281..103110286, +
3.27e-147FFCP PHASE1:Hg19::chr2:145267967..145267972,-#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr2:145267967..145267972, -
3.27e-147FFCP PHASE2:Hg19::chr8:103126233..103126242,-#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr8:103126233..103126242, -
3.27e-147FFCP PHASE1:Hg19::chr18:46360601..46360610,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr18:46360601..46360610, +
3.27e-147FFCP PHASE1:Hg19::chr2:240467130..240467134,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr2:240467130..240467134, +
3.27e-147FFCP PHASE1:Hg19::chr7:38357449..38357458,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr7:38357449..38357458, +
3.27e-147FFCP PHASE2:Hg19::chr8:103120766..103120771,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr8:103120766..103120771, +
3.27e-147FFCP PHASE2:Hg19::chr22:38597578..38597586,-#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr22:38597578..38597586, -
3.27e-147FFCP PHASE2:Hg19::chr7:38357449..38357458,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr7:38357449..38357458, +
3.27e-147FFCP PHASE2:Hg19::chr11:65401401..65401406,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr11:65401401..65401406, +
3.27e-147FFCP PHASE1:Hg19::chr8:103126233..103126242,-#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr8:103126233..103126242, -
3.27e-147FFCP PHASE2:Hg19::chr19:45953439..45953444,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr19:45953439..45953444, +
3.27e-147FFCP PHASE2:Hg19::chr8:66750085..66750091,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr8:66750085..66750091, +
3.27e-147FFCP PHASE1:Hg19::chr19:45953439..45953444,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr19:45953439..45953444, +
3.27e-147FFCP PHASE1:Hg19::chr8:103120766..103120771,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr8:103120766..103120771, +
3.27e-147FFCP PHASE2:Hg19::chr2:145267967..145267972,-#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr2:145267967..145267972, -
3.27e-147FFCP PHASE2:Hg19::chr9:136007795..136007801,-#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr9:136007795..136007801, -
3.27e-147FFCP PHASE1:Hg19::chr8:66750085..66750091,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr8:66750085..66750091, +
3.27e-147FFCP PHASE2:Hg19::chr18:46360601..46360610,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr18:46360601..46360610, +
3.27e-147FFCP PHASE1:Hg19::chr22:38597578..38597586,-#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr22:38597578..38597586, -
3.27e-147FFCP PHASE2:Hg19::chr2:240467130..240467134,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr2:240467130..240467134, +
3.27e-147FFCP PHASE1:Hg19::chr9:136007795..136007801,-#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr9:136007795..136007801, -
3.27e-147FFCP PHASE1:Hg19::chr11:65401401..65401406,+#_ed1ac21c0c49ef361fe05e6b6c93ec84p@chr11:65401401..65401406, +
8.93e-147FFCP PHASE2:Hg19::chr7:38320712..38320736,+#_e4fc741df057be2a4090c4c5abcdd5acp@chr7:38320712..38320736, +
8.93e-147FFCP PHASE1:Hg19::chr1:167420291..167420294,+#_e4fc741df057be2a4090c4c5abcdd5acp@chr1:167420291..167420294, +
8.93e-147FFCP PHASE2:Hg19::chr1:167400749..167400756,-#_e4fc741df057be2a4090c4c5abcdd5acp2@EF079882
8.93e-147FFCP PHASE2:Hg19::chr1:167420291..167420294,+#_e4fc741df057be2a4090c4c5abcdd5acp@chr1:167420291..167420294, +
8.93e-147FFCP PHASE1:Hg19::chr1:167400749..167400756,-#_e4fc741df057be2a4090c4c5abcdd5acp2@EF079882
8.93e-147FFCP PHASE1:Hg19::chr7:38320712..38320736,+#_e4fc741df057be2a4090c4c5abcdd5acp@chr7:38320712..38320736, +
8.98e-131FFCP PHASE2:Hg19::chr6:37019056..37019063,-#_989001e06e2baed88673381090b18fe4p@chr6:37019056..37019063, -
8.98e-131FFCP PHASE1:Hg19::chr12:9994967..9994968,+#_989001e06e2baed88673381090b18fe4p@chr12:9994967..9994968, +
8.98e-131FFCP PHASE1:Hg19::chr6:2940707..2940710,+#_989001e06e2baed88673381090b18fe4p@chr6:2940707..2940710, +
8.98e-131FFCP PHASE2:Hg19::chr5:172281403..172281405,-#_989001e06e2baed88673381090b18fe4p@chr5:172281403..172281405, -
8.98e-131FFCP PHASE2:Hg19::chr12:9994967..9994968,+#_989001e06e2baed88673381090b18fe4p@chr12:9994967..9994968, +
8.98e-131FFCP PHASE1:Hg19::chr18:74804978..74804993,+#_989001e06e2baed88673381090b18fe4p@chr18:74804978..74804993, +
8.98e-131FFCP PHASE1:Hg19::chr6:37019056..37019063,-#_989001e06e2baed88673381090b18fe4p@chr6:37019056..37019063, -
8.98e-131FFCP PHASE2:Hg19::chr18:74804978..74804993,+#_989001e06e2baed88673381090b18fe4p@chr18:74804978..74804993, +
8.98e-131FFCP PHASE2:Hg19::chr22:38597593..38597598,-#_989001e06e2baed88673381090b18fe4p@chr22:38597593..38597598, -
8.98e-131FFCP PHASE1:Hg19::chr22:38597593..38597598,-#_989001e06e2baed88673381090b18fe4p@chr22:38597593..38597598, -
8.98e-131FFCP PHASE2:Hg19::chr6:2940707..2940710,+#_989001e06e2baed88673381090b18fe4p@chr6:2940707..2940710, +
8.98e-131FFCP PHASE1:Hg19::chr5:172281403..172281405,-#_989001e06e2baed88673381090b18fe4p@chr5:172281403..172281405, -
2.33e-118FFCP PHASE1:Hg19::chr22:39474405..39474438,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr22:39474405..39474438, -
2.33e-118FFCP PHASE1:Hg19::chr5:169705868..169705875,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr5:169705868..169705875, -
2.33e-118FFCP PHASE1:Hg19::chr2:111610415..111610439,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr2:111610415..111610439, +
2.33e-118FFCP PHASE2:Hg19::chr17:33776655..33776667,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr17:33776655..33776667, -
2.33e-118FFCP PHASE1:Hg19::chr11:121353266..121353274,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr11:121353266..121353274, -
2.33e-118FFCP PHASE1:Hg19::chr17:33776655..33776667,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr17:33776655..33776667, -
2.33e-118FFCP PHASE1:Hg19::chr1:167458837..167458845,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr1:167458837..167458845, -
2.33e-118FFCP PHASE2:Hg19::chr11:67037100..67037109,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr11:67037100..67037109, +
2.33e-118FFCP PHASE2:Hg19::chr7:38320586..38320596,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr7:38320586..38320596, +
2.33e-118FFCP PHASE2:Hg19::chr1:167458837..167458845,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr1:167458837..167458845, -
2.33e-118FFCP PHASE1:Hg19::chr11:67037100..67037109,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr11:67037100..67037109, +
2.33e-118FFCP PHASE1:Hg19::chr4:48116513..48116522,-#_9aca30c791b6724d6efb2aa03bb8d65ap9@TXK
2.33e-118FFCP PHASE2:Hg19::chr19:41804394..41804429,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr19:41804394..41804429, +
2.33e-118FFCP PHASE2:Hg19::chr12:129281246..129281271,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr12:129281246..129281271, +
2.33e-118FFCP PHASE2:Hg19::chr11:121353266..121353274,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr11:121353266..121353274, -
2.33e-118FFCP PHASE1:Hg19::chr2:145263300..145263311,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr2:145263300..145263311, -
2.33e-118FFCP PHASE2:Hg19::chr2:145263300..145263311,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr2:145263300..145263311, -
2.33e-118FFCP PHASE1:Hg19::chr7:38320586..38320596,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr7:38320586..38320596, +
2.33e-118FFCP PHASE1:Hg19::chr1:19275176..19275185,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr1:19275176..19275185, +
2.33e-118FFCP PHASE2:Hg19::chr10:98431336..98431339,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr10:98431336..98431339, -
2.33e-118FFCP PHASE1:Hg19::chr18:46341777..46341782,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr18:46341777..46341782, +
2.33e-118FFCP PHASE2:Hg19::chr5:169705868..169705875,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr5:169705868..169705875, -
2.33e-118FFCP PHASE1:Hg19::chr1:162518235..162518252,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr1:162518235..162518252, +
2.33e-118FFCP PHASE1:Hg19::chr10:98431336..98431339,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr10:98431336..98431339, -
2.33e-118FFCP PHASE2:Hg19::chr17:34401981..34401994,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr17:34401981..34401994, +
2.33e-118FFCP PHASE1:Hg19::chr19:41804394..41804429,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr19:41804394..41804429, +
2.33e-118FFCP PHASE2:Hg19::chr18:46341777..46341782,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr18:46341777..46341782, +
2.33e-118FFCP PHASE1:Hg19::chr22:23480066..23480080,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr22:23480066..23480080, -
2.33e-118FFCP PHASE1:Hg19::chr17:34401981..34401994,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr17:34401981..34401994, +
2.33e-118FFCP PHASE2:Hg19::chr2:111610415..111610439,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr2:111610415..111610439, +
2.33e-118FFCP PHASE1:Hg19::chr12:129281246..129281271,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr12:129281246..129281271, +
2.33e-118FFCP PHASE2:Hg19::chr1:19275176..19275185,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr1:19275176..19275185, +
2.33e-118FFCP PHASE2:Hg19::chr1:162518235..162518252,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr1:162518235..162518252, +
2.33e-118FFCP PHASE1:Hg19::chr7:50428238..50428247,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr7:50428238..50428247, +
2.33e-118FFCP PHASE2:Hg19::chr4:48116513..48116522,-#_9aca30c791b6724d6efb2aa03bb8d65ap9@TXK
2.33e-118FFCP PHASE2:Hg19::chr22:39474405..39474438,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr22:39474405..39474438, -
2.33e-118FFCP PHASE2:Hg19::chr22:23480066..23480080,-#_9aca30c791b6724d6efb2aa03bb8d65ap@chr22:23480066..23480080, -
2.33e-118FFCP PHASE2:Hg19::chr7:50428238..50428247,+#_9aca30c791b6724d6efb2aa03bb8d65ap@chr7:50428238..50428247, +
3.48e-118FFCP PHASE1:Hg19::chr19:10213257..10213267,+#_43614a91b20cf383585c3e44b6206d4dp@chr19:10213257..10213267, +
3.48e-118FFCP PHASE1:Hg19::chr1:172502793..172502831,-#_43614a91b20cf383585c3e44b6206d4dp3@BC034700
3.48e-118FFCP PHASE2:Hg19::chr19:10213257..10213267,+#_43614a91b20cf383585c3e44b6206d4dp@chr19:10213257..10213267, +
3.48e-118FFCP PHASE1:Hg19::chr18:74804800..74804840,-#_43614a91b20cf383585c3e44b6206d4dp@chr18:74804800..74804840, -
3.48e-118FFCP PHASE2:Hg19::chr1:172502793..172502831,-#_43614a91b20cf383585c3e44b6206d4dp3@BC034700
3.48e-118FFCP PHASE2:Hg19::chr18:74804800..74804840,-#_43614a91b20cf383585c3e44b6206d4dp@chr18:74804800..74804840, -
3.48e-118FFCP PHASE1:Hg19::chr1:100494394..100494399,-#_43614a91b20cf383585c3e44b6206d4dp@chr1:100494394..100494399, -
3.48e-118FFCP PHASE2:Hg19::chr1:100494394..100494399,-#_43614a91b20cf383585c3e44b6206d4dp@chr1:100494394..100494399, -
5.2e-118FFCP PHASE2:Hg19::chr4:103421745..103421751,+#_1947c1f5821c17efb2b6f6430e2dc66bp@chr4:103421745..103421751, +
5.2e-118FFCP PHASE1:Hg19::chr4:103421745..103421751,+#_1947c1f5821c17efb2b6f6430e2dc66bp@chr4:103421745..103421751, +
7.78e-118FFCP PHASE1:Hg19::chr14:64108359..64108365,-#_2135eed309ef45e6e03c75869a4defbcp9@WDR89
7.78e-118FFCP PHASE1:Hg19::chr18:43268301..43268305,-#_2135eed309ef45e6e03c75869a4defbcp@chr18:43268301..43268305, -
7.78e-118FFCP PHASE2:Hg19::chr14:64108359..64108365,-#_2135eed309ef45e6e03c75869a4defbcp9@WDR89
7.78e-118FFCP PHASE2:Hg19::chr18:43268301..43268305,-#_2135eed309ef45e6e03c75869a4defbcp@chr18:43268301..43268305, -
4.06e-99FFCP PHASE1:Hg19::chr7:38320426..38320429,-#_203afa25eb01db5a5276ae95cb610bd4p@chr7:38320426..38320429, -
4.06e-99FFCP PHASE1:Hg19::chr9:116281787..116281792,-#_203afa25eb01db5a5276ae95cb610bd4p@chr9:116281787..116281792, -

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