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|def="An anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]. a microscopic structure in the kidney, which regulates the function of each nephron. The juxtaglomerular apparatus is named for its proximity to the glomerulus: it is found between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. The three cellular components of the apparatus are the macula densa, extraglomerular mesangial cells, and juxtaglomerular cells (also known as granular cells)[WP]." [GO:0072206, Wikipedia:Juxtaglomerular_apparatus]
|def="An anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]. a microscopic structure in the kidney, which regulates the function of each nephron. The juxtaglomerular apparatus is named for its proximity to the glomerulus: it is found between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. The three cellular components of the apparatus are the macula densa, extraglomerular mesangial cells, and juxtaglomerular cells (also known as granular cells)[WP]." [GO:0072206, Wikipedia:Juxtaglomerular_apparatus]
|xref=EMAPA:30449;;FMA:83599;;GAID:432;;MA:0002546;;MESH:A.05.810.453.736.520.520;;ncithesaurus:Juxtaglomerular_Apparatus;;SCTID:362219002
|xref=EMAPA:30449;;FMA:83599;;GAID:432;;MA:0002546;;MESH:A.05.810.453.736.520.520;;ncithesaurus:Juxtaglomerular_Apparatus;;SCTID:362219002
|is_a=UBERON:0000477;;UBERON:0004120
|is_a=UBERON:0000477;;UBERON:0006554
|synonym="juxtaglomerular complex" EXACT []
|synonym="juxtaglomerular complex" EXACT []
|comment=
|comment=
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|obo_creation_date=
|obo_creation_date=
|subset=uberon_slim
|subset=uberon_slim
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
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|located_in=
|located_in=
|part_of=UBERON:0001225
|part_of=UBERON:0001225
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.obo.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|is_obsolete=
|preceded_by=
}}
}}

Latest revision as of 13:31, 27 June 2012

Name:juxtaglomerular apparatus
Definition:"An anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate[GO]. a microscopic structure in the kidney, which regulates the function of each nephron. The juxtaglomerular apparatus is named for its proximity to the glomerulus: it is found between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. The three cellular components of the apparatus are the macula densa, extraglomerular mesangial cells, and juxtaglomerular cells (also known as granular cells)[WP]." [GO:0072206, Wikipedia:Juxtaglomerular_apparatus]
Xrefs:
links:

EMAPA:30449
FMA:83599
GAID:432
MA:0002546
MESH:A.05.810.453.736.520.520
ncithesaurus:Juxtaglomerular_Apparatus

SCTID:362219002
Synonyms: "juxtaglomerular complex" EXACT []
Alt_id: UBERON:FMA_83599-MA_0002546
Subset: uberon_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000477(anatomical cluster),UBERON:0006554(urinary system structure)
part_of:UBERON:0001225(cortex of kidney)



Children

part of:UBERON:0002321 (extraglomerular mesangium),CL:1000618 (juxtaglomerular complex cell)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002303 (juxtaglomerular apparatus), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
2.34e-79FFCP PHASE1:Hg19::chr2:133426030..133426041,-#_dcbda99bebc66206d6ce6bef07b59d2ep@chr2:133426030..133426041, -
2.34e-79FFCP PHASE2:Hg19::chr2:133426030..133426041,-#_dcbda99bebc66206d6ce6bef07b59d2ep@chr2:133426030..133426041, -
3.49e-79FFCP PHASE2:Hg19::chr1:51791596..51791607,-#_592857946cdb2026e8c371ae350f7fb5p23@TTC39A
3.49e-79FFCP PHASE1:Hg19::chr1:51791596..51791607,-#_592857946cdb2026e8c371ae350f7fb5p23@TTC39A
2.03e-66FFCP PHASE2:Hg19::chr2:133426106..133426117,-#_aed7f16c48d50e77fadd3cf2b99272fdp@chr2:133426106..133426117, -
2.03e-66FFCP PHASE1:Hg19::chr2:133426106..133426117,-#_aed7f16c48d50e77fadd3cf2b99272fdp@chr2:133426106..133426117, -
1.46e-50FFCP PHASE1:Hg19::chr10:134535354..134535366,-#_63f4d6c5597dea3779358f72a403160bp@chr10:134535354..134535366, -
1.46e-50FFCP PHASE1:Hg19::chr10:102495136..102495146,+#_63f4d6c5597dea3779358f72a403160bp8@PAX2
1.46e-50FFCP PHASE2:Hg19::chr10:134535354..134535366,-#_63f4d6c5597dea3779358f72a403160bp@chr10:134535354..134535366, -
1.46e-50FFCP PHASE2:Hg19::chr10:102495136..102495146,+#_63f4d6c5597dea3779358f72a403160bp8@PAX2
3.11e-50FFCP PHASE2:Hg19::chr17:17480803..17480814,-#_bdf7aff4d559ec3b983b96249c02d6c5p19@PEMT
3.11e-50FFCP PHASE1:Hg19::chr17:17480803..17480814,-#_bdf7aff4d559ec3b983b96249c02d6c5p19@PEMT
4.52e-50FFCP PHASE1:Hg19::chr10:102505655..102505689,+#_c195db9aaefab477c1ebb6184bc3f09ep10@PAX2
4.52e-50FFCP PHASE1:Hg19::chr9:81641483..81641491,-#_c195db9aaefab477c1ebb6184bc3f09ep@chr9:81641483..81641491, -
4.52e-50FFCP PHASE2:Hg19::chr10:102505655..102505689,+#_c195db9aaefab477c1ebb6184bc3f09ep10@PAX2
4.52e-50FFCP PHASE2:Hg19::chr9:81641483..81641491,-#_c195db9aaefab477c1ebb6184bc3f09ep@chr9:81641483..81641491, -
8.98e-41FFCP PHASE1:Hg19::chr17:171082..171101,+#_3da6e1735aff62cd330456d0dbbf3141p@chr17:171082..171101, +
8.98e-41FFCP PHASE2:Hg19::chr17:171082..171101,+#_3da6e1735aff62cd330456d0dbbf3141p@chr17:171082..171101, +
1.1e-40FFCP PHASE1:Hg19::chr3:172384246..172384250,+#_314df96c7ca898e294c045524fa90e7cp@chr3:172384246..172384250, +
1.1e-40FFCP PHASE2:Hg19::chr3:172384246..172384250,+#_314df96c7ca898e294c045524fa90e7cp@chr3:172384246..172384250, +
1.64e-40FFCP PHASE1:Hg19::chr1:45087902..45087912,+#_dbb14b674816f6fd1c8d1c4848847a6ep@chr1:45087902..45087912, +
1.64e-40FFCP PHASE2:Hg19::chr1:45087902..45087912,+#_dbb14b674816f6fd1c8d1c4848847a6ep@chr1:45087902..45087912, +
3.68e-40FFCP PHASE1:Hg19::chr10:102505552..102505563,+#_4813e042b9e11fe773988ed91e77c0a9p5@PAX2
3.68e-40FFCP PHASE2:Hg19::chr10:102505552..102505563,+#_4813e042b9e11fe773988ed91e77c0a9p5@PAX2
8.2e-37FFCP PHASE1:Hg19::chr10:102505312..102505320,+#_8751b21fa63c0c0ef3b562ca89090b60p6@PAX2
8.2e-37FFCP PHASE2:Hg19::chr10:102505312..102505320,+#_8751b21fa63c0c0ef3b562ca89090b60p6@PAX2
9.84e-37FFCP PHASE1:Hg19::chr9:126131131..126131159,+#_dd87a773d2cac3e879ca38ae25c20a61p3@CRB2
9.84e-37FFCP PHASE2:Hg19::chr9:126131131..126131159,+#_dd87a773d2cac3e879ca38ae25c20a61p3@CRB2
6.0e-34FFCP PHASE2:Hg19::chr2:113984760..113984792,+#_89389f6a33a931850ffea315292e2098p@chr2:113984760..113984792, +
6.0e-34FFCP PHASE1:Hg19::chr2:113984760..113984792,+#_89389f6a33a931850ffea315292e2098p@chr2:113984760..113984792, +
7.05e-34FFCP PHASE1:Hg19::chr11:555661..555679,+#_95788940942799a20fdc43c3dce0932bp@chr11:555661..555679, +
7.05e-34FFCP PHASE1:Hg19::chr1:858638..858648,+#_95788940942799a20fdc43c3dce0932bp@chr1:858638..858648, +
7.05e-34FFCP PHASE1:Hg19::chr7:27164585..27164612,-#_95788940942799a20fdc43c3dce0932bp@chr7:27164585..27164612, -
7.05e-34FFCP PHASE2:Hg19::chr11:555661..555679,+#_95788940942799a20fdc43c3dce0932bp@chr11:555661..555679, +
7.05e-34FFCP PHASE2:Hg19::chr1:858638..858648,+#_95788940942799a20fdc43c3dce0932bp@chr1:858638..858648, +
7.05e-34FFCP PHASE2:Hg19::chr7:27164585..27164612,-#_95788940942799a20fdc43c3dce0932bp@chr7:27164585..27164612, -
8.39e-34FFCP PHASE2:Hg19::chr10:73848549..73848564,-#_4ae1e0d766cd940576e6bac067ada613p13@SPOCK2
8.39e-34FFCP PHASE1:Hg19::chr10:73848549..73848564,-#_4ae1e0d766cd940576e6bac067ada613p13@SPOCK2
1.17e-33FFCP PHASE1:Hg19::chr11:118477144..118477156,+#_78f145044ee25735cf8b7c9d391d185ap25@PHLDB1
1.17e-33FFCP PHASE2:Hg19::chr11:118477144..118477156,+#_78f145044ee25735cf8b7c9d391d185ap25@PHLDB1
3.35e-32FFCP PHASE2:Hg19::chr2:693362..693373,+#_8e66c8b5855db7d1bbf581d695413d2ap@chr2:693362..693373, +
3.35e-32FFCP PHASE1:Hg19::chr2:693362..693373,+#_8e66c8b5855db7d1bbf581d695413d2ap@chr2:693362..693373, +
2.54e-31FFCP PHASE1:Hg19::chrX:106146562..106146577,-#_4ca2126aba23e0e8c89e556e2831ee7dp1@RIPPLY1
2.54e-31FFCP PHASE2:Hg19::chrX:106146562..106146577,-#_4ca2126aba23e0e8c89e556e2831ee7dp1@RIPPLY1
8.05e-30FFCP PHASE2:Hg19::chr17:171147..171161,+#_f6dab331726d6e23a7368735fb29924bp@chr17:171147..171161, +
8.05e-30FFCP PHASE1:Hg19::chr17:171147..171161,+#_f6dab331726d6e23a7368735fb29924bp@chr17:171147..171161, +
2.96e-29FFCP PHASE2:Hg19::chr2:165477405..165477418,-#_3b18f523e760e777c7540865e9a20071p@chr2:165477405..165477418, -
2.96e-29FFCP PHASE1:Hg19::chr2:165477405..165477418,-#_3b18f523e760e777c7540865e9a20071p@chr2:165477405..165477418, -
4.55e-29FFCP PHASE1:Hg19::chr1:874109..874143,+#_9676b015c49cf446beb00b54fa3b7de2p@chr1:874109..874143, +
4.55e-29FFCP PHASE2:Hg19::chr1:874109..874143,+#_9676b015c49cf446beb00b54fa3b7de2p@chr1:874109..874143, +
1.43e-28FFCP PHASE1:Hg19::chr2:113999199..113999214,+#_0383a530910c5794abae63b757c70ce2p@chr2:113999199..113999214, +
1.43e-28FFCP PHASE2:Hg19::chr2:113999199..113999214,+#_0383a530910c5794abae63b757c70ce2p@chr2:113999199..113999214, +
1.83e-27FFCP PHASE1:Hg19::chr20:6034598..6034603,-#_49dcb18d7cff528c9b1d85eeddeda35ap7@LRRN4
1.83e-27FFCP PHASE1:Hg19::chr16:86604624..86604648,+#_49dcb18d7cff528c9b1d85eeddeda35ap@chr16:86604624..86604648, +
1.83e-27FFCP PHASE2:Hg19::chr20:6034598..6034603,-#_49dcb18d7cff528c9b1d85eeddeda35ap7@LRRN4
1.83e-27FFCP PHASE2:Hg19::chr16:86604624..86604648,+#_49dcb18d7cff528c9b1d85eeddeda35ap@chr16:86604624..86604648, +
2.74e-27FFCP PHASE1:Hg19::chr19:56091499..56091517,-#_fd3ed4ddcfd6a4f24892294a1260e95bp@chr19:56091499..56091517, -
2.74e-27FFCP PHASE2:Hg19::chr19:56091499..56091517,-#_fd3ed4ddcfd6a4f24892294a1260e95bp@chr19:56091499..56091517, -
2.78e-26FFCP PHASE1:Hg19::chr9:112260040..112260045,+#_ee3cd0787f5a9c9fefa53afba5e0e235p@chr9:112260040..112260045, +
2.78e-26FFCP PHASE2:Hg19::chr9:112260040..112260045,+#_ee3cd0787f5a9c9fefa53afba5e0e235p@chr9:112260040..112260045, +
4.63e-26FFCP PHASE1:Hg19::chr22:30645170..30645182,-#_efebf90341ea2a3bf28b38df54ae58b5p@chr22:30645170..30645182, -
4.63e-26FFCP PHASE2:Hg19::chr22:30645170..30645182,-#_efebf90341ea2a3bf28b38df54ae58b5p@chr22:30645170..30645182, -
7.14e-26FFCP PHASE1:Hg19::chr8:22419319..22419327,+#_92a1ffa85605d59efcea50f310780391p@chr8:22419319..22419327, +
7.14e-26FFCP PHASE2:Hg19::chr8:22419319..22419327,+#_92a1ffa85605d59efcea50f310780391p@chr8:22419319..22419327, +
9.18e-26FFCP PHASE1:Hg19::chr6:31833005..31833017,-#_1f8ea54c22760bc7cadced968ceda6b9p@chr6:31833005..31833017, -
9.18e-26FFCP PHASE2:Hg19::chr11:32457397..32457404,-#_1f8ea54c22760bc7cadced968ceda6b9p15@WT1
9.18e-26FFCP PHASE2:Hg19::chr17:15555143..15555150,-#_1f8ea54c22760bc7cadced968ceda6b9p12@TRIM16
9.18e-26FFCP PHASE1:Hg19::chr8:28196820..28196830,+#_1f8ea54c22760bc7cadced968ceda6b9p@chr8:28196820..28196830, +
9.18e-26FFCP PHASE1:Hg19::chr2:176973165..176973169,-#_1f8ea54c22760bc7cadced968ceda6b9p@chr2:176973165..176973169, -
9.18e-26FFCP PHASE1:Hg19::chr20:6031540..6031548,-#_1f8ea54c22760bc7cadced968ceda6b9p@chr20:6031540..6031548, -
9.18e-26FFCP PHASE1:Hg19::chr10:102505946..102505949,+#_1f8ea54c22760bc7cadced968ceda6b9p14@PAX2
9.18e-26FFCP PHASE2:Hg19::chr6:31833005..31833017,-#_1f8ea54c22760bc7cadced968ceda6b9p@chr6:31833005..31833017, -
9.18e-26FFCP PHASE1:Hg19::chr11:32457397..32457404,-#_1f8ea54c22760bc7cadced968ceda6b9p15@WT1
9.18e-26FFCP PHASE2:Hg19::chr8:28196820..28196830,+#_1f8ea54c22760bc7cadced968ceda6b9p@chr8:28196820..28196830, +
9.18e-26FFCP PHASE2:Hg19::chr2:176973165..176973169,-#_1f8ea54c22760bc7cadced968ceda6b9p@chr2:176973165..176973169, -
9.18e-26FFCP PHASE1:Hg19::chr17:15555143..15555150,-#_1f8ea54c22760bc7cadced968ceda6b9p12@TRIM16
9.18e-26FFCP PHASE2:Hg19::chr20:6031540..6031548,-#_1f8ea54c22760bc7cadced968ceda6b9p@chr20:6031540..6031548, -
9.18e-26FFCP PHASE2:Hg19::chr10:102505946..102505949,+#_1f8ea54c22760bc7cadced968ceda6b9p14@PAX2
2.37e-25FFCP PHASE2:Hg19::chr7:27160553..27160560,+#_b552d88ff11ea0dbd194cfc73970714bp1@ENST00000523364, p1@uc010kux.1
2.37e-25FFCP PHASE1:Hg19::chr7:27160553..27160560,+#_b552d88ff11ea0dbd194cfc73970714bp1@ENST00000523364, p1@uc010kux.1
4.38e-25FFCP PHASE2:Hg19::chr7:27219754..27219759,-#_d3043d4d253b6eb896735c921442fa64p16@HOXA10
4.38e-25FFCP PHASE1:Hg19::chr7:27219754..27219759,-#_d3043d4d253b6eb896735c921442fa64p16@HOXA10
4.43e-25FFCP PHASE2:Hg19::chr1:149908263..149908281,-#_96371ef65c1838106f727bed245bfd0ap6@MTMR11
4.43e-25FFCP PHASE1:Hg19::chr1:149908263..149908281,-#_96371ef65c1838106f727bed245bfd0ap6@MTMR11
7.09e-25FFCP PHASE2:Hg19::chr10:102495147..102495159,+#_53872b6be914681a15e6d53b5dd5cd24p4@PAX2
7.09e-25FFCP PHASE1:Hg19::chr10:102495147..102495159,+#_53872b6be914681a15e6d53b5dd5cd24p4@PAX2
3.76e-24FFCP PHASE2:Hg19::chr1:46797583..46797614,-#_8d62271982664afee71b33b9889835e9p@chr1:46797583..46797614, -
3.76e-24FFCP PHASE1:Hg19::chr1:46797583..46797614,-#_8d62271982664afee71b33b9889835e9p@chr1:46797583..46797614, -
7.62e-24FFCP PHASE2:Hg19::chr6:94129519..94129544,+#_159975c4012aa573ef7adf273fe2592dp@chr6:94129519..94129544, +
7.62e-24FFCP PHASE1:Hg19::chr6:94129519..94129544,+#_159975c4012aa573ef7adf273fe2592dp@chr6:94129519..94129544, +
8.02e-24FFCP PHASE2:Hg19::chr2:693380..693398,+#_24ffabb38cf5d188d2484737bbec1d75p@chr2:693380..693398, +
8.02e-24FFCP PHASE1:Hg19::chr2:693380..693398,+#_24ffabb38cf5d188d2484737bbec1d75p@chr2:693380..693398, +
8.98e-24FFCP PHASE1:Hg19::chr2:133426077..133426103,-#_a865618d97ec06958853157194dfe2cap@chr2:133426077..133426103, -
8.98e-24FFCP PHASE2:Hg19::chr2:133426077..133426103,-#_a865618d97ec06958853157194dfe2cap@chr2:133426077..133426103, -
1.99e-23FFCP PHASE1:Hg19::chr11:32457350..32457361,+#_840bd6886d51d720cad08d0445a87cb9p5@WT1-AS
1.99e-23FFCP PHASE2:Hg19::chr11:32457350..32457361,+#_840bd6886d51d720cad08d0445a87cb9p5@WT1-AS
4.37e-23FFCP PHASE1:Hg19::chr2:176968471..176968476,-#_42126684df4c32190250d543a34e91a6p@chr2:176968471..176968476, -
4.37e-23FFCP PHASE2:Hg19::chr2:176968471..176968476,-#_42126684df4c32190250d543a34e91a6p@chr2:176968471..176968476, -
4.89e-23FFCP PHASE1:Hg19::chr12:15592437..15592438,+#_1b02a885eba09eb88d88fa7e475d92f9p1@ENST00000469884
4.89e-23FFCP PHASE2:Hg19::chr12:15592437..15592438,+#_1b02a885eba09eb88d88fa7e475d92f9p1@ENST00000469884

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