T-cell differentiation: Difference between revisions
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|series=IN_VITRO DIFFERENTIATION SERIES | |series=IN_VITRO DIFFERENTIATION SERIES | ||
|species=Mouse (Mus musculus) | |species=Mouse (Mus musculus) | ||
|tet_config=http://fantom.gsc.riken.jp/5/tet/search/?filename=mm9.cage_peak_phase1and2combined_tpm_ann_decoded.osc.txt.gz&file=1&c=1&c=33&c=34&c=35&c=36&c=37&c=38&c=39&c=40&c=42&c=41&c=44&c=45&c=46&c=47&c=48&c=49&c=50&c=51&c=52&c=53&c=54&c=55&c=56&c=57&c=58&c=59&c=60&c=61&c=63&c=64&c=65&c=66&c=67&c=68&c=69&c=70&c=71&c=72&c=73&c=74&c=75&c=76 | |tet_config=http://fantom.gsc.riken.jp/5/suppl/tet/T_cell.tsv.gz | ||
|tet_file=http://fantom.gsc.riken.jp/5/tet#!/search/?filename=mm9.cage_peak_phase1and2combined_tpm_ann_decoded.osc.txt.gz&file=1&c=1&c=33&c=34&c=35&c=36&c=37&c=38&c=39&c=40&c=42&c=41&c=44&c=45&c=46&c=47&c=48&c=49&c=50&c=51&c=52&c=53&c=54&c=55&c=56&c=57&c=58&c=59&c=60&c=61&c=63&c=64&c=65&c=66&c=67&c=68&c=69&c=70&c=71&c=72&c=73&c=74&c=75&c=76 | |||
|time_points= | |time_points= | ||
|time_span=6 days | |time_span=6 days |
Revision as of 15:28, 12 February 2015
Series: | IN_VITRO DIFFERENTIATION SERIES |
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Species: | Mouse (Mus musculus) |
Genomic View: | Zenbu |
Expression table: | FILE |
Link to TET: | TET |
Sample providers : | Hiroshi Kawamoto |
Germ layer: | mesoderm |
Primary cells or cell line: | primary cells |
Time span: | 6 days |
Number of time points: | 15 |
CollapseOverview |
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T cells are produced in the thymus. The earliest T cell progenitors in the thymus are not fully committed to the T cell lineage but retain potentials to give rise to other lineage cells, myeloid cells, dendritic cells and natural killer cells. The T cell progenitors gradually lose their potential and commit to the T cell lineage through interacting with thymic epithelial cells. However, the exact mechanisms are still poorly understood. Especially, the transcriptional networks controlling the T cell fate determination remain elusive because of the lack of suitable experimental systems. Here, we have established a coculture system using EBF1KO hematopoietic progenitor cells (HPCs) with the TSt-4/Delta-like (DLL) 1 stromal cells that support the T cell differentiation[1,2]. By applying this time course samples to CAGE analysis, we examined the gene regulatory networks underlying the T cell lineage commitment from multipotent hematopoietic progenitors. |
ExpandSample description |
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ExpandQuality control |
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Profiled time course samples
Only samples that passed quality controls (Arner et al. 2015) are shown here. The entire set of samples are downloadable from FANTOM5 human / mouse samples