Coexpression cluster:C3183

Full id: C3183_Osteoblast_breast_Mesenchymal_Melanocyte_Fibroblast_left_Adipocyte

Phase1 CAGE Peaks

Hg19::chr11:64003292..64003325,+	p@chr11:64003292..64003325 +
Hg19::chr11:64004888..64004909,+	p3@VEGFB
Hg19::chr17:7154873..7154884,-	p6@CTDNEP1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0005172	vascular endothelial growth factor receptor binding	0.00388555280819498
GO:0008201	heparin binding	0.0222339966246713
GO:0005539	glycosaminoglycan binding	0.0222339966246713
GO:0030247	polysaccharide binding	0.0222339966246713
GO:0001871	pattern binding	0.0222339966246713
GO:0001558	regulation of cell growth	0.0222339966246713
GO:0016049	cell growth	0.0222339966246713
GO:0040008	regulation of growth	0.0222339966246713
GO:0008361	regulation of cell size	0.0222339966246713
GO:0008284	positive regulation of cell proliferation	0.0223419286471212
GO:0008083	growth factor activity	0.0223419286471212
GO:0005125	cytokine activity	0.0250941952195926
GO:0042127	regulation of cell proliferation	0.0290202225362063
GO:0030246	carbohydrate binding	0.0290202225362063
GO:0032989	cellular structure morphogenesis	0.0290202225362063
GO:0000902	cell morphogenesis	0.0290202225362063
GO:0008283	cell proliferation	0.0425696594427245
GO:0065008	regulation of biological quality	0.046891557753444
GO:0048522	positive regulation of cellular process	0.046891557753444
GO:0005102	receptor binding	0.046891557753444
GO:0009653	anatomical structure morphogenesis	0.046891557753444
GO:0048518	positive regulation of biological process	0.046891557753444

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.