MCL coexpression mm9:2579

Phase1 CAGE Peaks

	Short description
Mm9::chr10:75322959..75322966,-	p2@Mif
Mm9::chr11:29447871..29447878,-	p7@Gm8430 p7@Rps27a
Mm9::chr3:91828403..91828446,+	p1@ENSMUST00000118636

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0050178	phenylpyruvate tautomerase activity	0.00142442338245768
GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	0.00462937599298745
GO:0007569	cell aging	0.00462937599298745
GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.00462937599298745
GO:0007568	aging	0.007976770941763
GO:0042770	DNA damage response, signal transduction	0.00830913639766979
GO:0016860	intramolecular oxidoreductase activity	0.00875002934938288
GO:0016853	isomerase activity	0.0270640442666959
GO:0006954	inflammatory response	0.029675487134535
GO:0005125	cytokine activity	0.029675487134535
GO:0006974	response to DNA damage stimulus	0.029675487134535
GO:0009719	response to endogenous stimulus	0.029675487134535
GO:0009611	response to wounding	0.0315564564729086
GO:0042127	regulation of cell proliferation	0.0322530151599346
GO:0009605	response to external stimulus	0.0411302251684655
GO:0008283	cell proliferation	0.0411302251684655
GO:0005102	receptor binding	0.0494358703323547

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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