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{{CL
{{CL
|id=CL:0000092
|alt_id=
|name=osteoclast
|namespace=cell;;efo
|def="A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
|xref=BTO:0000968;;FMA:66781
|is_a=CL:0000766;;CL:0002320
|synonym="chondroclast" RELATED []
|comment=Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
|comment=Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
|subset=
|derives_from=
|derives_from=
|develops_from=CL:0000576
|develops_from=CL:0000576
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000092
|is_a=CL:0000766 ;;CL:0001035
|is_obsolete=
|located_in=
|located_in=
|name=osteoclast
|namespace=cell;;efo
|obo_creation_date=
|part_of=UBERON:0001474
|part_of=UBERON:0001474
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="chondroclast" RELATED []
|union_of=
|xref=BTO:0000968;;FMA:66781
}}
}}

Revision as of 10:13, 12 September 2014

Name:osteoclast
Namespace:cell;;efo
Definition:"A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
Xrefs:
links:

BTO:0000968

FMA:66781
Synonyms: "chondroclast" RELATED []
Comments:Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000766(myeloid leukocyte),CL:0001035(bone cell)
develops_from:CL:0000576(monocyte)
part_of:UBERON:0001474(bone element)



Children


derives from:FF:0100969 (osteoclastoma cell sample),FF:0200020 (osteoclast, bone marrow-derived sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000092 (osteoclast), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.55e-98FFCP PHASE1:Hg19::chr16:77317713..77317723,+#_b903eca76d53485a4f1d302a80ba1931p1@CU687665
1.55e-98FFCP PHASE2:Hg19::chr16:77317713..77317723,+#_b903eca76d53485a4f1d302a80ba1931p1@CU687665
1.55e-98FFCP PHASE2:Hg19::chr11:101742272..101742276,-#_b903eca76d53485a4f1d302a80ba1931p@chr11:101742272..101742276, -
1.55e-98FFCP PHASE1:Hg19::chr11:101742272..101742276,-#_b903eca76d53485a4f1d302a80ba1931p@chr11:101742272..101742276, -
2.74e-50FFCP PHASE2:Hg19::chr16:51670868..51670880,-#_33220fce424e59c6ca585a69a9fb1376p@chr16:51670868..51670880, -
2.74e-50FFCP PHASE2:Hg19::chr11:81551043..81551054,-#_33220fce424e59c6ca585a69a9fb1376p@chr11:81551043..81551054, -
2.74e-50FFCP PHASE1:Hg19::chr16:51670868..51670880,-#_33220fce424e59c6ca585a69a9fb1376p@chr16:51670868..51670880, -
2.74e-50FFCP PHASE1:Hg19::chr11:81551043..81551054,-#_33220fce424e59c6ca585a69a9fb1376p@chr11:81551043..81551054, -
2.74e-50FFCP PHASE2:Hg19::chr5:14034644..14034647,-#_33220fce424e59c6ca585a69a9fb1376p@chr5:14034644..14034647, -
2.74e-50FFCP PHASE1:Hg19::chr18:71197490..71197495,-#_33220fce424e59c6ca585a69a9fb1376p@chr18:71197490..71197495, -
2.74e-50FFCP PHASE1:Hg19::chr5:14034644..14034647,-#_33220fce424e59c6ca585a69a9fb1376p@chr5:14034644..14034647, -
2.74e-50FFCP PHASE2:Hg19::chr18:71197490..71197495,-#_33220fce424e59c6ca585a69a9fb1376p@chr18:71197490..71197495, -
4.52e-50FFCP PHASE2:Hg19::chr3:106393655..106393659,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr3:106393655..106393659, +
4.52e-50FFCP PHASE1:Hg19::chr3:106393655..106393659,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr3:106393655..106393659, +
4.52e-50FFCP PHASE2:Hg19::chr3:45174403..45174415,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr3:45174403..45174415, +
4.52e-50FFCP PHASE1:Hg19::chr3:45174403..45174415,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr3:45174403..45174415, +
4.52e-50FFCP PHASE2:Hg19::chr5:23952305..23952310,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr5:23952305..23952310, +
4.52e-50FFCP PHASE1:Hg19::chr5:23952305..23952310,+#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr5:23952305..23952310, +
4.52e-50FFCP PHASE2:Hg19::chr4:34480309..34480321,-#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr4:34480309..34480321, -
4.52e-50FFCP PHASE1:Hg19::chr4:34480309..34480321,-#_bcc611bb0a9d91b1d95cfe9aa14af906p@chr4:34480309..34480321, -
3.61e-34FFCP PHASE2:Hg19::chr4:177796841..177796851,+#_c06849cd5e3fae14cd7426a8305dd2a6p1@ENST00000508790
3.61e-34FFCP PHASE1:Hg19::chr4:177796841..177796851,+#_c06849cd5e3fae14cd7426a8305dd2a6p1@ENST00000508790
3.61e-34FFCP PHASE1:Hg19::chr7:119353807..119353812,-#_c06849cd5e3fae14cd7426a8305dd2a6p@chr7:119353807..119353812, -
3.61e-34FFCP PHASE2:Hg19::chr7:119353807..119353812,-#_c06849cd5e3fae14cd7426a8305dd2a6p@chr7:119353807..119353812, -
5.04e-34FFCP PHASE2:Hg19::chr10:37004821..37004852,-#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr10:37004821..37004852, -
5.04e-34FFCP PHASE1:Hg19::chr10:37004821..37004852,-#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr10:37004821..37004852, -
5.04e-34FFCP PHASE1:Hg19::chr8:15939682..15939688,+#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr8:15939682..15939688, +
5.04e-34FFCP PHASE2:Hg19::chr8:15939682..15939688,+#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr8:15939682..15939688, +
5.04e-34FFCP PHASE2:Hg19::chrX:132231123..132231140,-#_d8e3c1647d49dfbb2f4c17d1404d654fp1@USP26
5.04e-34FFCP PHASE1:Hg19::chrX:132231123..132231140,-#_d8e3c1647d49dfbb2f4c17d1404d654fp1@USP26
5.04e-34FFCP PHASE2:Hg19::chr4:46093758..46093781,-#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr4:46093758..46093781, -
5.04e-34FFCP PHASE1:Hg19::chr4:46093758..46093781,-#_d8e3c1647d49dfbb2f4c17d1404d654fp@chr4:46093758..46093781, -
7.05e-34FFCP PHASE2:Hg19::chrX:89462083..89462089,+#_85c553399eb943d9f9d14fe1e1033c67p@chrX:89462083..89462089, +
7.05e-34FFCP PHASE1:Hg19::chrX:89462083..89462089,+#_85c553399eb943d9f9d14fe1e1033c67p@chrX:89462083..89462089, +
7.05e-34FFCP PHASE2:Hg19::chr11:84019133..84019135,-#_85c553399eb943d9f9d14fe1e1033c67p@chr11:84019133..84019135, -
7.05e-34FFCP PHASE1:Hg19::chr11:84019133..84019135,-#_85c553399eb943d9f9d14fe1e1033c67p@chr11:84019133..84019135, -
7.05e-34FFCP PHASE2:Hg19::chr6:155427848..155427862,+#_85c553399eb943d9f9d14fe1e1033c67p@chr6:155427848..155427862, +
7.05e-34FFCP PHASE1:Hg19::chr6:155427848..155427862,+#_85c553399eb943d9f9d14fe1e1033c67p@chr6:155427848..155427862, +
5.5e-31FFCP PHASE2:Hg19::chr3:106556598..106556609,-#_f68521af51a91f3238c0e54fb137aa1ep@chr3:106556598..106556609, -
5.5e-31FFCP PHASE1:Hg19::chr3:106556598..106556609,-#_f68521af51a91f3238c0e54fb137aa1ep@chr3:106556598..106556609, -
7.1e-28FFCP PHASE1:Hg19::chr6:68597008..68597030,-#_7e3f148977a24c49a4c7e2fb478f64d6p@chr6:68597008..68597030, -
7.1e-28FFCP PHASE2:Hg19::chr6:68597008..68597030,-#_7e3f148977a24c49a4c7e2fb478f64d6p@chr6:68597008..68597030, -
4.32e-26FFCP PHASE2:Hg19::chr5:27723923..27723927,-#_3d436b61f22464e3293afc5cb9600f13p@chr5:27723923..27723927, -
4.32e-26FFCP PHASE1:Hg19::chr5:27723923..27723927,-#_3d436b61f22464e3293afc5cb9600f13p@chr5:27723923..27723927, -
4.32e-26FFCP PHASE2:Hg19::chr11:81549961..81549965,-#_3d436b61f22464e3293afc5cb9600f13p@chr11:81549961..81549965, -
4.32e-26FFCP PHASE1:Hg19::chr11:81549961..81549965,-#_3d436b61f22464e3293afc5cb9600f13p@chr11:81549961..81549965, -
5.56e-26FFCP PHASE2:Hg19::chr5:167315847..167315852,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr5:167315847..167315852, +
5.56e-26FFCP PHASE1:Hg19::chr5:167315847..167315852,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr5:167315847..167315852, +
5.56e-26FFCP PHASE2:Hg19::chrX:89176902..89176913,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp1@TGIF2LX
5.56e-26FFCP PHASE1:Hg19::chrX:89176902..89176913,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp1@TGIF2LX
5.56e-26FFCP PHASE2:Hg19::chrX:124347061..124347063,-#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chrX:124347061..124347063, -
5.56e-26FFCP PHASE1:Hg19::chrX:124347061..124347063,-#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chrX:124347061..124347063, -
5.56e-26FFCP PHASE2:Hg19::chrX:132352373..132352384,-#_fcf427a9031ef6a1f81ae8af91e0d2fdp1@TFDP3
5.56e-26FFCP PHASE1:Hg19::chrX:132352373..132352384,-#_fcf427a9031ef6a1f81ae8af91e0d2fdp1@TFDP3
5.56e-26FFCP PHASE2:Hg19::chr5:153673183..153673186,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr5:153673183..153673186, +
5.56e-26FFCP PHASE1:Hg19::chr5:153673183..153673186,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr5:153673183..153673186, +
5.56e-26FFCP PHASE2:Hg19::chr4:189864018..189864037,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr4:189864018..189864037, +
5.56e-26FFCP PHASE1:Hg19::chr4:189864018..189864037,+#_fcf427a9031ef6a1f81ae8af91e0d2fdp@chr4:189864018..189864037, +
9.18e-26FFCP PHASE1:Hg19::chr7:12997533..12997536,+#_49480e96743bab033845ce4266ec09a5p@chr7:12997533..12997536, +
9.18e-26FFCP PHASE2:Hg19::chr7:12997533..12997536,+#_49480e96743bab033845ce4266ec09a5p@chr7:12997533..12997536, +
9.18e-26FFCP PHASE1:Hg19::chr18:14946224..14946236,+#_49480e96743bab033845ce4266ec09a5p1@FLJ44255
9.18e-26FFCP PHASE2:Hg19::chr18:14946224..14946236,+#_49480e96743bab033845ce4266ec09a5p1@FLJ44255
1.12e-25FFCP PHASE2:Hg19::chrX:55246809..55246816,+#_254b010d2b257690dc483a55542712c5p3@PAGE5
1.12e-25FFCP PHASE1:Hg19::chrX:55246809..55246816,+#_254b010d2b257690dc483a55542712c5p3@PAGE5
4.89e-23FFCP PHASE2:Hg19::chrX:55246818..55246829,+#_02f5a7edccb66aacd08df30b8950b7b4p2@PAGE5
4.89e-23FFCP PHASE1:Hg19::chrX:55246818..55246829,+#_02f5a7edccb66aacd08df30b8950b7b4p2@PAGE5
3.11e-21FFCP PHASE2:Hg19::chr5:27742047..27742052,-#_23a75e50def3185ec34c6e75eda71a15p@chr5:27742047..27742052, -
3.11e-21FFCP PHASE1:Hg19::chr5:27742047..27742052,-#_23a75e50def3185ec34c6e75eda71a15p@chr5:27742047..27742052, -
3.11e-21FFCP PHASE2:Hg19::chr12:127737083..127737103,-#_23a75e50def3185ec34c6e75eda71a15p@chr12:127737083..127737103, -
3.11e-21FFCP PHASE1:Hg19::chr12:127737083..127737103,-#_23a75e50def3185ec34c6e75eda71a15p@chr12:127737083..127737103, -
3.11e-21FFCP PHASE1:Hg19::chr8:119905427..119905438,-#_23a75e50def3185ec34c6e75eda71a15p@chr8:119905427..119905438, -
3.11e-21FFCP PHASE2:Hg19::chr8:119905427..119905438,-#_23a75e50def3185ec34c6e75eda71a15p@chr8:119905427..119905438, -
3.81e-21FFCP PHASE2:Hg19::chr9:118595109..118595124,+#_71c506c94b939e7505d1010920c0a5cbp@chr9:118595109..118595124, +
3.81e-21FFCP PHASE1:Hg19::chr9:118595109..118595124,+#_71c506c94b939e7505d1010920c0a5cbp@chr9:118595109..118595124, +
3.81e-21FFCP PHASE2:Hg19::chr5:135378750..135378757,+#_71c506c94b939e7505d1010920c0a5cbp@chr5:135378750..135378757, +
3.81e-21FFCP PHASE1:Hg19::chr5:135378750..135378757,+#_71c506c94b939e7505d1010920c0a5cbp@chr5:135378750..135378757, +
3.81e-21FFCP PHASE2:Hg19::chr2:145815206..145815208,+#_71c506c94b939e7505d1010920c0a5cbp@chr2:145815206..145815208, +
3.81e-21FFCP PHASE1:Hg19::chr2:145815206..145815208,+#_71c506c94b939e7505d1010920c0a5cbp@chr2:145815206..145815208, +
3.81e-21FFCP PHASE2:Hg19::chr13:87732242..87732246,-#_71c506c94b939e7505d1010920c0a5cbp@chr13:87732242..87732246, -
3.81e-21FFCP PHASE1:Hg19::chr13:87732242..87732246,-#_71c506c94b939e7505d1010920c0a5cbp@chr13:87732242..87732246, -
3.81e-21FFCP PHASE1:Hg19::chr19:9811101..9811112,-#_71c506c94b939e7505d1010920c0a5cbp3@ZNF812
3.81e-21FFCP PHASE2:Hg19::chr19:9811101..9811112,-#_71c506c94b939e7505d1010920c0a5cbp3@ZNF812
4.66e-21FFCP PHASE2:Hg19::chrX:140336680..140336697,-#_9c0b0d452b1dad3af03606a959be177fp2@SPANXC
4.66e-21FFCP PHASE1:Hg19::chrX:140336680..140336697,-#_9c0b0d452b1dad3af03606a959be177fp2@SPANXC
5.7e-21FFCP PHASE2:Hg19::chr5:142000787..142000807,-#_8540f02e5c5ad9ca3af574841967f8a4p@chr5:142000787..142000807, -
5.7e-21FFCP PHASE1:Hg19::chr5:142000787..142000807,-#_8540f02e5c5ad9ca3af574841967f8a4p@chr5:142000787..142000807, -
5.7e-21FFCP PHASE2:Hg19::chr2:33171944..33171945,+#_8540f02e5c5ad9ca3af574841967f8a4p15@LTBP1
5.7e-21FFCP PHASE1:Hg19::chr2:33171944..33171945,+#_8540f02e5c5ad9ca3af574841967f8a4p15@LTBP1
6.96e-21FFCP PHASE2:Hg19::chr3:60761167..60761179,+#_9878b9d457bc8a70757269c025f120b6p@chr3:60761167..60761179, +
6.96e-21FFCP PHASE1:Hg19::chr3:60761167..60761179,+#_9878b9d457bc8a70757269c025f120b6p@chr3:60761167..60761179, +
6.96e-21FFCP PHASE1:Hg19::chr8:76774227..76774234,+#_9878b9d457bc8a70757269c025f120b6p@chr8:76774227..76774234, +
6.96e-21FFCP PHASE2:Hg19::chr8:76774227..76774234,+#_9878b9d457bc8a70757269c025f120b6p@chr8:76774227..76774234, +
6.96e-21FFCP PHASE1:Hg19::chr18:63273310..63273317,+#_9878b9d457bc8a70757269c025f120b6p@chr18:63273310..63273317, +
6.96e-21FFCP PHASE2:Hg19::chr11:12061317..12061323,-#_9878b9d457bc8a70757269c025f120b6p@chr11:12061317..12061323, -
6.96e-21FFCP PHASE2:Hg19::chr18:63273310..63273317,+#_9878b9d457bc8a70757269c025f120b6p@chr18:63273310..63273317, +
6.96e-21FFCP PHASE1:Hg19::chr11:12061317..12061323,-#_9878b9d457bc8a70757269c025f120b6p@chr11:12061317..12061323, -
6.96e-21FFCP PHASE2:Hg19::chr5:81611412..81611423,+#_9878b9d457bc8a70757269c025f120b6p@chr5:81611412..81611423, +
6.96e-21FFCP PHASE1:Hg19::chr5:81611412..81611423,+#_9878b9d457bc8a70757269c025f120b6p@chr5:81611412..81611423, +
6.96e-21FFCP PHASE2:Hg19::chr11:28792916..28792929,+#_9878b9d457bc8a70757269c025f120b6p@chr11:28792916..28792929, +
6.96e-21FFCP PHASE1:Hg19::chr11:28792916..28792929,+#_9878b9d457bc8a70757269c025f120b6p@chr11:28792916..28792929, +

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