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|located_in=
|name=naive thymus-derived CD4-positive, alpha-beta T cell
|name=naive thymus-derived CD4-positive, alpha-beta T cell
|namespace=cell;;efo
|namespace=FANTOM
|obo_creation_date=
|obo_creation_date=
|part_of=
|part_of=

Latest revision as of 16:38, 12 September 2014

Name:naive thymus-derived CD4-positive, alpha-beta T cell
Namespace:FANTOM
Definition:"An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19100699]
Synonyms: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT []
"naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT []
"naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT []
"T.4Nve.Sp" EXACT []
"Th0" EXACT [GOC:tfm]
Comments:These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:CL:0000624(CD4-positive, alpha-beta T cell),CL:0000898(naive T cell)
develops_from:CL:0002436(mature CD4 single-positive thymocyte)



Children


is a:FF:0011121 (CD4-positiveCD25-CD45RA- naive conventional T cells expanded)
derives from:FF:0011122 (human CD4-positiveCD25-CD45RA- naive conventional T cells sample),FF:0011446 (CD4-positiveCD25-CD44- naive conventional T cells stimulated with alphaCD3_CD28 - 06hr- (C57BL_6J) sample),FF:0011447 (CD4-positiveCD25-CD44- naive conventional T cells stimulated with alphaCD3_CD28- 06hr- (Balb_cAJcl) sample),FF:0011448 (CD4-positiveCD25-CD44- naive conventional T cells stimulated with PMA an ionomycin- 02hr- (C57BL_6J) sample),FF:0011449 (CD4-positiveCD25-CD44- naive conventional T cells stimulated with PMA an ionomycin- 02hr- (Balb_cAJcl) sample),FF:0011450 (CD4-positiveCD25-CD44- naive conventional T cells- (C57BL_6J) sample),FF:0011451 (CD4-positiveCD25-CD44- naive conventional T cells- (Balb_cAJcl) sample)
develops from:CL:0000896 (activated CD4-positive, alpha-beta T cell)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

  • 11786-124B4 (CD4+CD25-CD45RA- memory conventional T cells, donor1)
  • 11813-124E4 (CD4+CD25-CD44- naive conventional T cells, pool1 (C57BL_6J))
  • 11815-124E6 (CD4+CD25-CD44- naive conventional T cells, antiCD3_CD28 stimulation, 06hr, pool1 (C57BL_6J))
  • 11816-124E7 (CD4+CD25-CD44- naive conventional T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL_6J))
  • 11817-124E8 (CD4+CD25-CD44- naive conventional T cells, pool2 (Balb_cAJcl))
  • 11819-124F1 (CD4+CD25-CD44- naive conventional T cells, antiCD3_CD28 stimulation, 06hr, pool2 (Balb_cAJcl))
  • 11820-124F2 (CD4+CD25-CD44- naive conventional T cells, PMA and ionomycin stimulation, 02hr, pool2 (Balb_cAJcl))

Mouse (Mus musculus)

  • 11786-124B4 (CD4+CD25-CD45RA- memory conventional T cells, donor1)
  • 11813-124E4 (CD4+CD25-CD44- naive conventional T cells, pool1 (C57BL_6J))
  • 11815-124E6 (CD4+CD25-CD44- naive conventional T cells, antiCD3_CD28 stimulation, 06hr, pool1 (C57BL_6J))
  • 11816-124E7 (CD4+CD25-CD44- naive conventional T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL_6J))
  • 11817-124E8 (CD4+CD25-CD44- naive conventional T cells, pool2 (Balb_cAJcl))
  • 11819-124F1 (CD4+CD25-CD44- naive conventional T cells, antiCD3_CD28 stimulation, 06hr, pool2 (Balb_cAJcl))
  • 11820-124F2 (CD4+CD25-CD44- naive conventional T cells, PMA and ionomycin stimulation, 02hr, pool2 (Balb_cAJcl))


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000895 (naive thymus-derived CD4-positive, alpha-beta T cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data