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Coexpression cluster:C525

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Full id: C525_tubular_vagina_cervix_rectum_Placental_colon_Hair



Phase1 CAGE Peaks

Hg19::chr10:4007246..4007251,+p@chr10:4007246..4007251
+
Hg19::chr11:65144695..65144697,-p@chr11:65144695..65144697
-
Hg19::chr14:102027518..102027524,-p@chr14:102027518..102027524
-
Hg19::chr14:102027537..102027598,-p@chr14:102027537..102027598
-
Hg19::chr14:102027607..102027620,-p@chr14:102027607..102027620
-
Hg19::chr14:102027691..102027715,-p@chr14:102027691..102027715
-
Hg19::chr16:1128952..1128957,+p4@SSTR5
Hg19::chr16:1129001..1129004,+p6@SSTR5
Hg19::chr20:42980646..42980651,+p@chr20:42980646..42980651
+
Hg19::chr21:36208874..36208890,+p@chr21:36208874..36208890
+
Hg19::chr21:36208893..36208906,+p@chr21:36208893..36208906
+
Hg19::chr2:109605543..109605554,-p4@EDAR
Hg19::chr2:109605568..109605573,-p6@EDAR
Hg19::chr2:109605588..109605606,-p2@EDAR
Hg19::chr4:93623257..93623261,+p@chr4:93623257..93623261
+
Hg19::chr6:137365402..137365416,-p8@IL20RA
Hg19::chr7:45928212..45928215,+p14@IGFBP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0065008regulation of biological quality0.0119799206895422
GO:0007431salivary gland development0.0124043961038235
GO:0004994somatostatin receptor activity0.0124043961038235
GO:0042346positive regulation of NF-kappaB import into nucleus0.0124043961038235
GO:0035272exocrine system development0.0124043961038235
GO:0042993positive regulation of transcription factor import into nucleus0.0124043961038235
GO:0050796regulation of insulin secretion0.0124043961038235
GO:0042307positive regulation of protein import into nucleus0.0124043961038235
GO:0046824positive regulation of nucleocytoplasmic transport0.0124043961038235
GO:0051222positive regulation of protein transport0.0124043961038235
GO:0042345regulation of NF-kappaB import into nucleus0.0124043961038235
GO:0042348NF-kappaB import into nucleus0.0124043961038235
GO:0065007biological regulation0.0124043961038235
GO:0030073insulin secretion0.0124043961038235
GO:0042593glucose homeostasis0.0124043961038235
GO:0033500carbohydrate homeostasis0.0124043961038235
GO:0022404molting cycle process0.0124043961038235
GO:0001942hair follicle development0.0124043961038235
GO:0022405hair cycle process0.0124043961038235
GO:0042633hair cycle0.0124043961038235
GO:0042303molting cycle0.0124043961038235
GO:0046883regulation of hormone secretion0.0124043961038235
GO:0002790peptide secretion0.0124043961038235
GO:0042475odontogenesis of dentine-containing teeth0.0124043961038235
GO:0030072peptide hormone secretion0.0124043961038235
GO:0042990regulation of transcription factor import into nucleus0.0124043961038235
GO:0042991transcription factor import into nucleus0.0124043961038235
GO:0042306regulation of protein import into nucleus0.0124043961038235
GO:0033157regulation of intracellular protein transport0.0124043961038235
GO:0004872receptor activity0.0127727213189944
GO:0042476odontogenesis0.0127727213189944
GO:0032386regulation of intracellular transport0.0127727213189944
GO:0051223regulation of protein transport0.0138701117521645
GO:0046822regulation of nucleocytoplasmic transport0.0139423432406483
GO:0046879hormone secretion0.0158756554137676
GO:0051050positive regulation of transport0.0166232626728935
GO:0005520insulin-like growth factor binding0.0166232626728935
GO:0015833peptide transport0.0166232626728935
GO:0004871signal transducer activity0.0166232626728935
GO:0060089molecular transducer activity0.0166232626728935
GO:0048732gland development0.0180796828083034
GO:0009653anatomical structure morphogenesis0.0180796828083034
GO:0008188neuropeptide receptor activity0.0181876457184049
GO:0042923neuropeptide binding0.0181876457184049
GO:0051046regulation of secretion0.0214033011731342
GO:0003001generation of a signal involved in cell-cell signaling0.0248296422928927
GO:0045177apical part of cell0.0298348531050072
GO:0019838growth factor binding0.0302283557850762
GO:0006606protein import into nucleus0.0316777496862145
GO:0051170nuclear import0.0316777496862145
GO:0007596blood coagulation0.0316777496862145
GO:0050817coagulation0.0316777496862145
GO:0007165signal transduction0.0316777496862145
GO:0007599hemostasis0.0316777496862145
GO:0051049regulation of transport0.0325756316374623
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messenger0.0340193783461287
GO:0019935cyclic-nucleotide-mediated signaling0.0342424189330173
GO:0017038protein import0.0342424189330173
GO:0050878regulation of body fluid levels0.0344852227673087
GO:0042060wound healing0.0350398057358722
GO:0007154cell communication0.0350398057358722
GO:0008544epidermis development0.0353904821731165
GO:0030594neurotransmitter receptor activity0.0353904821731165
GO:0050794regulation of cellular process0.0353904821731165
GO:0042165neurotransmitter binding0.0353904821731165
GO:0007398ectoderm development0.0353904821731165
GO:0001653peptide receptor activity0.0353904821731165
GO:0008528peptide receptor activity, G-protein coupled0.0353904821731165
GO:0006913nucleocytoplasmic transport0.0362248593712815
GO:0051169nuclear transport0.0362248593712815
GO:0001558regulation of cell growth0.0370784581505363
GO:0048856anatomical structure development0.0372283652565221
GO:0004888transmembrane receptor activity0.0373534571022978
GO:0050789regulation of biological process0.038333343120518
GO:0016049cell growth0.0429041116610036
GO:0040008regulation of growth0.0429041116610036
GO:0008361regulation of cell size0.0432464846577091
GO:0042277peptide binding0.0432464846577091
GO:0006605protein targeting0.0447321235486876
GO:0016021integral to membrane0.0449080317908855
GO:0008285negative regulation of cell proliferation0.0449080317908855
GO:0031224intrinsic to membrane0.0449080317908855



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
endoderm-derived structure7.92e-16169
endoderm7.92e-16169
presumptive endoderm7.92e-16169
digestive system2.87e-14155
digestive tract2.87e-14155
primitive gut2.87e-14155
mixed endoderm/mesoderm-derived structure8.18e-11130
subdivision of digestive tract1.16e-10129
endodermal part of digestive tract1.16e-10129
multi-tissue structure2.22e-10347
multi-cellular organism4.49e-09659
adult organism2.48e-08115
hindgut2.85e-0819
organ1.34e-07511
embryo2.47e-07612
mesenchyme4.37e-07238
entire embryonic mesenchyme4.37e-07238
gastrointestinal system5.52e-0735
Disease
Ontology termp-valuen
carcinoma7.75e-08106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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