Coexpression cluster:C645

Full id: C645_testicular_acute_diffuse_medulloblastoma_Prostate_carcinosarcoma_neuroectodermal

Phase1 CAGE Peaks

Hg19::chr10:120801539..120801558,-	p5@EIF3A
Hg19::chr10:120801648..120801714,-	p4@EIF3A
Hg19::chr10:120802000..120802019,-	p7@EIF3A
Hg19::chr10:120803632..120803647,-	p@chr10:120803632..120803647 -
Hg19::chr10:120809438..120809499,-	p3@EIF3A
Hg19::chr10:120810137..120810172,-	p1@BC014625
Hg19::chr10:120810174..120810192,-	p3@BC014625
Hg19::chr10:120810791..120810826,-	p@chr10:120810791..120810826 -
Hg19::chr10:120810828..120810844,-	p@chr10:120810828..120810844 -
Hg19::chr10:120816287..120816317,-	p@chr10:120816287..120816317 -
Hg19::chr10:120816324..120816355,-	p@chr10:120816324..120816355 -
Hg19::chr10:120816475..120816555,-	p@chr10:120816475..120816555 -
Hg19::chr10:120819141..120819169,-	p6@EIF3A

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005852	eukaryotic translation initiation factor 3 complex	0.0172200635817732
GO:0006446	regulation of translational initiation	0.0319380666431179
GO:0006413	translational initiation	0.0319380666431179
GO:0003743	translation initiation factor activity	0.0319380666431179
GO:0022618	protein-RNA complex assembly	0.0319380666431179
GO:0006417	regulation of translation	0.0319380666431179
GO:0031326	regulation of cellular biosynthetic process	0.0319380666431179
GO:0008135	translation factor activity, nucleic acid binding	0.0319380666431179
GO:0009889	regulation of biosynthetic process	0.0319380666431179
GO:0022613	ribonucleoprotein complex biogenesis and assembly	0.032585658777817

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br><br>disease_data<br>

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Disease

Ontology term	p-value	n
disease of cellular proliferation	3.65e-31	239
cancer	8.23e-30	235
cell type cancer	1.34e-16	143
carcinoma	6.79e-12	106
organ system cancer	1.13e-10	137
hematologic cancer	1.09e-07	51
immune system cancer	1.09e-07	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.