MCL coexpression mm9:976

Phase1 CAGE Peaks

	Short description
Mm9::chr18:38498588..38498639,-	p1@Gnpda1
Mm9::chr18:38498651..38498661,-	p2@Gnpda1
Mm9::chr2:125691960..125692018,+	p1@Galk2
Mm9::chr2:125692019..125692041,+	p2@Galk2
Mm9::chr2:164659341..164659352,+	p3@Ctsa
Mm9::chr2:25211831..25211838,-	p2@Dpp7
Mm9::chr9:114310210..114310251,+	p1@Tmppe p2@Glb1
Mm9::chrX:71176090..71176162,-	p1@Renbp

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	0.000128857921359924
GO:0019318	hexose metabolic process	0.000128857921359924
GO:0005996	monosaccharide metabolic process	0.000128857921359924
GO:0006041	glucosamine metabolic process	0.000185210849153496
GO:0006044	N-acetylglucosamine metabolic process	0.000185210849153496
GO:0006040	amino sugar metabolic process	0.000278238433679989
GO:0044262	cellular carbohydrate metabolic process	0.000329345436162799
GO:0006066	alcohol metabolic process	0.000329345436162799
GO:0016860	intramolecular oxidoreductase activity	0.000605618978561636
GO:0005975	carbohydrate metabolic process	0.000668734135780982
GO:0008238	exopeptidase activity	0.00184444566190033
GO:0004186	carboxypeptidase C activity	0.00184444566190033
GO:0046370	fructose biosynthetic process	0.00184444566190033
GO:0050121	N-acylglucosamine 2-epimerase activity	0.00184444566190033
GO:0006002	fructose 6-phosphate metabolic process	0.00184444566190033
GO:0004476	mannose-6-phosphate isomerase activity	0.00307373925502968
GO:0004342	glucosamine-6-phosphate deaminase activity	0.00307373925502968
GO:0004335	galactokinase activity	0.00307373925502968
GO:0016853	isomerase activity	0.00360238329815844
GO:0005764	lysosome	0.0040717293324298
GO:0000323	lytic vacuole	0.0040717293324298
GO:0005773	vacuole	0.00467577611898372
GO:0004185	serine carboxypeptidase activity	0.00467577611898372
GO:0008236	serine-type peptidase activity	0.00467577611898372
GO:0017171	serine hydrolase activity	0.00467577611898372
GO:0006000	fructose metabolic process	0.00512121488680332
GO:0006012	galactose metabolic process	0.00512121488680332
GO:0046835	carbohydrate phosphorylation	0.00592532787518543
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	0.00667377588904681
GO:0043170	macromolecule metabolic process	0.0071181114580042
GO:0007340	acrosome reaction	0.00863731630838491
GO:0006013	mannose metabolic process	0.00863731630838491
GO:0009308	amine metabolic process	0.00950603627406468
GO:0016854	racemase and epimerase activity	0.00975294890479075
GO:0006807	nitrogen compound metabolic process	0.010354764594616
GO:0044238	primary metabolic process	0.0120339471230969
GO:0044237	cellular metabolic process	0.0120339471230969
GO:0017156	calcium ion-dependent exocytosis	0.0145311266733661
GO:0019239	deaminase activity	0.0148648313442383
GO:0019319	hexose biosynthetic process	0.0158700377757918
GO:0046165	alcohol biosynthetic process	0.0164250103375253
GO:0046364	monosaccharide biosynthetic process	0.0164250103375253
GO:0019200	carbohydrate kinase activity	0.0186017631602618
GO:0004177	aminopeptidase activity	0.0231050532608269
GO:0006508	proteolysis	0.0231050532608269
GO:0007338	single fertilization	0.0243720217087801
GO:0004180	carboxypeptidase activity	0.0243720217087801
GO:0016787	hydrolase activity	0.0243720217087801
GO:0008233	peptidase activity	0.0252410139007344
GO:0009566	fertilization	0.026971109984213
GO:0016051	carbohydrate biosynthetic process	0.0424914869646335
GO:0006887	exocytosis	0.044810011066312

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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