MCL coexpression mm9:1584

Phase1 CAGE Peaks

	Short description
Mm9::chr11:72990738..72990763,+	p2@LOC100047518 p2@Tax1bp3
Mm9::chr3:104591944..104591964,+	p1@Rhoc
Mm9::chr7:148653285..148653326,+	p1@Cd151
Mm9::chr7:52273323..52273379,+	p1@Rras
Mm9::chr7:52273380..52273391,+	p3@Rras

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005525	GTP binding	0.0110787626567761
GO:0032561	guanyl ribonucleotide binding	0.0110787626567761
GO:0019001	guanyl nucleotide binding	0.0110787626567761
GO:0007264	small GTPase mediated signal transduction	0.0110787626567761
GO:0030336	negative regulation of cell migration	0.0196095154234119
GO:0051271	negative regulation of cell motility	0.0196095154234119
GO:0040013	negative regulation of locomotion	0.0196095154234119
GO:0007242	intracellular signaling cascade	0.0412773140694343
GO:0030334	regulation of cell migration	0.0412773140694343
GO:0051270	regulation of cell motility	0.0412773140694343
GO:0040012	regulation of locomotion	0.0412773140694343

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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