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MCL coexpression mm9:2686

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Phase1 CAGE Peaks

 Short description
Mm9::chr11:57997297..57997319,+p2@Gm12250
Mm9::chr11:57997328..57997373,+p1@Gm12250
Mm9::chr5:65324789..65324845,-p1@Tlr1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0032493response to bacterial lipoprotein0.00103179386036998
GO:0042495detection of triacylated bacterial lipoprotein0.00103179386036998
GO:0045335phagocytic vesicle0.00103179386036998
GO:0032490detection of molecule of bacterial origin0.00103179386036998
GO:0042497triacylated lipoprotein binding0.00103179386036998
GO:0042494detection of bacterial lipoprotein0.00103179386036998
GO:0016045detection of bacterium0.00265318421237996
GO:0042535positive regulation of tumor necrosis factor biosynthetic process0.00285727530563996
GO:0009595detection of biotic stimulus0.00285727530563996
GO:0007250activation of NF-kappaB-inducing kinase0.00285727530563996
GO:0042533tumor necrosis factor biosynthetic process0.00285727530563996
GO:0042534regulation of tumor necrosis factor biosynthetic process0.00285727530563996
GO:0045410positive regulation of interleukin-6 biosynthetic process0.00285727530563996
GO:0042116macrophage activation0.00353757894983995
GO:0045408regulation of interleukin-6 biosynthetic process0.00371445789733195
GO:0042226interleukin-6 biosynthetic process0.00386922697638745
GO:0030139endocytic vesicle0.00447110672826993
GO:0008034lipoprotein binding0.00447110672826993
GO:0032640tumor necrosis factor production0.00488744460175256
GO:0032635interleukin-6 production0.00495261052977593
GO:0002237response to molecule of bacterial origin0.00501157017893993
GO:0009593detection of chemical stimulus0.00590936483666446
GO:0002274myeloid leukocyte activation0.00726741762521468
GO:0032147activation of protein kinase activity0.00773845395277489
GO:0042108positive regulation of cytokine biosynthetic process0.00792417684764149
GO:0007249I-kappaB kinase/NF-kappaB cascade0.00833371964144987
GO:0045727positive regulation of translation0.00917150098106653
GO:0031328positive regulation of cellular biosynthetic process0.00950724342769486
GO:0009581detection of external stimulus0.010246780406433
GO:0042035regulation of cytokine biosynthetic process0.0103179386036999
GO:0009891positive regulation of biosynthetic process0.0105842079870211
GO:0042089cytokine biosynthetic process0.0114435319059217
GO:0042107cytokine metabolic process0.0114435319059217
GO:0051606detection of stimulus0.0125584052719318
GO:0051247positive regulation of protein metabolic process0.0125584052719318
GO:0045860positive regulation of protein kinase activity0.0141276390112198
GO:0033674positive regulation of kinase activity0.0141276390112198
GO:0051347positive regulation of transferase activity0.0141276390112198
GO:0045087innate immune response0.0141276390112198
GO:0001816cytokine production0.0153221388264943
GO:0009617response to bacterium0.0169113530285032
GO:0045859regulation of protein kinase activity0.0181685440630367
GO:0006417regulation of translation0.0181685440630367
GO:0043549regulation of kinase activity0.0181685440630367
GO:0043085positive regulation of catalytic activity0.0181685440630367
GO:0051338regulation of transferase activity0.0181685440630367
GO:0031326regulation of cellular biosynthetic process0.0183088527563525
GO:0009889regulation of biosynthetic process0.0199910060446685
GO:0051707response to other organism0.020720105277634
GO:0016023cytoplasmic membrane-bound vesicle0.0231534542267025
GO:0031988membrane-bound vesicle0.0235491775190326
GO:0045321leukocyte activation0.0239605463130363
GO:0006954inflammatory response0.0239605463130363
GO:0009607response to biotic stimulus0.0239605463130363
GO:0007243protein kinase cascade0.0244314046223321
GO:0001775cell activation0.0244314046223321
GO:0051246regulation of protein metabolic process0.02486978994478
GO:0051704multi-organism process0.02486978994478
GO:0050790regulation of catalytic activity0.0280158265137749
GO:0009611response to wounding0.0294314970007176
GO:0031410cytoplasmic vesicle0.0294314970007176
GO:0031982vesicle0.0296557525674083
GO:0065009regulation of a molecular function0.0304624854013996
GO:0031325positive regulation of cellular metabolic process0.0337590053689804
GO:0009893positive regulation of metabolic process0.0350492437491835
GO:0042221response to chemical stimulus0.0393621657776968
GO:0006412translation0.0393621657776968
GO:0009605response to external stimulus0.0398757980154753
GO:0006955immune response0.042797014904042



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
endoderm-derived structure2.02e-15118
endoderm2.02e-15118
presumptive endoderm2.02e-15118
digestive system3.74e-15116
digestive tract3.74e-15116
primitive gut3.74e-15116
subdivision of digestive tract1.29e-14114
hemolymphoid system2.74e-1348
immune system2.74e-1348
hematopoietic system3.37e-1245
blood island3.37e-1245
gastrointestinal system9.28e-1047
intestine3.94e-0831
gut epithelium4.89e-0855
mixed endoderm/mesoderm-derived structure5.43e-0835
unilaminar epithelium2.06e-0766
hemopoietic organ2.09e-0729
immune organ2.09e-0729
endo-epithelium2.21e-0769
foregut8.10e-0780


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0699972
MA0004.10.801718
MA0006.10.60285
MA0007.10.784593
MA0009.11.27673
MA0014.10.133574
MA0017.10.635031
MA0019.11.08369
MA0024.11.23079
MA0025.11.51835
MA0027.12.9431
MA0028.10.61552
MA0029.11.20789
MA0030.11.21482
MA0031.11.17722
MA0038.10.963265
MA0040.11.28983
MA0041.16.94821
MA0042.18.34609
MA0043.11.3775
MA0046.11.31428
MA0048.10.353763
MA0050.14.68424
MA0051.12.23119
MA0052.11.29825
MA0055.10.557057
MA0056.10
MA0057.10.337566
MA0058.10.690848
MA0059.10.705317
MA0060.10.502699
MA0061.10.5406
MA0063.10
MA0066.10.951196
MA0067.11.63197
MA0068.10.343188
MA0069.11.29861
MA0070.11.28847
MA0071.10.844726
MA0072.11.2796
MA0073.10.00834468
MA0074.10.911576
MA0076.10.657929
MA0077.11.2569
MA0078.11.0091
MA0081.10.732313
MA0083.11.37668
MA0084.11.96428
MA0087.11.33189
MA0088.10.27999
MA0089.10
MA0090.10.762482
MA0091.10.816659
MA0092.10.762845
MA0093.10.62555
MA0095.10
MA0098.10
MA0100.12.07939
MA0101.10.71579
MA0103.10.647985
MA0105.10.405648
MA0106.11.01755
MA0107.10.640607
MA0108.21.10817
MA0109.10
MA0111.10.778753
MA0113.10.986839
MA0114.10.537669
MA0115.11.38041
MA0116.10.602598
MA0117.11.34691
MA0119.10.716476
MA0122.11.36752
MA0124.11.57762
MA0125.11.5017
MA0130.10
MA0131.11.07881
MA0132.10
MA0133.10
MA0135.11.4152
MA0136.10.933582
MA0139.11.16863
MA0140.10.898603
MA0141.10.671467
MA0142.11.16183
MA0143.11.00467
MA0144.10.541532
MA0145.10.292366
MA0146.10.151124
MA0147.10.556853
MA0148.10.820161
MA0149.10.722227
MA0062.20.412742
MA0035.20.903829
MA0039.20.0481552
MA0138.21.07027
MA0002.20.466067
MA0137.20.668025
MA0104.20.48458
MA0047.20.962424
MA0112.20.29236
MA0065.20.292912
MA0150.10.784464
MA0151.10
MA0152.10.962542
MA0153.11.43238
MA0154.10.35067
MA0155.10.312898
MA0156.10.656895
MA0157.11.12772
MA0158.10
MA0159.10.569393
MA0160.10.823568
MA0161.10
MA0162.10.166722
MA0163.10.157796
MA0164.10.933981
MA0080.20.64167
MA0018.20.944669
MA0099.21.06348
MA0079.20.00137444
MA0102.22.01714
MA0258.10.520639
MA0259.10.543506
MA0442.10
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