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Coexpression cluster:C1121

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Full id: C1121_Hodgkin_CD4_acute_CD8_thymus_Natural_chronic



Phase1 CAGE Peaks

Hg19::chr10:73975408..73975422,+p5@ANAPC16
Hg19::chr2:240220167..240220189,-p11@HDAC4
Hg19::chr2:240220194..240220214,-p9@HDAC4
Hg19::chr2:240220219..240220235,-p8@HDAC4
Hg19::chr2:98330032..98330054,+p1@ZAP70
Hg19::chr5:133485552..133485556,+p@chr5:133485552..133485556
+
Hg19::chr7:142511881..142511883,+p@chr7:142511881..142511883
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0030098lymphocyte differentiation0.000537903997551219
GO:0002521leukocyte differentiation0.000537903997551219
GO:0046649lymphocyte activation0.000632053985636964
GO:0030097hemopoiesis0.000632053985636964
GO:0048534hemopoietic or lymphoid organ development0.000632053985636964
GO:0045321leukocyte activation0.000632053985636964
GO:0002520immune system development0.000632053985636964
GO:0001775cell activation0.000729830292807322
GO:0045059positive thymic T cell selection0.00182500551798389
GO:0043368positive T cell selection0.00182500551798389
GO:0045582positive regulation of T cell differentiation0.00331809417225125
GO:0045061thymic T cell selection0.0038019269439903
GO:0045621positive regulation of lymphocyte differentiation0.00491311479580289
GO:0045843negative regulation of striated muscle development0.00513229918112986
GO:0045058T cell selection0.00513229918112986
GO:0033077T cell differentiation in the thymus0.00513229918112986
GO:0045580regulation of T cell differentiation0.00536703125000323
GO:0042101T cell receptor complex0.00608245633918467
GO:0016202regulation of striated muscle development0.00624242908466399
GO:0045619regulation of lymphocyte differentiation0.007298517821056
GO:0001772immunological synapse0.00738529621235706
GO:0048513organ development0.00794090620559271
GO:0000118histone deacetylase complex0.00912220711952032
GO:0002376immune system process0.0105808254741684
GO:0030183B cell differentiation0.0105808254741684
GO:0004407histone deacetylase activity0.0119695475357714
GO:0048731system development0.0119695475357714
GO:0033558protein deacetylase activity0.0119695475357714
GO:0004715non-membrane spanning protein tyrosine kinase activity0.0119695475357714
GO:0050870positive regulation of T cell activation0.0119695475357714
GO:0030217T cell differentiation0.0119695475357714
GO:0019213deacetylase activity0.0119695475357714
GO:0048869cellular developmental process0.0129342269232722
GO:0030154cell differentiation0.0129342269232722
GO:0051251positive regulation of lymphocyte activation0.0132868791745255
GO:0050863regulation of T cell activation0.0145852078161808
GO:0048856anatomical structure development0.0145852078161808
GO:0042113B cell activation0.0146353502126821
GO:0051249regulation of lymphocyte activation0.0177390866745995
GO:0007275multicellular organismal development0.0177390866745995
GO:0050865regulation of cell activation0.0177844908429431
GO:0014706striated muscle development0.0188625001807961
GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides0.0188625001807961
GO:0042110T cell activation0.0202952075698475
GO:0043235receptor complex0.0222701656554202
GO:0043234protein complex0.0242595666410333
GO:0000122negative regulation of transcription from RNA polymerase II promoter0.0246116247363006
GO:0032502developmental process0.0313359353861005
GO:0007517muscle development0.0319505627797065
GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.033853171416462
GO:0045892negative regulation of transcription, DNA-dependent0.035282625829304
GO:0001501skeletal development0.035282625829304
GO:0005667transcription factor complex0.035282625829304
GO:0016564transcription repressor activity0.035282625829304
GO:0032501multicellular organismal process0.035282625829304
GO:0016568chromatin modification0.035282625829304
GO:0032991macromolecular complex0.035282625829304
GO:0008285negative regulation of cell proliferation0.035282625829304
GO:0051239regulation of multicellular organismal process0.0426678257933063
GO:0006954inflammatory response0.043345702468306
GO:0016481negative regulation of transcription0.043345702468306
GO:0004713protein-tyrosine kinase activity0.0449807666101281
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0459889232023415



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte1.11e-32140
hematopoietic stem cell8.97e-28172
angioblastic mesenchymal cell8.97e-28172
nongranular leukocyte9.08e-28119
hematopoietic cell1.59e-26182
hematopoietic lineage restricted progenitor cell8.14e-26124
hematopoietic oligopotent progenitor cell5.01e-25165
hematopoietic multipotent progenitor cell5.01e-25165
lymphocyte1.42e-2453
common lymphoid progenitor1.42e-2453
lymphoid lineage restricted progenitor cell2.89e-2452
T cell2.39e-1925
pro-T cell2.39e-1925
mature alpha-beta T cell8.88e-1518
alpha-beta T cell8.88e-1518
immature T cell8.88e-1518
mature T cell8.88e-1518
immature alpha-beta T cell8.88e-1518
CD8-positive, alpha-beta T cell1.22e-0911
myeloid leukocyte4.51e-0976
CD14-positive, CD16-negative classical monocyte2.77e-0842
classical monocyte5.65e-0745
myeloid cell8.57e-07112
common myeloid progenitor8.57e-07112
B cell9.29e-0714
Uber Anatomy
Ontology termp-valuen
adult organism2.02e-13115
hematopoietic system3.04e-13102
blood island3.04e-13102
hemolymphoid system2.71e-11112
blood4.25e-1115
haemolymphatic fluid4.25e-1115
organism substance4.25e-1115


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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