MCL coexpression mm9:39
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0051179 | localization | 2.32151821685269e-06 |
| GO:0030054 | cell junction | 2.32151821685269e-06 |
| GO:0007267 | cell-cell signaling | 2.32151821685269e-06 |
| GO:0003001 | generation of a signal involved in cell-cell signaling | 2.62346525575169e-06 |
| GO:0045045 | secretory pathway | 2.96217259454348e-06 |
| GO:0006810 | transport | 5.58819891179642e-06 |
| GO:0032940 | secretion by cell | 9.92136782370291e-06 |
| GO:0051234 | establishment of localization | 1.01668017394792e-05 |
| GO:0044456 | synapse part | 1.44703557302359e-05 |
| GO:0019226 | transmission of nerve impulse | 1.44703557302359e-05 |
| GO:0007269 | neurotransmitter secretion | 1.44703557302359e-05 |
| GO:0005886 | plasma membrane | 1.44703557302359e-05 |
| GO:0006887 | exocytosis | 1.44703557302359e-05 |
| GO:0016020 | membrane | 1.44703557302359e-05 |
| GO:0005509 | calcium ion binding | 1.55300041700964e-05 |
| GO:0007268 | synaptic transmission | 2.47598232293147e-05 |
| GO:0005515 | protein binding | 3.21595197843648e-05 |
| GO:0046903 | secretion | 3.21595197843648e-05 |
| GO:0045055 | regulated secretory pathway | 3.60933827462417e-05 |
| GO:0005216 | ion channel activity | 5.11564935482699e-05 |
| GO:0043167 | ion binding | 6.00028597823983e-05 |
| GO:0022838 | substrate specific channel activity | 6.14318273975488e-05 |
| GO:0017157 | regulation of exocytosis | 6.47370435970483e-05 |
| GO:0007214 | gamma-aminobutyric acid signaling pathway | 7.52169240291363e-05 |
| GO:0044459 | plasma membrane part | 7.52169240291363e-05 |
| GO:0015075 | ion transmembrane transporter activity | 7.52169240291363e-05 |
| GO:0022891 | substrate-specific transmembrane transporter activity | 7.52169240291363e-05 |
| GO:0022803 | passive transmembrane transporter activity | 7.52169240291363e-05 |
| GO:0015267 | channel activity | 7.52169240291363e-05 |
| GO:0050808 | synapse organization and biogenesis | 7.59979097866465e-05 |
| GO:0022857 | transmembrane transporter activity | 8.40630884453054e-05 |
| GO:0030425 | dendrite | 0.000110586890737406 |
| GO:0001505 | regulation of neurotransmitter levels | 0.000136492641972262 |
| GO:0022892 | substrate-specific transporter activity | 0.000243723980380846 |
| GO:0046872 | metal ion binding | 0.000253479031324889 |
| GO:0043169 | cation binding | 0.000293614735732008 |
| GO:0045211 | postsynaptic membrane | 0.000418361076808737 |
| GO:0014051 | gamma-aminobutyric acid secretion | 0.000574471591492585 |
| GO:0042734 | presynaptic membrane | 0.000581251160521816 |
| GO:0005261 | cation channel activity | 0.000622158483945083 |
| GO:0022836 | gated channel activity | 0.000982997819262159 |
| GO:0051649 | establishment of cellular localization | 0.00103428529720045 |
| GO:0051641 | cellular localization | 0.00119876074736673 |
| GO:0051049 | regulation of transport | 0.00125927167837907 |
| GO:0007635 | chemosensory behavior | 0.0014505968135894 |
| GO:0042995 | cell projection | 0.00159601684287277 |
| GO:0046873 | metal ion transmembrane transporter activity | 0.00159601684287277 |
| GO:0008324 | cation transmembrane transporter activity | 0.00167408423267116 |
| GO:0007416 | synaptogenesis | 0.00167911661812588 |
| GO:0007242 | intracellular signaling cascade | 0.00177822169767703 |
| GO:0017156 | calcium ion-dependent exocytosis | 0.00223760969577904 |
| GO:0043062 | extracellular structure organization and biogenesis | 0.00232793824383367 |
| GO:0005245 | voltage-gated calcium channel activity | 0.00250297982143019 |
| GO:0006811 | ion transport | 0.0026780677956115 |
| GO:0016192 | vesicle-mediated transport | 0.00277257078242223 |
| GO:0044425 | membrane part | 0.00277257078242223 |
| GO:0030073 | insulin secretion | 0.00307673487262195 |
| GO:0007270 | nerve-nerve synaptic transmission | 0.00342755151034203 |
| GO:0019933 | cAMP-mediated signaling | 0.00342755151034203 |
| GO:0019935 | cyclic-nucleotide-mediated signaling | 0.0040704937699486 |
| GO:0043005 | neuron projection | 0.00416422193114874 |
| GO:0005262 | calcium channel activity | 0.0049924660264488 |
| GO:0030072 | peptide hormone secretion | 0.005050214856554 |
| GO:0008331 | high voltage-gated calcium channel activity | 0.005050214856554 |
| GO:0019932 | second-messenger-mediated signaling | 0.0051228013534249 |
| GO:0002790 | peptide secretion | 0.00536504088555716 |
| GO:0022610 | biological adhesion | 0.00898280048413151 |
| GO:0007155 | cell adhesion | 0.00898280048413151 |
| GO:0007156 | homophilic cell adhesion | 0.0103808909875984 |
| GO:0009187 | cyclic nucleotide metabolic process | 0.0103808909875984 |
| GO:0035249 | synaptic transmission, glutamatergic | 0.0103808909875984 |
| GO:0021694 | cerebellar Purkinje cell layer formation | 0.0103808909875984 |
| GO:0021692 | cerebellar Purkinje cell layer morphogenesis | 0.0103808909875984 |
| GO:0021702 | cerebellar Purkinje cell differentiation | 0.0103808909875984 |
| GO:0015833 | peptide transport | 0.0105523355005315 |
| GO:0007399 | nervous system development | 0.011746400145839 |
| GO:0007409 | axonogenesis | 0.0119898936485521 |
| GO:0005246 | calcium channel regulator activity | 0.0122707534691437 |
| GO:0046879 | hormone secretion | 0.0125232637439188 |
| GO:0042391 | regulation of membrane potential | 0.0132702165872109 |
| GO:0021533 | cell differentiation in hindbrain | 0.0139831116215111 |
| GO:0021697 | cerebellar cortex formation | 0.0139831116215111 |
| GO:0009966 | regulation of signal transduction | 0.0139831116215111 |
| GO:0048667 | neuron morphogenesis during differentiation | 0.0139831116215111 |
| GO:0048812 | neurite morphogenesis | 0.0139831116215111 |
| GO:0019992 | diacylglycerol binding | 0.0150342036059529 |
| GO:0022832 | voltage-gated channel activity | 0.0150342036059529 |
| GO:0005244 | voltage-gated ion channel activity | 0.0150342036059529 |
| GO:0005624 | membrane fraction | 0.0172286699747199 |
| GO:0006816 | calcium ion transport | 0.0173120885999405 |
| GO:0048813 | dendrite morphogenesis | 0.0178579517217873 |
| GO:0021680 | cerebellar Purkinje cell layer development | 0.0178579517217873 |
| GO:0007154 | cell communication | 0.0190372760183657 |
| GO:0008289 | lipid binding | 0.0190372760183657 |
| GO:0006812 | cation transport | 0.0193094170197157 |
| GO:0005891 | voltage-gated calcium channel complex | 0.0196963653519286 |
| GO:0021696 | cerebellar cortex morphogenesis | 0.0196963653519286 |
| GO:0000904 | cellular morphogenesis during differentiation | 0.0211263130339868 |
| GO:0015457 | auxiliary transport protein activity | 0.0215425767875629 |
| GO:0016247 | channel regulator activity | 0.0215425767875629 |
| GO:0021587 | cerebellum morphogenesis | 0.0215425767875629 |
| GO:0004697 | protein kinase C activity | 0.0215425767875629 |
| GO:0022843 | voltage-gated cation channel activity | 0.0233259661479514 |
| GO:0021575 | hindbrain morphogenesis | 0.0237031026664616 |
| GO:0044464 | cell part | 0.0237031026664616 |
| GO:0005623 | cell | 0.0237031026664616 |
| GO:0043025 | cell soma | 0.023962745264999 |
| GO:0031175 | neurite development | 0.0240611113988555 |
| GO:0001565 | phorbol ester receptor activity | 0.0259421930320534 |
| GO:0030001 | metal ion transport | 0.0265952249843909 |
| GO:0000267 | cell fraction | 0.0265952249843909 |
| GO:0021695 | cerebellar cortex development | 0.0280608569138898 |
| GO:0043408 | regulation of MAPKKK cascade | 0.0280608569138898 |
| GO:0004089 | carbonate dehydratase activity | 0.030717113635209 |
| GO:0017137 | Rab GTPase binding | 0.030717113635209 |
| GO:0008081 | phosphoric diester hydrolase activity | 0.0318496969257443 |
| GO:0046058 | cAMP metabolic process | 0.0318496969257443 |
| GO:0007528 | neuromuscular junction development | 0.0318496969257443 |
| GO:0015674 | di-, tri-valent inorganic cation transport | 0.0318496969257443 |
| GO:0016043 | cellular component organization and biogenesis | 0.0318496969257443 |
| GO:0007610 | behavior | 0.0318496969257443 |
| GO:0048666 | neuron development | 0.0318496969257443 |
| GO:0048699 | generation of neurons | 0.0318496969257443 |
| GO:0021548 | pons development | 0.0318496969257443 |
| GO:0032353 | negative regulation of hormone biosynthetic process | 0.0318496969257443 |
| GO:0016014 | dystrobrevin complex | 0.0318496969257443 |
| GO:0004699 | calcium-independent protein kinase C activity | 0.0318496969257443 |
| GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway | 0.0318496969257443 |
| GO:0021626 | central nervous system maturation | 0.0318496969257443 |
| GO:0016921 | pyroglutamyl-peptidase II activity | 0.0318496969257443 |
| GO:0032351 | negative regulation of hormone metabolic process | 0.0318496969257443 |
| GO:0021679 | cerebellar molecular layer development | 0.0318496969257443 |
| GO:0021590 | cerebellum maturation | 0.0318496969257443 |
| GO:0021750 | vestibular nucleus development | 0.0318496969257443 |
| GO:0021578 | hindbrain maturation | 0.0318496969257443 |
| GO:0048541 | Peyer's patch development | 0.0318496969257443 |
| GO:0048690 | regulation of axon extension involved in regeneration | 0.0318496969257443 |
| GO:0048791 | calcium ion-dependent exocytosis of neurotransmitter | 0.0318496969257443 |
| GO:0048691 | positive regulation of axon extension involved in regeneration | 0.0318496969257443 |
| GO:0005923 | tight junction | 0.0327054851314931 |
| GO:0007628 | adult walking behavior | 0.0335166607142263 |
| GO:0022037 | metencephalon development | 0.0358279705425788 |
| GO:0048489 | synaptic vesicle transport | 0.0358279705425788 |
| GO:0021549 | cerebellum development | 0.0358279705425788 |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | 0.0386902995132172 |
| GO:0005911 | intercellular junction | 0.0409754530072106 |
| GO:0004890 | GABA-A receptor activity | 0.0412959273587842 |
| GO:0022008 | neurogenesis | 0.0412959273587842 |
| GO:0007411 | axon guidance | 0.0429898591606149 |
| GO:0004112 | cyclic-nucleotide phosphodiesterase activity | 0.0434673014937421 |
| GO:0031644 | regulation of neurological process | 0.0434673014937421 |
| GO:0016917 | GABA receptor activity | 0.0499001502345047 |
Relative expression of the co-expression cluster over median <br>Analyst:
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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
