MCL coexpression mm9:1753

Phase1 CAGE Peaks

	Short description
Mm9::chr1:74055065..74055086,-	p@chr1:74055065..74055086 -
Mm9::chr5:92816942..92816953,+	p9@Art3
Mm9::chr7:26173990..26174003,-	p8@Lipe
Mm9::chr7:26174005..26174021,-	p6@Lipe
Mm9::chr7:26174031..26174049,-	p7@Lipe

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0046340	diacylglycerol catabolic process	0.00317738575938492
GO:0042134	rRNA primary transcript binding	0.00317738575938492
GO:0044269	glycerol ether catabolic process	0.00317738575938492
GO:0046464	acylglycerol catabolic process	0.00317738575938492
GO:0046461	neutral lipid catabolic process	0.00317738575938492
GO:0046503	glycerolipid catabolic process	0.00317738575938492
GO:0003716	RNA polymerase I transcription termination factor activity	0.00317738575938492
GO:0019433	triacylglycerol catabolic process	0.00317738575938492
GO:0003715	transcription termination factor activity	0.00317738575938492
GO:0006361	transcription initiation from RNA polymerase I promoter	0.00381275845498797
GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	0.00586513943060342
GO:0016599	caveolar membrane	0.00586513943060342
GO:0046339	diacylglycerol metabolic process	0.00586513943060342
GO:0005901	caveola	0.00612680813617224
GO:0006360	transcription from RNA polymerase I promoter	0.00635355286224057
GO:0004806	triacylglycerol lipase activity	0.00714735525899337
GO:0006471	protein amino acid ADP-ribosylation	0.00896824701106051
GO:0006641	triacylglycerol metabolic process	0.0100573111953749
GO:0019843	rRNA binding	0.0103199969626036
GO:0006639	acylglycerol metabolic process	0.0103199969626036
GO:0006352	transcription initiation	0.0103199969626036
GO:0046486	glycerolipid metabolic process	0.0103199969626036
GO:0006638	neutral lipid metabolic process	0.0103199969626036
GO:0006662	glycerol ether metabolic process	0.0103199969626036
GO:0044242	cellular lipid catabolic process	0.0106687042123577
GO:0016763	transferase activity, transferring pentosyl groups	0.012088563880812
GO:0016298	lipase activity	0.0217513775917241
GO:0008203	cholesterol metabolic process	0.0217513775917241
GO:0016125	sterol metabolic process	0.0232938751559505
GO:0016042	lipid catabolic process	0.0294768293112085
GO:0004091	carboxylesterase activity	0.0318903656507904
GO:0048503	GPI anchor binding	0.0345512866110112
GO:0065004	protein-DNA complex assembly	0.0345512866110112
GO:0008202	steroid metabolic process	0.0391027453119521
GO:0035091	phosphoinositide binding	0.0444679609992793

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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