MCL coexpression mm9:221
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0032287 | myelin maintenance in the peripheral nervous system | 0.0107189771782449 |
GO:0043217 | myelin maintenance | 0.0107189771782449 |
GO:0050665 | hydrogen peroxide biosynthetic process | 0.0107189771782449 |
GO:0022011 | myelination in the peripheral nervous system | 0.0107189771782449 |
GO:0032292 | ensheathment of axons in the peripheral nervous system | 0.0107189771782449 |
GO:0042554 | superoxide release | 0.0107189771782449 |
GO:0060087 | relaxation of vascular smooth muscle | 0.0107189771782449 |
GO:0019430 | removal of superoxide radicals | 0.0107189771782449 |
GO:0014044 | Schwann cell development | 0.0107189771782449 |
GO:0004785 | copper, zinc superoxide dismutase activity | 0.0107189771782449 |
GO:0000303 | response to superoxide | 0.0107189771782449 |
GO:0001895 | retinal homeostasis | 0.0107189771782449 |
GO:0006590 | thyroid hormone generation | 0.0107189771782449 |
GO:0045986 | negative regulation of smooth muscle contraction | 0.0107189771782449 |
GO:0000305 | response to oxygen radical | 0.0107189771782449 |
GO:0048678 | response to axon injury | 0.0107189771782449 |
GO:0045932 | negative regulation of muscle contraction | 0.0107189771782449 |
GO:0016721 | oxidoreductase activity, acting on superoxide radicals as acceptor | 0.0107189771782449 |
GO:0004784 | superoxide dismutase activity | 0.0107189771782449 |
GO:0006807 | nitrogen compound metabolic process | 0.0107189771782449 |
GO:0006309 | DNA fragmentation during apoptosis | 0.0107189771782449 |
GO:0060122 | inner ear receptor stereocilium organization and biogenesis | 0.0107189771782449 |
GO:0060088 | auditory receptor cell stereocilium organization and biogenesis | 0.0107189771782449 |
GO:0002093 | auditory receptor cell morphogenesis | 0.0107189771782449 |
GO:0014037 | Schwann cell differentiation | 0.0107189771782449 |
GO:0002262 | myeloid cell homeostasis | 0.0107189771782449 |
GO:0060119 | inner ear receptor cell development | 0.0107189771782449 |
GO:0019841 | retinol binding | 0.0107189771782449 |
GO:0006921 | cell structure disassembly during apoptosis | 0.0107189771782449 |
GO:0060117 | auditory receptor cell development | 0.0107189771782449 |
GO:0060052 | neurofilament cytoskeleton organization and biogenesis | 0.0107189771782449 |
GO:0046716 | muscle maintenance | 0.0107189771782449 |
GO:0030262 | apoptotic nuclear changes | 0.0107189771782449 |
GO:0042743 | hydrogen peroxide metabolic process | 0.0107189771782449 |
GO:0045471 | response to ethanol | 0.0107189771782449 |
GO:0042542 | response to hydrogen peroxide | 0.0107189771782449 |
GO:0042403 | thyroid hormone metabolic process | 0.0107189771782449 |
GO:0016918 | retinal binding | 0.0107189771782449 |
GO:0021782 | glial cell development | 0.0107189771782449 |
GO:0007009 | plasma membrane organization and biogenesis | 0.0107189771782449 |
GO:0019840 | isoprenoid binding | 0.0129603531713899 |
GO:0005501 | retinoid binding | 0.0129603531713899 |
GO:0006308 | DNA catabolic process | 0.0129603531713899 |
GO:0042311 | vasodilation | 0.013639344489914 |
GO:0006801 | superoxide metabolic process | 0.0142880540346329 |
GO:0000302 | response to reactive oxygen species | 0.0149084567094372 |
GO:0045104 | intermediate filament cytoskeleton organization and biogenesis | 0.0151793935216803 |
GO:0006940 | regulation of smooth muscle contraction | 0.0151793935216803 |
GO:0001541 | ovarian follicle development | 0.0157434300619522 |
GO:0006749 | glutathione metabolic process | 0.0162848112175334 |
GO:0006302 | double-strand break repair | 0.0164816990927163 |
GO:0045103 | intermediate filament-based process | 0.0164816990927163 |
GO:0007566 | embryo implantation | 0.0166865981119955 |
GO:0022411 | cellular component disassembly | 0.0166865981119955 |
GO:0007422 | peripheral nervous system development | 0.0166865981119955 |
GO:0043524 | negative regulation of neuron apoptosis | 0.0166865981119955 |
GO:0042491 | auditory receptor cell differentiation | 0.0166865981119955 |
GO:0006879 | cellular iron ion homeostasis | 0.0166865981119955 |
GO:0055072 | iron ion homeostasis | 0.0166865981119955 |
GO:0001894 | tissue homeostasis | 0.0166865981119955 |
GO:0006997 | nuclear organization and biogenesis | 0.0166865981119955 |
GO:0006939 | smooth muscle contraction | 0.0166865981119955 |
GO:0048871 | multicellular organismal homeostasis | 0.0166865981119955 |
GO:0001776 | leukocyte homeostasis | 0.0166865981119955 |
GO:0042552 | myelination | 0.0166865981119955 |
GO:0060113 | inner ear receptor cell differentiation | 0.0166865981119955 |
GO:0048872 | homeostasis of number of cells | 0.0166865981119955 |
GO:0007568 | aging | 0.0166865981119955 |
GO:0007272 | ensheathment of neurons | 0.0166865981119955 |
GO:0051241 | negative regulation of multicellular organismal process | 0.0166865981119955 |
GO:0008366 | axon ensheathment | 0.0166865981119955 |
GO:0010033 | response to organic substance | 0.0166865981119955 |
GO:0006800 | oxygen and reactive oxygen species metabolic process | 0.0166865981119955 |
GO:0022601 | menstrual cycle phase | 0.0166865981119955 |
GO:0042493 | response to drug | 0.0166865981119955 |
GO:0009408 | response to heat | 0.0166865981119955 |
GO:0022602 | menstrual cycle process | 0.0166865981119955 |
GO:0006937 | regulation of muscle contraction | 0.0175405363270691 |
GO:0042490 | mechanoreceptor differentiation | 0.0175405363270691 |
GO:0035150 | regulation of tube size | 0.0175405363270691 |
GO:0050880 | regulation of blood vessel size | 0.0175405363270691 |
GO:0003018 | vascular process in circulatory system | 0.0175405363270691 |
GO:0043523 | regulation of neuron apoptosis | 0.0175405363270691 |
GO:0008585 | female gonad development | 0.0177164895652743 |
GO:0000187 | activation of MAPK activity | 0.0177164895652743 |
GO:0046660 | female sex differentiation | 0.0177164895652743 |
GO:0046545 | development of primary female sexual characteristics | 0.0177164895652743 |
GO:0001508 | regulation of action potential | 0.0180007112873751 |
GO:0051402 | neuron apoptosis | 0.0180753989237622 |
GO:0010001 | glial cell differentiation | 0.0180753989237622 |
GO:0042698 | menstrual cycle | 0.0184729230284163 |
GO:0008217 | regulation of blood pressure | 0.0184729230284163 |
GO:0007565 | female pregnancy | 0.0184729230284163 |
GO:0042063 | gliogenesis | 0.0184729230284163 |
GO:0043406 | positive regulation of MAP kinase activity | 0.0184729230284163 |
GO:0003015 | heart process | 0.0194126521668794 |
GO:0060047 | heart contraction | 0.0194126521668794 |
GO:0006979 | response to oxidative stress | 0.0196501810043307 |
GO:0009266 | response to temperature stimulus | 0.019882863913751 |
GO:0005496 | steroid binding | 0.020110846275557 |
GO:0008632 | apoptotic program | 0.0207567600192747 |
GO:0008406 | gonad development | 0.021389824937823 |
GO:0040014 | regulation of multicellular organism growth | 0.0215963087660436 |
GO:0048608 | reproductive structure development | 0.0217898213156336 |
GO:0005507 | copper ion binding | 0.0217898213156336 |
GO:0042472 | inner ear morphogenesis | 0.0217898213156336 |
GO:0045137 | development of primary sexual characteristics | 0.0231800685237416 |
GO:0042471 | ear morphogenesis | 0.0233228395653605 |
GO:0006790 | sulfur metabolic process | 0.0233228395653605 |
GO:0043405 | regulation of MAP kinase activity | 0.0233228395653605 |
GO:0035264 | multicellular organism growth | 0.0234966471543257 |
GO:0048839 | inner ear development | 0.026614254532153 |
GO:0048609 | reproductive process in a multicellular organism | 0.026614254532153 |
GO:0032504 | multicellular organism reproduction | 0.026614254532153 |
GO:0006576 | biogenic amine metabolic process | 0.0267529476252007 |
GO:0007548 | sex differentiation | 0.0268892090938311 |
GO:0043583 | ear development | 0.0277504102388111 |
GO:0042445 | hormone metabolic process | 0.0292932526269463 |
GO:0045860 | positive regulation of protein kinase activity | 0.0292932526269463 |
GO:0003012 | muscle system process | 0.0292932526269463 |
GO:0006936 | muscle contraction | 0.0292932526269463 |
GO:0003006 | reproductive developmental process | 0.030098302471113 |
GO:0006575 | amino acid derivative metabolic process | 0.030199078496392 |
GO:0033674 | positive regulation of kinase activity | 0.0302981913730126 |
GO:0051347 | positive regulation of transferase activity | 0.0303956810186028 |
GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 0.0304915860835648 |
GO:0007605 | sensory perception of sound | 0.0309203563178191 |
GO:0008015 | blood circulation | 0.0311866791041741 |
GO:0003013 | circulatory system process | 0.0311866791041741 |
GO:0030005 | cellular di-, tri-valent inorganic cation homeostasis | 0.0311866791041741 |
GO:0050954 | sensory perception of mechanical stimulus | 0.0315966940632543 |
GO:0055066 | di-, tri-valent inorganic cation homeostasis | 0.0316788577864999 |
GO:0030003 | cellular cation homeostasis | 0.033354623183995 |
GO:0019842 | vitamin binding | 0.0334221975041883 |
GO:0055080 | cation homeostasis | 0.0338028119167185 |
GO:0000165 | MAPKKK cascade | 0.0370205692594804 |
GO:0005179 | hormone activity | 0.0370205692594804 |
GO:0045859 | regulation of protein kinase activity | 0.0392058207943284 |
GO:0043549 | regulation of kinase activity | 0.0404450888437307 |
GO:0043085 | positive regulation of catalytic activity | 0.0407601450841903 |
GO:0051338 | regulation of transferase activity | 0.0407708495992517 |
GO:0006873 | cellular ion homeostasis | 0.043424470701464 |
GO:0055082 | cellular chemical homeostasis | 0.043424470701464 |
GO:0035239 | tube morphogenesis | 0.043424470701464 |
GO:0040008 | regulation of growth | 0.043424470701464 |
GO:0043066 | negative regulation of apoptosis | 0.043424470701464 |
GO:0043069 | negative regulation of programmed cell death | 0.0437031775315356 |
GO:0006732 | coenzyme metabolic process | 0.0456875550042585 |
GO:0050801 | ion homeostasis | 0.0470448710507012 |
GO:0007517 | muscle development | 0.0470448710507012 |
GO:0009628 | response to abiotic stimulus | 0.0472911694927452 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
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Ontology term | p-value | n |
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Ontology term | p-value | n |
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TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |