MCL coexpression mm9:2589

Phase1 CAGE Peaks

	Short description
Mm9::chr10:80363494..80363564,-	p1@Timm13
Mm9::chr11:5607661..5607711,-	p1@Mrps24
Mm9::chr2:155969939..155969981,+	p1@Romo1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0044429	mitochondrial part	0.0141976823458055
GO:0005744	mitochondrial inner membrane presequence translocase complex	0.0141976823458055
GO:0006626	protein targeting to mitochondrion	0.0141976823458055
GO:0000314	organellar small ribosomal subunit	0.0141976823458055
GO:0005763	mitochondrial small ribosomal subunit	0.0141976823458055
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	0.0164771950779731
GO:0022884	macromolecule transmembrane transporter activity	0.0164771950779731
GO:0008320	protein transmembrane transporter activity	0.0205562383033736
GO:0006839	mitochondrial transport	0.0205562383033736
GO:0005739	mitochondrion	0.0205562383033736
GO:0015935	small ribosomal subunit	0.0241860070486766
GO:0000313	organellar ribosome	0.0272792962298164
GO:0005761	mitochondrial ribosome	0.0272792962298164
GO:0044455	mitochondrial membrane part	0.027860796073819
GO:0031980	mitochondrial lumen	0.0293573975194805
GO:0005759	mitochondrial matrix	0.0293573975194805
GO:0033279	ribosomal subunit	0.031240360603001
GO:0043234	protein complex	0.031240360603001
GO:0007005	mitochondrion organization and biogenesis	0.031240360603001
GO:0007605	sensory perception of sound	0.0407243909325758
GO:0050954	sensory perception of mechanical stimulus	0.0408874067830024
GO:0032991	macromolecular complex	0.0425634602071351
GO:0015399	primary active transmembrane transporter activity	0.0471700039905898
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	0.0471700039905898
GO:0008565	protein transporter activity	0.0474081102660598
GO:0044446	intracellular organelle part	0.0474081102660598
GO:0044422	organelle part	0.0474081102660598
GO:0003735	structural constituent of ribosome	0.049237879306909
GO:0005840	ribosome	0.0496636615416406

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
animal cell	1.04e-23	115
eukaryotic cell	1.04e-23	115
somatic cell	1.40e-22	118
embryonic cell	6.42e-18	70
epithelial cell	3.68e-12	25
somatic stem cell	5.86e-12	91
multi fate stem cell	5.86e-12	91
stem cell	2.12e-10	97
endodermal cell	2.15e-10	20
non-terminally differentiated cell	9.54e-09	49
endo-epithelial cell	1.29e-08	15
motile cell	3.17e-08	54
ectodermal cell	2.25e-07	44
neurectodermal cell	2.25e-07	44
neural cell	3.29e-07	43

Uber Anatomy

Ontology term	p-value	n
mucosa	8.92e-07	15

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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