MCL coexpression mm9:665

Phase1 CAGE Peaks

	Short description
Mm9::chr12:5649804..5649807,+	p@chr12:5649804..5649807 +
Mm9::chr12:5649934..5649959,+	p@chr12:5649934..5649959 +
Mm9::chr8:96696674..96696692,+	p1@Mt2
Mm9::chr8:96697253..96697294,+	p@chr8:96697253..96697294 +
Mm9::chr8:96697364..96697394,-	p@chr8:96697364..96697394 -
Mm9::chr8:96703134..96703148,+	p1@Mt1
Mm9::chr8:96703993..96704103,+	p@chr8:96703993..96704103 +
Mm9::chr8:96704054..96704065,-	p@chr8:96704054..96704065 -
Mm9::chr8:96704117..96704156,+	p@chr8:96704117..96704156 +
Mm9::chr8:96704126..96704155,-	p@chr8:96704126..96704155 -
Mm9::chr8:96704157..96704191,-	p@chr8:96704157..96704191 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0046688	response to copper ion	4.14223155268884e-07
GO:0010273	detoxification of copper ion	4.14223155268884e-07
GO:0007263	nitric oxide mediated signal transduction	5.52297540358513e-07
GO:0006882	cellular zinc ion homeostasis	8.28446310537767e-07
GO:0055069	zinc ion homeostasis	8.28446310537767e-07
GO:0010038	response to metal ion	2.07111577634442e-06
GO:0010035	response to inorganic substance	3.07708629628314e-06
GO:0009636	response to toxin	5.90267996258159e-06
GO:0030005	cellular di-, tri-valent inorganic cation homeostasis	0.000130503306307213
GO:0055066	di-, tri-valent inorganic cation homeostasis	0.000130503306307213
GO:0030003	cellular cation homeostasis	0.000130503306307213
GO:0055080	cation homeostasis	0.000130503306307213
GO:0055082	cellular chemical homeostasis	0.000208788195167673
GO:0006873	cellular ion homeostasis	0.000208788195167673
GO:0050801	ion homeostasis	0.000252123827173661
GO:0048878	chemical homeostasis	0.000359886823724789
GO:0019725	cellular homeostasis	0.000359886823724789
GO:0042592	homeostatic process	0.000802764474911096
GO:0042221	response to chemical stimulus	0.00129721611498995
GO:0065008	regulation of biological quality	0.0025646626658473
GO:0007242	intracellular signaling cascade	0.006372724619251
GO:0005507	copper ion binding	0.0123536030994868
GO:0006875	cellular metal ion homeostasis	0.0142545463802805
GO:0055065	metal ion homeostasis	0.0142545463802805
GO:0008270	zinc ion binding	0.018566707919691
GO:0046914	transition metal ion binding	0.0274975137905994
GO:0005764	lysosome	0.0304599490349778
GO:0000323	lytic vacuole	0.0304599490349778
GO:0005773	vacuole	0.0330234601740568
GO:0043169	cation binding	0.0458567677081809

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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