MCL coexpression mm9:803

Phase1 CAGE Peaks

	Short description
Mm9::chr12:112512866..112512894,+	p2@Amn
Mm9::chr12:73312888..73312900,-	p@chr12:73312888..73312900 -
Mm9::chr14:68704745..68704754,+	p@chr14:68704745..68704754 +
Mm9::chr1:81073831..81073840,+	p10@9430031J16Rik
Mm9::chr4:101169150..101169203,+	p4@Dnajc6
Mm9::chr4:101169281..101169327,+	p5@Dnajc6
Mm9::chr5:108979194..108979227,-	p2@Cplx1
Mm9::chrX:149078392..149078404,-	p15@Shroom2
Mm9::chrX:149078961..149078972,-	p4@Shroom2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045177	apical part of cell	0.00587300717690243
GO:0002089	lens morphogenesis in camera-type eye	0.00587300717690243
GO:0008057	eye pigment granule organization and biogenesis	0.00587300717690243
GO:0043482	cellular pigment accumulation	0.00587300717690243
GO:0031201	SNARE complex	0.00587300717690243
GO:0043476	pigment accumulation	0.00978754086146336
GO:0032401	establishment of melanosome localization	0.0131874787814422
GO:0051905	establishment of pigment granule localization	0.0131874787814422
GO:0032438	melanosome organization and biogenesis	0.0131874787814422
GO:0032400	melanosome localization	0.0131874787814422
GO:0048753	pigment granule organization and biogenesis	0.0131874787814422
GO:0046903	secretion	0.0131874787814422
GO:0051875	pigment granule localization	0.0135475251447114
GO:0045176	apical protein localization	0.0146752793641013
GO:0033059	cellular pigmentation	0.016002817788394
GO:0008105	asymmetric protein localization	0.016002817788394
GO:0016079	synaptic vesicle exocytosis	0.016002817788394
GO:0051650	establishment of vesicle localization	0.016002817788394
GO:0030864	cortical actin cytoskeleton	0.016002817788394
GO:0002088	lens development in camera-type eye	0.016002817788394
GO:0019905	syntaxin binding	0.016002817788394
GO:0051648	vesicle localization	0.016002817788394
GO:0008013	beta-catenin binding	0.0165812670838333
GO:0007588	excretion	0.0183320410774228
GO:0000149	SNARE binding	0.0187704671304693
GO:0030863	cortical cytoskeleton	0.0191749827690667
GO:0048593	camera-type eye morphogenesis	0.0195493558366158
GO:0005326	neurotransmitter transporter activity	0.0209422952308881
GO:0051656	establishment of organelle localization	0.0212294093381044
GO:0030073	insulin secretion	0.02174760103004
GO:0048489	synaptic vesicle transport	0.02174760103004
GO:0051015	actin filament binding	0.0219821809304354
GO:0005913	cell-cell adherens junction	0.0227888411667048
GO:0051640	organelle localization	0.0227888411667048
GO:0044448	cell cortex part	0.0227888411667048
GO:0030072	peptide hormone secretion	0.0227888411667048
GO:0002790	peptide secretion	0.0229629289976598
GO:0051234	establishment of localization	0.026175522874545
GO:0015833	peptide transport	0.0277329542032488
GO:0008104	protein localization	0.0277329542032488
GO:0051649	establishment of cellular localization	0.0277329542032488
GO:0051641	cellular localization	0.0277329542032488
GO:0046879	hormone secretion	0.0277329542032488
GO:0033036	macromolecule localization	0.0277329542032488
GO:0048592	eye morphogenesis	0.0279632143724156
GO:0005938	cell cortex	0.0286644083003235
GO:0006836	neurotransmitter transport	0.0286644083003235
GO:0031072	heat shock protein binding	0.0286644083003235
GO:0051179	localization	0.0286644083003235
GO:0016324	apical plasma membrane	0.0286644083003235
GO:0007269	neurotransmitter secretion	0.0292445867094192
GO:0005912	adherens junction	0.0342779525188808
GO:0045055	regulated secretory pathway	0.0352764884670792
GO:0005923	tight junction	0.0378504666385024
GO:0043010	camera-type eye development	0.0396075725350841
GO:0043583	ear development	0.0396075725350841
GO:0006887	exocytosis	0.0420607361536764
GO:0004725	protein tyrosine phosphatase activity	0.0420607361536764
GO:0003001	generation of a signal involved in cell-cell signaling	0.0420607361536764
GO:0043296	apical junction complex	0.0420607361536764
GO:0001505	regulation of neurotransmitter levels	0.0420607361536764
GO:0016327	apicolateral plasma membrane	0.0423158831989473
GO:0001654	eye development	0.0480668038902779

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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