MCL coexpression mm9:1902

Phase1 CAGE Peaks

	Short description
Mm9::chr10:6373332..6373353,-	p3@Mthfd1l
Mm9::chr10:76495985..76496003,+	p1@Slc19a1
Mm9::chr10:76496005..76496029,+	p3@Slc19a1
Mm9::chr10:79786124..79786173,-	p2@Pcsk4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0009257	10-formyltetrahydrofolate biosynthetic process	0.00766955183299808
GO:0004329	formate-tetrahydrofolate ligase activity	0.00766955183299808
GO:0009256	10-formyltetrahydrofolate metabolic process	0.00766955183299808
GO:0008518	reduced folate carrier activity	0.00862777307470345
GO:0009396	folic acid and derivative biosynthetic process	0.016101646955729
GO:0005542	folic acid binding	0.0180693161461342
GO:0006760	folic acid and derivative metabolic process	0.0180693161461342
GO:0004289	subtilase activity	0.0201193395732448

Relative expression of the co-expression cluster over median <br>Analyst:

---

"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}