Coexpression cluster:C135
From FANTOM5_SSTAR
Full id: C135_neuroblastoma_retinoblastoma_carcinoid_choriocarcinoma_testicular_acute_rectum
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0032989 | cellular structure morphogenesis | 0.012351859015746 |
| GO:0000902 | cell morphogenesis | 0.012351859015746 |
| GO:0032501 | multicellular organismal process | 0.012351859015746 |
| GO:0030141 | secretory granule | 0.012351859015746 |
| GO:0032990 | cell part morphogenesis | 0.012351859015746 |
| GO:0048858 | cell projection morphogenesis | 0.012351859015746 |
| GO:0030030 | cell projection organization and biogenesis | 0.012351859015746 |
| GO:0005333 | norepinephrine transmembrane transporter activity | 0.0185446838572942 |
| GO:0005334 | norephinephrine:sodium symporter activity | 0.0185446838572942 |
| GO:0042583 | chromaffin granule | 0.0185446838572942 |
| GO:0015874 | norepinephrine transport | 0.0185446838572942 |
| GO:0007268 | synaptic transmission | 0.0200921373067378 |
| GO:0050877 | neurological system process | 0.0226023037666984 |
| GO:0019226 | transmission of nerve impulse | 0.0233722017898953 |
| GO:0006836 | neurotransmitter transport | 0.0233722017898953 |
| GO:0009914 | hormone transport | 0.023991938083013 |
| GO:0050774 | negative regulation of dendrite morphogenesis | 0.023991938083013 |
| GO:0015370 | solute:sodium symporter activity | 0.0247353766381847 |
| GO:0048814 | regulation of dendrite morphogenesis | 0.0291244924816904 |
| GO:0004988 | mu-opioid receptor activity | 0.0291244924816904 |
| GO:0030672 | synaptic vesicle membrane | 0.0291244924816904 |
| GO:0003008 | system process | 0.0293082164144434 |
| GO:0006887 | exocytosis | 0.0293082164144434 |
| GO:0015294 | solute:cation symporter activity | 0.0293082164144434 |
| GO:0050773 | regulation of dendrite development | 0.0293082164144434 |
| GO:0048813 | dendrite morphogenesis | 0.0293082164144434 |
| GO:0048667 | neuron morphogenesis during differentiation | 0.0293082164144434 |
| GO:0048812 | neurite morphogenesis | 0.0293082164144434 |
| GO:0000904 | cellular morphogenesis during differentiation | 0.0311410238356019 |
| GO:0032502 | developmental process | 0.0313272232327204 |
| GO:0048265 | response to pain | 0.0313272232327204 |
| GO:0008504 | monoamine transmembrane transporter activity | 0.0313272232327204 |
| GO:0031175 | neurite development | 0.0313272232327204 |
| GO:0009653 | anatomical structure morphogenesis | 0.0342713320105026 |
| GO:0015844 | monoamine transport | 0.0349185433074233 |
| GO:0048666 | neuron development | 0.0371398780115165 |
| GO:0030667 | secretory granule membrane | 0.0385248908208417 |
| GO:0008508 | bile acid:sodium symporter activity | 0.0417582874367942 |
| GO:0004500 | dopamine beta-monooxygenase activity | 0.0417582874367942 |
| GO:0042423 | catecholamine biosynthetic process | 0.0496224120078445 |
| GO:0015125 | bile acid transmembrane transporter activity | 0.0496224120078445 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| migratory neural crest cell | 7.46e-15 | 41 |
| neurectodermal cell | 8.52e-11 | 59 |
| ectodermal cell | 4.40e-09 | 72 |
| Ontology term | p-value | n |
|---|---|---|
| sympathetic nervous system | 7.76e-118 | 5 |
| autonomic nervous system | 7.76e-118 | 5 |
| peripheral nervous system | 3.75e-66 | 8 |
| nervous system | 1.68e-07 | 89 |
| Ontology term | p-value | n |
|---|---|---|
| neuroendocrine tumor | 1.83e-98 | 6 |
| neuroectodermal tumor | 1.10e-59 | 10 |
| germ cell and embryonal cancer | 7.08e-28 | 22 |
| germ cell cancer | 7.08e-28 | 22 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| CTBP2#1488 | 8 | 3.7165629830713 | 0.00153685565965633 | 0.00976977711600508 |
| EP300#2033 | 42 | 2.10744853704722 | 1.16633482712618e-06 | 4.76009546737908e-05 |
| GATA2#2624 | 40 | 3.77627606920118 | 1.00033832709499e-13 | 1.56868370185396e-11 |
| RAD21#5885 | 23 | 1.76419095996663 | 0.00519328683404514 | 0.0240694809470507 |
| REST#5978 | 29 | 2.07296913161269 | 0.000113285334354298 | 0.00155165993896767 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
