MCL coexpression mm9:2287

Phase1 CAGE Peaks

	Short description
Mm9::chr1:137662662..137662752,+	p1@Phlda3
Mm9::chr2:32483932..32483935,+	p10@Ak1
Mm9::chr2:32483938..32483982,+	p2@Ak1
Mm9::chrX:92407127..92407141,-	p1@ENSMUST00000121659

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004017	adenylate kinase activity	0.015953541883526
GO:0019201	nucleotide kinase activity	0.015953541883526
GO:0016776	phosphotransferase activity, phosphate group as acceptor	0.015953541883526
GO:0019205	nucleobase, nucleoside, nucleotide kinase activity	0.015953541883526
GO:0046034	ATP metabolic process	0.015953541883526
GO:0007050	cell cycle arrest	0.015953541883526
GO:0009205	purine ribonucleoside triphosphate metabolic process	0.015953541883526
GO:0009199	ribonucleoside triphosphate metabolic process	0.015953541883526
GO:0009144	purine nucleoside triphosphate metabolic process	0.015953541883526
GO:0009141	nucleoside triphosphate metabolic process	0.015953541883526
GO:0009150	purine ribonucleotide metabolic process	0.0162165123541336
GO:0009259	ribonucleotide metabolic process	0.0162165123541336
GO:0006163	purine nucleotide metabolic process	0.0162165123541336
GO:0045786	negative regulation of progression through cell cycle	0.0236047303378701
GO:0000074	regulation of progression through cell cycle	0.0307042373551989
GO:0009117	nucleotide metabolic process	0.0307042373551989
GO:0051186	cofactor metabolic process	0.0307042373551989
GO:0055086	nucleobase, nucleoside and nucleotide metabolic process	0.0307042373551989

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
migratory neural crest cell	3.72e-07	10
neuron associated cell	3.72e-07	10
glial cell (sensu Vertebrata)	3.72e-07	10
neuron associated cell (sensu Vertebrata)	3.72e-07	10
glial cell	3.72e-07	10
glioblast	3.72e-07	10
glioblast (sensu Vertebrata)	3.72e-07	10

Uber Anatomy

Ontology term	p-value	n
peripheral nervous system	6.06e-07	11

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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